Abstract：
:Bone health status is largely absent in South Africa, the main reasons being the absence and cost-effectiveness of specific screening equipment for assessing bone mineral density (BMD). Various risk factors seem to play a role, some of which can be modified to change bone health status. Urbanisation is also a public health concern. Changing nutritional, as well as social behaviour, play integral roles in the prevalence and incidence of decreased BMD. Furthermore, human immunodeficiency virus (HIV) specifically, has a negative impact on BMD and although highly active antiretroviral therapy increases the prognosis for HIV-infected individuals, BMD still seem to decrease further. Dual energy X-ray absorptiometry is considered the gold standard for BMD assessment; however, recent developments have provided more cost-effective screening methods, among which heel quantitative ultrasound appears to be the most widely used in resource limited countries such as South Africa.
journal_name
AIDS Res Therjournal_title
AIDS research and therapyauthors
Kruger MJ,Nell TAdoi
10.1186/s12981-017-0162-ysubject
Has Abstractpub_date
2017-07-26 00:00:00pages
35issue
1issn
1742-6405pii
10.1186/s12981-017-0162-yjournal_volume
14pub_type
杂志文章,评审abstract：BACKGROUND:A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine (PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques if treatment begins within 24 hours after SIVmne inoculation, but is less effective if treatment is delay...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-29
更新日期：2006-11-28 00:00:00
abstract：BACKGROUND:People who inject drugs (PWID) living with HIV often experience sub-optimal antiretroviral therapy (ART) treatment outcomes, including HIV plasma viral load (PVL) rebound. While previous studies have identified risk factors for PVL rebound among PWID, no study has examined the perspectives of PWID who have e...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-016-0108-9
更新日期：2016-07-25 00:00:00
abstract：OBJECTIVE:Recent studies have shown that the current guidelines suggesting immunologic monitoring to determine response to highly active antiretroviral therapy (HAART) are inadequate. We assessed whether routinely collected clinical markers could improve prediction of concurrent HIV RNA levels. METHODS:We included ind...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-7-25
更新日期：2010-07-23 00:00:00
abstract：:Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a unique vaccine for every world region or virus subtype may not be necessary. ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-2-3
更新日期：2005-04-28 00:00:00
abstract：BACKGROUND:Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-5-2
更新日期：2008-01-29 00:00:00
abstract：:Against the current global trends, in the former Soviet Union (FSU) countries HIV prevalence is on the rise. Visa-free movement across borders has facilitated migrant-associated HIV transmission within this region. Despite efforts from the governments to curtail the growing epidemic, there is still a serious need for ...
journal_title：AIDS research and therapy
pub_type： 杂志文章,评审
doi：10.1186/s12981-019-0251-1
更新日期：2019-11-19 00:00:00
abstract：OBJECTIVES:To compare outcomes with single tablet regimens (STR) versus multi-tablet regimens (MTR) for human immunodeficiency virus (HIV) treatment using published data. DESIGN:Systematic review and random-effects meta-analysis of literature on approved and investigational HIV regimens. METHODS:The research followed...
journal_title：AIDS research and therapy
pub_type： 杂志文章,meta分析
doi：10.1186/s12981-018-0204-0
更新日期：2018-10-30 00:00:00
abstract：BACKGROUND:Community-drug distribution point is a care model for stable patients in the community designed to make ART delivery more efficient for the health system and provide appropriate support to encourage long-term retention of patients. We examined program retention among ART program participants in rural Uganda,...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0077-4
更新日期：2015-11-12 00:00:00
abstract：BACKGROUND:Minocycline is a tetracycline antibiotic that has been shown to attenuate central nervous system (CNS) lentivirus infection, immune activation, and brain injury in model systems. To initiate assessment of minocycline as an adjuvant therapy in human CNS HIV infection, we conducted an open-labelled pilot study...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-17
更新日期：2011-05-12 00:00:00
abstract：BACKGROUND:HIV/AIDS has orphaned 11.6 million children in sub-Saharan Africa. Expanded antiretroviral therapy (ART) use may reduce AIDS orphanhood by decreasing adult mortality and population-level HIV transmission. METHODS:We modeled two scenarios to measure the impact of adult ART use on the incidence of orphanhood ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-13
更新日期：2011-03-07 00:00:00
abstract：BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-11-6
更新日期：2014-01-22 00:00:00
abstract：BACKGROUND:Highly active antiretroviral therapy (HAART) improves the immune function and decreases morbidity, mortality and opportunistic infections (OIs) in HIV-infected patients. However, since the use of HAART, immune restoration disease (IRD) has been described in association with many OIs. Our objective was to det...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-7-46
更新日期：2010-12-21 00:00:00
abstract：: In HIV-1 infected patients, increase of liver enzymes may be mainly due to viral coinfections, alcohol intake, hepatotoxic drugs or autoimmune diseases. Three cases of aminotransferase elevation occurred during a phase of uncontrolled viral replication combined with a severe immunodeficiency and resolved by an effect...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-9
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Separately, chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements, including atrophy and wasting, weakness, and fatigue. One prospective cohort study reported that 41% of HIV-infected patients met the criteria for alcoholism, however; few reports exist on the c...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-30
更新日期：2011-08-16 00:00:00
abstract：BACKGROUND:The search for disease biomarkers within human peripheral fluids has become a favorable approach to preventative therapeutics throughout the past few years. The comparison of normal versus disease states can identify an overexpression or a suppression of critical proteins where illness has directly altered a...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-7-21
更新日期：2010-07-06 00:00:00
abstract：UNLABELLED: OBJECTIVE:To investigate anti-infective treatments in HIV-infected surgical patients during the perioperative period. METHODS:A retrospective study of sepsis and surgical site infections (SSIs) was conducted in 266 HIV-infected patients. The patients were divided into 3 groups based on CD4+ T cells counts...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-9-36
更新日期：2012-11-27 00:00:00
abstract：BACKGROUND:Identifying those at increased risk of death during TB treatment is a priority in resource-constrained settings. We performed this study to determine predictors of mortality during TB treatment. METHODS:We performed a retrospective analysis of a TB surveillance population in a high HIV prevalence area that ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0076-5
更新日期：2015-10-06 00:00:00
abstract：BACKGROUND:Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neuropsychological testing for diagnosis. We aimed to develop a brief and clinically feasible battery t...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-019-0224-4
更新日期：2019-04-15 00:00:00
abstract：:A segment of the HIV infected population develops abnormal and excessive accumulation of adipose tissue in the trunk, including accumulation of visceral (deep abdominal) adipose tissue. This condition, known as HIV-related adipose redistribution syndrome (HARS), may also be accompanied by fat accumulation in the upper...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-4-16
更新日期：2007-07-16 00:00:00
abstract：BACKGROUND:About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with limited documentation of long-term trends in the numbers testing HIV positive and initiating ART. We ex...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-020-00277-0
更新日期：2020-05-14 00:00:00
abstract：BACKGROUND:Despite the conventional approaches to HIV prevention being the bedrock for early reductions in HIV infections in Uganda, innovations that demonstrate reduction in risk to infection in vulnerable populations need to be embraced urgently. In the past 2 years, a USAID-funded project tested a quality improvemen...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-018-0190-2
更新日期：2018-01-25 00:00:00
abstract：PURPOSE:We studied the safety, tolerability, virologic, and immunologic effects of mycophenolate mofetil (MMF) added to a stable antiretroviral therapy (ART) in the setting of low-level viremia. METHODS:MMF 500 mg BID or placebo was given to patients thought to be adherent on stable ART with plasma viremia between 200...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-16
更新日期：2006-05-26 00:00:00
abstract：:APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entrapment in inactive ...
journal_title：AIDS research and therapy
pub_type： 杂志文章,评审
doi：10.1186/s12981-017-0173-8
更新日期：2017-09-12 00:00:00
abstract：BACKGROUND:Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings. We assessed the effect of HAART on patient mortality and tuberculosis incidence rate under routine clinical care conditions in Ethiopia. The objective of this stu...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-10
更新日期：2006-04-07 00:00:00
abstract：BACKGROUND:Tubular dysfunction is common in HIV-infected people and detection of proteinuria is essential to identify this problem. In low-income countries, resources for detection of proteinuria using the Kidney Disease Improve Global Outcomes (KDIGO) gold standard urinary protein/creatinine ratio (uPCR) is rarely pos...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0047-x
更新日期：2015-03-21 00:00:00
abstract：BACKGROUND:Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevirapine concentration and clinical response in African women are limited. We investigated the impact o...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0052-0
更新日期：2015-04-15 00:00:00
abstract：:Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples de...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-5
更新日期：2006-02-20 00:00:00
abstract：BACKGROUND:To quarantine the spreading possibility of HIV virus to general population boosting public awareness is must. But the proper awareness level is substantially low in Bangladesh. This paper aims to identify the factors associated with the awareness regarding HIV/AIDS through a bivariate and multivariate analys...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-4-10
更新日期：2007-05-12 00:00:00
abstract：BACKGROUND:Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple drug-resistant HIV-1 variants. The few studies on HIV-1 mutagenesis in HIV infected children have no...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-4-15
更新日期：2007-07-09 00:00:00
abstract：BACKGROUND:A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming non-infected HIV-exposed infants (HEIs) and prompting timely initiation of ART in HIV-infected babi...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-019-0245-z
更新日期：2019-09-14 00:00:00
