C-reactive protein may be a prognostic factor for the whole gastroenteropancreatic neuroendocrine tumor group.


BACKGROUND:Long non-coding RNAs (lncRNAs) are a kind of single-stranded RNA of more than 200 nucleotides in length and have no protein-coding function. Amounting studies have indicated that lncRNAs could play a vital role in the initiation and development of cancers, including gastric cancer (GC). Considering the crucial functions of lncRNAs, the identification and exploration of novel lncRNAs in GC is necessary. AIM:To identify independent prognostic markers for the whole gastroenteropancreatic neuroendocrine tumor (GEP-NET) group. METHODS:Ninety-three patients diagnosed with GEP-NETs within a specified period were included in this study. Patient data were retrospectively analyzed. The relationships between all independent variables and 5-year survival status calculated during the follow-up period (months) were assessed. In addition, the relationships between the independent variables were investigated. RESULTS:When 5-year survival rate was compared, a statistically significant relationship between the age at diagnosis, male gender, tumor size, tumor stage, liver and/or distant metastasis, and tumor grade determined by the Ki-67 level and mitotic count, and the level of C-reactive protein (CRP), was observed. The mean survival (overall survival) of the study group was 102.5 ± 6.3 (SD) mo. The percentages of 1, 3 and 5-year survival were 90%, 72%, and 61%, respectively. In 63 of 93 patients, Ki-67 and the mitotic count determined the same grade. The Ki-67 levels in 29 patients and the mitotic count in only 1 patient were in the higher grade. The risk of death increased by 4% for every 1 year increase at the diagnosis age and was 2.0-fold higher for male patients, 3.0-fold higher for G3 according to the mitotic count, 3.7-fold higher for G3 according to the Ki-67 level, 12.7-fold higher for cases with tumor stage 3 or 4 by a 1 cm increase in the ratio of 9% in tumor size, and 6.1-fold higher for patients with liver metastasis for every 1 mg/dL increase in the ratio of 1.5% in CRP level. There was a significant difference between pancreatic and stomach NETs in favor of stomach tumors in terms of survival. CONCLUSION:Tumor site, stage, grade and Ki-67 level affected patient survival, and it was observed that CRP affected disease progression (particularly if it was > 20 mg/dL). However, a relationship between surgical resection of the lesion and survival was not shown. Larger scale prospective studies are required to determine whether CRP level may be a poor prognostic factor for the entire GEP-NET group.


Komaç Ö,Bengi G,Sağol Ö,Akarsu M




Has Abstract


2019-02-15 00:00:00










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    authors: Satolli MA,Buffoni L,Spadi R,Roato I

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    更新日期:2020-12-15 00:00:00

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    authors: Kayhanian H,Smyth EC,Braconi C

    更新日期:2017-07-15 00:00:00

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    abstract::Surgery remains the only chance of cure for pancreatic cancer, but only 15%-25% of patients present with resectable disease at the time of primary diagnosis. Important goals in clinical research must therefore be to allow early detection with suitable diagnostic procedures, to further broaden operation techniques and ...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审


    authors: Sinn M,Bahra M,Denecke T,Travis S,Pelzer U,Riess H

    更新日期:2016-03-15 00:00:00

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    abstract::Most patients treated with curative intent for colorectal cancer (CRC) are included in a follow-up program involving periodic evaluations. The survival benefits of a follow-up program are well delineated, and previous meta-analyses have suggested an overall survival improvement of 5%-10% by intensive follow-up. Howeve...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审


    authors: Augestad KM,Rose J,Crawshaw B,Cooper G,Delaney C

    更新日期:2014-05-15 00:00:00

  • Current status of robot-assisted gastric surgery.

    abstract::In an effort to minimize the limitations of laparoscopy, a robotic surgery system was introduced, but its role for gastric cancer is still unclear. The objective of this article is to assess the current status of robotic surgery for gastric cancer and to predict future prospects. Although the current study was limited...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章


    authors: Baek SJ,Lee DW,Park SS,Kim SH

    更新日期:2011-10-15 00:00:00

  • Pathological aspects of so called "hilar cholangiocarcinoma".

    abstract::Cholangiocarcinoma (CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group. However, "hilar and perihilar CC" are also used to refer exclusively to the intrahepatic hilar type CC or, more commonly, t...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章


    authors: Castellano-Megías VM,Ibarrola-de Andrés C,Colina-Ruizdelgado F

    更新日期:2013-07-15 00:00:00

  • Parenchyma-sparing pancreatectomies for benign or border-line tumors of the pancreas.

    abstract::Standard pancreatic resections, such as pancreaticoduodenectomy, distal pancreatectomy, or total pancreatectomy, result in an important loss of normal pancreatic parenchyma and may cause impairment of exocrine and endocrine function. Whilst these procedures are mandatory for malignant tumors, they seem to be too exten...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章


    authors: Sperti C,Beltrame V,Milanetto AC,Moro M,Pedrazzoli S

    更新日期:2010-06-15 00:00:00

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    abstract::Paraneoplastic leukemoid reaction is a rare syndrome defined by a leukocyte count exceeding 50 Giga/Liter (G/L), mostly described with progressive lung or renal carcinoma. We report a case of a 68-year-old man with recurrent pancreatic carcinoma presenting a leukemoid reaction with a white blood cell count of 63.87 G/...

    journal_title:World journal of gastrointestinal oncology



    authors: Dos Santos M,Bouhier K,Dao MT

    更新日期:2015-10-15 00:00:00

  • Endoscopic electronic record: A new approach for improving management of colorectal cancer prevention.

    abstract::Digestive endoscopy is currently the main diagnostic procedure for investigation of the digestive tract when a digestive disease is suspected. The use of computers and electronic medical records for the management of endoscopic data are an important key to improving endoscopy unit efficiency and productivity. This tec...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章


    authors: Maserat E,Safdari R,Maserat E,Zali MR

    更新日期:2012-04-15 00:00:00

  • Targeted therapy or immunotherapy? Optimal treatment in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer mortality in the United States and the second leading cause of cancer mortality worldwide. Sorafenib is the only food and drug administration (FDA) approved as first line systemic treatment in HCC. Regorafenib and nivolumab are the only FDA approved s...

    journal_title:World journal of gastrointestinal oncology

    pub_type: 杂志文章,评审


    authors: Contratto M,Wu J

    更新日期:2018-05-15 00:00:00

  • Colorectal cancer metastatic to the breast: A case report.

    abstract:BACKGROUND:Breast metastases from colorectal cancer (CRC) are very uncommon. There is no unanimous consensus regarding the best treatment for this rare condition, and management is, especially in elderly patients, limited to diagnosis and palliative care. Capecitabine, an oral fluoropyrimidine derivative, might be help...

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    authors: Taccogna S,Gozzi E,Rossi L,Caruso D,Conte D,Trenta P,Leoni V,Tomao S,Raimondi L,Angelini F

    更新日期:2020-09-15 00:00:00

  • Novel therapeutic agents in the treatment of metastatic colorectal cancer.

    abstract::Over the past couple of decades considerable progress has been made in the management of metastatic colorectal cancers (mCRC) leading to a significant improvement in five-year survival. Although part of this success has been rightly attributed to aggressive surgical management and advances in other adjunct treatments,...

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    authors: Pai SG,Fuloria J

    更新日期:2016-01-15 00:00:00

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    abstract::Pancreaticobiliary maljunction (PBM) is a high risk factor for biliary tract cancer. In PBM, since the pancreatic duct and bile duct converge outside the duodenal wall beyond the influence of the sphincter of Oddi, pancreatic juice and bile are constantly mixed, producing a variety of harmful substances. Because of th...

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    authors: Tsuchida A,Itoi T

    更新日期:2010-03-15 00:00:00

  • From traditional serrated adenoma to tubulovillous adenoma and beyond.

    abstract::It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous adenomas (VA/TVA), sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA). Of these, TSAs are least common and account for only 5% of all serrated poly...

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    authors: Kalimuthu SN,Chelliah A,Chetty R

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    abstract::Pancreatic adenocarcinoma is the fourth cause of cancer-related death in the United States. Surgery is the only potentially curative treatment, but most patients present at diagnosis with unresectable or metastatic disease. Moreover, even with an R0 resection, the majority of patients will die of disease recurrence. M...

    journal_title:World journal of gastrointestinal oncology

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    authors: Sperti C,Moletta L,Merigliano S

    更新日期:2015-12-15 00:00:00

  • Epigenetic reduction of DNA repair in progression to gastrointestinal cancer.

    abstract::Deficiencies in DNA repair due to inherited germ-line mutations in DNA repair genes cause increased risk of gastrointestinal (GI) cancer. In sporadic GI cancers, mutations in DNA repair genes are relatively rare. However, epigenetic alterations that reduce expression of DNA repair genes are frequent in sporadic GI can...

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    authors: Bernstein C,Bernstein H

    更新日期:2015-05-15 00:00:00

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    abstract:AIM:To assess the practice of Egyptian physicians in screening patients for hepatocellular carcinoma (HCC). METHODS:The study included 154 physicians from all over Egypt caring for patients at risk for HCC. The study was based on a questionnaire with 20 items. Each questionnaire consisted of two parts: (1) personal in...

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    authors: Hassany SM,Moustafa EF,Taher ME,Abdeltwab AA,Blum HE

    更新日期:2015-09-15 00:00:00

  • Epigenetic field defects in progression to cancer.

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    journal_title:World journal of gastrointestinal oncology

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    authors: Bernstein C,Nfonsam V,Prasad AR,Bernstein H

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  • Ileal inflammatory fibroid polyp causing chronic ileocolic intussusception and mimicking cecal carcinoma.

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    journal_title:World journal of gastrointestinal oncology

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    authors: Gara N,Falzarano JS,Limm WM,Namiki TS,Tom LK

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    更新日期:2020-02-15 00:00:00

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    更新日期:2015-12-15 00:00:00

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