当前位置： SCI文献检索 > AIDS Research and Therapy期刊下所有文献 > Estimating the impact of expanded access to antiretroviral therapy on maternal, paternal and double orphans in sub-Saharan Africa, 2009-2020.

Estimating the impact of expanded access to antiretroviral therapy on maternal, paternal and double orphans in sub-Saharan Africa, 2009-2020.

Abstract：

BACKGROUND:HIV/AIDS has orphaned 11.6 million children in sub-Saharan Africa. Expanded antiretroviral therapy (ART) use may reduce AIDS orphanhood by decreasing adult mortality and population-level HIV transmission. METHODS:We modeled two scenarios to measure the impact of adult ART use on the incidence of orphanhood in 10 sub-Saharan African countries, from 2009 to 2020. Demographic model data inputs were obtained from cohort studies, UNAIDS, UN Population Division, WHO and the US Census Bureau. RESULTS:Compared to current rates of ART uptake, universal ART access averted 4.37 million more AIDS orphans by year 2020, including 3.15 million maternal, 1.89 million paternal and 0.75 million double orphans. The number of AIDS orphans averted was highest in South Africa (901.71 thousand) and Nigeria (839.01 thousand), and lowest in Zimbabwe (86.96 thousand) and Côte d'Ivoire (109.12 thousand). CONCLUSION:Universal ART use may significantly reduce orphanhood in sub-Saharan Africa.

journal_name

AIDS Res Ther

journal_title

AIDS research and therapy

authors

Anema A,Au-Yeung CG,Joffres M,Kaida A,Vasarhelyi K,Kanters S,Montaner JS,Hogg RS

doi

10.1186/1742-6405-8-13

subject

Has Abstract

pub_date

2011-03-07 00:00:00

pages

13

issn

1742-6405

pii

1742-6405-8-13

journal_volume

8

pub_type

杂志文章

相关文献

AIDS Research and Therapy文献大全
  • Clade, Country and Region-specific HIV-1 Vaccines: Are they necessary?

    abstract：:Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a unique vaccine for every world region or virus subtype may not be necessary. ...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-2-3

    authors： Slobod KS,Coleclough C,Brown SA,Stambas J,Zhan X,Surman S,Jones BG,Zirkel A,Freiden PJ,Brown B,Sealy R,Bonsignori M,Hurwitz JL

    更新日期：2005-04-28 00:00:00

  • High rates of transmitted NNRTI resistance among persons with acute HIV infection in Malawi: implications for first-line dolutegravir scale-up.

    abstract：:High rates of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was a key consideration in the WHO policies transitioning first-line regimens to include integrase inhibitors (dolutegravir [DTG]). However, recent data suggests a relationship between DTG and neural tube defects among women exposed durin...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/s12981-019-0220-8

    authors： Rutstein SE,Chen JS,Nelson JAE,Phiri S,Miller WC,Hosseinipour MC

    更新日期：2019-02-22 00:00:00

  • Reverse transcriptase drug resistance mutations in HIV-1 subtype C infected patients on ART in Karonga District, Malawi.

    abstract：BACKGROUND:Drug resistance testing before initiation of, or during, antiretroviral therapy (ART) is not routinely performed in resource-limited settings. High levels of viral resistance circulating within the population will have impact on treatment programs by increasing the chances of transmission of resistant strain...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-8-38

    authors： Bansode VB,Travers SA,Crampin AC,Ngwira B,French N,Glynn JR,McCormack GP

    更新日期：2011-10-13 00:00:00

  • Plasma HIV-1 RNA viral load rebound among people who inject drugs receiving antiretroviral therapy (ART) in a Canadian setting: an ethno-epidemiological study.

    abstract：BACKGROUND:People who inject drugs (PWID) living with HIV often experience sub-optimal antiretroviral therapy (ART) treatment outcomes, including HIV plasma viral load (PVL) rebound. While previous studies have identified risk factors for PVL rebound among PWID, no study has examined the perspectives of PWID who have e...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/s12981-016-0108-9

    authors： Small W,Milloy MJ,McNeil R,Maher L,Kerr T

    更新日期：2016-07-25 00:00:00

  • HLA-B*57:01 screening and hypersensitivity reaction to abacavir between 1999 and 2016 in the OPERA® observational database: a cohort study.

    abstract：BACKGROUND:HLA-B*57:01 screening was added to clinical care guidelines in 2008 to reduce the risk of hypersensitivity reaction from abacavir. The uptake of HLA-B*57:01 screening and incidence of hypersensitivity reaction were assessed in a prospective clinical cohort in the United States to evaluate the effectiveness o...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/s12981-019-0217-3

    authors： Mounzer K,Hsu R,Fusco JS,Brunet L,Henegar CE,Vannappagari V,Stainsby CM,Shaefer MS,Ragone L,Fusco GP

    更新日期：2019-01-16 00:00:00

  • Community-based ART distribution system can effectively facilitate long-term program retention and low-rates of death and virologic failure in rural Uganda.

    abstract：BACKGROUND:Community-drug distribution point is a care model for stable patients in the community designed to make ART delivery more efficient for the health system and provide appropriate support to encourage long-term retention of patients. We examined program retention among ART program participants in rural Uganda,...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/s12981-015-0077-4

    authors： Okoboi S,Ding E,Persuad S,Wangisi J,Birungi J,Shurgold S,Kato D,Nyonyintono M,Egessa A,Bakanda C,Munderi P,Kaleebu P,Moore DM

    更新日期：2015-11-12 00:00:00

  • Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus-1 (HIV-1) infected pediatric patients: a cross-sectional study.

    abstract：BACKGROUND:Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple drug-resistant HIV-1 variants. The few studies on HIV-1 mutagenesis in HIV infected children have no...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-4-15

    authors： Malhotra A,Gaur S,Whitley-Williams P,Loomis C,Petrova A

    更新日期：2007-07-09 00:00:00

  • Inhibition of highly productive HIV-1 infection in T cells, primary human macrophages, microglia, and astrocytes by Sargassum fusiforme.

    abstract：BACKGROUND:The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown to inhibit HIV-1 replication during various stages of the virus life cycle, and therefore represen...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-3-15

    authors： Paskaleva EE,Lin X,Li W,Cotter R,Klein MT,Roberge E,Yu EK,Clark B,Veille JC,Liu Y,Lee DY,Canki M

    更新日期：2006-05-25 00:00:00

  • HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector.

    abstract：:BACKGROUND: RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs against cellular coreceptors CXCR4 and CCR5 had shown that down regulation of these surface molecules co...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-2-1

    authors： Anderson J,Akkina R

    更新日期：2005-01-13 00:00:00

  • Successful use of extracorporeal membrane oxygenation in a human immunodeficiency virus infected patient with severe acute respiratory distress syndrome.

    abstract：INTRODUCTION:We report a case of an adult patient with human immunodeficiency virus (HIV), acute respiratory distress syndrome (ARDS) and ventilator associated pneumonia (VAP) caused by multidrug resistant (MDR) bacteria that was successfully managed with veno-venous extracorporeal membrane oxygenation (ECMO). CASE RE...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-11-37

    authors： Samalavicius R,Serpytis M,Ringaitiene D,Grazulyte D,Bertasiute R,Rimkus B,Matulionyte R,Ambrazaitiene R,Sipylaite J,Kacergius T,Griskevicius L

    更新日期：2014-11-21 00:00:00

  • Hospitalization causes and outcomes in HIV patients in the late antiretroviral era in Colombia.

    abstract：BACKGROUND:Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reasons for hospitalization have changed; OIs are no longer the most common reason for admission. This s...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/s12981-017-0186-3

    authors： Álvarez Barreneche MF,Restrepo Castro CA,Hidrón Botero A,Villa Franco JP,Trompa Romero IM,Restrepo Carvajal L,Eusse García A,Ocampo Mesa A,Echeverri Toro LM,Porras Fernández de Castro GP,Ramírez Rivera JM,Agudelo Restrepo CA

    更新日期：2017-11-13 00:00:00

  • Effect of mobile text messages on antiretroviral medication adherence and patient retention in early HIV care: an open-label, randomized, single center study in south Florida.

    abstract：BACKGROUND:People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. METHODS:ART-n...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/s12981-020-00275-2

    authors： Sherman EM,Niu J,Elrod S,Clauson KA,Alkhateeb F,Eckardt P

    更新日期：2020-05-13 00:00:00

  • Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture.

    abstract：BACKGROUND:Most in vitro assays of drug potency may not adequately predict the performance in vivo. Methods to assess the persistence of antiviral activity of deoxynucleoside analogs, which require intracellular activation to the active metabolites that can persist in cells, will be important for designing dosages, com...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-6-5

    authors： Paintsil E,Grill SP,Dutschman GE,Cheng YC

    更新日期：2009-04-22 00:00:00

  • Sexual behavior of HIV-positive adults not accessing HIV treatment in Mombasa, Kenya: Defining their prevention needs.

    abstract：BACKGROUND:HIV spread continues at high rates from infected persons to their sexual partners. In 2009, an estimated 2.6 million new infections occurred globally. People living with HIV (PLHIV) receiving treatment are in contact with health workers and therefore exposed to prevention messages. By contrast, PLHIV not rec...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-9-9

    authors： Sarna A,Luchters S,Pickett M,Chersich M,Okal J,Geibel S,Kingola N,Temmerman M

    更新日期：2012-03-19 00:00:00

  • Injection drug use and patterns of highly active antiretroviral therapy use: an analysis of ALIVE, WIHS, and MACS cohorts.

    abstract：BACKGROUND:Sustained use of antiretroviral therapy has been consistently shown to be one of the primary predictors of long-term effectiveness. Switching and discontinuation reflect patient and provider decisions that may limit future treatment options. In this study, we utilize data reported at semi-annual study visits...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-4-12

    authors： Morris JD,Golub ET,Mehta SH,Jacobson LP,Gange SJ

    更新日期：2007-06-06 00:00:00

  • Impact of WHO guidelines on trends in HIV testing and ART initiation among children living with HIV in Zambia.

    abstract：BACKGROUND:About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with limited documentation of long-term trends in the numbers testing HIV positive and initiating ART. We ex...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/s12981-020-00277-0

    authors： Munthali T,Michelo C,Mee P,Moyo C,Kashoka A,Liswaniso L,Chiboma I,Todd J

    更新日期：2020-05-14 00:00:00

  • Detection of HIV-1 RNA/DNA and CD4 mRNA in feces and urine from chronic HIV-1 infected subjects with and without anti-retroviral therapy.

    abstract：:HIV-1 infects gut associated lymphoid tissues (GALT) very early after transmission by multiple routes. The infected GALT consequently serves as the major reservoir for HIV-1 infection and could constantly shed HIV-1 and CD4+ T cells into the intestinal lumen. To examine this hypothesis, we monitored HIV-1 RNA/DNA and ...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-6-20

    authors： Chakrabarti AK,Caruso L,Ding M,Shen C,Buchanan W,Gupta P,Rinaldo CR,Chen Y

    更新日期：2009-10-02 00:00:00

  • Validation of a self-reported HIV symptoms list: the ISS-HIV symptoms scale.

    abstract：BACKGROUND:To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). METHODS:The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went t...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/s12981-016-0102-2

    authors： Bucciardini R,Pugliese K,Francisci D,Costantini A,Schiaroli E,Cognigni M,Tontini C,Lucattini S,Fucili L,Di Gregorio M,Mirra M,Fragola V,Pompili S,Murri R,Vella S

    更新日期：2016-04-09 00:00:00

  • The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma.

    abstract：BACKGROUND:Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to ...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-5-2

    authors： Feller L,Masipa J,Wood N,Raubenheimer E,Lemmer J

    更新日期：2008-01-29 00:00:00

  • The identification of unique serum proteins of HIV-1 latently infected long-term non-progressor patients.

    abstract：BACKGROUND:The search for disease biomarkers within human peripheral fluids has become a favorable approach to preventative therapeutics throughout the past few years. The comparison of normal versus disease states can identify an overexpression or a suppression of critical proteins where illness has directly altered a...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-7-21

    authors： Van Duyne R,Guendel I,Kehn-Hall K,Easley R,Klase Z,Liu C,Young M,Kashanchi F

    更新日期：2010-07-06 00:00:00

  • Evasion of adaptive immunity by HIV through the action of host APOBEC3G/F enzymes.

    abstract：:APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entrapment in inactive ...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章,评审

    doi：10.1186/s12981-017-0173-8

    authors： Grant M,Larijani M

    更新日期：2017-09-12 00:00:00

  • Media and education play a tremendous role in mounting AIDS awareness among married couples in Bangladesh.

    abstract：BACKGROUND:To quarantine the spreading possibility of HIV virus to general population boosting public awareness is must. But the proper awareness level is substantially low in Bangladesh. This paper aims to identify the factors associated with the awareness regarding HIV/AIDS through a bivariate and multivariate analys...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-4-10

    authors： Rahman MS,Rahman ML

    更新日期：2007-05-12 00:00:00

  • Susac's syndrome as HIV-associated immune reconstitution inflammatory syndrome.

    abstract：:Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-10-22

    authors： Ferretti F,Gerevini S,Colombo B,Testa M,Guffanti M,Franciotta D,Bernardi G,Lazzarin A,Cinque P

    更新日期：2013-09-03 00:00:00

  • Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats.

    abstract：BACKGROUND:Separately, chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements, including atrophy and wasting, weakness, and fatigue. One prospective cohort study reported that 41% of HIV-infected patients met the criteria for alcoholism, however; few reports exist on the c...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-8-30

    authors： Clary CR,Guidot DM,Bratina MA,Otis JS

    更新日期：2011-08-16 00:00:00

  • Independent predictors of tuberculosis mortality in a high HIV prevalence setting: a retrospective cohort study.

    abstract：BACKGROUND:Identifying those at increased risk of death during TB treatment is a priority in resource-constrained settings. We performed this study to determine predictors of mortality during TB treatment. METHODS:We performed a retrospective analysis of a TB surveillance population in a high HIV prevalence area that ...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/s12981-015-0076-5

    authors： Pepper DJ,Schomaker M,Wilkinson RJ,de Azevedo V,Maartens G

    更新日期：2015-10-06 00:00:00

  • Eradication of HIV-1 latent reservoirs through therapeutic vaccination.

    abstract：:Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such ...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章,评审

    doi：10.1186/s12981-017-0177-4

    authors： Pankrac J,Klein K,Mann JFS

    更新日期：2017-09-12 00:00:00

  • Validity assessment of the PROMIS fatigue domain among people living with HIV.

    abstract：PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/s12981-017-0146-y

    authors： Gibbons LE,Fredericksen R,Batey DS,Dant L,Edwards TC,Mayer KH,Mathews WC,Morales LS,Mugavero MJ,Yang FM,Paez E,Kitahata MM,Patrick DL,Crane HM,Crane PK,Centers for AIDS Research Network of Integrated Clinical Systems (CNICS

    更新日期：2017-04-11 00:00:00

  • Morning free and total testosterone in HIV-infected men: implications for the assessment of hypogonadism.

    abstract：BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/1742-6405-11-6

    authors： Monroe AK,Dobs AS,Palella FJ,Kingsley LA,Witt MD,Brown TT

    更新日期：2014-01-22 00:00:00

  • Stem cell transplantation in strategies for curing HIV/AIDS.

    abstract：:HIV-1 can persist in a latent form in resting memory CD4+ cells and macrophages carrying an integrated copy of the HIV genome. Because of the presence of these stable reservoir cells, eradication by antiretroviral therapy is unlikely and in order to achieve eradication, alternative treatment options are required. Stem...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章,评审

    doi：10.1186/s12981-016-0114-y

    authors： Hütter G

    更新日期：2016-09-13 00:00:00

  • Cytochrome P450 2B6 genetic variants are associated with plasma nevirapine levels and clinical response in HIV-1 infected Kenyan women: a prospective cohort study.

    abstract：BACKGROUND:Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevirapine concentration and clinical response in African women are limited. We investigated the impact o...

    journal_title：AIDS research and therapy

    pub_type： 杂志文章

    doi：10.1186/s12981-015-0052-0

    authors： Oluka MN,Okalebo FA,Guantai AN,McClelland RS,Graham SM

    更新日期：2015-04-15 00:00:00