Abstract:
BACKGROUND:Sustained use of antiretroviral therapy has been consistently shown to be one of the primary predictors of long-term effectiveness. Switching and discontinuation reflect patient and provider decisions that may limit future treatment options. In this study, we utilize data reported at semi-annual study visits from three prospective cohort studies, the AIDS Link to IntraVenous Exposure (ALIVE), the Women's Interagency HIV Study (WIHS), and the Multicenter AIDS Cohort Study (MACS), to investigate determinants of HAART modification with a particular focus on reported injection drug use (IDU). METHODS:Longitudinal data collected between 1996 and 2004 contributed from 2,266 participants (37% with a reported history of IDU) who reported initiating their first HAART regimen during follow-up were utilized. Separate proportional-hazards models were used to identify factors measured prior to HAART-initiation associated with the time to first HAART discontinuation and first switch of components of HAART among continuous HAART users. RESULTS:The use of PI- vs. NNRTI-based regimens among HAART users with and without any history of IDU was similar over follow-up. The median time to a first report of discontinuation of HAART was 1.1 years for individuals with a history of IDU but 2.5 years for those without a history of IDU and multivariate analyses confirmed overall that individuals with a history of IDU were at greater risk for HAART discontinuation (adj RH = 1.24, 95% CI: 1.03-1.48). However, when restricting to data contributed after 1999, there was no longer any significant increased risk (adj RH = 1.05, 95% CI: 0.81-1.36). After adjusting for pre-HAART health status and prior ARV exposure, individuals who were ethnic/racial minorities, reported an annual income < $10,000/year, and were not employed were at significantly greater risk for HAART discontinuation. The median time to a first change in HAART regimen was approximately 1.5 years after first HAART report and was not elevated among those with a history of IDU (adj RH = 1.09, 95% CI: 0.89-1.34). CONCLUSION:Our analyses demonstrate that injection drug use by itself does not appear to be an independent risk factor for HAART switching or discontinuation in more recent years. However, as continued HAART use is of paramount importance for long-term control of HIV infection, efforts to improve maintenance to therapy among disadvantaged and minority populations remain greatly needed.
journal_name
AIDS Res Therjournal_title
AIDS research and therapyauthors
Morris JD,Golub ET,Mehta SH,Jacobson LP,Gange SJdoi
10.1186/1742-6405-4-12subject
Has Abstractpub_date
2007-06-06 00:00:00pages
12issn
1742-6405pii
1742-6405-4-12journal_volume
4pub_type
杂志文章abstract:OBJECTIVES:To compare outcomes with single tablet regimens (STR) versus multi-tablet regimens (MTR) for human immunodeficiency virus (HIV) treatment using published data. DESIGN:Systematic review and random-effects meta-analysis of literature on approved and investigational HIV regimens. METHODS:The research followed...
journal_title:AIDS research and therapy
pub_type: 杂志文章,meta分析
doi:10.1186/s12981-018-0204-0
更新日期:2018-10-30 00:00:00
abstract:BACKGROUND:A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming non-infected HIV-exposed infants (HEIs) and prompting timely initiation of ART in HIV-infected babi...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-019-0245-z
更新日期:2019-09-14 00:00:00
abstract:BACKGROUND:Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharmacokinetics (PK) of antiretroviral drugs metabolized via the same pathways. However, in vitro drug interaction activity may no...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0140-4
更新日期:2017-03-14 00:00:00
abstract:BACKGROUND:Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevirapine concentration and clinical response in African women are limited. We investigated the impact o...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0052-0
更新日期:2015-04-15 00:00:00
abstract:OBJECTIVE:To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors. METHOD:We determine levels of NT-pro BNP in peripheral blood of HIV patients from Costa del Sol Hospital, ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0058-7
更新日期:2015-05-10 00:00:00
abstract:: In HIV-1 infected patients, increase of liver enzymes may be mainly due to viral coinfections, alcohol intake, hepatotoxic drugs or autoimmune diseases. Three cases of aminotransferase elevation occurred during a phase of uncontrolled viral replication combined with a severe immunodeficiency and resolved by an effect...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-9
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced partic...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-9-14
更新日期:2012-05-14 00:00:00
abstract:BACKGROUND:Tubular dysfunction is common in HIV-infected people and detection of proteinuria is essential to identify this problem. In low-income countries, resources for detection of proteinuria using the Kidney Disease Improve Global Outcomes (KDIGO) gold standard urinary protein/creatinine ratio (uPCR) is rarely pos...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0047-x
更新日期:2015-03-21 00:00:00
abstract:OBJECTIVE:Recent studies have shown that the current guidelines suggesting immunologic monitoring to determine response to highly active antiretroviral therapy (HAART) are inadequate. We assessed whether routinely collected clinical markers could improve prediction of concurrent HIV RNA levels. METHODS:We included ind...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-7-25
更新日期:2010-07-23 00:00:00
abstract::Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such ...
journal_title:AIDS research and therapy
pub_type: 杂志文章,评审
doi:10.1186/s12981-017-0177-4
更新日期:2017-09-12 00:00:00
abstract:BACKGROUND:Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neuropsychological testing for diagnosis. We aimed to develop a brief and clinically feasible battery t...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-019-0224-4
更新日期:2019-04-15 00:00:00
abstract:INTRODUCTION:We report a case of an adult patient with human immunodeficiency virus (HIV), acute respiratory distress syndrome (ARDS) and ventilator associated pneumonia (VAP) caused by multidrug resistant (MDR) bacteria that was successfully managed with veno-venous extracorporeal membrane oxygenation (ECMO). CASE RE...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-37
更新日期:2014-11-21 00:00:00
abstract:BACKGROUND:To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). METHODS:The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went t...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-016-0102-2
更新日期:2016-04-09 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) use by people living with HIV reduces HIV transmission, morbidity, mortality, and improves quality of life. Good ART adherence is required to achieve these benefits. We investigated how the environmental, social, economic and behavioural experiences of people living with HIV with...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0214-y
更新日期:2019-01-21 00:00:00
abstract:BACKGROUND:HIV spread continues at high rates from infected persons to their sexual partners. In 2009, an estimated 2.6 million new infections occurred globally. People living with HIV (PLHIV) receiving treatment are in contact with health workers and therefore exposed to prevention messages. By contrast, PLHIV not rec...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-9-9
更新日期:2012-03-19 00:00:00
abstract:BACKGROUND:To quarantine the spreading possibility of HIV virus to general population boosting public awareness is must. But the proper awareness level is substantially low in Bangladesh. This paper aims to identify the factors associated with the awareness regarding HIV/AIDS through a bivariate and multivariate analys...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-10
更新日期:2007-05-12 00:00:00
abstract:BACKGROUND:The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown to inhibit HIV-1 replication during various stages of the virus life cycle, and therefore represen...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-3-15
更新日期:2006-05-25 00:00:00
abstract:BACKGROUND:Varicella-zoster virus (VZV) reactivation is common but difficult to predict in HIV-infected persons. OBJECTIVE:Since qualitative VZV antibodies can determine past VZV disease or vaccination, we evaluated whether quantitative VZV antibody levels over time can predict future zoster. STUDY DESIGN:US Military...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0212-0
更新日期:2018-12-11 00:00:00
abstract:BACKGROUND:Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple drug-resistant HIV-1 variants. The few studies on HIV-1 mutagenesis in HIV infected children have no...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-15
更新日期:2007-07-09 00:00:00
abstract:BACKGROUND:Voriconazole is metabolized by cytochrome P450 (CYP) 2C19 and CYP 3A4. Drug-drug interactions and genetic polymorphisms modulate their activities. CASE PRESENTATION:A 35-year old African female patient with resistant HIV and a cerebral mass of unknown origin was treated with voriconazole for a suspicion of ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-25
更新日期:2014-08-04 00:00:00
abstract:BACKGROUND:About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with limited documentation of long-term trends in the numbers testing HIV positive and initiating ART. We ex...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-020-00277-0
更新日期:2020-05-14 00:00:00
abstract:BACKGROUND:A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine (PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques if treatment begins within 24 hours after SIVmne inoculation, but is less effective if treatment is delay...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-3-29
更新日期:2006-11-28 00:00:00
abstract:BACKGROUND:Minocycline is a tetracycline antibiotic that has been shown to attenuate central nervous system (CNS) lentivirus infection, immune activation, and brain injury in model systems. To initiate assessment of minocycline as an adjuvant therapy in human CNS HIV infection, we conducted an open-labelled pilot study...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-17
更新日期:2011-05-12 00:00:00
abstract:BACKGROUND:Identifying those at increased risk of death during TB treatment is a priority in resource-constrained settings. We performed this study to determine predictors of mortality during TB treatment. METHODS:We performed a retrospective analysis of a TB surveillance population in a high HIV prevalence area that ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0076-5
更新日期:2015-10-06 00:00:00
abstract:BACKGROUND:Despite the conventional approaches to HIV prevention being the bedrock for early reductions in HIV infections in Uganda, innovations that demonstrate reduction in risk to infection in vulnerable populations need to be embraced urgently. In the past 2 years, a USAID-funded project tested a quality improvemen...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0190-2
更新日期:2018-01-25 00:00:00
abstract:BACKGROUND:Vitamin D is an important determinant of bone health and also plays a major role in the regulation of the immune system. Interestingly, vitamin D status before the start of highly active antiretroviral therapy (HAART) has been recently associated with HIV disease progression and overall mortality in HIV-posi...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-7-40
更新日期:2010-11-23 00:00:00
abstract:: The December 2011 5th International Workshop on HIV Persistence during Therapy addressed the issue of HIV persistence among 210 scientists from 10 countries involved in the study of HIV reservoirs and the search of an HIV cure. High quality abstracts were selected and discussed as oral or poster presentations. The ai...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-9-7
更新日期:2012-03-12 00:00:00
abstract::Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-10-22
更新日期:2013-09-03 00:00:00
abstract:BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-6
更新日期:2014-01-22 00:00:00
abstract:BACKGROUND:Highly active antiretroviral therapy (HAART) improves the immune function and decreases morbidity, mortality and opportunistic infections (OIs) in HIV-infected patients. However, since the use of HAART, immune restoration disease (IRD) has been described in association with many OIs. Our objective was to det...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-7-46
更新日期:2010-12-21 00:00:00