Novel therapeutic agents in the treatment of metastatic colorectal cancer.

abstract：:It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous adenomas (VA/TVA), sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA). Of these, TSAs are least common and account for only 5% of all serrated poly...

journal_title：World journal of gastrointestinal oncology

authors： Kalimuthu SN,Chelliah A,Chetty R

更新日期：2016-12-15 00:00:00

abstract：:Primary non-Hodgkin lymphomas in the esophagus are rare. Tracheoesophageal fistulas mainly arise from solid esophageal carcinoma or mediastinal malignancies. Our patient presented with cough, dysphagia and weight loss, and upon initial computed tomography imaging and esophagogastroduodenoscopy, a malignant mass in the...

journal_title：World journal of gastrointestinal oncology

authors： Teerakanok J,DeWitt JP,Juarez E,Thein KZ,Warraich I

更新日期：2017-10-15 00:00:00

abstract：:Gastric metastases from lung adenocarcinoma are rare. Because gastric metastasis grossly resembles advanced gastric cancer, it is difficult to diagnose gastric metastasis especially when the histology of the primary lung cancer is adenocarcinoma. We describe a case of gastric metastasis from primary lung adenocarcinom...

journal_title：World journal of gastrointestinal oncology

authors： Kim MJ,Hong JH,Park ES,Byun JH

更新日期：2015-03-15 00:00:00

abstract：:Despite significant advances in imaging techniques, the incidence of colorectal cancer has been increasing in recent years, with many cases still being diagnosed in advanced stages. Early detection and accurate staging remain the main factors that lead to a decrease in the cost and invasiveness of the curative techniq...

journal_title：World journal of gastrointestinal oncology

authors： Ciocalteu A,Gheonea DI,Saftoiu A,Streba L,Dragoescu NA,Tenea-Cojan TS

更新日期：2018-12-15 00:00:00

abstract：:Pancreatic surgery for malignancy is recognized as challenging for the surgeons and risky for the patients due to consistent perioperative morbidity and mortality. Furthermore, the oncological long-term results are largely disappointing, even for those patients who experience an uneventfully hospital stay. Nevertheles...

journal_title：World journal of gastrointestinal oncology

authors： Bencini L,Annecchiarico M,Farsi M,Bartolini I,Mirasolo V,Guerra F,Coratti A

更新日期：2015-12-15 00:00:00

abstract：:Pancreatic adenocarcinoma is the fourth cause of cancer-related death in the United States. Surgery is the only potentially curative treatment, but most patients present at diagnosis with unresectable or metastatic disease. Moreover, even with an R0 resection, the majority of patients will die of disease recurrence. M...

journal_title：World journal of gastrointestinal oncology

authors： Sperti C,Moletta L,Merigliano S

更新日期：2015-12-15 00:00:00

abstract：AIM:To correct the misclassification in registered gastric cancer incidence across Iranian provinces in cancer registry data. METHODS:Gastric cancer data is extracted from Iranian annual of national cancer registration report 2008. A Bayesian method with beta prior is implemented to estimate the rate of misclassificat...

journal_title：World journal of gastrointestinal oncology

authors： Hajizadeh N,Pourhoseingholi MA,Baghestani AR,Abadi A,Zali MR

更新日期：2017-02-15 00:00:00

abstract：:Colorectal carcinogenesis (CRC) imposes a major health burden in developing countries. It is the third major cause of cancer deaths. Despite several treatment strategies, novel drugs are warranted to reduce the severity of this disease. Adenomatous polyps in the colon are the major culprits in CRC and found in 45% of ...

journal_title：World journal of gastrointestinal oncology

authors： Pandurangan AK,Divya T,Kumar K,Dineshbabu V,Velavan B,Sudhandiran G

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:Pathological manifestations of hepatic tumours are often associated with prognosis. Although surgical specimens (SS) can provide more information, currently, pre-treatment needle core biopsy (NCB) is increasingly showing important value in understanding the nature of liver tumors and even in diagnosis and tr...

journal_title：World journal of gastrointestinal oncology

authors： Wu JS,Feng JL,Zhu RD,Liu SG,Zhao DW,Li N

更新日期：2019-05-15 00:00:00

abstract：:Biliary tract carcinomas are relatively rare, representing less than 1% of cancers. However, their incidence has increased in Japan and in industrialized countries like the USA. Biliary tract tumors have a poor prognosis and a high mortality rate because they are usually detected late in the course of the disease; the...

journal_title：World journal of gastrointestinal oncology

authors： Malaguarnera G,Giordano M,Paladina I,Rando A,Uccello M,Basile F,Biondi A,Carnazzo S,Alessandria I,Mazzarino C

更新日期：2011-04-15 00:00:00

abstract：:Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival outcomes. Positive peritoneal cytology similarly worsens the survival of patients with gastric cancer and treatment options for these patients have been limite...

journal_title：World journal of gastrointestinal oncology

authors： Leiting JL,Grotz TE

更新日期：2018-10-15 00:00:00

abstract：:Deficiencies in DNA repair due to inherited germ-line mutations in DNA repair genes cause increased risk of gastrointestinal (GI) cancer. In sporadic GI cancers, mutations in DNA repair genes are relatively rare. However, epigenetic alterations that reduce expression of DNA repair genes are frequent in sporadic GI can...

journal_title：World journal of gastrointestinal oncology

authors： Bernstein C,Bernstein H

更新日期：2015-05-15 00:00:00

abstract：:Pancreaticobiliary maljunction (PBM) is a high risk factor for biliary tract cancer. In PBM, since the pancreatic duct and bile duct converge outside the duodenal wall beyond the influence of the sphincter of Oddi, pancreatic juice and bile are constantly mixed, producing a variety of harmful substances. Because of th...

journal_title：World journal of gastrointestinal oncology

authors： Tsuchida A,Itoi T

更新日期：2010-03-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the second leading cause of cancer mortality worldwide. The cornerstone to improving the prognosis of HCC patients has been the control of loco-regional disease progression and the lesser toxicities of local treatment. Although radiotherapy has not...

journal_title：World journal of gastrointestinal oncology

authors： Hsu CY,Wang CW,Cheng AL,Kuo SH

更新日期：2019-08-15 00:00:00

abstract：AIM:To identify genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer patients. METHODS:The NEIL1 promoter region in DNA from 80 Japanese patients with gastric cancer was searched for genetic polymorphisms by polymerase chain reaction-single-strand conformation pol...

journal_title：World journal of gastrointestinal oncology

authors： Goto M,Shinmura K,Tao H,Tsugane S,Sugimura H

更新日期：2010-02-15 00:00:00

abstract：:Gastric cancer is the third leading cause of cancer death worldwide. Even though during these last decades gastric cancer incidence decreased in Western countries, it remains endemic and with a high incidence in Eastern countries. The survival in advanced and metastatic stage of gastric cancer is still very poor. Rece...

journal_title：World journal of gastrointestinal oncology

authors： Satolli MA,Buffoni L,Spadi R,Roato I

更新日期：2015-11-15 00:00:00

abstract：:Most patients treated with curative intent for colorectal cancer (CRC) are included in a follow-up program involving periodic evaluations. The survival benefits of a follow-up program are well delineated, and previous meta-analyses have suggested an overall survival improvement of 5%-10% by intensive follow-up. Howeve...

journal_title：World journal of gastrointestinal oncology

authors： Augestad KM,Rose J,Crawshaw B,Cooper G,Delaney C

更新日期：2014-05-15 00:00:00

abstract：AIM:To study tumor response, and tolerability of arterially directed embolic therapy (ADET) with polyethylene glycol embolics loaded with irinotecan for the treatment of colorectal cancer liver metastases (CRC-LM). Secondary objectives were to monitor quality of life, time to progression and survival of patients. METH...

journal_title：World journal of gastrointestinal oncology

authors： Fiorentini G,Carandina R,Sarti D,Nardella M,Zoras O,Guadagni S,Inchingolo R,Nestola M,Felicioli A,Barnes Navarro D,Munoz Gomez F,Aliberti C

更新日期：2017-09-15 00:00:00

abstract：:Adenocarcinoma of small intestines (SBA) is a relatively rare malignancy with poor outcomes due to delayed diagnosis. Fifty percent of patients have metastases on presentation and therefore early detection and treatment offers the best long term outcomes. Certain genetic polyposis syndromes and familial diseases are a...

journal_title：World journal of gastrointestinal oncology

authors： Shenoy S

更新日期：2016-06-15 00:00:00

abstract：:Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stomach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distensi...

journal_title：World journal of gastrointestinal oncology

authors： Ulla M,Gentile E,Yeyati EL,Diez ML,Cavadas D,Garcia-Monaco RD,Ros PR

更新日期：2013-12-15 00:00:00

abstract：BACKGROUND:Brain metastasis (BM) from colorectal cancer (CRC) is rarely encountered clinically, and its prognosis has not been fully evaluated. AIM:To construct a scoring system and accurately predict the survival of patients with synchronous BM at diagnosis of CRC. METHODS:A retrospective study of 371 patients with ...

journal_title：World journal of gastrointestinal oncology

authors： Quan JC,Guan X,Ma CX,Liu Z,Yang M,Zhao ZX,Sun P,Zhuang M,Wang S,Jiang Z,Wang XS

更新日期：2020-02-15 00:00:00

abstract：:Intussusception is a rare condition in the adult population. However, in contrast to its presentation in children, an identifiable etiology is found in the majority of cases. Clinical manifestations of adult intussusception are non-specific and patients may present with acute, intermittent or chronic symptoms, predomi...

journal_title：World journal of gastrointestinal oncology

authors： Nuño-Guzmán CM,Arróniz-Jáuregui J,Espejo I,Solís-Ugalde J,Gómez-Ontiveros JI,Vargas-Gerónimo A,Valle-González J

更新日期：2011-06-15 00:00:00

abstract：:Paraneoplastic leukemoid reaction is a rare syndrome defined by a leukocyte count exceeding 50 Giga/Liter (G/L), mostly described with progressive lung or renal carcinoma. We report a case of a 68-year-old man with recurrent pancreatic carcinoma presenting a leukemoid reaction with a white blood cell count of 63.87 G/...

journal_title：World journal of gastrointestinal oncology

authors： Dos Santos M,Bouhier K,Dao MT

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:Epstein-Barr virus (EBV)-associated carcinoma is a gastric cancer subtype with a morphology characterized by gastric carcinoma with lymphoid stroma (GCLS). Clinicopathological studies have indicated a better prognosis for GCLS than for common gastric carcinomas. Some previous cases of early gastric cancer as...

journal_title：World journal of gastrointestinal oncology

authors： Kobayashi Y,Kunogi T,Tanabe H,Murakami Y,Iwama T,Sasaki T,Takahashi K,Ando K,Nomura Y,Ueno N,Kashima S,Moriichi K,Takei H,Fujiya M,Okumura T

更新日期：2019-10-15 00:00:00

abstract：:Pancreatic cancer, with a 5% 5-year survival rate, is the fourth leading cause of cancer death in Western countries. Unfortunately, only 20% of all patients benefit from surgical treatment. The need to prolong survival has prompted pathologists to develop improved protocols to evaluate pancreatic specimens and their s...

journal_title：World journal of gastrointestinal oncology

authors： Gómez-Mateo Mdel C,Sabater-Ortí L,Ferrández-Izquierdo A

更新日期：2014-09-15 00:00:00

abstract：:Solid pseudopapillary neoplasm (SPN), also known as Gruber-Frantz tumor, is a rare form of neoplasm that almost exclusively occurs in the pancreas and in young females. While the potential of malignancy is low for SPN, these tumors can mimic other diseases and require a meticulous investigation and a standard treatmen...

journal_title：World journal of gastrointestinal oncology

authors： Wu H,Huang YF,Liu XH,Xu MH

更新日期：2017-12-15 00:00:00

abstract：:Cholangiocarcinoma (CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group. However, "hilar and perihilar CC" are also used to refer exclusively to the intrahepatic hilar type CC or, more commonly, t...

journal_title：World journal of gastrointestinal oncology

authors： Castellano-Megías VM,Ibarrola-de Andrés C,Colina-Ruizdelgado F

更新日期：2013-07-15 00:00:00

abstract：BACKGROUND:It has been recognized for a long time that gastric cancer behavior and outcomes might be different between patients living in Asian countries vs patients living in Western countries. It is not clear if these differences would persist between patients of Asian ancestry and patients of other racial subgroups ...

journal_title：World journal of gastrointestinal oncology

authors： Abdel-Rahman O

更新日期：2019-12-15 00:00:00

abstract：:Cancer research over the past decades has focused on neoplastic cells, or a fraction of them, i.e. tumor stem cells, as the ultimate causes of tumorigenesis. However, during recent years, scientists have come to realize that tumorigenesis is not a solo act of neoplastic cells, but rather a cooperative process in which...

journal_title：World journal of gastrointestinal oncology

authors： Zhu J,Ding J,Ding F

更新日期：2010-05-15 00:00:00

abstract：BACKGROUND:In recent years, intraoperative radiotherapy (IORT) has been increasingly used for the treatment of rectal cancer. However, the efficacy and safety of IORT for the treatment of rectal cancer are still controversial. AIM:To evaluate the value of IORT for patients with rectal cancer. METHODS:We searched PubM...

journal_title：World journal of gastrointestinal oncology

authors： Liu B,Ge L,Wang J,Chen YQ,Ma SX,Ma PL,Zhang YQ,Yang KH,Cai H

更新日期：2021-01-15 00:00:00