Abstract:
:Recent evidence suggests that parallel synapses from the same axonal branch onto the same dendritic branch have almost identical strength. It has been proposed that this alignment is only possible through learning rules that integrate activity over long time spans. However, learning mechanisms such as spike-timing-dependent plasticity (STDP) are commonly assumed to be temporally local. Here, we propose that the combination of temporally local STDP and a multiplicative synaptic normalization mechanism is sufficient to explain the alignment of parallel synapses. To address this issue, we introduce three increasingly complex models: First, we model the idealized interaction of STDP and synaptic normalization in a single neuron as a simple stochastic process and derive analytically that the alignment effect can be described by a so-called Kesten process. From this we can derive that synaptic efficacy alignment requires potentiation-dominated learning regimes. We verify these conditions in a single-neuron model with independent spiking activities but more realistic synapses. As expected, we only observe synaptic efficacy alignment for long-term potentiation-biased STDP. Finally, we explore how well the findings transfer to recurrent neural networks where the learning mechanisms interact with the correlated activity of the network. We find that due to the self-reinforcing correlations in recurrent circuits under STDP, alignment occurs for both long-term potentiation- and depression-biased STDP, because the learning will be potentiation dominated in both cases due to the potentiating events induced by correlated activity. This is in line with recent results demonstrating a dominance of potentiation over depression during waking and normalization during sleep. This leads us to predict that individual spine pairs will be more similar after sleep compared to after sleep deprivation. In conclusion, we show that synaptic normalization in conjunction with coordinated potentiation--in this case, from STDP in the presence of correlated pre- and post-synaptic activity--naturally leads to an alignment of parallel synapses.
journal_name
Front Neural Circuitsjournal_title
Frontiers in neural circuitsauthors
Hartmann C,Miner DC,Triesch Jdoi
10.3389/fncir.2015.00090subject
Has Abstractpub_date
2016-01-13 00:00:00pages
90issn
1662-5110journal_volume
9pub_type
杂志文章abstract::The characterization of the subthreshold, ongoing activity in cortical neurons has been the focus of numerous studies. This activity, described as spontaneous slow waves in membrane potential, has been observed in a span of species in diverse cortical and subcortical areas. We here characterized membrane potential flu...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00116
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abstract::Fluorescent calcium (Ca(2+)) indicator proteins (FCIPs) are promising tools for functional imaging of cellular activity in living animals. However, they have still not reached their full potential for in vivo imaging of neuronal activity due to limitations in expression levels, dynamic range, and sensitivity for repor...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
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abstract::CORTICAL GABAERGIC INTERNEURONS IN RODENTS ORIGINATE IN THREE SUBCORTICAL REGIONS: the medial ganglionic eminence (MGE), the lateral/caudal ganglionic eminence (LGE/CGE), and the preoptic area (POA). Each of these neuroepithelial precursor domains contributes different interneuron subtypes to the cortex. Neuronal NOS ...
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journal_title:Frontiers in neural circuits
pub_type: 杂志文章
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journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
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journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
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journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2017.00063
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journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2016.00027
更新日期:2016-04-25 00:00:00
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journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00086
更新日期:2018-10-11 00:00:00
abstract::FOXP2 is a transcription factor functionally relevant for learned vocalizations in humans and songbirds. In songbirds, FoxP2 mRNA expression in the medium spiny neurons of the basal ganglia song nucleus Area X is developmentally regulated and varies with singing conditions in different social contexts. How individual ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00024
更新日期:2013-02-28 00:00:00
abstract::A fluorescent voltage sensor protein "Flare" was created from a Kv1.4 potassium channel with YFP situated to report voltage-induced conformational changes in vivo. The RNA virus Sindbis introduced Flare into neurons in the binocular region of visual cortex in rat. Injection sites were selected based on intrinsic optic...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00015
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journal_title:Frontiers in neural circuits
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doi:10.3389/fncir.2018.00118
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abstract:BACKGROUND:Major depressive disorder (MDD) is a public health problem worldwide. There is increasing interest in using non-invasive therapies such as repetitive transcranial magnetic stimulation (rTMS) to treat MDD. However, the changes induced by rTMS on neural circuits remain poorly characterized. The present study a...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00050
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journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2016.00101
更新日期:2016-12-15 00:00:00
abstract::Genetic programs controlling ontogeny drive many of the essential connectivity patterns within the brain. Yet it is activity, derived from the experience of interacting with the world, that sculpts the precise circuitry of the central nervous system. Such experience-dependent plasticity has been observed throughout th...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2014.00123
更新日期:2014-10-02 00:00:00
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journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2014.00057
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journal_title:Frontiers in neural circuits
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journal_title:Frontiers in neural circuits
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journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00207
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journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
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更新日期:2014-07-04 00:00:00
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journal_title:Frontiers in neural circuits
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doi:10.3389/fncir.2015.00046
更新日期:2015-09-01 00:00:00
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journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00091
更新日期:2016-02-01 00:00:00
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journal_title:Frontiers in neural circuits
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journal_title:Frontiers in neural circuits
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journal_title:Frontiers in neural circuits
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pub_type: 杂志文章,评审
doi:10.3389/fncir.2018.00114
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