Abstract:
:Cancer research over the past decades has focused on neoplastic cells, or a fraction of them, i.e. tumor stem cells, as the ultimate causes of tumorigenesis. However, during recent years, scientists have come to realize that tumorigenesis is not a solo act of neoplastic cells, but rather a cooperative process in which the roles of numerous types of non-neoplastic cells should be recognized. These tumor-residing non-neoplastic cells constitute the so-called tumor-associated stroma, which in certain cases even greatly surpasses the neoplastic cellular compartment that was previously thought of as a sole determiner leading to a seemingly autonomous growth pattern. In this review, we summarize several recent research highlights that have unveiled many previously unappreciated roles for microenvironmental factors, especially during the initiation stage of tumorigenesis. It is becoming increasingly clear that the stroma's regulatory effects constitute not only an essential force for maintaining tumor growth, but also primary causes initiating tumorigenesis.
journal_name
World J Gastrointest Oncoljournal_title
World journal of gastrointestinal oncologyauthors
Zhu J,Ding J,Ding Fdoi
10.4251/wjgo.v2.i5.218subject
Has Abstractpub_date
2010-05-15 00:00:00pages
218-21issue
5issn
1948-5204journal_volume
2pub_type
杂志文章abstract::In an effort to minimize the limitations of laparoscopy, a robotic surgery system was introduced, but its role for gastric cancer is still unclear. The objective of this article is to assess the current status of robotic surgery for gastric cancer and to predict future prospects. Although the current study was limited...
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journal_title:World journal of gastrointestinal oncology
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
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pub_type: 临床试验
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