Two-photon imaging with diffractive optical elements.

abstract：:MRI has been extensively used in neurodegenerative disorders, such as Alzheimer's disease (AD), frontal-temporal dementia (FTD), mild cognitive impairment (MCI), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). MRI is important for monitoring the neurodegenerative components...

journal_title：Frontiers in neural circuits

authors： Saar G,Koretsky AP

更新日期：2019-01-07 00:00:00

abstract：:The brain contains a large diversity of unique cell types that use specific genetic programs to control development and instruct the intricate wiring of sensory, motor, and cognitive brain regions. In addition to their cellular diversity and specialized connectivity maps, each region's dedicated function is also expre...

journal_title：Frontiers in neural circuits

authors： Miterko LN,Lackey EP,Heck DH,Sillitoe RV

更新日期：2018-10-10 00:00:00

abstract：:Complex spatial representations in the hippocampal formation and related cortical areas require input from the head direction system. However, a recurrent finding is that behavior apparently supported by these spatial representations does not appear to require input from generative head direction regions, i.e., latera...

journal_title：Frontiers in neural circuits

authors： Dillingham CM,Vann SD

更新日期：2019-09-13 00:00:00

abstract：:Optogenetic stimulation of the mouse cortex can be used to generate motor maps that are similar to maps derived from electrode-based stimulation. Here we present a refined set of procedures for repeated light-based motor mapping in ChR2-expressing mice implanted with a bilateral thinned-skull chronic window and a chro...

journal_title：Frontiers in neural circuits

authors： Silasi G,Boyd JD,Ledue J,Murphy TH

更新日期：2013-07-25 00:00:00

abstract：:In this study, we explore the functional role of striatal cholinergic interneurons, hereinafter referred to as tonically active neurons (TANs), via computational modeling; specifically, we investigate the mechanistic relationship between TAN activity and dopamine variations and how changes in this relationship affect ...

journal_title：Frontiers in neural circuits

authors： Kim T,Capps RA,Hamade KC,Barnett WH,Todorov DI,Latash EM,Markin SN,Rybak IA,Molkov YI

更新日期：2019-02-21 00:00:00

abstract：:Mitral and tufted cells (MTCs) of the mammalian olfactory bulb are connected via dendrodendritic synapses with inhibitory interneurons in the external plexiform layer. The range, spatial layout, and temporal properties of inhibitory interactions between MTCs mediated by inhibitory interneurons remain unclear. Therefor...

journal_title：Frontiers in neural circuits

authors： Lehmann A,D'Errico A,Vogel M,Spors H

更新日期：2016-03-22 00:00:00

abstract：:Both abnormalities of resting-state cerebral blood flow (CBF) and functional connectivity in Wilson's disease (WD) have been identified by several studies. Whether the coupling of CBF and functional connectivity is imbalanced in WD remains largely unknown. To assess this possibility, 27 patients with WD and 27 sex- an...

journal_title：Frontiers in neural circuits

authors： Hu S,Wu H,Xu C,Wang A,Wang Y,Shen T,Huang F,Kan H,Li C

更新日期：2019-04-18 00:00:00

abstract：:mRNP granules at adult central synapses are postulated to regulate local mRNA translation and synapse plasticity. However, they are very poorly characterized in vivo. Here, in Drosophila olfactory synapses, we present early observations and characterization of candidate synaptic mRNP particles, one of which contains a...

journal_title：Frontiers in neural circuits

authors： Hillebrand J,Pan K,Kokaram A,Barbee S,Parker R,Ramaswami M

更新日期：2010-11-03 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fncir.2018.00028.]. ...

journal_title：Frontiers in neural circuits

authors： Wen TC,Lall S,Pagnotta C,Markward J,Gupta D,Ratnadurai-Giridharan S,Bucci J,Greenwald L,Klugman M,Hill NJ,Carmel JB

更新日期：2018-09-25 00:00:00

abstract：:We investigate the importance of the degree of peripheral or central target differentiation for mouse auditory afferent navigation to the organ of Corti and auditory nuclei in three different mouse models: first, a mouse in which the differentiation of hair cells, but not central auditory nuclei neurons is compromised...

journal_title：Frontiers in neural circuits

authors： Elliott KL,Kersigo J,Pan N,Jahan I,Fritzsch B

更新日期：2017-04-13 00:00:00

abstract：:"Dye-coupling", whole-mount immunohistochemistry for gap junction channel protein connexin 35 (Cx35), and freeze-fracture replica immunogold labeling (FRIL) reveal an abundance of electrical synapses/gap junctions at glutamatergic mixed synapses in the 14th spinal segment that innervates the adult male gonopodium of W...

journal_title：Frontiers in neural circuits

authors： Serrano-Velez JL,Rodriguez-Alvarado M,Torres-Vazquez II,Fraser SE,Yasumura T,Vanderpool KG,Rash JE,Rosa-Molinar E

更新日期：2014-06-26 00:00:00

abstract：:The goal of sensory neuroscience is to understand how the brain creates its myriad of representations of the world, and uses these representations to produce perception and behavior. Circuits of neurons in spatially segregated regions of brain tissue have distinct functional specializations, and these regions are conn...

journal_title：Frontiers in neural circuits

authors： Zavitz E,Price NSC

更新日期：2019-01-09 00:00:00

abstract：:The firing rates of neurons in primate motor cortex have been related to multiple parameters of voluntary movement. This finding has been corroborated by stimulation-based studies that have mapped complex movements in rodent and primate motor cortex. However, it has been difficult to link the movement tuning of a neur...

journal_title：Frontiers in neural circuits

authors： Harrison TC,Murphy TH

更新日期：2013-01-18 00:00:00

abstract：:Since the discovery of grid cells in rat entorhinal cortex, many models of their hexagonally arrayed spatial firing fields have been suggested. We review the models and organize them according to the mechanisms they use to encode position, update the positional code, read it out in the spatial grid pattern, and learn ...

journal_title：Frontiers in neural circuits

authors： Zilli EA

更新日期：2012-04-18 00:00:00

abstract：:A moving visual figure may contain first-order signals defined by variation in mean luminance, as well as second-order signals defined by constant mean luminance and variation in luminance envelope, or higher-order signals that cannot be estimated by taking higher moments of the luminance distribution. Separating thes...

journal_title：Frontiers in neural circuits

authors： Aptekar JW,Keles MF,Mongeau JM,Lu PM,Frye MA,Shoemaker PA

更新日期：2014-10-31 00:00:00

abstract：:Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to be synthesized and released from GABAergic neurons in the brain. However, recent studies have shown that not only neurons but also astrocytes contain a considerable amount of GABA that can be released and activate GABA receptors ...

journal_title：Frontiers in neural circuits

authors： Yoon BE,Lee CJ

更新日期：2014-12-17 00:00:00

abstract：:Defensive behavioral responses are essential for survival in threating situations. The superior colliculus (SC) has been implicated in the generation of defensive behaviors elicited by visual, tactile and auditory stimuli. Furthermore, substantia nigra pars reticulata (SNr) neurons are known to exert a modulatory effe...

journal_title：Frontiers in neural circuits

authors： Almada RC,Genewsky AJ,Heinz DE,Kaplick PM,Coimbra NC,Wotjak CT

更新日期：2018-05-07 00:00:00

abstract：:In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify crucial features and...

journal_title：Frontiers in neural circuits

authors： Puig MV,Rose J,Schmidt R,Freund N

更新日期：2014-08-05 00:00:00

abstract：:Multiple components of "γ-oscillations" between 30-170 Hz in the CA1 region of the hippocampus have been described, based on their coherence with oscillations in other brain regions and on their cross-frequency coupling with local θ-oscillations. However, it remains unclear whether the different sub-bands are generate...

journal_title：Frontiers in neural circuits

authors： Balakrishnan S,Pearce RA

更新日期：2015-01-12 00:00:00

abstract：:[This corrects the article on p. 33 in vol. 8, PMID: 24782714.]. ...

journal_title：Frontiers in neural circuits

authors： Noudoost B,Clark KL

更新日期：2014-12-02 00:00:00

abstract：:Fluorescent calcium (Ca(2+)) indicator proteins (FCIPs) are promising tools for functional imaging of cellular activity in living animals. However, they have still not reached their full potential for in vivo imaging of neuronal activity due to limitations in expression levels, dynamic range, and sensitivity for repor...

journal_title：Frontiers in neural circuits

authors： Lütcke H,Murayama M,Hahn T,Margolis DJ,Astori S,Zum Alten Borgloh SM,Göbel W,Yang Y,Tang W,Kügler S,Sprengel R,Nagai T,Miyawaki A,Larkum ME,Helmchen F,Hasan MT

更新日期：2010-04-29 00:00:00

abstract：:Serotonin (5-HT) selectively excites subpopulations of pyramidal neurons in the neocortex via activation of 5-HT2A (2A) receptors coupled to Gq subtype G-protein alpha subunits. Gq-mediated excitatory responses have been attributed primarily to suppression of potassium conductances, including those mediated by KV7 pot...

journal_title：Frontiers in neural circuits

authors： Stephens EK,Baker AL,Gulledge AT

更新日期：2018-01-18 00:00:00

abstract：:Local field potentials (LFPs) in cortex reflect synchronous fluctuations in the synaptic activity of local populations of neurons. The power of high frequency (>30 Hz) oscillations in LFPs is locked to the phase of low frequency (<30 Hz) oscillations, an effect known as phase-amplitude coupling (PAC). While PAC has be...

journal_title：Frontiers in neural circuits

authors： Esghaei M,Daliri MR,Treue S

更新日期：2015-12-22 00:00:00

abstract：:The olfactory system has a unique capacity for recovery from peripheral damage. After injury to the olfactory epithelium (OE), olfactory sensory neurons (OSNs) regenerate and re-converge on target glomeruli of the olfactory bulb (OB). Thus far, this process has been described anatomically for only a few defined popula...

journal_title：Frontiers in neural circuits

authors： Cheung MC,Jang W,Schwob JE,Wachowiak M

更新日期：2014-01-07 00:00:00

abstract：:The delay eyeblink conditioning (EBC) is a cerebellum-dependent type of associative motor learning. However, the exact roles played by the various cerebellar synapses, as well as the underlying molecular mechanisms, remain to be determined. It is also unclear whether long-term potentiation (LTP) or long-term depressio...

journal_title：Frontiers in neural circuits

authors： Emi K,Kakegawa W,Miura E,Ito-Ishida A,Kohda K,Yuzaki M

更新日期：2013-11-15 00:00:00

abstract：:Research efforts over the past decades have unraveled both genetic and environmental factors, which contribute to the development of autism spectrum disorders (ASD). It is, to date, largely unknown how different underlying causes result in a common phenotype. However, the individual course of development and the diffe...

journal_title：Frontiers in neural circuits

authors： Schoen M,Asoglu H,Bauer HF,Müller HP,Abaei A,Sauer AK,Zhang R,Song TJ,Bockmann J,Kassubek J,Rasche V,Grabrucker AM,Boeckers TM

更新日期：2019-02-22 00:00:00

abstract：:One of the large remaining challenges in the field of zebrafish neuroscience is the establishment of techniques and preparations that permit the recording and perturbation of neural activity in animals that can interact meaningfully with the environment. Since it is very difficult to do this in freely behaving zebrafi...

journal_title：Frontiers in neural circuits

authors： Engert F

更新日期：2013-01-25 00:00:00

abstract：:The perirhinal (PER) and entorhinal cortex (EC) receive input from the agranular insular cortex (AiP) and the subcortical lateral amygdala (LA) and the main output area is the hippocampus. Information transfer through the PER/EC network however, is not always guaranteed. It is hypothesized that this network actively r...

journal_title：Frontiers in neural circuits

authors： Willems JG,Wadman WJ,Cappaert NL

更新日期：2016-06-14 00:00:00

abstract：:How do local circuits in the inferior colliculus (IC) process and transform spectral and temporal sound information? Using a four-tetrode array we examined the functional properties of the IC and metrics of its micro circuitry by recording neural activity from neighboring single neurons in the cat. Spectral and tempor...

journal_title：Frontiers in neural circuits

authors： Chen C,Rodriguez FC,Read HL,Escabí MA

更新日期：2012-09-27 00:00:00

abstract：:The integration of the visual stimulus takes place at the level of the neocortex, organized in anatomically distinct and functionally unique areas. Primates, including humans, are heavily dependent on vision, with approximately 50% of their neocortical surface dedicated to visual processing and possess many more visua...

journal_title：Frontiers in neural circuits

authors： Homman-Ludiye J,Bourne JA

更新日期：2014-07-04 00:00:00