Status of colitis-associated cancer in ulcerative colitis.

Abstract:

:Surgical therapy for ulcerative colitis (UC) depends on the medical therapy administered for the patient's condition. UC is a benign disease. However, it has been reported that the rare cases of cancer in UC patients are increasing, and such cases have a worse prognosis. Recently, surgical therapy has greatly changed, there has been quite an increase in the number of UC patients with high-grade dysplasia and/or cancer. These lesions are known as colitis-associated cancer (CAC). The relationship between inflammation and tumorigenesis is well-established, and in the last decade, a great deal of supporting evidence has been obtained from genetic, pharmacological, and epidemiological studies. Inflammatory bowel disease, especially UC, is an important risk factor for the development of colon cancer. We should determine the risk factors for UC patients with cancer based on a large body of data, and we should attempt to prevent the increase in the number of such patients using these newly identified risk factors in the near future. Actively introducing the surgical treatment in addition to medical treatment should be considered. Several physicians should analyze UC from their unique perspectives in order to establish new clinically relevant diagnostic and treatment methods in the future. This article discusses CAC, including its etiology, mechanism, diagnosis, and treatment in UC patients.

authors

Kinugasa T,Akagi Y

doi

10.4251/wjgo.v8.i4.351

subject

Has Abstract

pub_date

2016-04-15 00:00:00

pages

351-7

issue

4

issn

1948-5204

journal_volume

8

pub_type

杂志文章,评审
  • Robotic- vs laparoscopic-assisted proctectomy for locally advanced rectal cancer based on propensity score matching: Short-term outcomes at a colorectal center in China.

    abstract:BACKGROUND:Reports in the field of robotic surgery for rectal cancer are increasing year by year. However, most of these studies enroll patients at a relatively early stage and have small sample sizes. In fact, studies only on patients with locally advanced rectal cancer (LARC) and with relatively large sample sizes ar...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v12.i4.424

    authors: Ye SP,Zhu WQ,Liu DN,Lei X,Jiang QG,Hu HM,Tang B,He PH,Gao GM,Tang HC,Shi J,Li TY

    更新日期:2020-04-15 00:00:00

  • Relationship between celiac artery variation and number of lymph nodes dissection in gastric cancer surgery.

    abstract:BACKGROUND:Radical D2 lymphadenectomy for advanced gastric cancer as a standard procedure has gained global consensus. Mounting studies have shown that the number of lymph nodes dissection directly affects the prognosis and recurrence of gastric cancer. Our previous study showed that there was no obvious lymph node aro...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v11.i6.499

    authors: Mu GC,Huang Y,Liu ZM,Chen ZB,Wu XH,Qin XG,Zeng YJ

    更新日期:2019-06-15 00:00:00

  • Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation.

    abstract::Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stomach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distensi...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v5.i12.222

    authors: Ulla M,Gentile E,Yeyati EL,Diez ML,Cavadas D,Garcia-Monaco RD,Ros PR

    更新日期:2013-12-15 00:00:00

  • Aberrant promoter methylation of p16 in colorectal adenocarcinoma in North Indian patients.

    abstract:AIM:To investigate p16 gene methylation and its expression in 30 patients with sporadic colorectal adenocarcinoma in a North Indian population. METHODS:Methylation specific polymerase chain reaction was used to detect p16 gene methylation and immunohistochemistry was used to study the p16 expression in 30 sporadic col...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v2.i7.295

    authors: Malhotra P,Kochhar R,Vaiphei K,Wig JD,Mahmood S

    更新日期:2010-07-15 00:00:00

  • Perioperative treatment options in resectable pancreatic cancer - how to improve long-term survival.

    abstract::Surgery remains the only chance of cure for pancreatic cancer, but only 15%-25% of patients present with resectable disease at the time of primary diagnosis. Important goals in clinical research must therefore be to allow early detection with suitable diagnostic procedures, to further broaden operation techniques and ...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v8.i3.248

    authors: Sinn M,Bahra M,Denecke T,Travis S,Pelzer U,Riess H

    更新日期:2016-03-15 00:00:00

  • Outcome of curative resection for perihilar cholangiocarcinoma in Northeast Thailand.

    abstract:AIM:To examine survival outcomes of perihilar cholangiocarcinoma (PCCA) resection including mortality, morbidity and prognostic factors. METHODS:Multivariate analyses were carried out based on the survival data of all patients with histologically confirmed PCCA who underwent curative resection at Srinagarind Hospital ...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v7.i12.503

    authors: Titapun A,Pugkhem A,Luvira V,Srisuk T,Somintara O,Saeseow OT,Sripanuskul A,Nimboriboonporn A,Thinkhamrop B,Khuntikeo N

    更新日期:2015-12-15 00:00:00

  • Emerging molecular targets and therapy for cholangiocarcinoma.

    abstract::Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v9.i7.268

    authors: Kayhanian H,Smyth EC,Braconi C

    更新日期:2017-07-15 00:00:00

  • Clinical significance of SQSTM1/P62 and nuclear factor-κB expression in pancreatic carcinoma.

    abstract:BACKGROUND:Overexpression of SQSTM1 (sequestosome 1, P62) and nuclear factor-κB (NF-κB) plays an important role in the invasion and metastasis of a variety of malignant tumors. AIM:To explore the expression of P62 and NF-κB in pancreatic cancer and their relationship with clinicopathological features. METHODS:The exp...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v12.i7.719

    authors: Zhang ZY,Guo S,Zhao R,Ji ZP,Zhuang ZN

    更新日期:2020-07-15 00:00:00

  • Pathological aspects of so called "hilar cholangiocarcinoma".

    abstract::Cholangiocarcinoma (CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group. However, "hilar and perihilar CC" are also used to refer exclusively to the intrahepatic hilar type CC or, more commonly, t...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v5.i7.159

    authors: Castellano-Megías VM,Ibarrola-de Andrés C,Colina-Ruizdelgado F

    更新日期:2013-07-15 00:00:00

  • Gastric cancer: The times they are a-changin'.

    abstract::Gastric cancer is the third leading cause of cancer death worldwide. Even though during these last decades gastric cancer incidence decreased in Western countries, it remains endemic and with a high incidence in Eastern countries. The survival in advanced and metastatic stage of gastric cancer is still very poor. Rece...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v7.i11.303

    authors: Satolli MA,Buffoni L,Spadi R,Roato I

    更新日期:2015-11-15 00:00:00

  • Apoptotic pathways as a therapeutic target for colorectal cancer treatment.

    abstract::Colorectal cancer is the second leading cause of death from cancer among adults. The disease begins as a benign adenomatous polyp, which develops into an advanced adenoma with high-grade dysplasia and then progresses to an invasive cancer. Appropriate apoptotic signaling is fundamentally important to preserve a health...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v8.i8.583

    authors: Abraha AM,Ketema EB

    更新日期:2016-08-15 00:00:00

  • Prognostic significance of KIF23 expression in gastric cancer.

    abstract:BACKGROUND:Kinesin super family 23 (KIF23) is a member of the KIF family, and it plays an important role in mitosis and cytokinesis. Loss of expression can cause mitotic arrest. The Oncomine database is one of the largest oncogene chip databases in the world, and is an integrated data mining platform for cancer gene in...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v12.i10.1104

    authors: Liang WT,Liu XF,Huang HB,Gao ZM,Li K

    更新日期:2020-10-15 00:00:00

  • Epigenetic field defects in progression to cancer.

    abstract::A field defect is a field of pre-malignant tissue in which a new cancer is likely to arise. Field defects often appear to be histologically normal under the microscope. Recent research indicates that cells within a field defect characteristically have an increased frequency of epigenetic alterations and these may be f...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v5.i3.43

    authors: Bernstein C,Nfonsam V,Prasad AR,Bernstein H

    更新日期:2013-03-15 00:00:00

  • Bayesian adjustment for over-estimation and under-estimation of gastric cancer incidence across Iranian provinces.

    abstract:AIM:To correct the misclassification in registered gastric cancer incidence across Iranian provinces in cancer registry data. METHODS:Gastric cancer data is extracted from Iranian annual of national cancer registration report 2008. A Bayesian method with beta prior is implemented to estimate the rate of misclassificat...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v9.i2.87

    authors: Hajizadeh N,Pourhoseingholi MA,Baghestani AR,Abadi A,Zali MR

    更新日期:2017-02-15 00:00:00

  • Adult intussusception secondary to an ileum hamartoma.

    abstract::Intussusception is a rare condition in the adult population. However, in contrast to its presentation in children, an identifiable etiology is found in the majority of cases. Clinical manifestations of adult intussusception are non-specific and patients may present with acute, intermittent or chronic symptoms, predomi...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v3.i6.103

    authors: Nuño-Guzmán CM,Arróniz-Jáuregui J,Espejo I,Solís-Ugalde J,Gómez-Ontiveros JI,Vargas-Gerónimo A,Valle-González J

    更新日期:2011-06-15 00:00:00

  • Tumor stem cell, or its niche, which plays a primary role in tumorigenesis?

    abstract::Cancer research over the past decades has focused on neoplastic cells, or a fraction of them, i.e. tumor stem cells, as the ultimate causes of tumorigenesis. However, during recent years, scientists have come to realize that tumorigenesis is not a solo act of neoplastic cells, but rather a cooperative process in which...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v2.i5.218

    authors: Zhu J,Ding J,Ding F

    更新日期:2010-05-15 00:00:00

  • Histopathological characteristics of needle core biopsy and surgical specimens from patients with solitary hepatocellular carcinoma or intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND:Pathological manifestations of hepatic tumours are often associated with prognosis. Although surgical specimens (SS) can provide more information, currently, pre-treatment needle core biopsy (NCB) is increasingly showing important value in understanding the nature of liver tumors and even in diagnosis and tr...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v11.i5.404

    authors: Wu JS,Feng JL,Zhu RD,Liu SG,Zhao DW,Li N

    更新日期:2019-05-15 00:00:00

  • Comparison of survival between adolescent and young adult vs older patients with hepatocellular carcinoma.

    abstract:BACKGROUND:Due to the special clinical features and biologic characteristics of adolescent and young adult (AYA) cancers, AYA cancers are different from cancers in children and elderly individuals. However, there are few reports on AYA hepatocellular carcinoma (HCC). AIM:To investigate the overall survival (OS) of AYA...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v12.i12.1394

    authors: Ren J,Tong YM,Cui RX,Wang Z,Li QL,Liu W,Qu K,Zhang JY,Liu C,Wan Y

    更新日期:2020-12-15 00:00:00

  • Optimizing outcomes for patients with gastric cancer peritoneal carcinomatosis.

    abstract::Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival outcomes. Positive peritoneal cytology similarly worsens the survival of patients with gastric cancer and treatment options for these patients have been limite...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 社论

    doi:10.4251/wjgo.v10.i10.282

    authors: Leiting JL,Grotz TE

    更新日期:2018-10-15 00:00:00

  • Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of micro-ribonucleic acids.

    abstract::5-flurouracil (5-FU)-based chemotherapy is the main pharmacological therapy for advanced colorectal cancer (CRC). Despite significant progress in the treatment of CRC during the last decades, 5-FU drug resistance remains the most important cause of failure in CRC therapy. Resistance to 5-FU is a complex and multistep ...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v12.i9.942

    authors: Sabeti Aghabozorgi A,Moradi Sarabi M,Jafarzadeh-Esfehani R,Koochakkhani S,Hassanzadeh M,Kavousipour S,Eftekhar E

    更新日期:2020-09-15 00:00:00

  • Utilizing gastric cancer organoids to assess tumor biology and personalize medicine.

    abstract::While the incidence and mortality of gastric cancer (GC) have declined due to public health programs, it remains the third deadliest cancer worldwide. For patients with early disease, innovative endoscopic and complex surgical techniques have improved survival. However, for patients with advanced disease, there are li...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v11.i7.509

    authors: Lin M,Gao M,Cavnar MJ,Kim J

    更新日期:2019-07-15 00:00:00

  • Hypofractionated particle beam therapy for hepatocellular carcinoma-a brief review of clinical effectiveness.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the second leading cause of cancer mortality worldwide. The cornerstone to improving the prognosis of HCC patients has been the control of loco-regional disease progression and the lesser toxicities of local treatment. Although radiotherapy has not...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v11.i8.579

    authors: Hsu CY,Wang CW,Cheng AL,Kuo SH

    更新日期:2019-08-15 00:00:00

  • Potential of casein kinase I in digestive cancer screening.

    abstract::Casein kinase I is a group of ubiquitous Serine/Threonine kinases that have been implicated in both normal cellular functions and several pathological conditions including Alzheimer's disease and cancer. Recent findings in colon and pancreatic cancer have brought tremendous attention to these molecules as potential th...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v1.i1.26

    authors: Modak C,Chai J

    更新日期:2009-10-15 00:00:00

  • Laparoscopic and endoscopic cooperative surgery for gastric tumors: Perspective for actual practice and oncological benefits.

    abstract::Laparoscopic and endoscopic cooperative surgery (LECS) is a surgical technique that combines laparoscopic partial gastrectomy and endoscopic submucosal dissection. LECS requires close collaboration between skilled laparoscopic surgeons and experienced endoscopists. For successful LECS, experience alone is not sufficie...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v10.i11.381

    authors: Aisu Y,Yasukawa D,Kimura Y,Hori T

    更新日期:2018-11-15 00:00:00

  • From traditional serrated adenoma to tubulovillous adenoma and beyond.

    abstract::It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous adenomas (VA/TVA), sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA). Of these, TSAs are least common and account for only 5% of all serrated poly...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v8.i12.805

    authors: Kalimuthu SN,Chelliah A,Chetty R

    更新日期:2016-12-15 00:00:00

  • Targeted agents for second-line treatment of advanced hepatocellular carcinoma.

    abstract::Over the past ten years, sorafenib, a multikinase inhibitor, has been the standard of care for patients with unresectable hepatocellular carcinoma (HCC) and well-preserved liver function. Recently, lenvatinib, a different multikinase inhibitor, was shown to be non-inferior to sorafenib, in terms of survival, while all...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v11.i10.788

    authors: Personeni N,Pressiani T,Bozzarelli S,Rimassa L

    更新日期:2019-10-15 00:00:00

  • Targeted therapy or immunotherapy? Optimal treatment in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer mortality in the United States and the second leading cause of cancer mortality worldwide. Sorafenib is the only food and drug administration (FDA) approved as first line systemic treatment in HCC. Regorafenib and nivolumab are the only FDA approved s...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审

    doi:10.4251/wjgo.v10.i5.108

    authors: Contratto M,Wu J

    更新日期:2018-05-15 00:00:00

  • Ileal inflammatory fibroid polyp causing chronic ileocolic intussusception and mimicking cecal carcinoma.

    abstract::Inflammatory fibroid polyp (IFP) is a rare, idiopathic pseudotumorous lesion of the gastrointestinal tract. While mostly reported as solitary gastric lesions, multiple cases of small bowel IFPs are also reported. It is a documented cause of intussusception in adults. In the case reports of ileal inflammatory fibroid p...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v1.i1.89

    authors: Gara N,Falzarano JS,Limm WM,Namiki TS,Tom LK

    更新日期:2009-10-15 00:00:00

  • Primary esophageal diffuse large B cell lymphoma presenting with tracheoesophageal fistula: A rare case and review.

    abstract::Primary non-Hodgkin lymphomas in the esophagus are rare. Tracheoesophageal fistulas mainly arise from solid esophageal carcinoma or mediastinal malignancies. Our patient presented with cough, dysphagia and weight loss, and upon initial computed tomography imaging and esophagogastroduodenoscopy, a malignant mass in the...

    journal_title:World journal of gastrointestinal oncology

    pub_type:

    doi:10.4251/wjgo.v9.i10.431

    authors: Teerakanok J,DeWitt JP,Juarez E,Thein KZ,Warraich I

    更新日期:2017-10-15 00:00:00

  • Perineural invasion as a prognostic factor in patients with stage I-III rectal cancer - 5-year follow up.

    abstract:BACKGROUND:Rectal cancer (RC) is one of the most common diagnosed cancers, and one of the major causes of cancer-related death nowadays. Majority of the current guidelines rely on TNM classification regarding therapy regiments, however recent studies suggest that additional histopathological findings could affect the d...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章

    doi:10.4251/wjgo.v12.i5.592

    authors: Stojkovic Lalosevic M,Milovanovic T,Micev M,Stojkovic M,Dragasevic S,Stulic M,Rankovic I,Dugalic V,Krivokapic Z,Pavlovic Markovic A

    更新日期:2020-05-15 00:00:00