Abstract:
BACKGROUND:Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neuropsychological testing for diagnosis. We aimed to develop a brief and clinically feasible battery to screen for HIV-associated neurocognitive disorders (HAND) in resource-limited settings even where English is not the native language. METHODS:A total of 53 outpatients were recruited from a multi-ethnic Southeast Asian HIV-positive cohort. Performance on a neuropsychological protocol was used to define cognitive impairment, of which 28 patients (52.8%) were identified with HAND. Receiver operating characteristic analysis was used to determine the best combinations of cognitive tests for the screening battery. RESULTS:3 different combinations of cognitive tests that required minimal literacy, time to administer, and administrator training were found to classify HAND with fair accuracy. Montreal Cognitive Assessment (MoCA), in combination with tests of psychomotor coordination, verbal learning and speed processing, yielded area under curve scores of above 0.75, the primary outcome of receiver operating characteristic analysis. CONCLUSION:The 3-test combinations presented in this study appear to be promising screening options for HAND in HIV-infected patients. The addition of 2 tests to MoCA improves the overall accuracy while retaining its convenience, giving more potential for the inclusion of cognitive screening in routine clinical care. Further validation of the batteries in specific settings is warranted to determine specific screening cut-offs to a global cognitive score.
journal_name
AIDS Res Therjournal_title
AIDS research and therapyauthors
Chan LG,Ho MJ,Lin YC,Ong Y,Wong CSdoi
10.1186/s12981-019-0224-4subject
Has Abstractpub_date
2019-04-15 00:00:00pages
9issue
1issn
1742-6405pii
10.1186/s12981-019-0224-4journal_volume
16pub_type
杂志文章abstract:BACKGROUND:HIV/AIDS has orphaned 11.6 million children in sub-Saharan Africa. Expanded antiretroviral therapy (ART) use may reduce AIDS orphanhood by decreasing adult mortality and population-level HIV transmission. METHODS:We modeled two scenarios to measure the impact of adult ART use on the incidence of orphanhood ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-13
更新日期:2011-03-07 00:00:00
abstract:BACKGROUND:Minocycline is a tetracycline antibiotic that has been shown to attenuate central nervous system (CNS) lentivirus infection, immune activation, and brain injury in model systems. To initiate assessment of minocycline as an adjuvant therapy in human CNS HIV infection, we conducted an open-labelled pilot study...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-17
更新日期:2011-05-12 00:00:00
abstract:INTRODUCTION:We report a case of an adult patient with human immunodeficiency virus (HIV), acute respiratory distress syndrome (ARDS) and ventilator associated pneumonia (VAP) caused by multidrug resistant (MDR) bacteria that was successfully managed with veno-venous extracorporeal membrane oxygenation (ECMO). CASE RE...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-37
更新日期:2014-11-21 00:00:00
abstract:OBJECTIVES:To compare outcomes with single tablet regimens (STR) versus multi-tablet regimens (MTR) for human immunodeficiency virus (HIV) treatment using published data. DESIGN:Systematic review and random-effects meta-analysis of literature on approved and investigational HIV regimens. METHODS:The research followed...
journal_title:AIDS research and therapy
pub_type: 杂志文章,meta分析
doi:10.1186/s12981-018-0204-0
更新日期:2018-10-30 00:00:00
abstract::High rates of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was a key consideration in the WHO policies transitioning first-line regimens to include integrase inhibitors (dolutegravir [DTG]). However, recent data suggests a relationship between DTG and neural tube defects among women exposed durin...
journal_title:AIDS research and therapy
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12981-019-0220-8
更新日期:2019-02-22 00:00:00
abstract:BACKGROUND:Separately, chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements, including atrophy and wasting, weakness, and fatigue. One prospective cohort study reported that 41% of HIV-infected patients met the criteria for alcoholism, however; few reports exist on the c...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-30
更新日期:2011-08-16 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0047-x
更新日期:2015-03-21 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章,评审
doi:10.1186/s12981-016-0114-y
更新日期:2016-09-13 00:00:00
abstract:BACKGROUND:Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharmacokinetics (PK) of antiretroviral drugs metabolized via the same pathways. However, in vitro drug interaction activity may no...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0140-4
更新日期:2017-03-14 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章,评审
doi:10.1186/s12981-019-0251-1
更新日期:2019-11-19 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-6-20
更新日期:2009-10-02 00:00:00
abstract::APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entrapment in inactive ...
journal_title:AIDS research and therapy
pub_type: 杂志文章,评审
doi:10.1186/s12981-017-0173-8
更新日期:2017-09-12 00:00:00
abstract:BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced partic...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-9-14
更新日期:2012-05-14 00:00:00
abstract:PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0146-y
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:The search for disease biomarkers within human peripheral fluids has become a favorable approach to preventative therapeutics throughout the past few years. The comparison of normal versus disease states can identify an overexpression or a suppression of critical proteins where illness has directly altered a...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-7-21
更新日期:2010-07-06 00:00:00
abstract::Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples de...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-3-5
更新日期:2006-02-20 00:00:00
abstract:: In HIV-1 infected patients, increase of liver enzymes may be mainly due to viral coinfections, alcohol intake, hepatotoxic drugs or autoimmune diseases. Three cases of aminotransferase elevation occurred during a phase of uncontrolled viral replication combined with a severe immunodeficiency and resolved by an effect...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-9
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Community-drug distribution point is a care model for stable patients in the community designed to make ART delivery more efficient for the health system and provide appropriate support to encourage long-term retention of patients. We examined program retention among ART program participants in rural Uganda,...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0077-4
更新日期:2015-11-12 00:00:00
abstract:BACKGROUND:People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. METHODS:ART-n...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-020-00275-2
更新日期:2020-05-13 00:00:00
abstract:BACKGROUND:Highly active antiretroviral therapy (HAART) improves the immune function and decreases morbidity, mortality and opportunistic infections (OIs) in HIV-infected patients. However, since the use of HAART, immune restoration disease (IRD) has been described in association with many OIs. Our objective was to det...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-7-46
更新日期:2010-12-21 00:00:00
abstract::BACKGROUND: RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs against cellular coreceptors CXCR4 and CCR5 had shown that down regulation of these surface molecules co...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-2-1
更新日期:2005-01-13 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-019-0256-9
更新日期:2019-12-07 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-12
更新日期:2007-06-06 00:00:00
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journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-38
更新日期:2011-10-13 00:00:00
abstract:BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-6
更新日期:2014-01-22 00:00:00
abstract:BACKGROUND:Non-AIDS defining cancers (NADCs) have been an increasing cause of morbidity and mortality in patients with HIV. There is no data on the spectrum of NADCs in Mexico. We describe the type of neoplasms, clinical characteristics, and outcomes of HIV-infected patients with NADCs. METHODS:We conducted a retrospe...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0202-2
更新日期:2018-10-27 00:00:00
abstract:BACKGROUND:Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevirapine concentration and clinical response in African women are limited. We investigated the impact o...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0052-0
更新日期:2015-04-15 00:00:00
abstract::Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such ...
journal_title:AIDS research and therapy
pub_type: 杂志文章,评审
doi:10.1186/s12981-017-0177-4
更新日期:2017-09-12 00:00:00
abstract:BACKGROUND:Most in vitro assays of drug potency may not adequately predict the performance in vivo. Methods to assess the persistence of antiviral activity of deoxynucleoside analogs, which require intracellular activation to the active metabolites that can persist in cells, will be important for designing dosages, com...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-6-5
更新日期:2009-04-22 00:00:00
abstract:UNLABELLED: OBJECTIVE:To investigate anti-infective treatments in HIV-infected surgical patients during the perioperative period. METHODS:A retrospective study of sepsis and surgical site infections (SSIs) was conducted in 266 HIV-infected patients. The patients were divided into 3 groups based on CD4+ T cells counts...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-9-36
更新日期:2012-11-27 00:00:00