Abstract：
BACKGROUND:Identifying those at increased risk of death during TB treatment is a priority in resource-constrained settings. We performed this study to determine predictors of mortality during TB treatment. METHODS:We performed a retrospective analysis of a TB surveillance population in a high HIV prevalence area that was recorded in ETR.net (Electronic Tuberculosis Register). Adult TB cases initiated TB treatment from 2007 through 2009 in Khayelitsha, South Africa. Cox proportional hazards models were used to identify risk factors for death (after multiple imputations for missing data). Model selection was performed using Akaike's Information Criterion to obtain the most relevant predictors of death. RESULTS:Of 16,209 adult TB cases, 851 (5.3 %) died during TB treatment. In all TB cases, advancing age, co-infection with HIV, a prior history of TB and the presence of both pulmonary and extra-pulmonary TB were independently associated with an increasing hazard of death. In HIV-infected TB cases, advancing age and female gender were independently associated with an increasing hazard of death. Increasing CD4 counts and antiretroviral treatment during TB treatment were protective against death. In HIV-uninfected TB cases, advancing age was independently associated with death, whereas smear-positive disease was protective. CONCLUSION:We identified several independent predictors of death during TB treatment in resource-constrained settings. Our findings inform resource-constrained settings about certain subgroups of TB patients that should be targeted to improve mortality during TB treatment.
journal_name
AIDS Res Therjournal_title
AIDS research and therapyauthors
Pepper DJ,Schomaker M,Wilkinson RJ,de Azevedo V,Maartens Gdoi
10.1186/s12981-015-0076-5subject
Has Abstractpub_date
2015-10-06 00:00:00pages
35issn
1742-6405pii
76journal_volume
12pub_type
杂志文章abstract：BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced partic...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-9-14
更新日期：2012-05-14 00:00:00
abstract：BACKGROUND:Varicella-zoster virus (VZV) reactivation is common but difficult to predict in HIV-infected persons. OBJECTIVE:Since qualitative VZV antibodies can determine past VZV disease or vaccination, we evaluated whether quantitative VZV antibody levels over time can predict future zoster. STUDY DESIGN:US Military...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-018-0212-0
更新日期：2018-12-11 00:00:00
abstract：BACKGROUND:Vitamin D is an important determinant of bone health and also plays a major role in the regulation of the immune system. Interestingly, vitamin D status before the start of highly active antiretroviral therapy (HAART) has been recently associated with HIV disease progression and overall mortality in HIV-posi...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-7-40
更新日期：2010-11-23 00:00:00
abstract：BACKGROUND:Sustained use of antiretroviral therapy has been consistently shown to be one of the primary predictors of long-term effectiveness. Switching and discontinuation reflect patient and provider decisions that may limit future treatment options. In this study, we utilize data reported at semi-annual study visits...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-4-12
更新日期：2007-06-06 00:00:00
abstract：BACKGROUND:The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown to inhibit HIV-1 replication during various stages of the virus life cycle, and therefore represen...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-15
更新日期：2006-05-25 00:00:00
abstract：BACKGROUND:People who inject drugs (PWID) living with HIV often experience sub-optimal antiretroviral therapy (ART) treatment outcomes, including HIV plasma viral load (PVL) rebound. While previous studies have identified risk factors for PVL rebound among PWID, no study has examined the perspectives of PWID who have e...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-016-0108-9
更新日期：2016-07-25 00:00:00
abstract：BACKGROUND:Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple drug-resistant HIV-1 variants. The few studies on HIV-1 mutagenesis in HIV infected children have no...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-4-15
更新日期：2007-07-09 00:00:00
abstract：:BACKGROUND: RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs against cellular coreceptors CXCR4 and CCR5 had shown that down regulation of these surface molecules co...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-2-1
更新日期：2005-01-13 00:00:00
abstract：BACKGROUND:The population of HIV replicating within a host consists of independently evolving and interacting sub-populations that can be genetically distinct within anatomical compartments. HIV replicating within the brain causes neurocognitive disorders in up to 20-30% of infected individuals and is a viral sanctuary...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-7-43
更新日期：2010-12-14 00:00:00
abstract：BACKGROUND:Antiretroviral therapy (ART) use by people living with HIV reduces HIV transmission, morbidity, mortality, and improves quality of life. Good ART adherence is required to achieve these benefits. We investigated how the environmental, social, economic and behavioural experiences of people living with HIV with...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-018-0214-y
更新日期：2019-01-21 00:00:00
abstract：BACKGROUND:Separately, chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements, including atrophy and wasting, weakness, and fatigue. One prospective cohort study reported that 41% of HIV-infected patients met the criteria for alcoholism, however; few reports exist on the c...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-30
更新日期：2011-08-16 00:00:00
abstract：BACKGROUND:Drug resistance testing before initiation of, or during, antiretroviral therapy (ART) is not routinely performed in resource-limited settings. High levels of viral resistance circulating within the population will have impact on treatment programs by increasing the chances of transmission of resistant strain...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-38
更新日期：2011-10-13 00:00:00
abstract：:APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entrapment in inactive ...
journal_title：AIDS research and therapy
pub_type： 杂志文章,评审
doi：10.1186/s12981-017-0173-8
更新日期：2017-09-12 00:00:00
abstract：BACKGROUND:Current German and European HIV guidelines recommend early evaluation of HCV treatment in all HIV/HCV co-infected patients. However, there are still considerable barriers to initiate HCV therapy in everyday clinical practice. This study evaluates baseline characteristics, "intention-to-treat" pattern and out...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-11-16
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Minocycline is a tetracycline antibiotic that has been shown to attenuate central nervous system (CNS) lentivirus infection, immune activation, and brain injury in model systems. To initiate assessment of minocycline as an adjuvant therapy in human CNS HIV infection, we conducted an open-labelled pilot study...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-17
更新日期：2011-05-12 00:00:00
abstract：BACKGROUND:Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-5-2
更新日期：2008-01-29 00:00:00
abstract：BACKGROUND:To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). METHODS:The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went t...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-016-0102-2
更新日期：2016-04-09 00:00:00
abstract：BACKGROUND:As a simplification strategy for treatment-experienced HIV-infected patients who have achieved virologic suppression on a multi-drug, multi-class antiretroviral regimen, the aim of this study was to evaluate the safety, efficacy, and pharmacokinetics of once-daily elvitegravir/cobicistat/emtricitabine/tenofo...
journal_title：AIDS research and therapy
pub_type： 临床试验,杂志文章
doi：10.1186/s12981-017-0185-4
更新日期：2017-11-02 00:00:00
abstract：BACKGROUND:Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prodrug of tenofovir, causes less renal impairment and can improve renal function in patients switched f...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-019-0256-9
更新日期：2019-12-07 00:00:00
abstract：OBJECTIVES:To compare outcomes with single tablet regimens (STR) versus multi-tablet regimens (MTR) for human immunodeficiency virus (HIV) treatment using published data. DESIGN:Systematic review and random-effects meta-analysis of literature on approved and investigational HIV regimens. METHODS:The research followed...
journal_title：AIDS research and therapy
pub_type： 杂志文章,meta分析
doi：10.1186/s12981-018-0204-0
更新日期：2018-10-30 00:00:00
abstract：BACKGROUND:Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevirapine concentration and clinical response in African women are limited. We investigated the impact o...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0052-0
更新日期：2015-04-15 00:00:00
abstract：BACKGROUND:HIV/AIDS has orphaned 11.6 million children in sub-Saharan Africa. Expanded antiretroviral therapy (ART) use may reduce AIDS orphanhood by decreasing adult mortality and population-level HIV transmission. METHODS:We modeled two scenarios to measure the impact of adult ART use on the incidence of orphanhood ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-13
更新日期：2011-03-07 00:00:00
abstract：:High rates of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was a key consideration in the WHO policies transitioning first-line regimens to include integrase inhibitors (dolutegravir [DTG]). However, recent data suggests a relationship between DTG and neural tube defects among women exposed durin...
journal_title：AIDS research and therapy
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12981-019-0220-8
更新日期：2019-02-22 00:00:00
abstract：BACKGROUND:The search for disease biomarkers within human peripheral fluids has become a favorable approach to preventative therapeutics throughout the past few years. The comparison of normal versus disease states can identify an overexpression or a suppression of critical proteins where illness has directly altered a...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-7-21
更新日期：2010-07-06 00:00:00
abstract：PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-017-0146-y
更新日期：2017-04-11 00:00:00
abstract：BACKGROUND:South Africa has a huge burden of illness due to HIV infection. Many health care workers managing HIV infected patients, particularly those in rural areas and primary care health facilities, have minimal access to information resources and to advice and support from experienced clinicians. The Medicines Info...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-4
更新日期：2011-01-26 00:00:00
abstract：BACKGROUND:Psychosocial factors have been linked with loss to follow-up (LTFU) and clinical outcomes among people living with HIV (PLH), however little is known about the effect of psychosocial support on LTFU among PLH in treatment and care. The purpose of this study was to explore the effect of NAMWEZA ("Yes, togethe...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-017-0145-z
更新日期：2017-03-28 00:00:00
abstract：BACKGROUND:A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine (PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques if treatment begins within 24 hours after SIVmne inoculation, but is less effective if treatment is delay...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-29
更新日期：2006-11-28 00:00:00
abstract：:Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-10-22
更新日期：2013-09-03 00:00:00
abstract：BACKGROUND:Little is known about HIV-1 subtype distribution in Morocco. Some data suggest an emergence of new HIV subtypes. We conducted phylogenetic analysis on a nationally representative sample of 60 HIV-1 viral specimens collected during 2004-2005 through the Morocco national HIV sentinel surveillance survey. RESU...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-9-5
更新日期：2012-02-14 00:00:00
