Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of micro-ribonucleic acids.

abstract：:Pancreatic cancer, with a 5% 5-year survival rate, is the fourth leading cause of cancer death in Western countries. Unfortunately, only 20% of all patients benefit from surgical treatment. The need to prolong survival has prompted pathologists to develop improved protocols to evaluate pancreatic specimens and their s...

journal_title：World journal of gastrointestinal oncology

authors： Gómez-Mateo Mdel C,Sabater-Ortí L,Ferrández-Izquierdo A

更新日期：2014-09-15 00:00:00

abstract：BACKGROUND:Overexpression of SQSTM1 (sequestosome 1, P62) and nuclear factor-κB (NF-κB) plays an important role in the invasion and metastasis of a variety of malignant tumors. AIM:To explore the expression of P62 and NF-κB in pancreatic cancer and their relationship with clinicopathological features. METHODS:The exp...

journal_title：World journal of gastrointestinal oncology

authors： Zhang ZY,Guo S,Zhao R,Ji ZP,Zhuang ZN

更新日期：2020-07-15 00:00:00

abstract：BACKGROUND:Regorafenib is an oral small-molecule multikinase inhibitor approved in third or later line of treatment for patients with metastatic colorectal cancer (mCRC). Regorafenib has shown significant benefits in overall survival and progression free survival in two phase III trials compared to placebo in patients ...

journal_title：World journal of gastrointestinal oncology

authors： Ricci V,Granetto C,Falletta A,Paccagnella M,Abbona A,Fea E,Fabozzi T,Lo Nigro C,Merlano MC

更新日期：2020-03-15 00:00:00

abstract：:Diarrhea is a common side effect of chemotherapy. Pseudomembranous colitis is a well known complication of antibiotic treatment that can also be observed, albeit rarely, with certain chemotherapeutic agents. We present four cases of severe colitis in patients undergoing treatment with taxane-based chemotherapy for pan...

journal_title：World journal of gastrointestinal oncology

authors： Carrion AF,Hosein PJ,Cooper EM,Lopes G,Pelaez L,Rocha-Lima CM

更新日期：2010-10-15 00:00:00

abstract：:Most patients treated with curative intent for colorectal cancer (CRC) are included in a follow-up program involving periodic evaluations. The survival benefits of a follow-up program are well delineated, and previous meta-analyses have suggested an overall survival improvement of 5%-10% by intensive follow-up. Howeve...

journal_title：World journal of gastrointestinal oncology

authors： Augestad KM,Rose J,Crawshaw B,Cooper G,Delaney C

更新日期：2014-05-15 00:00:00

abstract：:Gastric cancer is the third leading cause of cancer death worldwide. Even though during these last decades gastric cancer incidence decreased in Western countries, it remains endemic and with a high incidence in Eastern countries. The survival in advanced and metastatic stage of gastric cancer is still very poor. Rece...

journal_title：World journal of gastrointestinal oncology

authors： Satolli MA,Buffoni L,Spadi R,Roato I

更新日期：2015-11-15 00:00:00

abstract：:A field defect is a field of pre-malignant tissue in which a new cancer is likely to arise. Field defects often appear to be histologically normal under the microscope. Recent research indicates that cells within a field defect characteristically have an increased frequency of epigenetic alterations and these may be f...

journal_title：World journal of gastrointestinal oncology

authors： Bernstein C,Nfonsam V,Prasad AR,Bernstein H

更新日期：2013-03-15 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic...

journal_title：World journal of gastrointestinal oncology

authors： Kayhanian H,Smyth EC,Braconi C

更新日期：2017-07-15 00:00:00

abstract：AIM:To investigate p16 gene methylation and its expression in 30 patients with sporadic colorectal adenocarcinoma in a North Indian population. METHODS:Methylation specific polymerase chain reaction was used to detect p16 gene methylation and immunohistochemistry was used to study the p16 expression in 30 sporadic col...

journal_title：World journal of gastrointestinal oncology

authors： Malhotra P,Kochhar R,Vaiphei K,Wig JD,Mahmood S

更新日期：2010-07-15 00:00:00

abstract：:Despite significant advances in imaging techniques, the incidence of colorectal cancer has been increasing in recent years, with many cases still being diagnosed in advanced stages. Early detection and accurate staging remain the main factors that lead to a decrease in the cost and invasiveness of the curative techniq...

journal_title：World journal of gastrointestinal oncology

authors： Ciocalteu A,Gheonea DI,Saftoiu A,Streba L,Dragoescu NA,Tenea-Cojan TS

更新日期：2018-12-15 00:00:00

abstract：:While the incidence and mortality of gastric cancer (GC) have declined due to public health programs, it remains the third deadliest cancer worldwide. For patients with early disease, innovative endoscopic and complex surgical techniques have improved survival. However, for patients with advanced disease, there are li...

journal_title：World journal of gastrointestinal oncology

authors： Lin M,Gao M,Cavnar MJ,Kim J

更新日期：2019-07-15 00:00:00

abstract：BACKGROUND:Esophagectomy is a pivotal curative modality for localized esophageal or esophagogastric junction cancer (EC or EJC). Postoperative anastomotic leakage (AL) remains problematic. The use of fibrin sealant (FS) may improve the strength of esophageal anastomosis and reduce the incidence of AL. AIM:To assess th...

journal_title：World journal of gastrointestinal oncology

authors： Lin YB,Fu JH,Huang Y,Hu YH,Luo KJ,Wang KX,Bella AÉ,Situ DR,Chen JY,Lin T,D'Journo XB,Novoa NM,Brunelli A,Fernando HC,Cerfolio RJ,Ismail M,Yang H,AME Thoracic Surgery Collaborative Group.

更新日期：2020-06-15 00:00:00

abstract：BACKGROUND:In recent years, intraoperative radiotherapy (IORT) has been increasingly used for the treatment of rectal cancer. However, the efficacy and safety of IORT for the treatment of rectal cancer are still controversial. AIM:To evaluate the value of IORT for patients with rectal cancer. METHODS:We searched PubM...

journal_title：World journal of gastrointestinal oncology

authors： Liu B,Ge L,Wang J,Chen YQ,Ma SX,Ma PL,Zhang YQ,Yang KH,Cai H

更新日期：2021-01-15 00:00:00

abstract：:Inflammatory fibroid polyp (IFP) is a rare, idiopathic pseudotumorous lesion of the gastrointestinal tract. While mostly reported as solitary gastric lesions, multiple cases of small bowel IFPs are also reported. It is a documented cause of intussusception in adults. In the case reports of ileal inflammatory fibroid p...

journal_title：World journal of gastrointestinal oncology

authors： Gara N,Falzarano JS,Limm WM,Namiki TS,Tom LK

更新日期：2009-10-15 00:00:00

abstract：:Pancreatic adenocarcinoma is the fourth cause of cancer-related death in the United States. Surgery is the only potentially curative treatment, but most patients present at diagnosis with unresectable or metastatic disease. Moreover, even with an R0 resection, the majority of patients will die of disease recurrence. M...

journal_title：World journal of gastrointestinal oncology

authors： Sperti C,Moletta L,Merigliano S

更新日期：2015-12-15 00:00:00

abstract：:Over the past couple of decades considerable progress has been made in the management of metastatic colorectal cancers (mCRC) leading to a significant improvement in five-year survival. Although part of this success has been rightly attributed to aggressive surgical management and advances in other adjunct treatments,...

journal_title：World journal of gastrointestinal oncology

authors： Pai SG,Fuloria J

更新日期：2016-01-15 00:00:00

abstract：:Because of the aging of the population, prevalence of medical checkups, and advances in imaging studies, the number of pancreatic cystic lesions detected has increased. Once these lesions are detected, neoplastic cysts should be differentiated from non-neoplastic cysts. Furthermore, because of the malignant potential ...

journal_title：World journal of gastrointestinal oncology

authors： Kawaguchi Y,Mine T

更新日期：2016-02-15 00:00:00

abstract：:Deficiencies in DNA repair due to inherited germ-line mutations in DNA repair genes cause increased risk of gastrointestinal (GI) cancer. In sporadic GI cancers, mutations in DNA repair genes are relatively rare. However, epigenetic alterations that reduce expression of DNA repair genes are frequent in sporadic GI can...

journal_title：World journal of gastrointestinal oncology

authors： Bernstein C,Bernstein H

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:Due to the special clinical features and biologic characteristics of adolescent and young adult (AYA) cancers, AYA cancers are different from cancers in children and elderly individuals. However, there are few reports on AYA hepatocellular carcinoma (HCC). AIM:To investigate the overall survival (OS) of AYA...

journal_title：World journal of gastrointestinal oncology

authors： Ren J,Tong YM,Cui RX,Wang Z,Li QL,Liu W,Qu K,Zhang JY,Liu C,Wan Y

更新日期：2020-12-15 00:00:00

abstract：:Biliary tract carcinomas are relatively rare, representing less than 1% of cancers. However, their incidence has increased in Japan and in industrialized countries like the USA. Biliary tract tumors have a poor prognosis and a high mortality rate because they are usually detected late in the course of the disease; the...

journal_title：World journal of gastrointestinal oncology

authors： Malaguarnera G,Giordano M,Paladina I,Rando A,Uccello M,Basile F,Biondi A,Carnazzo S,Alessandria I,Mazzarino C

更新日期：2011-04-15 00:00:00

abstract：AIM:To correct the misclassification in registered gastric cancer incidence across Iranian provinces in cancer registry data. METHODS:Gastric cancer data is extracted from Iranian annual of national cancer registration report 2008. A Bayesian method with beta prior is implemented to estimate the rate of misclassificat...

journal_title：World journal of gastrointestinal oncology

authors： Hajizadeh N,Pourhoseingholi MA,Baghestani AR,Abadi A,Zali MR

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:Bile duct cancer constitutes gallbladder cancer (GBC), intrahepatic cholangiocarcinoma (ICA), and extrahepatic cholangiocarcinoma (ECA). These three entities show morphological and immunohistochemical resemblance so that it is difficult to differentiate between primary ICA and liver metastasis of GBC, which ...

journal_title：World journal of gastrointestinal oncology

authors： Inagaki C,Maeda D,Kimura A,Otsuru T,Iwagami Y,Nishida N,Sakai D,Shitotsuki R,Yachida S,Doki Y,Satoh T

更新日期：2019-09-15 00:00:00

abstract：AIM:To identify genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer patients. METHODS:The NEIL1 promoter region in DNA from 80 Japanese patients with gastric cancer was searched for genetic polymorphisms by polymerase chain reaction-single-strand conformation pol...

journal_title：World journal of gastrointestinal oncology

authors： Goto M,Shinmura K,Tao H,Tsugane S,Sugimura H

更新日期：2010-02-15 00:00:00

abstract：:Progress in the molecular oncology of gastrointestinal carcinomas depends on high quality cancer tissues for research. Recent acceleration on new technological platforms as well as the "omics" revolution increases the demands on tissues and peripheral blood for research at the DNA, mRNA and protein levels. Tissue bank...

journal_title：World journal of gastrointestinal oncology

authors： Yu YY,Zhu ZG

更新日期：2010-01-15 00:00:00

abstract：:Cholangiocarcinoma (CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group. However, "hilar and perihilar CC" are also used to refer exclusively to the intrahepatic hilar type CC or, more commonly, t...

journal_title：World journal of gastrointestinal oncology

authors： Castellano-Megías VM,Ibarrola-de Andrés C,Colina-Ruizdelgado F

更新日期：2013-07-15 00:00:00

abstract：BACKGROUND:Breast metastases from colorectal cancer (CRC) are very uncommon. There is no unanimous consensus regarding the best treatment for this rare condition, and management is, especially in elderly patients, limited to diagnosis and palliative care. Capecitabine, an oral fluoropyrimidine derivative, might be help...

journal_title：World journal of gastrointestinal oncology

authors： Taccogna S,Gozzi E,Rossi L,Caruso D,Conte D,Trenta P,Leoni V,Tomao S,Raimondi L,Angelini F

更新日期：2020-09-15 00:00:00

abstract：:Standard pancreatic resections, such as pancreaticoduodenectomy, distal pancreatectomy, or total pancreatectomy, result in an important loss of normal pancreatic parenchyma and may cause impairment of exocrine and endocrine function. Whilst these procedures are mandatory for malignant tumors, they seem to be too exten...

journal_title：World journal of gastrointestinal oncology

authors： Sperti C,Beltrame V,Milanetto AC,Moro M,Pedrazzoli S

更新日期：2010-06-15 00:00:00

abstract：:It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous adenomas (VA/TVA), sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA). Of these, TSAs are least common and account for only 5% of all serrated poly...

journal_title：World journal of gastrointestinal oncology

authors： Kalimuthu SN,Chelliah A,Chetty R

更新日期：2016-12-15 00:00:00

abstract：:Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stomach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distensi...

journal_title：World journal of gastrointestinal oncology

authors： Ulla M,Gentile E,Yeyati EL,Diez ML,Cavadas D,Garcia-Monaco RD,Ros PR

更新日期：2013-12-15 00:00:00

abstract：:Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival outcomes. Positive peritoneal cytology similarly worsens the survival of patients with gastric cancer and treatment options for these patients have been limite...

journal_title：World journal of gastrointestinal oncology

authors： Leiting JL,Grotz TE

更新日期：2018-10-15 00:00:00