Abstract:
BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced participants and longitudinal studies examining the behavior of the same individuals pre- and post-ART start. Meta-analyses were performed both stratified by type of study and combined. Outcome variables assessed for association with ART experience were any sexual activity, unprotected sex and having multiple sexual partners. Random-effect models were applied to determine the overall odds ratios. Sub-group analyses and meta-regression analyses were performed to examine sources of heterogeneity among the studies. Sensitivity analysis was also conducted to evaluate the stability of the overall odds ratio in the presence of outliers. RESULTS:The meta-analysis failed to show a statistically significant association of any sexual activity with ART experience. It did, however, show an overall statistically significant reduction of any unprotected sex, having multiple sexual partners and unprotected sex with HIV negative or unknown HIV status with ART experience. Meta-regression showed no interaction between duration of ART use or recall period of sexual behavior with the sexual activity variables. However, there was an association between the percentage of married or cohabiting participants included in a study and reductions in the practice of unprotected sex with ART. CONCLUSION:In general, this meta-analysis demonstrated a significant reduction in risky sexual behavior among people on ART in sub-Saharan Africa. Future studies should investigate the reproducibility and continuity of the observed positive behavioural changes as the duration of ART lasts a decade or more.
journal_name
AIDS Res Therjournal_title
AIDS research and therapyauthors
Berhan A,Berhan Ydoi
10.1186/1742-6405-9-14subject
Has Abstractpub_date
2012-05-14 00:00:00pages
14issue
1issn
1742-6405pii
1742-6405-9-14journal_volume
9pub_type
杂志文章abstract:BACKGROUND:A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming non-infected HIV-exposed infants (HEIs) and prompting timely initiation of ART in HIV-infected babi...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-019-0245-z
更新日期:2019-09-14 00:00:00
abstract:BACKGROUND:To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). METHODS:The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went t...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-016-0102-2
更新日期:2016-04-09 00:00:00
abstract:OBJECTIVES:To compare outcomes with single tablet regimens (STR) versus multi-tablet regimens (MTR) for human immunodeficiency virus (HIV) treatment using published data. DESIGN:Systematic review and random-effects meta-analysis of literature on approved and investigational HIV regimens. METHODS:The research followed...
journal_title:AIDS research and therapy
pub_type: 杂志文章,meta分析
doi:10.1186/s12981-018-0204-0
更新日期:2018-10-30 00:00:00
abstract:BACKGROUND:As a simplification strategy for treatment-experienced HIV-infected patients who have achieved virologic suppression on a multi-drug, multi-class antiretroviral regimen, the aim of this study was to evaluate the safety, efficacy, and pharmacokinetics of once-daily elvitegravir/cobicistat/emtricitabine/tenofo...
journal_title:AIDS research and therapy
pub_type: 临床试验,杂志文章
doi:10.1186/s12981-017-0185-4
更新日期:2017-11-02 00:00:00
abstract:BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-6
更新日期:2014-01-22 00:00:00
abstract::A segment of the HIV infected population develops abnormal and excessive accumulation of adipose tissue in the trunk, including accumulation of visceral (deep abdominal) adipose tissue. This condition, known as HIV-related adipose redistribution syndrome (HARS), may also be accompanied by fat accumulation in the upper...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-16
更新日期:2007-07-16 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reasons for hospitalization have changed; OIs are no longer the most common reason for admission. This s...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0186-3
更新日期:2017-11-13 00:00:00
abstract:BACKGROUND:Varicella-zoster virus (VZV) reactivation is common but difficult to predict in HIV-infected persons. OBJECTIVE:Since qualitative VZV antibodies can determine past VZV disease or vaccination, we evaluated whether quantitative VZV antibody levels over time can predict future zoster. STUDY DESIGN:US Military...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0212-0
更新日期:2018-12-11 00:00:00
abstract:BACKGROUND:Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple drug-resistant HIV-1 variants. The few studies on HIV-1 mutagenesis in HIV infected children have no...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-15
更新日期:2007-07-09 00:00:00
abstract:BACKGROUND:The search for disease biomarkers within human peripheral fluids has become a favorable approach to preventative therapeutics throughout the past few years. The comparison of normal versus disease states can identify an overexpression or a suppression of critical proteins where illness has directly altered a...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-7-21
更新日期:2010-07-06 00:00:00
abstract:BACKGROUND:About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with limited documentation of long-term trends in the numbers testing HIV positive and initiating ART. We ex...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-020-00277-0
更新日期:2020-05-14 00:00:00
abstract:BACKGROUND:Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings. We assessed the effect of HAART on patient mortality and tuberculosis incidence rate under routine clinical care conditions in Ethiopia. The objective of this stu...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-3-10
更新日期:2006-04-07 00:00:00
abstract:BACKGROUND:In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter might be due to high levels of sero-discordant couples and increasing transmission from male to fema...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-016-0124-9
更新日期:2016-11-15 00:00:00
abstract::HIV-1 can persist in a latent form in resting memory CD4+ cells and macrophages carrying an integrated copy of the HIV genome. Because of the presence of these stable reservoir cells, eradication by antiretroviral therapy is unlikely and in order to achieve eradication, alternative treatment options are required. Stem...
journal_title:AIDS research and therapy
pub_type: 杂志文章,评审
doi:10.1186/s12981-016-0114-y
更新日期:2016-09-13 00:00:00
abstract:BACKGROUND:Sustained use of antiretroviral therapy has been consistently shown to be one of the primary predictors of long-term effectiveness. Switching and discontinuation reflect patient and provider decisions that may limit future treatment options. In this study, we utilize data reported at semi-annual study visits...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-12
更新日期:2007-06-06 00:00:00
abstract:BACKGROUND:People who inject drugs (PWID) living with HIV often experience sub-optimal antiretroviral therapy (ART) treatment outcomes, including HIV plasma viral load (PVL) rebound. While previous studies have identified risk factors for PVL rebound among PWID, no study has examined the perspectives of PWID who have e...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-016-0108-9
更新日期:2016-07-25 00:00:00
abstract:BACKGROUND:Vitamin D is an important determinant of bone health and also plays a major role in the regulation of the immune system. Interestingly, vitamin D status before the start of highly active antiretroviral therapy (HAART) has been recently associated with HIV disease progression and overall mortality in HIV-posi...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-7-40
更新日期:2010-11-23 00:00:00
abstract:BACKGROUND:Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevirapine concentration and clinical response in African women are limited. We investigated the impact o...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0052-0
更新日期:2015-04-15 00:00:00
abstract:BACKGROUND:Little is known about HIV-1 subtype distribution in Morocco. Some data suggest an emergence of new HIV subtypes. We conducted phylogenetic analysis on a nationally representative sample of 60 HIV-1 viral specimens collected during 2004-2005 through the Morocco national HIV sentinel surveillance survey. RESU...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-9-5
更新日期:2012-02-14 00:00:00
abstract:BACKGROUND:Psychosocial factors have been linked with loss to follow-up (LTFU) and clinical outcomes among people living with HIV (PLH), however little is known about the effect of psychosocial support on LTFU among PLH in treatment and care. The purpose of this study was to explore the effect of NAMWEZA ("Yes, togethe...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0145-z
更新日期:2017-03-28 00:00:00
abstract:BACKGROUND:Community-drug distribution point is a care model for stable patients in the community designed to make ART delivery more efficient for the health system and provide appropriate support to encourage long-term retention of patients. We examined program retention among ART program participants in rural Uganda,...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0077-4
更新日期:2015-11-12 00:00:00
abstract::HIV-1 infects gut associated lymphoid tissues (GALT) very early after transmission by multiple routes. The infected GALT consequently serves as the major reservoir for HIV-1 infection and could constantly shed HIV-1 and CD4+ T cells into the intestinal lumen. To examine this hypothesis, we monitored HIV-1 RNA/DNA and ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-6-20
更新日期:2009-10-02 00:00:00
abstract:PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0146-y
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:Non-AIDS defining cancers (NADCs) have been an increasing cause of morbidity and mortality in patients with HIV. There is no data on the spectrum of NADCs in Mexico. We describe the type of neoplasms, clinical characteristics, and outcomes of HIV-infected patients with NADCs. METHODS:We conducted a retrospe...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0202-2
更新日期:2018-10-27 00:00:00
abstract:BACKGROUND:Current German and European HIV guidelines recommend early evaluation of HCV treatment in all HIV/HCV co-infected patients. However, there are still considerable barriers to initiate HCV therapy in everyday clinical practice. This study evaluates baseline characteristics, "intention-to-treat" pattern and out...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-16
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharmacokinetics (PK) of antiretroviral drugs metabolized via the same pathways. However, in vitro drug interaction activity may no...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0140-4
更新日期:2017-03-14 00:00:00
abstract:BACKGROUND:A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine (PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques if treatment begins within 24 hours after SIVmne inoculation, but is less effective if treatment is delay...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-3-29
更新日期:2006-11-28 00:00:00
abstract::Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a unique vaccine for every world region or virus subtype may not be necessary. ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-2-3
更新日期:2005-04-28 00:00:00
abstract:BACKGROUND:People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. METHODS:ART-n...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-020-00275-2
更新日期:2020-05-13 00:00:00
abstract:BACKGROUND:HIV spread continues at high rates from infected persons to their sexual partners. In 2009, an estimated 2.6 million new infections occurred globally. People living with HIV (PLHIV) receiving treatment are in contact with health workers and therefore exposed to prevention messages. By contrast, PLHIV not rec...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-9-9
更新日期:2012-03-19 00:00:00