Abstract:
:HIV-1 infects gut associated lymphoid tissues (GALT) very early after transmission by multiple routes. The infected GALT consequently serves as the major reservoir for HIV-1 infection and could constantly shed HIV-1 and CD4+ T cells into the intestinal lumen. To examine this hypothesis, we monitored HIV-1 RNA/DNA and CD4 mRNA in fecal samples of chronically infected subjects with and without antiretroviral therapy (ART). We compared this to levels of HIV-1 RNA/DNA in urine and blood from the same subjects. Our results show that HIV-1 DNA, RNA and CD4 mRNA were detected in 8%, 19% and 31% respectively, of feces samples from infected subjects with detectable plasma viral load, and were not detected in any of subjects on ART with undetectable plasma viral load. In urine samples, HIV-1 DNA was detected in 24% of infected subjects with detectable plasma viral load and 23% of subjects on ART with undetectable plasma viral load. Phylogenetic analysis of the envelope sequences of HIV-1 revealed distinct virus populations in concurrently collected serum, feces and urine samples from one subject. In addition, our study demonstrated for the first time the presence of CD4 mRNA in fecal specimens of HIV-1 infected subjects, which could be used to assess GALT pathogenesis in HIV-1 infection.
journal_name
AIDS Res Therjournal_title
AIDS research and therapyauthors
Chakrabarti AK,Caruso L,Ding M,Shen C,Buchanan W,Gupta P,Rinaldo CR,Chen Ydoi
10.1186/1742-6405-6-20subject
Has Abstractpub_date
2009-10-02 00:00:00pages
20issn
1742-6405pii
1742-6405-6-20journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Antiretroviral therapy (ART) use by people living with HIV reduces HIV transmission, morbidity, mortality, and improves quality of life. Good ART adherence is required to achieve these benefits. We investigated how the environmental, social, economic and behavioural experiences of people living with HIV with...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0214-y
更新日期:2019-01-21 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:AIDS research and therapy
pub_type: 杂志文章,评审
doi:10.1186/s12981-019-0251-1
更新日期:2019-11-19 00:00:00
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pub_type: 杂志文章
doi:10.1186/1742-6405-7-40
更新日期:2010-11-23 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-25
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journal_title:AIDS research and therapy
pub_type: 临床试验,杂志文章
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更新日期:2017-11-02 00:00:00
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journal_title:AIDS research and therapy
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-17
更新日期:2011-05-12 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-2-1
更新日期:2005-01-13 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-15
更新日期:2007-07-09 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-7-25
更新日期:2010-07-23 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0076-5
更新日期:2015-10-06 00:00:00
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pub_type: 杂志文章,评审
doi:10.1186/s12981-017-0162-y
更新日期:2017-07-26 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-9-14
更新日期:2012-05-14 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-6-5
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-7-21
更新日期:2010-07-06 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0190-2
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-16
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-019-0217-3
更新日期:2019-01-16 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-02-22 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章,meta分析
doi:10.1186/s12981-018-0204-0
更新日期:2018-10-30 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-16
更新日期:2007-07-16 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0047-x
更新日期:2015-03-21 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-13
更新日期:2011-03-07 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0052-0
更新日期:2015-04-15 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-019-0224-4
更新日期:2019-04-15 00:00:00