Conference highlights of the 5th international workshop on HIV persistence during therapy, 6-9 December 2011, St. Maartin, West Indies.

Abstract:

: The December 2011 5th International Workshop on HIV Persistence during Therapy addressed the issue of HIV persistence among 210 scientists from 10 countries involved in the study of HIV reservoirs and the search of an HIV cure. High quality abstracts were selected and discussed as oral or poster presentations. The aim of this review is to distribute the scientific highlights of this workshop outside the group as analyzed and represented by experts in retrovirology, immunology and clinical research.

journal_name

AIDS Res Ther

authors

Stevenson M,Chomont N,Lafeuillade A

doi

10.1186/1742-6405-9-7

subject

Has Abstract

pub_date

2012-03-12 00:00:00

pages

7

issue

1

issn

1742-6405

pii

1742-6405-9-7

journal_volume

9

pub_type

杂志文章
  • Hospitalization causes and outcomes in HIV patients in the late antiretroviral era in Colombia.

    abstract:BACKGROUND:Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reasons for hospitalization have changed; OIs are no longer the most common reason for admission. This s...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-017-0186-3

    authors: Álvarez Barreneche MF,Restrepo Castro CA,Hidrón Botero A,Villa Franco JP,Trompa Romero IM,Restrepo Carvajal L,Eusse García A,Ocampo Mesa A,Echeverri Toro LM,Porras Fernández de Castro GP,Ramírez Rivera JM,Agudelo Restrepo CA

    更新日期:2017-11-13 00:00:00

  • Management of HIV-1 associated hepatitis in patients with acquired immunodeficiency syndrome: role of a successful control of viral replication.

    abstract:: In HIV-1 infected patients, increase of liver enzymes may be mainly due to viral coinfections, alcohol intake, hepatotoxic drugs or autoimmune diseases. Three cases of aminotransferase elevation occurred during a phase of uncontrolled viral replication combined with a severe immunodeficiency and resolved by an effect...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-8-9

    authors: Esposito A,Conti V,Cagliuso M,Pastori D,Fantauzzi A,Mezzaroma I

    更新日期:2011-03-01 00:00:00

  • Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects.

    abstract::Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples de...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-3-5

    authors: Venketaraman V,Rodgers T,Linares R,Reilly N,Swaminathan S,Hom D,Millman AC,Wallis R,Connell ND

    更新日期:2006-02-20 00:00:00

  • Effect of mobile text messages on antiretroviral medication adherence and patient retention in early HIV care: an open-label, randomized, single center study in south Florida.

    abstract:BACKGROUND:People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. METHODS:ART-n...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-020-00275-2

    authors: Sherman EM,Niu J,Elrod S,Clauson KA,Alkhateeb F,Eckardt P

    更新日期:2020-05-13 00:00:00

  • Eradication of HIV-1 latent reservoirs through therapeutic vaccination.

    abstract::Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章,评审

    doi:10.1186/s12981-017-0177-4

    authors: Pankrac J,Klein K,Mann JFS

    更新日期:2017-09-12 00:00:00

  • HIV-associated adipose redistribution syndrome (HARS): definition, epidemiology and clinical impact.

    abstract::A segment of the HIV infected population develops abnormal and excessive accumulation of adipose tissue in the trunk, including accumulation of visceral (deep abdominal) adipose tissue. This condition, known as HIV-related adipose redistribution syndrome (HARS), may also be accompanied by fat accumulation in the upper...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-4-16

    authors: Lichtenstein K,Balasubramanyam A,Sekhar R,Freedland E

    更新日期:2007-07-16 00:00:00

  • Successful use of extracorporeal membrane oxygenation in a human immunodeficiency virus infected patient with severe acute respiratory distress syndrome.

    abstract:INTRODUCTION:We report a case of an adult patient with human immunodeficiency virus (HIV), acute respiratory distress syndrome (ARDS) and ventilator associated pneumonia (VAP) caused by multidrug resistant (MDR) bacteria that was successfully managed with veno-venous extracorporeal membrane oxygenation (ECMO). CASE RE...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-11-37

    authors: Samalavicius R,Serpytis M,Ringaitiene D,Grazulyte D,Bertasiute R,Rimkus B,Matulionyte R,Ambrazaitiene R,Sipylaite J,Kacergius T,Griskevicius L

    更新日期:2014-11-21 00:00:00

  • Impact of WHO guidelines on trends in HIV testing and ART initiation among children living with HIV in Zambia.

    abstract:BACKGROUND:About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with limited documentation of long-term trends in the numbers testing HIV positive and initiating ART. We ex...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-020-00277-0

    authors: Munthali T,Michelo C,Mee P,Moyo C,Kashoka A,Liswaniso L,Chiboma I,Todd J

    更新日期:2020-05-14 00:00:00

  • Reverse transcriptase drug resistance mutations in HIV-1 subtype C infected patients on ART in Karonga District, Malawi.

    abstract:BACKGROUND:Drug resistance testing before initiation of, or during, antiretroviral therapy (ART) is not routinely performed in resource-limited settings. High levels of viral resistance circulating within the population will have impact on treatment programs by increasing the chances of transmission of resistant strain...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-8-38

    authors: Bansode VB,Travers SA,Crampin AC,Ngwira B,French N,Glynn JR,McCormack GP

    更新日期:2011-10-13 00:00:00

  • Is the Sexual Behaviour of HIV Patients on Antiretroviral therapy safe or risky in Sub-Saharan Africa? Meta-Analysis and Meta-Regression.

    abstract:BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced partic...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-9-14

    authors: Berhan A,Berhan Y

    更新日期:2012-05-14 00:00:00

  • Implementation of antiretroviral therapy (ART) in former Soviet Union countries.

    abstract::Against the current global trends, in the former Soviet Union (FSU) countries HIV prevalence is on the rise. Visa-free movement across borders has facilitated migrant-associated HIV transmission within this region. Despite efforts from the governments to curtail the growing epidemic, there is still a serious need for ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章,评审

    doi:10.1186/s12981-019-0251-1

    authors: Amangaldiyeva A,Davlidova S,Baiserkin B,Dzissyuk N,DeHovitz J,Ali S

    更新日期:2019-11-19 00:00:00

  • Total Lymphocyte Count as surrogate marker for CD4 Cell Count in HIV-Infected Individuals in Gondar University Hospital, Northwest Ethiopia.

    abstract:UNLABELLED: BACKGROUND:The high cost of CD4 count estimation in resource-limited countries is a major challenge in initiating patients on highly active antiretroviral therapy (HAART). Therefore, assessment of inexpensive and simple laboratory diagnostic marker is mandatory to diagnose immuno-suppression. OBJECTIVE:To...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-9-21

    authors: Wondimeneh Y,Ferede G,Yismaw G,Muluye D

    更新日期:2012-07-15 00:00:00

  • Inhibition of highly productive HIV-1 infection in T cells, primary human macrophages, microglia, and astrocytes by Sargassum fusiforme.

    abstract:BACKGROUND:The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown to inhibit HIV-1 replication during various stages of the virus life cycle, and therefore represen...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-3-15

    authors: Paskaleva EE,Lin X,Li W,Cotter R,Klein MT,Roberge E,Yu EK,Clark B,Veille JC,Liu Y,Lee DY,Canki M

    更新日期:2006-05-25 00:00:00

  • Non-AIDS defining cancer (NADC) among HIV-infected patients at an oncology tertiary-care center in Mexico.

    abstract:BACKGROUND:Non-AIDS defining cancers (NADCs) have been an increasing cause of morbidity and mortality in patients with HIV. There is no data on the spectrum of NADCs in Mexico. We describe the type of neoplasms, clinical characteristics, and outcomes of HIV-infected patients with NADCs. METHODS:We conducted a retrospe...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-018-0202-2

    authors: Cornejo-Juárez P,Cavildo-Jerónimo D,Volkow-Fernández P

    更新日期:2018-10-27 00:00:00

  • Cytochrome P450 2B6 genetic variants are associated with plasma nevirapine levels and clinical response in HIV-1 infected Kenyan women: a prospective cohort study.

    abstract:BACKGROUND:Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevirapine concentration and clinical response in African women are limited. We investigated the impact o...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-015-0052-0

    authors: Oluka MN,Okalebo FA,Guantai AN,McClelland RS,Graham SM

    更新日期:2015-04-15 00:00:00

  • Association between quantitative varicella-zoster virus antibody levels and zoster reactivation in HIV-infected persons.

    abstract:BACKGROUND:Varicella-zoster virus (VZV) reactivation is common but difficult to predict in HIV-infected persons. OBJECTIVE:Since qualitative VZV antibodies can determine past VZV disease or vaccination, we evaluated whether quantitative VZV antibody levels over time can predict future zoster. STUDY DESIGN:US Military...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-018-0212-0

    authors: Pomerantz HS,Xu X,White J,Sunil TS,Deiss RG,Ganesan A,Agan BK,Okulicz JF

    更新日期:2018-12-11 00:00:00

  • Clade, Country and Region-specific HIV-1 Vaccines: Are they necessary?

    abstract::Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a unique vaccine for every world region or virus subtype may not be necessary. ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-2-3

    authors: Slobod KS,Coleclough C,Brown SA,Stambas J,Zhan X,Surman S,Jones BG,Zirkel A,Freiden PJ,Brown B,Sealy R,Bonsignori M,Hurwitz JL

    更新日期:2005-04-28 00:00:00

  • Bone mineral density in people living with HIV: a narrative review of the literature.

    abstract::Bone health status is largely absent in South Africa, the main reasons being the absence and cost-effectiveness of specific screening equipment for assessing bone mineral density (BMD). Various risk factors seem to play a role, some of which can be modified to change bone health status. Urbanisation is also a public h...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章,评审

    doi:10.1186/s12981-017-0162-y

    authors: Kruger MJ,Nell TA

    更新日期:2017-07-26 00:00:00

  • Decrease of vitamin D concentration in patients with HIV infection on a non nucleoside reverse transcriptase inhibitor-containing regimen.

    abstract:BACKGROUND:Vitamin D is an important determinant of bone health and also plays a major role in the regulation of the immune system. Interestingly, vitamin D status before the start of highly active antiretroviral therapy (HAART) has been recently associated with HIV disease progression and overall mortality in HIV-posi...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-7-40

    authors: Conesa-Botella A,Florence E,Lynen L,Colebunders R,Menten J,Moreno-Reyes R

    更新日期:2010-11-23 00:00:00

  • Independent predictors of tuberculosis mortality in a high HIV prevalence setting: a retrospective cohort study.

    abstract:BACKGROUND:Identifying those at increased risk of death during TB treatment is a priority in resource-constrained settings. We performed this study to determine predictors of mortality during TB treatment. METHODS:We performed a retrospective analysis of a TB surveillance population in a high HIV prevalence area that ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-015-0076-5

    authors: Pepper DJ,Schomaker M,Wilkinson RJ,de Azevedo V,Maartens G

    更新日期:2015-10-06 00:00:00

  • Injection drug use and patterns of highly active antiretroviral therapy use: an analysis of ALIVE, WIHS, and MACS cohorts.

    abstract:BACKGROUND:Sustained use of antiretroviral therapy has been consistently shown to be one of the primary predictors of long-term effectiveness. Switching and discontinuation reflect patient and provider decisions that may limit future treatment options. In this study, we utilize data reported at semi-annual study visits...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-4-12

    authors: Morris JD,Golub ET,Mehta SH,Jacobson LP,Gange SJ

    更新日期:2007-06-06 00:00:00

  • Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activity.

    abstract:BACKGROUND:Voriconazole is metabolized by cytochrome P450 (CYP) 2C19 and CYP 3A4. Drug-drug interactions and genetic polymorphisms modulate their activities. CASE PRESENTATION:A 35-year old African female patient with resistant HIV and a cerebral mass of unknown origin was treated with voriconazole for a suspicion of ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-11-25

    authors: Bouatou Y,Samer CF,Ing Lorenzini KR,Daali Y,Daou S,Fathi M,Rebsamen M,Desmeules J,Calmy A,Escher M

    更新日期:2014-08-04 00:00:00

  • Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot study.

    abstract:BACKGROUND:Minocycline is a tetracycline antibiotic that has been shown to attenuate central nervous system (CNS) lentivirus infection, immune activation, and brain injury in model systems. To initiate assessment of minocycline as an adjuvant therapy in human CNS HIV infection, we conducted an open-labelled pilot study...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-8-17

    authors: Ho EL,Spudich SS,Lee E,Fuchs D,Sinclair E,Price RW

    更新日期:2011-05-12 00:00:00

  • Correlates and determinants of Early Infant Diagnosis outcomes in North-Central Nigeria.

    abstract:BACKGROUND:A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming non-infected HIV-exposed infants (HEIs) and prompting timely initiation of ART in HIV-infected babi...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-019-0245-z

    authors: Dakum P,Tola M,Iboro N,Okolo CA,Anuforom O,Chime C,Peters S,Jumare J,Ogbanufe O,Ahmad A,Ndembi N

    更新日期:2019-09-14 00:00:00

  • HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector.

    abstract::BACKGROUND: RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs against cellular coreceptors CXCR4 and CCR5 had shown that down regulation of these surface molecules co...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-2-1

    authors: Anderson J,Akkina R

    更新日期:2005-01-13 00:00:00

  • Quality improvement as a framework for behavior change interventions in HIV-predisposed communities: a case of adolescent girls and young women in northern Uganda.

    abstract:BACKGROUND:Despite the conventional approaches to HIV prevention being the bedrock for early reductions in HIV infections in Uganda, innovations that demonstrate reduction in risk to infection in vulnerable populations need to be embraced urgently. In the past 2 years, a USAID-funded project tested a quality improvemen...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-018-0190-2

    authors: Karamagi E,Sensalire S,Nabwire J,Byabagambi J,Awio AO,Aluma G,Rahimzai M,Calnan J,Kyobutungi S

    更新日期:2018-01-25 00:00:00

  • Validity assessment of the PROMIS fatigue domain among people living with HIV.

    abstract:PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-017-0146-y

    authors: Gibbons LE,Fredericksen R,Batey DS,Dant L,Edwards TC,Mayer KH,Mathews WC,Morales LS,Mugavero MJ,Yang FM,Paez E,Kitahata MM,Patrick DL,Crane HM,Crane PK,Centers for AIDS Research Network of Integrated Clinical Systems (CNICS

    更新日期:2017-04-11 00:00:00

  • Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats.

    abstract:BACKGROUND:Separately, chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements, including atrophy and wasting, weakness, and fatigue. One prospective cohort study reported that 41% of HIV-infected patients met the criteria for alcoholism, however; few reports exist on the c...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-8-30

    authors: Clary CR,Guidot DM,Bratina MA,Otis JS

    更新日期:2011-08-16 00:00:00

  • Antiretroviral therapy at a district hospital in Ethiopia prevents death and tuberculosis in a cohort of HIV patients.

    abstract:BACKGROUND:Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings. We assessed the effect of HAART on patient mortality and tuberculosis incidence rate under routine clinical care conditions in Ethiopia. The objective of this stu...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-3-10

    authors: Jerene D,Naess A,Lindtjørn B

    更新日期:2006-04-07 00:00:00

  • HIV sero-discordance among married HIV patients initiating anti-retroviral therapy in northern Vietnam.

    abstract:BACKGROUND:In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter might be due to high levels of sero-discordant couples and increasing transmission from male to fema...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-016-0124-9

    authors: Van Tam V,Cuong DD,Alfven T,Phuc HD,Chuc NT,Hoa NP,Diwan V,Larsson M

    更新日期:2016-11-15 00:00:00