Abstract:
:While the incidence and mortality of gastric cancer (GC) have declined due to public health programs, it remains the third deadliest cancer worldwide. For patients with early disease, innovative endoscopic and complex surgical techniques have improved survival. However, for patients with advanced disease, there are limited treatment options and survival remains poor. Therefore, there is an urgent need for more effective therapies. Since novel therapies require extensive preclinical testing prior to human trials, it is important to identify methods to expedite this process. Traditional cancer models are restricted by the inability to accurately recapitulate the primary human tumor, exorbitant costs, and the requirement for extended periods of development time. An emerging in vitro model to study human disease is the patient-derived organoid, which is a three-dimensional system created from fresh surgical or biopsy tissues of a patient's gastric tumor. Organoids are cultured in plastic wells and suspended in a gelatinous matrix, providing a substrate for extension and growth in all dimensions. They are rapid-growing and highly representative of the molecular landscape, histology, and morphology of the various subtypes of GC. Organoids uniquely model tumor initiation and growth, including steps taken by normal stomach cells to transform into invasive, intestinal-type tumor cells. Additionally, they provide ample material for biobanking and screening novel therapies. Lastly, organoids are a promising model for personalized therapy and warrant further investigation in drug sensitivity studies for GC patients.
journal_name
World J Gastrointest Oncoljournal_title
World journal of gastrointestinal oncologyauthors
Lin M,Gao M,Cavnar MJ,Kim Jdoi
10.4251/wjgo.v11.i7.509subject
Has Abstractpub_date
2019-07-15 00:00:00pages
509-517issue
7issn
1948-5204journal_volume
11pub_type
杂志文章,评审abstract::Pancreaticobiliary maljunction (PBM) is a high risk factor for biliary tract cancer. In PBM, since the pancreatic duct and bile duct converge outside the duodenal wall beyond the influence of the sphincter of Oddi, pancreatic juice and bile are constantly mixed, producing a variety of harmful substances. Because of th...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v2.i3.130
更新日期:2010-03-15 00:00:00
abstract::Primary non-Hodgkin lymphomas in the esophagus are rare. Tracheoesophageal fistulas mainly arise from solid esophageal carcinoma or mediastinal malignancies. Our patient presented with cough, dysphagia and weight loss, and upon initial computed tomography imaging and esophagogastroduodenoscopy, a malignant mass in the...
journal_title:World journal of gastrointestinal oncology
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doi:10.4251/wjgo.v9.i10.431
更新日期:2017-10-15 00:00:00
abstract::Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic...
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更新日期:2017-07-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v12.i4.424
更新日期:2020-04-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v2.i10.390
更新日期:2010-10-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v2.i6.272
更新日期:2010-06-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v11.i8.579
更新日期:2019-08-15 00:00:00
abstract::Digestive endoscopy is currently the main diagnostic procedure for investigation of the digestive tract when a digestive disease is suspected. The use of computers and electronic medical records for the management of endoscopic data are an important key to improving endoscopy unit efficiency and productivity. This tec...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v4.i4.76
更新日期:2012-04-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
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更新日期:2019-09-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
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更新日期:2019-06-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v8.i1.99
更新日期:2016-01-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v11.i10.788
更新日期:2019-10-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v8.i12.805
更新日期:2016-12-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v7.i12.375
更新日期:2015-12-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type:
doi:10.4251/wjgo.v7.i3.12
更新日期:2015-03-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v2.i2.117
更新日期:2010-02-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v1.i1.89
更新日期:2009-10-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v7.i5.30
更新日期:2015-05-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v2.i5.218
更新日期:2010-05-15 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-12-15 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
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更新日期:2016-04-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 社论
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更新日期:2018-10-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v2.i1.5
更新日期:2010-01-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v11.i2.139
更新日期:2019-02-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 临床试验
doi:10.4251/wjgo.v12.i6.651
更新日期:2020-06-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
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更新日期:2010-04-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
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更新日期:2017-09-15 00:00:00
abstract::Cholangiocarcinoma (CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group. However, "hilar and perihilar CC" are also used to refer exclusively to the intrahepatic hilar type CC or, more commonly, t...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v5.i7.159
更新日期:2013-07-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v8.i2.159
更新日期:2016-02-15 00:00:00