Abstract：
:HIV-1 infects gut associated lymphoid tissues (GALT) very early after transmission by multiple routes. The infected GALT consequently serves as the major reservoir for HIV-1 infection and could constantly shed HIV-1 and CD4+ T cells into the intestinal lumen. To examine this hypothesis, we monitored HIV-1 RNA/DNA and CD4 mRNA in fecal samples of chronically infected subjects with and without antiretroviral therapy (ART). We compared this to levels of HIV-1 RNA/DNA in urine and blood from the same subjects. Our results show that HIV-1 DNA, RNA and CD4 mRNA were detected in 8%, 19% and 31% respectively, of feces samples from infected subjects with detectable plasma viral load, and were not detected in any of subjects on ART with undetectable plasma viral load. In urine samples, HIV-1 DNA was detected in 24% of infected subjects with detectable plasma viral load and 23% of subjects on ART with undetectable plasma viral load. Phylogenetic analysis of the envelope sequences of HIV-1 revealed distinct virus populations in concurrently collected serum, feces and urine samples from one subject. In addition, our study demonstrated for the first time the presence of CD4 mRNA in fecal specimens of HIV-1 infected subjects, which could be used to assess GALT pathogenesis in HIV-1 infection.
journal_name
AIDS Res Therjournal_title
AIDS research and therapyauthors
Chakrabarti AK,Caruso L,Ding M,Shen C,Buchanan W,Gupta P,Rinaldo CR,Chen Ydoi
10.1186/1742-6405-6-20subject
Has Abstractpub_date
2009-10-02 00:00:00pages
20issn
1742-6405pii
1742-6405-6-20journal_volume
6pub_type
杂志文章abstract：:APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entrapment in inactive ...
journal_title：AIDS research and therapy
pub_type： 杂志文章,评审
doi：10.1186/s12981-017-0173-8
更新日期：2017-09-12 00:00:00
abstract：OBJECTIVES:To compare outcomes with single tablet regimens (STR) versus multi-tablet regimens (MTR) for human immunodeficiency virus (HIV) treatment using published data. DESIGN:Systematic review and random-effects meta-analysis of literature on approved and investigational HIV regimens. METHODS:The research followed...
journal_title：AIDS research and therapy
pub_type： 杂志文章,meta分析
doi：10.1186/s12981-018-0204-0
更新日期：2018-10-30 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-4-16
更新日期：2007-07-16 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0058-7
更新日期：2015-05-10 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0076-5
更新日期：2015-10-06 00:00:00
abstract：BACKGROUND:Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharmacokinetics (PK) of antiretroviral drugs metabolized via the same pathways. However, in vitro drug interaction activity may no...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-017-0140-4
更新日期：2017-03-14 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-9
更新日期：2011-03-01 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章,评审
doi：10.1186/s12981-017-0162-y
更新日期：2017-07-26 00:00:00
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journal_title：AIDS research and therapy
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doi：10.1186/1742-6405-7-43
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0077-4
更新日期：2015-11-12 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-017-0145-z
更新日期：2017-03-28 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-5
更新日期：2006-02-20 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12981-019-0220-8
更新日期：2019-02-22 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-7-25
更新日期：2010-07-23 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章,评审
doi：10.1186/s12981-016-0114-y
更新日期：2016-09-13 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-11-25
更新日期：2014-08-04 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-38
更新日期：2011-10-13 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-10
更新日期：2006-04-07 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-9-9
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0047-x
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-29
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-4-10
更新日期：2007-05-12 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0052-0
更新日期：2015-04-15 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-019-0256-9
更新日期：2019-12-07 00:00:00
abstract：:Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-10-22
更新日期：2013-09-03 00:00:00
abstract：BACKGROUND:Despite the conventional approaches to HIV prevention being the bedrock for early reductions in HIV infections in Uganda, innovations that demonstrate reduction in risk to infection in vulnerable populations need to be embraced urgently. In the past 2 years, a USAID-funded project tested a quality improvemen...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-018-0190-2
更新日期：2018-01-25 00:00:00
abstract：BACKGROUND:Most in vitro assays of drug potency may not adequately predict the performance in vivo. Methods to assess the persistence of antiviral activity of deoxynucleoside analogs, which require intracellular activation to the active metabolites that can persist in cells, will be important for designing dosages, com...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-6-5
更新日期：2009-04-22 00:00:00
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journal_title：AIDS research and therapy
pub_type： 杂志文章,评审
doi：10.1186/s12981-017-0177-4
更新日期：2017-09-12 00:00:00
abstract：BACKGROUND:Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neuropsychological testing for diagnosis. We aimed to develop a brief and clinically feasible battery t...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-019-0224-4
更新日期：2019-04-15 00:00:00
abstract：BACKGROUND:Current German and European HIV guidelines recommend early evaluation of HCV treatment in all HIV/HCV co-infected patients. However, there are still considerable barriers to initiate HCV therapy in everyday clinical practice. This study evaluates baseline characteristics, "intention-to-treat" pattern and out...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-11-16
更新日期：2014-07-01 00:00:00
