Severe colitis associated with docetaxel use: A report of four cases.

Abstract:

:Diarrhea is a common side effect of chemotherapy. Pseudomembranous colitis is a well known complication of antibiotic treatment that can also be observed, albeit rarely, with certain chemotherapeutic agents. We present four cases of severe colitis in patients undergoing treatment with taxane-based chemotherapy for pancreatic, lung and breast cancer. None of them had recently received antibiotics. One patient presented with a bowel perforation and three had endoscopic findings of pseudomembranous colitis. Two of these three patients had negative stool toxin assays for Clostridium difficile. In the patient presenting with perforation, an emergency left hemicolectomy was performed and the pathological findings in the colon were acute inflammation and ischemic necrosis; the other three patients were treated with oral vancomycin and/or oral or intravenous metronidazole leading to complete resolution of the symptoms. Apart from pseudomembranous colitis, we describe patients presenting with neutropenic enterocolitis as well as ischemic colitis after docetaxel use. These cases provide some insight into the spectrum and varied clinical presentations of severe colitis associated with taxane-based chemotherapy.

authors

Carrion AF,Hosein PJ,Cooper EM,Lopes G,Pelaez L,Rocha-Lima CM

doi

10.4251/wjgo.v2.i10.390

subject

Has Abstract

pub_date

2010-10-15 00:00:00

pages

390-4

issue

10

issn

1948-5204

journal_volume

2

pub_type

杂志文章
  • C-reactive protein may be a prognostic factor for the whole gastroenteropancreatic neuroendocrine tumor group.

    abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) are a kind of single-stranded RNA of more than 200 nucleotides in length and have no protein-coding function. Amounting studies have indicated that lncRNAs could play a vital role in the initiation and development of cancers, including gastric cancer (GC). Considering the cruci...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v11.i2.139

    authors: Komaç Ö,Bengi G,Sağol Ö,Akarsu M

    更新日期:2019-02-15 00:00:00

  • Potential of casein kinase I in digestive cancer screening.

    abstract::Casein kinase I is a group of ubiquitous Serine/Threonine kinases that have been implicated in both normal cellular functions and several pathological conditions including Alzheimer's disease and cancer. Recent findings in colon and pancreatic cancer have brought tremendous attention to these molecules as potential th...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v1.i1.26

    authors: Modak C,Chai J

    更新日期:2009-10-15 00:00:00

  • Do the benefits outweigh the side effects of colorectal cancer surveillance? A systematic review.

    abstract::Most patients treated with curative intent for colorectal cancer (CRC) are included in a follow-up program involving periodic evaluations. The survival benefits of a follow-up program are well delineated, and previous meta-analyses have suggested an overall survival improvement of 5%-10% by intensive follow-up. Howeve...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v6.i5.104

    authors: Augestad KM,Rose J,Crawshaw B,Cooper G,Delaney C

    更新日期:2014-05-15 00:00:00

  • Clinical significance of SQSTM1/P62 and nuclear factor-κB expression in pancreatic carcinoma.

    abstract:BACKGROUND:Overexpression of SQSTM1 (sequestosome 1, P62) and nuclear factor-κB (NF-κB) plays an important role in the invasion and metastasis of a variety of malignant tumors. AIM:To explore the expression of P62 and NF-κB in pancreatic cancer and their relationship with clinicopathological features. METHODS:The exp...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v12.i7.719

    authors: Zhang ZY,Guo S,Zhao R,Ji ZP,Zhuang ZN

    更新日期:2020-07-15 00:00:00

  • Gastric submucosa-invasive carcinoma associated with Epstein-Barr virus and endoscopic submucosal dissection: A case report.

    abstract:BACKGROUND:Epstein-Barr virus (EBV)-associated carcinoma is a gastric cancer subtype with a morphology characterized by gastric carcinoma with lymphoid stroma (GCLS). Clinicopathological studies have indicated a better prognosis for GCLS than for common gastric carcinomas. Some previous cases of early gastric cancer as...

    journal_title:World journal of gastrointestinal oncology

    pub_type:

    doi:10.4251/wjgo.v11.i10.925

    authors: Kobayashi Y,Kunogi T,Tanabe H,Murakami Y,Iwama T,Sasaki T,Takahashi K,Ando K,Nomura Y,Ueno N,Kashima S,Moriichi K,Takei H,Fujiya M,Okumura T

    更新日期:2019-10-15 00:00:00

  • Pathological aspects of so called "hilar cholangiocarcinoma".

    abstract::Cholangiocarcinoma (CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group. However, "hilar and perihilar CC" are also used to refer exclusively to the intrahepatic hilar type CC or, more commonly, t...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v5.i7.159

    authors: Castellano-Megías VM,Ibarrola-de Andrés C,Colina-Ruizdelgado F

    更新日期:2013-07-15 00:00:00

  • Extrapancreatic solid pseudopapillary neoplasm followed by multiple metastases: Case report.

    abstract::Solid pseudopapillary neoplasm (SPN), also known as Gruber-Frantz tumor, is a rare form of neoplasm that almost exclusively occurs in the pancreas and in young females. While the potential of malignancy is low for SPN, these tumors can mimic other diseases and require a meticulous investigation and a standard treatmen...

    journal_title:World journal of gastrointestinal oncology

    pub_type:

    doi:10.4251/wjgo.v9.i12.497

    authors: Wu H,Huang YF,Liu XH,Xu MH

    更新日期:2017-12-15 00:00:00

  • Emerging molecular targets and therapy for cholangiocarcinoma.

    abstract::Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v9.i7.268

    authors: Kayhanian H,Smyth EC,Braconi C

    更新日期:2017-07-15 00:00:00

  • Markers of bile duct tumors.

    abstract::Biliary tract carcinomas are relatively rare, representing less than 1% of cancers. However, their incidence has increased in Japan and in industrialized countries like the USA. Biliary tract tumors have a poor prognosis and a high mortality rate because they are usually detected late in the course of the disease; the...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v3.i4.49

    authors: Malaguarnera G,Giordano M,Paladina I,Rando A,Uccello M,Basile F,Biondi A,Carnazzo S,Alessandria I,Mazzarino C

    更新日期:2011-04-15 00:00:00

  • Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer.

    abstract:AIM:To study tumor response, and tolerability of arterially directed embolic therapy (ADET) with polyethylene glycol embolics loaded with irinotecan for the treatment of colorectal cancer liver metastases (CRC-LM). Secondary objectives were to monitor quality of life, time to progression and survival of patients. METH...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v9.i9.379

    authors: Fiorentini G,Carandina R,Sarti D,Nardella M,Zoras O,Guadagni S,Inchingolo R,Nestola M,Felicioli A,Barnes Navarro D,Munoz Gomez F,Aliberti C

    更新日期:2017-09-15 00:00:00

  • Status of colitis-associated cancer in ulcerative colitis.

    abstract::Surgical therapy for ulcerative colitis (UC) depends on the medical therapy administered for the patient's condition. UC is a benign disease. However, it has been reported that the rare cases of cancer in UC patients are increasing, and such cases have a worse prognosis. Recently, surgical therapy has greatly changed,...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v8.i4.351

    authors: Kinugasa T,Akagi Y

    更新日期:2016-04-15 00:00:00

  • Gastrointestinal neuroendocrine tumors in 2020.

    abstract::Gastrointestinal neuroendocrine tumors are rare slow-growing tumors with distinct histological, biological, and clinical characteristics that have increased in incidence and prevalence within the last few decades. They contain chromogranin A, synaptophysin and neuron-specific enolase which are necessary for making a d...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v12.i8.791

    authors: Ahmed M

    更新日期:2020-08-15 00:00:00

  • Efficacy and safety of intraoperative radiotherapy in rectal cancer: A systematic review and meta-analysis.

    abstract:BACKGROUND:In recent years, intraoperative radiotherapy (IORT) has been increasingly used for the treatment of rectal cancer. However, the efficacy and safety of IORT for the treatment of rectal cancer are still controversial. AIM:To evaluate the value of IORT for patients with rectal cancer. METHODS:We searched PubM...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v13.i1.69

    authors: Liu B,Ge L,Wang J,Chen YQ,Ma SX,Ma PL,Zhang YQ,Yang KH,Cai H

    更新日期:2021-01-15 00:00:00

  • Endoscopic approach to the diagnosis of pancreatic cystic tumor.

    abstract::Because of the aging of the population, prevalence of medical checkups, and advances in imaging studies, the number of pancreatic cystic lesions detected has increased. Once these lesions are detected, neoplastic cysts should be differentiated from non-neoplastic cysts. Furthermore, because of the malignant potential ...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v8.i2.159

    authors: Kawaguchi Y,Mine T

    更新日期:2016-02-15 00:00:00

  • Novel therapeutic agents in the treatment of metastatic colorectal cancer.

    abstract::Over the past couple of decades considerable progress has been made in the management of metastatic colorectal cancers (mCRC) leading to a significant improvement in five-year survival. Although part of this success has been rightly attributed to aggressive surgical management and advances in other adjunct treatments,...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v8.i1.99

    authors: Pai SG,Fuloria J

    更新日期:2016-01-15 00:00:00

  • Multiple solid pancreatic hamartomas: A case report and review of the literature.

    abstract::Non-neoplastic tumor-like lesions in the pancreas are uncommon. Here, we present a case of multiple solid pancreatic hamartomas in a 78-year-old Japanese woman. Her computed tomography revealed a pancreatic mass, measuring 1.8 cm in maximum diameter. However, no symptoms were found. She was not an alcoholic and had no...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v4.i9.202

    authors: Kawakami F,Shimizu M,Yamaguchi H,Hara S,Matsumoto I,Ku Y,Itoh T

    更新日期:2012-09-15 00:00:00

  • Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation.

    abstract::Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stomach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distensi...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v5.i12.222

    authors: Ulla M,Gentile E,Yeyati EL,Diez ML,Cavadas D,Garcia-Monaco RD,Ros PR

    更新日期:2013-12-15 00:00:00

  • Hypofractionated particle beam therapy for hepatocellular carcinoma-a brief review of clinical effectiveness.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the second leading cause of cancer mortality worldwide. The cornerstone to improving the prognosis of HCC patients has been the control of loco-regional disease progression and the lesser toxicities of local treatment. Although radiotherapy has not...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v11.i8.579

    authors: Hsu CY,Wang CW,Cheng AL,Kuo SH

    更新日期:2019-08-15 00:00:00

  • From traditional serrated adenoma to tubulovillous adenoma and beyond.

    abstract::It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous adenomas (VA/TVA), sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA). Of these, TSAs are least common and account for only 5% of all serrated poly...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v8.i12.805

    authors: Kalimuthu SN,Chelliah A,Chetty R

    更新日期:2016-12-15 00:00:00

  • Epigenetic reduction of DNA repair in progression to gastrointestinal cancer.

    abstract::Deficiencies in DNA repair due to inherited germ-line mutations in DNA repair genes cause increased risk of gastrointestinal (GI) cancer. In sporadic GI cancers, mutations in DNA repair genes are relatively rare. However, epigenetic alterations that reduce expression of DNA repair genes are frequent in sporadic GI can...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v7.i5.30

    authors: Bernstein C,Bernstein H

    更新日期:2015-05-15 00:00:00

  • Primary esophageal diffuse large B cell lymphoma presenting with tracheoesophageal fistula: A rare case and review.

    abstract::Primary non-Hodgkin lymphomas in the esophagus are rare. Tracheoesophageal fistulas mainly arise from solid esophageal carcinoma or mediastinal malignancies. Our patient presented with cough, dysphagia and weight loss, and upon initial computed tomography imaging and esophagogastroduodenoscopy, a malignant mass in the...

    journal_title:World journal of gastrointestinal oncology

    pub_type:

    doi:10.4251/wjgo.v9.i10.431

    authors: Teerakanok J,DeWitt JP,Juarez E,Thein KZ,Warraich I

    更新日期:2017-10-15 00:00:00

  • Perioperative treatment options in resectable pancreatic cancer - how to improve long-term survival.

    abstract::Surgery remains the only chance of cure for pancreatic cancer, but only 15%-25% of patients present with resectable disease at the time of primary diagnosis. Important goals in clinical research must therefore be to allow early detection with suitable diagnostic procedures, to further broaden operation techniques and ...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v8.i3.248

    authors: Sinn M,Bahra M,Denecke T,Travis S,Pelzer U,Riess H

    更新日期:2016-03-15 00:00:00

  • Current status of robot-assisted gastric surgery.

    abstract::In an effort to minimize the limitations of laparoscopy, a robotic surgery system was introduced, but its role for gastric cancer is still unclear. The objective of this article is to assess the current status of robotic surgery for gastric cancer and to predict future prospects. Although the current study was limited...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v3.i10.137

    authors: Baek SJ,Lee DW,Park SS,Kim SH

    更新日期:2011-10-15 00:00:00

  • Prognostic scoring system for synchronous brain metastasis at diagnosis of colorectal cancer: A population-based study.

    abstract:BACKGROUND:Brain metastasis (BM) from colorectal cancer (CRC) is rarely encountered clinically, and its prognosis has not been fully evaluated. AIM:To construct a scoring system and accurately predict the survival of patients with synchronous BM at diagnosis of CRC. METHODS:A retrospective study of 371 patients with ...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v12.i2.195

    authors: Quan JC,Guan X,Ma CX,Liu Z,Yang M,Zhao ZX,Sun P,Zhuang M,Wang S,Jiang Z,Wang XS

    更新日期:2020-02-15 00:00:00

  • Epigenetic field defects in progression to cancer.

    abstract::A field defect is a field of pre-malignant tissue in which a new cancer is likely to arise. Field defects often appear to be histologically normal under the microscope. Recent research indicates that cells within a field defect characteristically have an increased frequency of epigenetic alterations and these may be f...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v5.i3.43

    authors: Bernstein C,Nfonsam V,Prasad AR,Bernstein H

    更新日期:2013-03-15 00:00:00

  • Ileal inflammatory fibroid polyp causing chronic ileocolic intussusception and mimicking cecal carcinoma.

    abstract::Inflammatory fibroid polyp (IFP) is a rare, idiopathic pseudotumorous lesion of the gastrointestinal tract. While mostly reported as solitary gastric lesions, multiple cases of small bowel IFPs are also reported. It is a documented cause of intussusception in adults. In the case reports of ileal inflammatory fibroid p...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v1.i1.89

    authors: Gara N,Falzarano JS,Limm WM,Namiki TS,Tom LK

    更新日期:2009-10-15 00:00:00

  • Isolated pancreatic metastasis of hepatocellular carcinoma after curative resection.

    abstract::Hepatocellular carcinoma (HCC) is a highly malignant tumor and extrahepatic metastasis is not rare. The most common organ of HCC metastasis is lung, followed by bone and adrenal gland. To the best of our knowledge, isolated pancreatic metastasis of HCC that developed after curative resection has not been described pre...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v2.i4.209

    authors: Woo SM,Park JW,Han SS,Choi JI,Lee WJ,Park SJ,Hong EK,Kim CM

    更新日期:2010-04-15 00:00:00

  • Precision medicine for gastrointestinal cancer: Recent progress and future perspective.

    abstract::Gastrointestinal (GI) cancer has a high tumor incidence and mortality rate worldwide. Despite significant improvements in radiotherapy, chemotherapy, and targeted therapy for GI cancer over the last decade, GI cancer is characterized by high recurrence rates and a dismal prognosis. There is an urgent need for new diag...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v12.i1.1

    authors: Matsuoka T,Yashiro M

    更新日期:2020-01-15 00:00:00

  • Carcinogenesis and chemoprevention of biliary tract cancer in pancreaticobiliary maljunction.

    abstract::Pancreaticobiliary maljunction (PBM) is a high risk factor for biliary tract cancer. In PBM, since the pancreatic duct and bile duct converge outside the duodenal wall beyond the influence of the sphincter of Oddi, pancreatic juice and bile are constantly mixed, producing a variety of harmful substances. Because of th...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v2.i3.130

    authors: Tsuchida A,Itoi T

    更新日期:2010-03-15 00:00:00

  • Pathology handling of pancreatoduodenectomy specimens: Approaches and controversies.

    abstract::Pancreatic cancer, with a 5% 5-year survival rate, is the fourth leading cause of cancer death in Western countries. Unfortunately, only 20% of all patients benefit from surgical treatment. The need to prolong survival has prompted pathologists to develop improved protocols to evaluate pancreatic specimens and their s...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v6.i9.351

    authors: Gómez-Mateo Mdel C,Sabater-Ortí L,Ferrández-Izquierdo A

    更新日期:2014-09-15 00:00:00