HIV-associated adipose redistribution syndrome (HARS): definition, epidemiology and clinical impact.

abstract：BACKGROUND:Despite the conventional approaches to HIV prevention being the bedrock for early reductions in HIV infections in Uganda, innovations that demonstrate reduction in risk to infection in vulnerable populations need to be embraced urgently. In the past 2 years, a USAID-funded project tested a quality improvemen...

journal_title：AIDS research and therapy

authors： Karamagi E,Sensalire S,Nabwire J,Byabagambi J,Awio AO,Aluma G,Rahimzai M,Calnan J,Kyobutungi S

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:Non-AIDS defining cancers (NADCs) have been an increasing cause of morbidity and mortality in patients with HIV. There is no data on the spectrum of NADCs in Mexico. We describe the type of neoplasms, clinical characteristics, and outcomes of HIV-infected patients with NADCs. METHODS:We conducted a retrospe...

journal_title：AIDS research and therapy

authors： Cornejo-Juárez P,Cavildo-Jerónimo D,Volkow-Fernández P

更新日期：2018-10-27 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reasons for hospitalization have changed; OIs are no longer the most common reason for admission. This s...

journal_title：AIDS research and therapy

authors： Álvarez Barreneche MF,Restrepo Castro CA,Hidrón Botero A,Villa Franco JP,Trompa Romero IM,Restrepo Carvajal L,Eusse García A,Ocampo Mesa A,Echeverri Toro LM,Porras Fernández de Castro GP,Ramírez Rivera JM,Agudelo Restrepo CA

更新日期：2017-11-13 00:00:00

abstract：:APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entrapment in inactive ...

journal_title：AIDS research and therapy

authors： Grant M,Larijani M

更新日期：2017-09-12 00:00:00

abstract：:Against the current global trends, in the former Soviet Union (FSU) countries HIV prevalence is on the rise. Visa-free movement across borders has facilitated migrant-associated HIV transmission within this region. Despite efforts from the governments to curtail the growing epidemic, there is still a serious need for ...

journal_title：AIDS research and therapy

authors： Amangaldiyeva A,Davlidova S,Baiserkin B,Dzissyuk N,DeHovitz J,Ali S

更新日期：2019-11-19 00:00:00

abstract：BACKGROUND:Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to ...

journal_title：AIDS research and therapy

authors： Feller L,Masipa J,Wood N,Raubenheimer E,Lemmer J

更新日期：2008-01-29 00:00:00

abstract：BACKGROUND:People who inject drugs (PWID) living with HIV often experience sub-optimal antiretroviral therapy (ART) treatment outcomes, including HIV plasma viral load (PVL) rebound. While previous studies have identified risk factors for PVL rebound among PWID, no study has examined the perspectives of PWID who have e...

journal_title：AIDS research and therapy

authors： Small W,Milloy MJ,McNeil R,Maher L,Kerr T

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Current German and European HIV guidelines recommend early evaluation of HCV treatment in all HIV/HCV co-infected patients. However, there are still considerable barriers to initiate HCV therapy in everyday clinical practice. This study evaluates baseline characteristics, "intention-to-treat" pattern and out...

journal_title：AIDS research and therapy

authors： Beisel C,Heuer M,Otto B,Jochum J,Schmiedel S,Hertling S,Degen O,Lüth S,van Lunzen J,Schulze Zur Wiesch J

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with limited documentation of long-term trends in the numbers testing HIV positive and initiating ART. We ex...

journal_title：AIDS research and therapy

authors： Munthali T,Michelo C,Mee P,Moyo C,Kashoka A,Liswaniso L,Chiboma I,Todd J

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:Varicella-zoster virus (VZV) reactivation is common but difficult to predict in HIV-infected persons. OBJECTIVE:Since qualitative VZV antibodies can determine past VZV disease or vaccination, we evaluated whether quantitative VZV antibody levels over time can predict future zoster. STUDY DESIGN:US Military...

journal_title：AIDS research and therapy

authors： Pomerantz HS,Xu X,White J,Sunil TS,Deiss RG,Ganesan A,Agan BK,Okulicz JF

更新日期：2018-12-11 00:00:00

abstract：:BACKGROUND: RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs against cellular coreceptors CXCR4 and CCR5 had shown that down regulation of these surface molecules co...

journal_title：AIDS research and therapy

authors： Anderson J,Akkina R

更新日期：2005-01-13 00:00:00

abstract：BACKGROUND:Community-drug distribution point is a care model for stable patients in the community designed to make ART delivery more efficient for the health system and provide appropriate support to encourage long-term retention of patients. We examined program retention among ART program participants in rural Uganda,...

journal_title：AIDS research and therapy

authors： Okoboi S,Ding E,Persuad S,Wangisi J,Birungi J,Shurgold S,Kato D,Nyonyintono M,Egessa A,Bakanda C,Munderi P,Kaleebu P,Moore DM

更新日期：2015-11-12 00:00:00

abstract：OBJECTIVE:To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors. METHOD:We determine levels of NT-pro BNP in peripheral blood of HIV patients from Costa del Sol Hospital, ...

journal_title：AIDS research and therapy

authors： Olalla J,Crespo E,De la Torre J,Sempere M,Del Arco A,Prada JL,Malvarez R,Pérez J,García-Alegría J

更新日期：2015-05-10 00:00:00

abstract：BACKGROUND:Little is known about HIV-1 subtype distribution in Morocco. Some data suggest an emergence of new HIV subtypes. We conducted phylogenetic analysis on a nationally representative sample of 60 HIV-1 viral specimens collected during 2004-2005 through the Morocco national HIV sentinel surveillance survey. RESU...

journal_title：AIDS research and therapy

authors： Akrim M,Lemrabet S,Elharti E,Gray RR,Tardy JC,Cook RL,Salemi M,Andre P,Azarian T,Aouad RE

更新日期：2012-02-14 00:00:00

abstract：BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced partic...

journal_title：AIDS research and therapy

authors： Berhan A,Berhan Y

更新日期：2012-05-14 00:00:00

abstract：BACKGROUND:A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine (PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques if treatment begins within 24 hours after SIVmne inoculation, but is less effective if treatment is delay...

journal_title：AIDS research and therapy

authors： Emau P,Jiang Y,Agy MB,Tian B,Bekele G,Tsai CC

更新日期：2006-11-28 00:00:00

abstract：:Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a unique vaccine for every world region or virus subtype may not be necessary. ...

journal_title：AIDS research and therapy

authors： Slobod KS,Coleclough C,Brown SA,Stambas J,Zhan X,Surman S,Jones BG,Zirkel A,Freiden PJ,Brown B,Sealy R,Bonsignori M,Hurwitz JL

更新日期：2005-04-28 00:00:00

abstract：BACKGROUND:To quarantine the spreading possibility of HIV virus to general population boosting public awareness is must. But the proper awareness level is substantially low in Bangladesh. This paper aims to identify the factors associated with the awareness regarding HIV/AIDS through a bivariate and multivariate analys...

journal_title：AIDS research and therapy

authors： Rahman MS,Rahman ML

更新日期：2007-05-12 00:00:00

abstract：OBJECTIVES:To compare outcomes with single tablet regimens (STR) versus multi-tablet regimens (MTR) for human immunodeficiency virus (HIV) treatment using published data. DESIGN:Systematic review and random-effects meta-analysis of literature on approved and investigational HIV regimens. METHODS:The research followed...

journal_title：AIDS research and therapy

authors： Clay PG,Yuet WC,Moecklinghoff CH,Duchesne I,Tronczyński KL,Shah S,Shao D

更新日期：2018-10-30 00:00:00

abstract：:High rates of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was a key consideration in the WHO policies transitioning first-line regimens to include integrase inhibitors (dolutegravir [DTG]). However, recent data suggests a relationship between DTG and neural tube defects among women exposed durin...

journal_title：AIDS research and therapy

authors： Rutstein SE,Chen JS,Nelson JAE,Phiri S,Miller WC,Hosseinipour MC

更新日期：2019-02-22 00:00:00

abstract：BACKGROUND:In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter might be due to high levels of sero-discordant couples and increasing transmission from male to fema...

journal_title：AIDS research and therapy

authors： Van Tam V,Cuong DD,Alfven T,Phuc HD,Chuc NT,Hoa NP,Diwan V,Larsson M

更新日期：2016-11-15 00:00:00

abstract：UNLABELLED: OBJECTIVE:To investigate anti-infective treatments in HIV-infected surgical patients during the perioperative period. METHODS:A retrospective study of sepsis and surgical site infections (SSIs) was conducted in 266 HIV-infected patients. The patients were divided into 3 groups based on CD4+ T cells counts...

journal_title：AIDS research and therapy

authors： Liu B,Zhang L,Guo R,Su J,Li L,Si Y

更新日期：2012-11-27 00:00:00

abstract：PURPOSE:We studied the safety, tolerability, virologic, and immunologic effects of mycophenolate mofetil (MMF) added to a stable antiretroviral therapy (ART) in the setting of low-level viremia. METHODS:MMF 500 mg BID or placebo was given to patients thought to be adherent on stable ART with plasma viremia between 200...

journal_title：AIDS research and therapy

authors： Kaur R,Bedimo R,Kvanli MB,Turner D,Shaw L,Margolis D

更新日期：2006-05-26 00:00:00

abstract：BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...

journal_title：AIDS research and therapy

authors： Monroe AK,Dobs AS,Palella FJ,Kingsley LA,Witt MD,Brown TT

更新日期：2014-01-22 00:00:00

abstract：BACKGROUND:Identifying those at increased risk of death during TB treatment is a priority in resource-constrained settings. We performed this study to determine predictors of mortality during TB treatment. METHODS:We performed a retrospective analysis of a TB surveillance population in a high HIV prevalence area that ...

journal_title：AIDS research and therapy

authors： Pepper DJ,Schomaker M,Wilkinson RJ,de Azevedo V,Maartens G

更新日期：2015-10-06 00:00:00

abstract：:Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such ...

journal_title：AIDS research and therapy

authors： Pankrac J,Klein K,Mann JFS

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:Most in vitro assays of drug potency may not adequately predict the performance in vivo. Methods to assess the persistence of antiviral activity of deoxynucleoside analogs, which require intracellular activation to the active metabolites that can persist in cells, will be important for designing dosages, com...

journal_title：AIDS research and therapy

authors： Paintsil E,Grill SP,Dutschman GE,Cheng YC

更新日期：2009-04-22 00:00:00

abstract：OBJECTIVE:Recent studies have shown that the current guidelines suggesting immunologic monitoring to determine response to highly active antiretroviral therapy (HAART) are inadequate. We assessed whether routinely collected clinical markers could improve prediction of concurrent HIV RNA levels. METHODS:We included ind...

journal_title：AIDS research and therapy

authors： Lau B,Chander G,Gange SJ,Moore RD

更新日期：2010-07-23 00:00:00

abstract：BACKGROUND:Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prodrug of tenofovir, causes less renal impairment and can improve renal function in patients switched f...

journal_title：AIDS research and therapy

authors： Turner D,Drak D,O'Connor CC,Templeton DJ,Gracey DM

更新日期：2019-12-07 00:00:00

abstract：BACKGROUND:Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple drug-resistant HIV-1 variants. The few studies on HIV-1 mutagenesis in HIV infected children have no...

journal_title：AIDS research and therapy

authors： Malhotra A,Gaur S,Whitley-Williams P,Loomis C,Petrova A

更新日期：2007-07-09 00:00:00