Abstract:
BACKGROUND:Overexpression of SQSTM1 (sequestosome 1, P62) and nuclear factor-κB (NF-κB) plays an important role in the invasion and metastasis of a variety of malignant tumors. AIM:To explore the expression of P62 and NF-κB in pancreatic cancer and their relationship with clinicopathological features. METHODS:The expression levels of P62 and NF-κB were analyzed by immunohistochemistry with a tissue chip containing 40 cases of human pancreatic carcinoma. Then we analyzed the correlation among P62 expression, phospho-P65 expression, and clinicopathological features of pancreatic carcinoma samples. RESULTS:P62 expression was mainly observed in the cytoplasm of pancreatic carcinoma cells. Phosphorylated P65 (phospho-P65) was mainly expressed in the nucleus and cytoplasm of pancreatic carcinoma cells. There was a significant difference in P62 expression among T stages. And a significant difference in phosphor-P65 expression among pathology types was noted. In the cases with strongly positive P62 expression, significant differences were found in age. And there were significant differences in T stage and tumor-node-metastasis stage in the cases with strongly positive phosphor-P65 expression. CONCLUSION:In pancreatic carcinoma, P62 expression is significantly correlated with T stage. It may be a valuable malignant indicator for human pancreatic carcinoma.
journal_name
World J Gastrointest Oncoljournal_title
World journal of gastrointestinal oncologyauthors
Zhang ZY,Guo S,Zhao R,Ji ZP,Zhuang ZNdoi
10.4251/wjgo.v12.i7.719subject
Has Abstractpub_date
2020-07-15 00:00:00pages
719-731issue
7issn
1948-5204journal_volume
12pub_type
杂志文章abstract::Adenocarcinoma of small intestines (SBA) is a relatively rare malignancy with poor outcomes due to delayed diagnosis. Fifty percent of patients have metastases on presentation and therefore early detection and treatment offers the best long term outcomes. Certain genetic polyposis syndromes and familial diseases are a...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v8.i6.509
更新日期:2016-06-15 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a highly malignant tumor and extrahepatic metastasis is not rare. The most common organ of HCC metastasis is lung, followed by bone and adrenal gland. To the best of our knowledge, isolated pancreatic metastasis of HCC that developed after curative resection has not been described pre...
journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v12.i12.1394
更新日期:2020-12-15 00:00:00
abstract::Intussusception is a rare condition in the adult population. However, in contrast to its presentation in children, an identifiable etiology is found in the majority of cases. Clinical manifestations of adult intussusception are non-specific and patients may present with acute, intermittent or chronic symptoms, predomi...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v3.i6.103
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abstract::Because of the aging of the population, prevalence of medical checkups, and advances in imaging studies, the number of pancreatic cystic lesions detected has increased. Once these lesions are detected, neoplastic cysts should be differentiated from non-neoplastic cysts. Furthermore, because of the malignant potential ...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
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更新日期:2016-02-15 00:00:00
abstract:BACKGROUND:Brain metastasis (BM) from colorectal cancer (CRC) is rarely encountered clinically, and its prognosis has not been fully evaluated. AIM:To construct a scoring system and accurately predict the survival of patients with synchronous BM at diagnosis of CRC. METHODS:A retrospective study of 371 patients with ...
journal_title:World journal of gastrointestinal oncology
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doi:10.4251/wjgo.v12.i2.195
更新日期:2020-02-15 00:00:00
abstract:BACKGROUND:Bile duct cancer constitutes gallbladder cancer (GBC), intrahepatic cholangiocarcinoma (ICA), and extrahepatic cholangiocarcinoma (ECA). These three entities show morphological and immunohistochemical resemblance so that it is difficult to differentiate between primary ICA and liver metastasis of GBC, which ...
journal_title:World journal of gastrointestinal oncology
pub_type:
doi:10.4251/wjgo.v11.i9.761
更新日期:2019-09-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
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doi:10.4251/wjgo.v7.i9.161
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journal_title:World journal of gastrointestinal oncology
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更新日期:2019-10-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v7.i12.503
更新日期:2015-12-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type:
doi:10.4251/wjgo.v7.i3.12
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v11.i8.579
更新日期:2019-08-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
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更新日期:2013-07-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v2.i7.295
更新日期:2010-07-15 00:00:00
abstract::Paraneoplastic leukemoid reaction is a rare syndrome defined by a leukocyte count exceeding 50 Giga/Liter (G/L), mostly described with progressive lung or renal carcinoma. We report a case of a 68-year-old man with recurrent pancreatic carcinoma presenting a leukemoid reaction with a white blood cell count of 63.87 G/...
journal_title:World journal of gastrointestinal oncology
pub_type:
doi:10.4251/wjgo.v7.i10.259
更新日期:2015-10-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v11.i12.1151
更新日期:2019-12-15 00:00:00
abstract::Solid pseudopapillary neoplasm (SPN), also known as Gruber-Frantz tumor, is a rare form of neoplasm that almost exclusively occurs in the pancreas and in young females. While the potential of malignancy is low for SPN, these tumors can mimic other diseases and require a meticulous investigation and a standard treatmen...
journal_title:World journal of gastrointestinal oncology
pub_type:
doi:10.4251/wjgo.v9.i12.497
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journal_title:World journal of gastrointestinal oncology
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v11.i11.998
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journal_title:World journal of gastrointestinal oncology
pub_type:
doi:10.4251/wjgo.v12.i9.1073
更新日期:2020-09-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v8.i1.99
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journal_title:World journal of gastrointestinal oncology
pub_type:
doi:10.4251/wjgo.v11.i10.925
更新日期:2019-10-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v1.i1.89
更新日期:2009-10-15 00:00:00
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v12.i1.1
更新日期:2020-01-15 00:00:00
abstract::Cancer research over the past decades has focused on neoplastic cells, or a fraction of them, i.e. tumor stem cells, as the ultimate causes of tumorigenesis. However, during recent years, scientists have come to realize that tumorigenesis is not a solo act of neoplastic cells, but rather a cooperative process in which...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v2.i5.218
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v1.i1.26
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journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v11.i1.48
更新日期:2019-01-15 00:00:00
abstract::In an effort to minimize the limitations of laparoscopy, a robotic surgery system was introduced, but its role for gastric cancer is still unclear. The objective of this article is to assess the current status of robotic surgery for gastric cancer and to predict future prospects. Although the current study was limited...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v3.i10.137
更新日期:2011-10-15 00:00:00