Epigenetic field defects in progression to cancer.

abstract：:Biliary tract carcinomas are relatively rare, representing less than 1% of cancers. However, their incidence has increased in Japan and in industrialized countries like the USA. Biliary tract tumors have a poor prognosis and a high mortality rate because they are usually detected late in the course of the disease; the...

journal_title：World journal of gastrointestinal oncology

authors： Malaguarnera G,Giordano M,Paladina I,Rando A,Uccello M,Basile F,Biondi A,Carnazzo S,Alessandria I,Mazzarino C

更新日期：2011-04-15 00:00:00

abstract：:Pancreatic adenocarcinoma is the fourth cause of cancer-related death in the United States. Surgery is the only potentially curative treatment, but most patients present at diagnosis with unresectable or metastatic disease. Moreover, even with an R0 resection, the majority of patients will die of disease recurrence. M...

journal_title：World journal of gastrointestinal oncology

authors： Sperti C,Moletta L,Merigliano S

更新日期：2015-12-15 00:00:00

abstract：:Despite significant advances in imaging techniques, the incidence of colorectal cancer has been increasing in recent years, with many cases still being diagnosed in advanced stages. Early detection and accurate staging remain the main factors that lead to a decrease in the cost and invasiveness of the curative techniq...

journal_title：World journal of gastrointestinal oncology

authors： Ciocalteu A,Gheonea DI,Saftoiu A,Streba L,Dragoescu NA,Tenea-Cojan TS

更新日期：2018-12-15 00:00:00

abstract：BACKGROUND:Recent studies have proved the important role of many oncogenic long non-coding RNAs (lncRNAs) in the progression of pancreatic cancer, but little is known about the mechanisms of tumor suppression in pancreatic cancer. AIM:To evaluate the function of tumor suppressor lncRNA C9orf139 in pancreatic cancer pr...

journal_title：World journal of gastrointestinal oncology

authors： Ge JN,Yan D,Ge CL,Wei MJ

更新日期：2020-11-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer mortality in the United States and the second leading cause of cancer mortality worldwide. Sorafenib is the only food and drug administration (FDA) approved as first line systemic treatment in HCC. Regorafenib and nivolumab are the only FDA approved s...

journal_title：World journal of gastrointestinal oncology

authors： Contratto M,Wu J

更新日期：2018-05-15 00:00:00

abstract：:Casein kinase I is a group of ubiquitous Serine/Threonine kinases that have been implicated in both normal cellular functions and several pathological conditions including Alzheimer's disease and cancer. Recent findings in colon and pancreatic cancer have brought tremendous attention to these molecules as potential th...

journal_title：World journal of gastrointestinal oncology

authors： Modak C,Chai J

更新日期：2009-10-15 00:00:00

abstract：AIM:To study tumor response, and tolerability of arterially directed embolic therapy (ADET) with polyethylene glycol embolics loaded with irinotecan for the treatment of colorectal cancer liver metastases (CRC-LM). Secondary objectives were to monitor quality of life, time to progression and survival of patients. METH...

journal_title：World journal of gastrointestinal oncology

authors： Fiorentini G,Carandina R,Sarti D,Nardella M,Zoras O,Guadagni S,Inchingolo R,Nestola M,Felicioli A,Barnes Navarro D,Munoz Gomez F,Aliberti C

更新日期：2017-09-15 00:00:00

abstract：:Digestive endoscopy is currently the main diagnostic procedure for investigation of the digestive tract when a digestive disease is suspected. The use of computers and electronic medical records for the management of endoscopic data are an important key to improving endoscopy unit efficiency and productivity. This tec...

journal_title：World journal of gastrointestinal oncology

authors： Maserat E,Safdari R,Maserat E,Zali MR

更新日期：2012-04-15 00:00:00

abstract：:Pancreatic surgery for malignancy is recognized as challenging for the surgeons and risky for the patients due to consistent perioperative morbidity and mortality. Furthermore, the oncological long-term results are largely disappointing, even for those patients who experience an uneventfully hospital stay. Nevertheles...

journal_title：World journal of gastrointestinal oncology

authors： Bencini L,Annecchiarico M,Farsi M,Bartolini I,Mirasolo V,Guerra F,Coratti A

更新日期：2015-12-15 00:00:00

abstract：:It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous adenomas (VA/TVA), sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA). Of these, TSAs are least common and account for only 5% of all serrated poly...

journal_title：World journal of gastrointestinal oncology

authors： Kalimuthu SN,Chelliah A,Chetty R

更新日期：2016-12-15 00:00:00

abstract：BACKGROUND:Breast metastases from colorectal cancer (CRC) are very uncommon. There is no unanimous consensus regarding the best treatment for this rare condition, and management is, especially in elderly patients, limited to diagnosis and palliative care. Capecitabine, an oral fluoropyrimidine derivative, might be help...

journal_title：World journal of gastrointestinal oncology

authors： Taccogna S,Gozzi E,Rossi L,Caruso D,Conte D,Trenta P,Leoni V,Tomao S,Raimondi L,Angelini F

更新日期：2020-09-15 00:00:00

abstract：:Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stomach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distensi...

journal_title：World journal of gastrointestinal oncology

authors： Ulla M,Gentile E,Yeyati EL,Diez ML,Cavadas D,Garcia-Monaco RD,Ros PR

更新日期：2013-12-15 00:00:00

abstract：BACKGROUND:In recent years, intraoperative radiotherapy (IORT) has been increasingly used for the treatment of rectal cancer. However, the efficacy and safety of IORT for the treatment of rectal cancer are still controversial. AIM:To evaluate the value of IORT for patients with rectal cancer. METHODS:We searched PubM...

journal_title：World journal of gastrointestinal oncology

authors： Liu B,Ge L,Wang J,Chen YQ,Ma SX,Ma PL,Zhang YQ,Yang KH,Cai H

更新日期：2021-01-15 00:00:00

abstract：:Low rectal cancer is traditionally treated by abdominoperineal resection. In recent years, several new techniques for the treatment of very low rectal cancer patients aiming to preserve the gastrointestinal continuity and to improve both the oncological as well as the functional outcomes, have been emerged. Literature...

journal_title：World journal of gastrointestinal oncology

authors： Dimitriou N,Michail O,Moris D,Griniatsos J

更新日期：2015-07-15 00:00:00

abstract：:Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival outcomes. Positive peritoneal cytology similarly worsens the survival of patients with gastric cancer and treatment options for these patients have been limite...

journal_title：World journal of gastrointestinal oncology

authors： Leiting JL,Grotz TE

更新日期：2018-10-15 00:00:00

abstract：:Over the past ten years, sorafenib, a multikinase inhibitor, has been the standard of care for patients with unresectable hepatocellular carcinoma (HCC) and well-preserved liver function. Recently, lenvatinib, a different multikinase inhibitor, was shown to be non-inferior to sorafenib, in terms of survival, while all...

journal_title：World journal of gastrointestinal oncology

authors： Personeni N,Pressiani T,Bozzarelli S,Rimassa L

更新日期：2019-10-15 00:00:00

abstract：:Deficiencies in DNA repair due to inherited germ-line mutations in DNA repair genes cause increased risk of gastrointestinal (GI) cancer. In sporadic GI cancers, mutations in DNA repair genes are relatively rare. However, epigenetic alterations that reduce expression of DNA repair genes are frequent in sporadic GI can...

journal_title：World journal of gastrointestinal oncology

authors： Bernstein C,Bernstein H

更新日期：2015-05-15 00:00:00

abstract：:Pancreaticobiliary maljunction (PBM) is a high risk factor for biliary tract cancer. In PBM, since the pancreatic duct and bile duct converge outside the duodenal wall beyond the influence of the sphincter of Oddi, pancreatic juice and bile are constantly mixed, producing a variety of harmful substances. Because of th...

journal_title：World journal of gastrointestinal oncology

authors： Tsuchida A,Itoi T

更新日期：2010-03-15 00:00:00

abstract：:While the incidence and mortality of gastric cancer (GC) have declined due to public health programs, it remains the third deadliest cancer worldwide. For patients with early disease, innovative endoscopic and complex surgical techniques have improved survival. However, for patients with advanced disease, there are li...

journal_title：World journal of gastrointestinal oncology

authors： Lin M,Gao M,Cavnar MJ,Kim J

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:Overexpression of SQSTM1 (sequestosome 1, P62) and nuclear factor-κB (NF-κB) plays an important role in the invasion and metastasis of a variety of malignant tumors. AIM:To explore the expression of P62 and NF-κB in pancreatic cancer and their relationship with clinicopathological features. METHODS:The exp...

journal_title：World journal of gastrointestinal oncology

authors： Zhang ZY,Guo S,Zhao R,Ji ZP,Zhuang ZN

更新日期：2020-07-15 00:00:00

abstract：BACKGROUND:Esophagectomy is a pivotal curative modality for localized esophageal or esophagogastric junction cancer (EC or EJC). Postoperative anastomotic leakage (AL) remains problematic. The use of fibrin sealant (FS) may improve the strength of esophageal anastomosis and reduce the incidence of AL. AIM:To assess th...

journal_title：World journal of gastrointestinal oncology

authors： Lin YB,Fu JH,Huang Y,Hu YH,Luo KJ,Wang KX,Bella AÉ,Situ DR,Chen JY,Lin T,D'Journo XB,Novoa NM,Brunelli A,Fernando HC,Cerfolio RJ,Ismail M,Yang H,AME Thoracic Surgery Collaborative Group.

更新日期：2020-06-15 00:00:00

abstract：BACKGROUND:Due to the special clinical features and biologic characteristics of adolescent and young adult (AYA) cancers, AYA cancers are different from cancers in children and elderly individuals. However, there are few reports on AYA hepatocellular carcinoma (HCC). AIM:To investigate the overall survival (OS) of AYA...

journal_title：World journal of gastrointestinal oncology

authors： Ren J,Tong YM,Cui RX,Wang Z,Li QL,Liu W,Qu K,Zhang JY,Liu C,Wan Y

更新日期：2020-12-15 00:00:00

abstract：:Paraneoplastic leukemoid reaction is a rare syndrome defined by a leukocyte count exceeding 50 Giga/Liter (G/L), mostly described with progressive lung or renal carcinoma. We report a case of a 68-year-old man with recurrent pancreatic carcinoma presenting a leukemoid reaction with a white blood cell count of 63.87 G/...

journal_title：World journal of gastrointestinal oncology

authors： Dos Santos M,Bouhier K,Dao MT

更新日期：2015-10-15 00:00:00

abstract：:Pancreatic cancer, with a 5% 5-year survival rate, is the fourth leading cause of cancer death in Western countries. Unfortunately, only 20% of all patients benefit from surgical treatment. The need to prolong survival has prompted pathologists to develop improved protocols to evaluate pancreatic specimens and their s...

journal_title：World journal of gastrointestinal oncology

authors： Gómez-Mateo Mdel C,Sabater-Ortí L,Ferrández-Izquierdo A

更新日期：2014-09-15 00:00:00

abstract：:Standard pancreatic resections, such as pancreaticoduodenectomy, distal pancreatectomy, or total pancreatectomy, result in an important loss of normal pancreatic parenchyma and may cause impairment of exocrine and endocrine function. Whilst these procedures are mandatory for malignant tumors, they seem to be too exten...

journal_title：World journal of gastrointestinal oncology

authors： Sperti C,Beltrame V,Milanetto AC,Moro M,Pedrazzoli S

更新日期：2010-06-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly malignant tumor and extrahepatic metastasis is not rare. The most common organ of HCC metastasis is lung, followed by bone and adrenal gland. To the best of our knowledge, isolated pancreatic metastasis of HCC that developed after curative resection has not been described pre...

journal_title：World journal of gastrointestinal oncology

authors： Woo SM,Park JW,Han SS,Choi JI,Lee WJ,Park SJ,Hong EK,Kim CM

更新日期：2010-04-15 00:00:00

abstract：:Cholangiocarcinoma (CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group. However, "hilar and perihilar CC" are also used to refer exclusively to the intrahepatic hilar type CC or, more commonly, t...

journal_title：World journal of gastrointestinal oncology

authors： Castellano-Megías VM,Ibarrola-de Andrés C,Colina-Ruizdelgado F

更新日期：2013-07-15 00:00:00

abstract：:Solid pseudopapillary neoplasm (SPN), also known as Gruber-Frantz tumor, is a rare form of neoplasm that almost exclusively occurs in the pancreas and in young females. While the potential of malignancy is low for SPN, these tumors can mimic other diseases and require a meticulous investigation and a standard treatmen...

journal_title：World journal of gastrointestinal oncology

authors： Wu H,Huang YF,Liu XH,Xu MH

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Regorafenib is an oral small-molecule multikinase inhibitor approved in third or later line of treatment for patients with metastatic colorectal cancer (mCRC). Regorafenib has shown significant benefits in overall survival and progression free survival in two phase III trials compared to placebo in patients ...

journal_title：World journal of gastrointestinal oncology

authors： Ricci V,Granetto C,Falletta A,Paccagnella M,Abbona A,Fea E,Fabozzi T,Lo Nigro C,Merlano MC

更新日期：2020-03-15 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic...

journal_title：World journal of gastrointestinal oncology

authors： Kayhanian H,Smyth EC,Braconi C

更新日期：2017-07-15 00:00:00