Abstract:
:Surgery remains the only chance of cure for pancreatic cancer, but only 15%-25% of patients present with resectable disease at the time of primary diagnosis. Important goals in clinical research must therefore be to allow early detection with suitable diagnostic procedures, to further broaden operation techniques and to determine the most effective perioperative treatment of either chemotherapy and/or radiation therapy. More extensive operations involving extended pancreatectomy, portal vein resection and pancreatic resection in resectable pancreatic cancer with limited liver metastasis, performed in specialized centers seem to be the surgical procedures with a possible impact on survival. After many years of stagnation in pharmacological clinical research on advanced pancreatic ductal adenocarcinomas (PDAC) - since the approval of gemcitabine in 1997 - more effective cytotoxic substances (nab-paclitaxel) and combinations (FOLFIRINOX) are now available for perioperative treatment. Additionally, therapies with a broader mechanism of action are emerging (stroma depletion, immunotherapy, anti-inflammation), raising hopes for more effective adjuvant and neoadjuvant treatment concepts, especially in the context of "borderline resectability". Only multidisciplinary approaches including radiology, surgery, medical and radiation oncology as the backbones of the treatment of potentially resectable PDAC may be able to further improve the rate of cure in the future.
journal_name
World J Gastrointest Oncoljournal_title
World journal of gastrointestinal oncologyauthors
Sinn M,Bahra M,Denecke T,Travis S,Pelzer U,Riess Hdoi
10.4251/wjgo.v8.i3.248subject
Has Abstractpub_date
2016-03-15 00:00:00pages
248-57issue
3issn
1948-5204journal_volume
8pub_type
杂志文章,评审abstract:BACKGROUND:Bile duct cancer constitutes gallbladder cancer (GBC), intrahepatic cholangiocarcinoma (ICA), and extrahepatic cholangiocarcinoma (ECA). These three entities show morphological and immunohistochemical resemblance so that it is difficult to differentiate between primary ICA and liver metastasis of GBC, which ...
journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
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更新日期:2014-05-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v2.i2.117
更新日期:2010-02-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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更新日期:2020-01-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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