Abstract:
:Gastrointestinal (GI) cancer has a high tumor incidence and mortality rate worldwide. Despite significant improvements in radiotherapy, chemotherapy, and targeted therapy for GI cancer over the last decade, GI cancer is characterized by high recurrence rates and a dismal prognosis. There is an urgent need for new diagnostic and therapeutic approaches. Recent technological advances and the accumulation of clinical data are moving toward the use of precision medicine in GI cancer. Here we review the application and status of precision medicine in GI cancer. Analyses of liquid biopsy specimens provide comprehensive real-time data of the tumor-associated changes in an individual GI cancer patient with malignancy. With the introduction of gene panels including next-generation sequencing, it has become possible to identify a variety of mutations and genetic biomarkers in GI cancer. Although the genomic aberration of GI cancer is apparently less actionable compared to other solid tumors, novel informative analyses derived from comprehensive gene profiling may lead to the discovery of precise molecular targeted drugs. These progressions will make it feasible to incorporate clinical, genome-based, and phenotype-based diagnostic and therapeutic approaches and apply them to individual GI cancer patients for precision medicine.
journal_name
World J Gastrointest Oncoljournal_title
World journal of gastrointestinal oncologyauthors
Matsuoka T,Yashiro Mdoi
10.4251/wjgo.v12.i1.1subject
Has Abstractpub_date
2020-01-15 00:00:00pages
1-20issue
1issn
1948-5204journal_volume
12pub_type
杂志文章,评审abstract::Most patients treated with curative intent for colorectal cancer (CRC) are included in a follow-up program involving periodic evaluations. The survival benefits of a follow-up program are well delineated, and previous meta-analyses have suggested an overall survival improvement of 5%-10% by intensive follow-up. Howeve...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v6.i5.104
更新日期:2014-05-15 00:00:00
abstract::Deficiencies in DNA repair due to inherited germ-line mutations in DNA repair genes cause increased risk of gastrointestinal (GI) cancer. In sporadic GI cancers, mutations in DNA repair genes are relatively rare. However, epigenetic alterations that reduce expression of DNA repair genes are frequent in sporadic GI can...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v7.i5.30
更新日期:2015-05-15 00:00:00
abstract::Gastrointestinal neuroendocrine tumors are rare slow-growing tumors with distinct histological, biological, and clinical characteristics that have increased in incidence and prevalence within the last few decades. They contain chromogranin A, synaptophysin and neuron-specific enolase which are necessary for making a d...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v12.i8.791
更新日期:2020-08-15 00:00:00
abstract:BACKGROUND:It has been recognized for a long time that gastric cancer behavior and outcomes might be different between patients living in Asian countries vs patients living in Western countries. It is not clear if these differences would persist between patients of Asian ancestry and patients of other racial subgroups ...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v11.i12.1151
更新日期:2019-12-15 00:00:00
abstract::Laparoscopic and endoscopic cooperative surgery (LECS) is a surgical technique that combines laparoscopic partial gastrectomy and endoscopic submucosal dissection. LECS requires close collaboration between skilled laparoscopic surgeons and experienced endoscopists. For successful LECS, experience alone is not sufficie...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v10.i11.381
更新日期:2018-11-15 00:00:00
abstract:BACKGROUND:Kinesin super family 23 (KIF23) is a member of the KIF family, and it plays an important role in mitosis and cytokinesis. Loss of expression can cause mitotic arrest. The Oncomine database is one of the largest oncogene chip databases in the world, and is an integrated data mining platform for cancer gene in...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v12.i10.1104
更新日期:2020-10-15 00:00:00
abstract:BACKGROUND:Radical D2 lymphadenectomy for advanced gastric cancer as a standard procedure has gained global consensus. Mounting studies have shown that the number of lymph nodes dissection directly affects the prognosis and recurrence of gastric cancer. Our previous study showed that there was no obvious lymph node aro...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v11.i6.499
更新日期:2019-06-15 00:00:00
abstract:AIM:To examine survival outcomes of perihilar cholangiocarcinoma (PCCA) resection including mortality, morbidity and prognostic factors. METHODS:Multivariate analyses were carried out based on the survival data of all patients with histologically confirmed PCCA who underwent curative resection at Srinagarind Hospital ...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v7.i12.503
更新日期:2015-12-15 00:00:00
abstract::5-flurouracil (5-FU)-based chemotherapy is the main pharmacological therapy for advanced colorectal cancer (CRC). Despite significant progress in the treatment of CRC during the last decades, 5-FU drug resistance remains the most important cause of failure in CRC therapy. Resistance to 5-FU is a complex and multistep ...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v12.i9.942
更新日期:2020-09-15 00:00:00
abstract::Solid pseudopapillary neoplasm (SPN), also known as Gruber-Frantz tumor, is a rare form of neoplasm that almost exclusively occurs in the pancreas and in young females. While the potential of malignancy is low for SPN, these tumors can mimic other diseases and require a meticulous investigation and a standard treatmen...
journal_title:World journal of gastrointestinal oncology
pub_type:
doi:10.4251/wjgo.v9.i12.497
更新日期:2017-12-15 00:00:00
abstract::Inflammatory fibroid polyp (IFP) is a rare, idiopathic pseudotumorous lesion of the gastrointestinal tract. While mostly reported as solitary gastric lesions, multiple cases of small bowel IFPs are also reported. It is a documented cause of intussusception in adults. In the case reports of ileal inflammatory fibroid p...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v1.i1.89
更新日期:2009-10-15 00:00:00
abstract::Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stomach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distensi...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v5.i12.222
更新日期:2013-12-15 00:00:00
abstract::Colorectal carcinogenesis (CRC) imposes a major health burden in developing countries. It is the third major cause of cancer deaths. Despite several treatment strategies, novel drugs are warranted to reduce the severity of this disease. Adenomatous polyps in the colon are the major culprits in CRC and found in 45% of ...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v10.i9.244
更新日期:2018-09-15 00:00:00
abstract::It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous adenomas (VA/TVA), sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA). Of these, TSAs are least common and account for only 5% of all serrated poly...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v8.i12.805
更新日期:2016-12-15 00:00:00
abstract::Over the past ten years, sorafenib, a multikinase inhibitor, has been the standard of care for patients with unresectable hepatocellular carcinoma (HCC) and well-preserved liver function. Recently, lenvatinib, a different multikinase inhibitor, was shown to be non-inferior to sorafenib, in terms of survival, while all...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v11.i10.788
更新日期:2019-10-15 00:00:00
abstract::Despite significant advances in imaging techniques, the incidence of colorectal cancer has been increasing in recent years, with many cases still being diagnosed in advanced stages. Early detection and accurate staging remain the main factors that lead to a decrease in the cost and invasiveness of the curative techniq...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v10.i12.465
更新日期:2018-12-15 00:00:00
abstract:BACKGROUND:Rectal cancer (RC) is one of the most common diagnosed cancers, and one of the major causes of cancer-related death nowadays. Majority of the current guidelines rely on TNM classification regarding therapy regiments, however recent studies suggest that additional histopathological findings could affect the d...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v12.i5.592
更新日期:2020-05-15 00:00:00
abstract::Paraneoplastic leukemoid reaction is a rare syndrome defined by a leukocyte count exceeding 50 Giga/Liter (G/L), mostly described with progressive lung or renal carcinoma. We report a case of a 68-year-old man with recurrent pancreatic carcinoma presenting a leukemoid reaction with a white blood cell count of 63.87 G/...
journal_title:World journal of gastrointestinal oncology
pub_type:
doi:10.4251/wjgo.v7.i10.259
更新日期:2015-10-15 00:00:00
abstract::Pancreaticobiliary maljunction (PBM) is a high risk factor for biliary tract cancer. In PBM, since the pancreatic duct and bile duct converge outside the duodenal wall beyond the influence of the sphincter of Oddi, pancreatic juice and bile are constantly mixed, producing a variety of harmful substances. Because of th...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v2.i3.130
更新日期:2010-03-15 00:00:00
abstract:BACKGROUND:Due to the special clinical features and biologic characteristics of adolescent and young adult (AYA) cancers, AYA cancers are different from cancers in children and elderly individuals. However, there are few reports on AYA hepatocellular carcinoma (HCC). AIM:To investigate the overall survival (OS) of AYA...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v12.i12.1394
更新日期:2020-12-15 00:00:00
abstract::Surgical therapy for ulcerative colitis (UC) depends on the medical therapy administered for the patient's condition. UC is a benign disease. However, it has been reported that the rare cases of cancer in UC patients are increasing, and such cases have a worse prognosis. Recently, surgical therapy has greatly changed,...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v8.i4.351
更新日期:2016-04-15 00:00:00
abstract::Because of the aging of the population, prevalence of medical checkups, and advances in imaging studies, the number of pancreatic cystic lesions detected has increased. Once these lesions are detected, neoplastic cysts should be differentiated from non-neoplastic cysts. Furthermore, because of the malignant potential ...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章,评审
doi:10.4251/wjgo.v8.i2.159
更新日期:2016-02-15 00:00:00
abstract::Intussusception is a rare condition in the adult population. However, in contrast to its presentation in children, an identifiable etiology is found in the majority of cases. Clinical manifestations of adult intussusception are non-specific and patients may present with acute, intermittent or chronic symptoms, predomi...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v3.i6.103
更新日期:2011-06-15 00:00:00
abstract:BACKGROUND:Overexpression of SQSTM1 (sequestosome 1, P62) and nuclear factor-κB (NF-κB) plays an important role in the invasion and metastasis of a variety of malignant tumors. AIM:To explore the expression of P62 and NF-κB in pancreatic cancer and their relationship with clinicopathological features. METHODS:The exp...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v12.i7.719
更新日期:2020-07-15 00:00:00
abstract::Casein kinase I is a group of ubiquitous Serine/Threonine kinases that have been implicated in both normal cellular functions and several pathological conditions including Alzheimer's disease and cancer. Recent findings in colon and pancreatic cancer have brought tremendous attention to these molecules as potential th...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v1.i1.26
更新日期:2009-10-15 00:00:00
abstract::In an effort to minimize the limitations of laparoscopy, a robotic surgery system was introduced, but its role for gastric cancer is still unclear. The objective of this article is to assess the current status of robotic surgery for gastric cancer and to predict future prospects. Although the current study was limited...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v3.i10.137
更新日期:2011-10-15 00:00:00
abstract:AIM:To study tumor response, and tolerability of arterially directed embolic therapy (ADET) with polyethylene glycol embolics loaded with irinotecan for the treatment of colorectal cancer liver metastases (CRC-LM). Secondary objectives were to monitor quality of life, time to progression and survival of patients. METH...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v9.i9.379
更新日期:2017-09-15 00:00:00
abstract::Biliary tract carcinomas are relatively rare, representing less than 1% of cancers. However, their incidence has increased in Japan and in industrialized countries like the USA. Biliary tract tumors have a poor prognosis and a high mortality rate because they are usually detected late in the course of the disease; the...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v3.i4.49
更新日期:2011-04-15 00:00:00
abstract::Gastric metastases from lung adenocarcinoma are rare. Because gastric metastasis grossly resembles advanced gastric cancer, it is difficult to diagnose gastric metastasis especially when the histology of the primary lung cancer is adenocarcinoma. We describe a case of gastric metastasis from primary lung adenocarcinom...
journal_title:World journal of gastrointestinal oncology
pub_type:
doi:10.4251/wjgo.v7.i3.12
更新日期:2015-03-15 00:00:00
abstract::Pancreatic adenocarcinoma is the fourth cause of cancer-related death in the United States. Surgery is the only potentially curative treatment, but most patients present at diagnosis with unresectable or metastatic disease. Moreover, even with an R0 resection, the majority of patients will die of disease recurrence. M...
journal_title:World journal of gastrointestinal oncology
pub_type: 杂志文章
doi:10.4251/wjgo.v7.i12.375
更新日期:2015-12-15 00:00:00