Abstract:
AIM:To identify genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer patients. METHODS:The NEIL1 promoter region in DNA from 80 Japanese patients with gastric cancer was searched for genetic polymorphisms by polymerase chain reaction-single-strand conformation polymorphism and subsequent sequencing analyses. RESULTS:Three novel genetic polymorphisms, i.e. c.-3769C>T, c.-3170T>G, and c.-2681TA[8], were identified in the NEIL1 promoter region at an allele frequency of 0.6%, 9.4%, and 4.4%, respectively, in Japanese gastric cancer patients. CONCLUSION:Three NEIL1 promoter polymorphisms detected in this study may be of importance in gastric carcinogenesis.
journal_name
World J Gastrointest Oncoljournal_title
World journal of gastrointestinal oncologyauthors
Goto M,Shinmura K,Tao H,Tsugane S,Sugimura Hdoi
10.4251/wjgo.v2.i2.117subject
Has Abstractpub_date
2010-02-15 00:00:00pages
117-20issue
2issn
1948-5204journal_volume
2pub_type
杂志文章abstract:BACKGROUND:Radical D2 lymphadenectomy for advanced gastric cancer as a standard procedure has gained global consensus. Mounting studies have shown that the number of lymph nodes dissection directly affects the prognosis and recurrence of gastric cancer. Our previous study showed that there was no obvious lymph node aro...
journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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pub_type: 杂志文章,评审
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
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journal_title:World journal of gastrointestinal oncology
pub_type: 临床试验
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pub_type: 杂志文章,评审
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
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journal_title:World journal of gastrointestinal oncology
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pub_type: 杂志文章,评审
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
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