Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot study.

abstract：:A segment of the HIV infected population develops abnormal and excessive accumulation of adipose tissue in the trunk, including accumulation of visceral (deep abdominal) adipose tissue. This condition, known as HIV-related adipose redistribution syndrome (HARS), may also be accompanied by fat accumulation in the upper...

journal_title：AIDS research and therapy

authors： Lichtenstein K,Balasubramanyam A,Sekhar R,Freedland E

更新日期：2007-07-16 00:00:00

abstract：BACKGROUND:A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine (PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques if treatment begins within 24 hours after SIVmne inoculation, but is less effective if treatment is delay...

journal_title：AIDS research and therapy

authors： Emau P,Jiang Y,Agy MB,Tian B,Bekele G,Tsai CC

更新日期：2006-11-28 00:00:00

abstract：INTRODUCTION:We report a case of an adult patient with human immunodeficiency virus (HIV), acute respiratory distress syndrome (ARDS) and ventilator associated pneumonia (VAP) caused by multidrug resistant (MDR) bacteria that was successfully managed with veno-venous extracorporeal membrane oxygenation (ECMO). CASE RE...

journal_title：AIDS research and therapy

authors： Samalavicius R,Serpytis M,Ringaitiene D,Grazulyte D,Bertasiute R,Rimkus B,Matulionyte R,Ambrazaitiene R,Sipylaite J,Kacergius T,Griskevicius L

更新日期：2014-11-21 00:00:00

abstract：BACKGROUND:Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neuropsychological testing for diagnosis. We aimed to develop a brief and clinically feasible battery t...

journal_title：AIDS research and therapy

authors： Chan LG,Ho MJ,Lin YC,Ong Y,Wong CS

更新日期：2019-04-15 00:00:00

abstract：:Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (...

journal_title：AIDS research and therapy

authors： Ferretti F,Gerevini S,Colombo B,Testa M,Guffanti M,Franciotta D,Bernardi G,Lazzarin A,Cinque P

更新日期：2013-09-03 00:00:00

abstract：BACKGROUND:Voriconazole is metabolized by cytochrome P450 (CYP) 2C19 and CYP 3A4. Drug-drug interactions and genetic polymorphisms modulate their activities. CASE PRESENTATION:A 35-year old African female patient with resistant HIV and a cerebral mass of unknown origin was treated with voriconazole for a suspicion of ...

journal_title：AIDS research and therapy

authors： Bouatou Y,Samer CF,Ing Lorenzini KR,Daali Y,Daou S,Fathi M,Rebsamen M,Desmeules J,Calmy A,Escher M

更新日期：2014-08-04 00:00:00

abstract：:HIV-1 infects gut associated lymphoid tissues (GALT) very early after transmission by multiple routes. The infected GALT consequently serves as the major reservoir for HIV-1 infection and could constantly shed HIV-1 and CD4+ T cells into the intestinal lumen. To examine this hypothesis, we monitored HIV-1 RNA/DNA and ...

journal_title：AIDS research and therapy

authors： Chakrabarti AK,Caruso L,Ding M,Shen C,Buchanan W,Gupta P,Rinaldo CR,Chen Y

更新日期：2009-10-02 00:00:00

abstract：BACKGROUND:About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with limited documentation of long-term trends in the numbers testing HIV positive and initiating ART. We ex...

journal_title：AIDS research and therapy

authors： Munthali T,Michelo C,Mee P,Moyo C,Kashoka A,Liswaniso L,Chiboma I,Todd J

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...

journal_title：AIDS research and therapy

authors： Monroe AK,Dobs AS,Palella FJ,Kingsley LA,Witt MD,Brown TT

更新日期：2014-01-22 00:00:00

abstract：:Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a unique vaccine for every world region or virus subtype may not be necessary. ...

journal_title：AIDS research and therapy

authors： Slobod KS,Coleclough C,Brown SA,Stambas J,Zhan X,Surman S,Jones BG,Zirkel A,Freiden PJ,Brown B,Sealy R,Bonsignori M,Hurwitz JL

更新日期：2005-04-28 00:00:00

abstract：BACKGROUND:Non-AIDS defining cancers (NADCs) have been an increasing cause of morbidity and mortality in patients with HIV. There is no data on the spectrum of NADCs in Mexico. We describe the type of neoplasms, clinical characteristics, and outcomes of HIV-infected patients with NADCs. METHODS:We conducted a retrospe...

journal_title：AIDS research and therapy

authors： Cornejo-Juárez P,Cavildo-Jerónimo D,Volkow-Fernández P

更新日期：2018-10-27 00:00:00

abstract：OBJECTIVE:To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors. METHOD:We determine levels of NT-pro BNP in peripheral blood of HIV patients from Costa del Sol Hospital, ...

journal_title：AIDS research and therapy

authors： Olalla J,Crespo E,De la Torre J,Sempere M,Del Arco A,Prada JL,Malvarez R,Pérez J,García-Alegría J

更新日期：2015-05-10 00:00:00

abstract：PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...

journal_title：AIDS research and therapy

authors： Gibbons LE,Fredericksen R,Batey DS,Dant L,Edwards TC,Mayer KH,Mathews WC,Morales LS,Mugavero MJ,Yang FM,Paez E,Kitahata MM,Patrick DL,Crane HM,Crane PK,Centers for AIDS Research Network of Integrated Clinical Systems (CNICS

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:HIV spread continues at high rates from infected persons to their sexual partners. In 2009, an estimated 2.6 million new infections occurred globally. People living with HIV (PLHIV) receiving treatment are in contact with health workers and therefore exposed to prevention messages. By contrast, PLHIV not rec...

journal_title：AIDS research and therapy

authors： Sarna A,Luchters S,Pickett M,Chersich M,Okal J,Geibel S,Kingola N,Temmerman M

更新日期：2012-03-19 00:00:00

abstract：: The December 2011 5th International Workshop on HIV Persistence during Therapy addressed the issue of HIV persistence among 210 scientists from 10 countries involved in the study of HIV reservoirs and the search of an HIV cure. High quality abstracts were selected and discussed as oral or poster presentations. The ai...

journal_title：AIDS research and therapy

authors： Stevenson M,Chomont N,Lafeuillade A

更新日期：2012-03-12 00:00:00

abstract：BACKGROUND:People who inject drugs (PWID) living with HIV often experience sub-optimal antiretroviral therapy (ART) treatment outcomes, including HIV plasma viral load (PVL) rebound. While previous studies have identified risk factors for PVL rebound among PWID, no study has examined the perspectives of PWID who have e...

journal_title：AIDS research and therapy

authors： Small W,Milloy MJ,McNeil R,Maher L,Kerr T

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Little is known about HIV-1 subtype distribution in Morocco. Some data suggest an emergence of new HIV subtypes. We conducted phylogenetic analysis on a nationally representative sample of 60 HIV-1 viral specimens collected during 2004-2005 through the Morocco national HIV sentinel surveillance survey. RESU...

journal_title：AIDS research and therapy

authors： Akrim M,Lemrabet S,Elharti E,Gray RR,Tardy JC,Cook RL,Salemi M,Andre P,Azarian T,Aouad RE

更新日期：2012-02-14 00:00:00

abstract：BACKGROUND:The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown to inhibit HIV-1 replication during various stages of the virus life cycle, and therefore represen...

journal_title：AIDS research and therapy

authors： Paskaleva EE,Lin X,Li W,Cotter R,Klein MT,Roberge E,Yu EK,Clark B,Veille JC,Liu Y,Lee DY,Canki M

更新日期：2006-05-25 00:00:00

abstract：UNLABELLED: BACKGROUND:The high cost of CD4 count estimation in resource-limited countries is a major challenge in initiating patients on highly active antiretroviral therapy (HAART). Therefore, assessment of inexpensive and simple laboratory diagnostic marker is mandatory to diagnose immuno-suppression. OBJECTIVE:To...

journal_title：AIDS research and therapy

authors： Wondimeneh Y,Ferede G,Yismaw G,Muluye D

更新日期：2012-07-15 00:00:00

abstract：BACKGROUND:Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings. We assessed the effect of HAART on patient mortality and tuberculosis incidence rate under routine clinical care conditions in Ethiopia. The objective of this stu...

journal_title：AIDS research and therapy

authors： Jerene D,Naess A,Lindtjørn B

更新日期：2006-04-07 00:00:00

abstract：BACKGROUND:To quarantine the spreading possibility of HIV virus to general population boosting public awareness is must. But the proper awareness level is substantially low in Bangladesh. This paper aims to identify the factors associated with the awareness regarding HIV/AIDS through a bivariate and multivariate analys...

journal_title：AIDS research and therapy

authors： Rahman MS,Rahman ML

更新日期：2007-05-12 00:00:00

abstract：:BACKGROUND: RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs against cellular coreceptors CXCR4 and CCR5 had shown that down regulation of these surface molecules co...

journal_title：AIDS research and therapy

authors： Anderson J,Akkina R

更新日期：2005-01-13 00:00:00

abstract：BACKGROUND:Most in vitro assays of drug potency may not adequately predict the performance in vivo. Methods to assess the persistence of antiviral activity of deoxynucleoside analogs, which require intracellular activation to the active metabolites that can persist in cells, will be important for designing dosages, com...

journal_title：AIDS research and therapy

authors： Paintsil E,Grill SP,Dutschman GE,Cheng YC

更新日期：2009-04-22 00:00:00

abstract：BACKGROUND:Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevirapine concentration and clinical response in African women are limited. We investigated the impact o...

journal_title：AIDS research and therapy

authors： Oluka MN,Okalebo FA,Guantai AN,McClelland RS,Graham SM

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:Psychosocial factors have been linked with loss to follow-up (LTFU) and clinical outcomes among people living with HIV (PLH), however little is known about the effect of psychosocial support on LTFU among PLH in treatment and care. The purpose of this study was to explore the effect of NAMWEZA ("Yes, togethe...

journal_title：AIDS research and therapy

authors： Siril HN,Kaaya SF,Smith Fawzi MK,Mtisi E,Somba M,Kilewo J,Mugusi F,Minja A,Kaale A,Todd J

更新日期：2017-03-28 00:00:00

abstract：BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced partic...

journal_title：AIDS research and therapy

authors： Berhan A,Berhan Y

更新日期：2012-05-14 00:00:00

abstract：BACKGROUND:Varicella-zoster virus (VZV) reactivation is common but difficult to predict in HIV-infected persons. OBJECTIVE:Since qualitative VZV antibodies can determine past VZV disease or vaccination, we evaluated whether quantitative VZV antibody levels over time can predict future zoster. STUDY DESIGN:US Military...

journal_title：AIDS research and therapy

authors： Pomerantz HS,Xu X,White J,Sunil TS,Deiss RG,Ganesan A,Agan BK,Okulicz JF

更新日期：2018-12-11 00:00:00

abstract：UNLABELLED: OBJECTIVE:To investigate anti-infective treatments in HIV-infected surgical patients during the perioperative period. METHODS:A retrospective study of sepsis and surgical site infections (SSIs) was conducted in 266 HIV-infected patients. The patients were divided into 3 groups based on CD4+ T cells counts...

journal_title：AIDS research and therapy

authors： Liu B,Zhang L,Guo R,Su J,Li L,Si Y

更新日期：2012-11-27 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reasons for hospitalization have changed; OIs are no longer the most common reason for admission. This s...

journal_title：AIDS research and therapy

authors： Álvarez Barreneche MF,Restrepo Castro CA,Hidrón Botero A,Villa Franco JP,Trompa Romero IM,Restrepo Carvajal L,Eusse García A,Ocampo Mesa A,Echeverri Toro LM,Porras Fernández de Castro GP,Ramírez Rivera JM,Agudelo Restrepo CA

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:HIV/AIDS has orphaned 11.6 million children in sub-Saharan Africa. Expanded antiretroviral therapy (ART) use may reduce AIDS orphanhood by decreasing adult mortality and population-level HIV transmission. METHODS:We modeled two scenarios to measure the impact of adult ART use on the incidence of orphanhood ...

journal_title：AIDS research and therapy

authors： Anema A,Au-Yeung CG,Joffres M,Kaida A,Vasarhelyi K,Kanters S,Montaner JS,Hogg RS

更新日期：2011-03-07 00:00:00