Abstract:
BACKGROUND:Breast metastases from colorectal cancer (CRC) are very uncommon. There is no unanimous consensus regarding the best treatment for this rare condition, and management is, especially in elderly patients, limited to diagnosis and palliative care. Capecitabine, an oral fluoropyrimidine derivative, might be helpful in controlling the disease and may be a treatment option for patients unable to receive more aggressive chemotherapy. CASE SUMMARY:We report a case of synchronous massive breast metastasis from CRC in an 85 year old patient who came to the hospital presenting a huge mass originating from the axillary extension of the right breast. A whole body computed tomography also showed a mass in the right colon. The patient underwent a simple right mastectomy along with right hemicolectomy. The resected breast showed massive metastasis from CRC with intense and homogeneous nuclear CDX2 staining, while the colon specimen revealed poorly differentiated adenocarcinoma stage pT4a pN0 pM1 (breast) (Tumor Node Metastasis 2017). Three months later she developed a subcutaneous mass at the site of the previous mastectomy. An ultrasound guided biopsy was carried out again and revealed a metastasis from CRC. The patient then started treatment with capecitabine plus bevacizumab, obtaining stable disease (RECIST criteria) and a clinical benefit after 3 mo of therapy. CONCLUSION:In our experience, capecitabine and bevacizumab may be a useful treatment option for breast metastases from primary CRC in elderly patients.
journal_name
World J Gastrointest Oncoljournal_title
World journal of gastrointestinal oncologyauthors
Taccogna S,Gozzi E,Rossi L,Caruso D,Conte D,Trenta P,Leoni V,Tomao S,Raimondi L,Angelini Fdoi
10.4251/wjgo.v12.i9.1073subject
Has Abstractpub_date
2020-09-15 00:00:00pages
1073-1079issue
9issn
1948-5204journal_volume
12pub_type
abstract:BACKGROUND:Radical D2 lymphadenectomy for advanced gastric cancer as a standard procedure has gained global consensus. Mounting studies have shown that the number of lymph nodes dissection directly affects the prognosis and recurrence of gastric cancer. Our previous study showed that there was no obvious lymph node aro...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v11.i6.499
更新日期:2019-06-15 00:00:00
abstract::Most patients treated with curative intent for colorectal cancer (CRC) are included in a follow-up program involving periodic evaluations. The survival benefits of a follow-up program are well delineated, and previous meta-analyses have suggested an overall survival improvement of 5%-10% by intensive follow-up. Howeve...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v6.i5.104
更新日期:2014-05-15 00:00:00
abstract:BACKGROUND:Toll-like receptors (TLRs) are the first line of host defense, and are involved in Helicobacter pylori (H. pylori) recognition and activation of both inflammatory and carcinogenic processes. The presence of single nucleotide polymorphisms (SNPs) in genes that activate the immune response may modulate the ris...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v11.i11.998
更新日期:2019-11-15 00:00:00
abstract:BACKGROUND:It has been recognized for a long time that gastric cancer behavior and outcomes might be different between patients living in Asian countries vs patients living in Western countries. It is not clear if these differences would persist between patients of Asian ancestry and patients of other racial subgroups ...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v11.i12.1151
更新日期:2019-12-15 00:00:00
abstract:BACKGROUND:Pathological manifestations of hepatic tumours are often associated with prognosis. Although surgical specimens (SS) can provide more information, currently, pre-treatment needle core biopsy (NCB) is increasingly showing important value in understanding the nature of liver tumors and even in diagnosis and tr...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v11.i5.404
更新日期:2019-05-15 00:00:00
abstract::Cholangiocarcinoma (CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group. However, "hilar and perihilar CC" are also used to refer exclusively to the intrahepatic hilar type CC or, more commonly, t...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v5.i7.159
更新日期:2013-07-15 00:00:00
abstract:BACKGROUND:Kinesin super family 23 (KIF23) is a member of the KIF family, and it plays an important role in mitosis and cytokinesis. Loss of expression can cause mitotic arrest. The Oncomine database is one of the largest oncogene chip databases in the world, and is an integrated data mining platform for cancer gene in...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v12.i10.1104
更新日期:2020-10-15 00:00:00
abstract::Gastrointestinal (GI) cancer has a high tumor incidence and mortality rate worldwide. Despite significant improvements in radiotherapy, chemotherapy, and targeted therapy for GI cancer over the last decade, GI cancer is characterized by high recurrence rates and a dismal prognosis. There is an urgent need for new diag...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v12.i1.1
更新日期:2020-01-15 00:00:00
abstract::Casein kinase I is a group of ubiquitous Serine/Threonine kinases that have been implicated in both normal cellular functions and several pathological conditions including Alzheimer's disease and cancer. Recent findings in colon and pancreatic cancer have brought tremendous attention to these molecules as potential th...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v1.i1.26
更新日期:2009-10-15 00:00:00
abstract::Because of the aging of the population, prevalence of medical checkups, and advances in imaging studies, the number of pancreatic cystic lesions detected has increased. Once these lesions are detected, neoplastic cysts should be differentiated from non-neoplastic cysts. Furthermore, because of the malignant potential ...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v8.i2.159
更新日期:2016-02-15 00:00:00
abstract::Cancer research over the past decades has focused on neoplastic cells, or a fraction of them, i.e. tumor stem cells, as the ultimate causes of tumorigenesis. However, during recent years, scientists have come to realize that tumorigenesis is not a solo act of neoplastic cells, but rather a cooperative process in which...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v2.i5.218
更新日期:2010-05-15 00:00:00
abstract:AIM:To assess the practice of Egyptian physicians in screening patients for hepatocellular carcinoma (HCC). METHODS:The study included 154 physicians from all over Egypt caring for patients at risk for HCC. The study was based on a questionnaire with 20 items. Each questionnaire consisted of two parts: (1) personal in...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v7.i9.161
更新日期:2015-09-15 00:00:00
abstract::Paraneoplastic leukemoid reaction is a rare syndrome defined by a leukocyte count exceeding 50 Giga/Liter (G/L), mostly described with progressive lung or renal carcinoma. We report a case of a 68-year-old man with recurrent pancreatic carcinoma presenting a leukemoid reaction with a white blood cell count of 63.87 G/...
journal_title:World journal of gastrointestinal oncology
pub_type:
doi:10.4251/wjgo.v7.i10.259
更新日期:2015-10-15 00:00:00
abstract::Pancreatic surgery for malignancy is recognized as challenging for the surgeons and risky for the patients due to consistent perioperative morbidity and mortality. Furthermore, the oncological long-term results are largely disappointing, even for those patients who experience an uneventfully hospital stay. Nevertheles...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v7.i12.411
更新日期:2015-12-15 00:00:00
abstract::Gastrointestinal neuroendocrine tumors are rare slow-growing tumors with distinct histological, biological, and clinical characteristics that have increased in incidence and prevalence within the last few decades. They contain chromogranin A, synaptophysin and neuron-specific enolase which are necessary for making a d...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v12.i8.791
更新日期:2020-08-15 00:00:00
abstract::Gastric metastases from lung adenocarcinoma are rare. Because gastric metastasis grossly resembles advanced gastric cancer, it is difficult to diagnose gastric metastasis especially when the histology of the primary lung cancer is adenocarcinoma. We describe a case of gastric metastasis from primary lung adenocarcinom...
journal_title:World journal of gastrointestinal oncology
pub_type:
doi:10.4251/wjgo.v7.i3.12
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:Esophagectomy is a pivotal curative modality for localized esophageal or esophagogastric junction cancer (EC or EJC). Postoperative anastomotic leakage (AL) remains problematic. The use of fibrin sealant (FS) may improve the strength of esophageal anastomosis and reduce the incidence of AL. AIM:To assess th...
journal_title:World journal of gastrointestinal oncology
pub_type: 临床试验
doi:10.4251/wjgo.v12.i6.651
更新日期:2020-06-15 00:00:00
abstract::Pancreaticobiliary maljunction (PBM) is a high risk factor for biliary tract cancer. In PBM, since the pancreatic duct and bile duct converge outside the duodenal wall beyond the influence of the sphincter of Oddi, pancreatic juice and bile are constantly mixed, producing a variety of harmful substances. Because of th...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v2.i3.130
更新日期:2010-03-15 00:00:00
abstract:AIM:To examine survival outcomes of perihilar cholangiocarcinoma (PCCA) resection including mortality, morbidity and prognostic factors. METHODS:Multivariate analyses were carried out based on the survival data of all patients with histologically confirmed PCCA who underwent curative resection at Srinagarind Hospital ...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v7.i12.503
更新日期:2015-12-15 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) are a kind of single-stranded RNA of more than 200 nucleotides in length and have no protein-coding function. Amounting studies have indicated that lncRNAs could play a vital role in the initiation and development of cancers, including gastric cancer (GC). Considering the cruci...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v11.i2.139
更新日期:2019-02-15 00:00:00
abstract::Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stomach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distensi...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v5.i12.222
更新日期:2013-12-15 00:00:00
abstract::Non-neoplastic tumor-like lesions in the pancreas are uncommon. Here, we present a case of multiple solid pancreatic hamartomas in a 78-year-old Japanese woman. Her computed tomography revealed a pancreatic mass, measuring 1.8 cm in maximum diameter. However, no symptoms were found. She was not an alcoholic and had no...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v4.i9.202
更新日期:2012-09-15 00:00:00
abstract::Colorectal cancer is the second leading cause of death from cancer among adults. The disease begins as a benign adenomatous polyp, which develops into an advanced adenoma with high-grade dysplasia and then progresses to an invasive cancer. Appropriate apoptotic signaling is fundamentally important to preserve a health...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v8.i8.583
更新日期:2016-08-15 00:00:00
abstract::A 40-year-old male, diagnosed with mild Crohn's disease (CD) 11 years ago but with no prior abdominal surgeries, was diagnosed with a small bowel stricture, due to ongoing abdominal pain and intolerance of enteral diet, and referred for surgical treatment. Exploratory laparoscopy revealed a white solid mass causing a ...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v4.i7.184
更新日期:2012-07-15 00:00:00
abstract::A field defect is a field of pre-malignant tissue in which a new cancer is likely to arise. Field defects often appear to be histologically normal under the microscope. Recent research indicates that cells within a field defect characteristically have an increased frequency of epigenetic alterations and these may be f...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v5.i3.43
更新日期:2013-03-15 00:00:00
abstract:BACKGROUND:Overexpression of SQSTM1 (sequestosome 1, P62) and nuclear factor-κB (NF-κB) plays an important role in the invasion and metastasis of a variety of malignant tumors. AIM:To explore the expression of P62 and NF-κB in pancreatic cancer and their relationship with clinicopathological features. METHODS:The exp...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v12.i7.719
更新日期:2020-07-15 00:00:00
abstract:BACKGROUND:In recent years, intraoperative radiotherapy (IORT) has been increasingly used for the treatment of rectal cancer. However, the efficacy and safety of IORT for the treatment of rectal cancer are still controversial. AIM:To evaluate the value of IORT for patients with rectal cancer. METHODS:We searched PubM...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v13.i1.69
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:Brain metastasis (BM) from colorectal cancer (CRC) is rarely encountered clinically, and its prognosis has not been fully evaluated. AIM:To construct a scoring system and accurately predict the survival of patients with synchronous BM at diagnosis of CRC. METHODS:A retrospective study of 371 patients with ...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v12.i2.195
更新日期:2020-02-15 00:00:00
abstract::Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival outcomes. Positive peritoneal cytology similarly worsens the survival of patients with gastric cancer and treatment options for these patients have been limite...
journal_title:World journal of gastrointestinal oncology
pub_type: 社论
doi:10.4251/wjgo.v10.i10.282
更新日期:2018-10-15 00:00:00
abstract::Digestive endoscopy is currently the main diagnostic procedure for investigation of the digestive tract when a digestive disease is suspected. The use of computers and electronic medical records for the management of endoscopic data are an important key to improving endoscopy unit efficiency and productivity. This tec...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v4.i4.76
更新日期:2012-04-15 00:00:00