Abstract：
BACKGROUND:Non-AIDS defining cancers (NADCs) have been an increasing cause of morbidity and mortality in patients with HIV. There is no data on the spectrum of NADCs in Mexico. We describe the type of neoplasms, clinical characteristics, and outcomes of HIV-infected patients with NADCs. METHODS:We conducted a retrospective study of all patients with confirmed diagnosis of NADC attending the HIV/AIDS clinic at the National Cancer Institute in Mexico City (a tertiary-care center for adult patients with cancer) from January 1990 to December 2016. RESULTS:From 1126 HIV-positive individuals seen at the institute since 1990, 127 (11.3%) were diagnosed with NADCs; seven patients developed two NADCs during their follow-up. At diagnosis of NADC median age was 43.7 ± 10.9 years; 101 (79.5%) were male; median CD4 was 273 cells/mm3, 70 patients had a CD4 count of > 200 cells/mm3, 73 had undetectable HIV viral load and 82 had taken combined antiretroviral therapy (cART) for more than 1 year. The most frequent NADCs were in men, Hodgkin lymphoma (34.3%) followed by anal cancer (15.7%), whereas in women, were vulvo-vaginal cancers associated to human papilloma virus (HPV) (51.8%), followed by breast cancer (25.9%). The main risk factor associated with death was cancer progression or relapse (OR, 28.2, 2.5-317.1; p = 0.007). CONCLUSIONS:HL- and HPV-related neoplasms are the commonest NADC in a cancer referral hospital from a middle-income country with universal access to cART since year 2005. Screening for early anogenital lesions should be emphasized in patients with HIV. It is essential to establish multidisciplinary groups involving Hemato-oncologists, Oncologists, Gynecologists, and HIV Specialists in the treatment of these patients.
journal_name
AIDS Res Therjournal_title
AIDS research and therapyauthors
Cornejo-Juárez P,Cavildo-Jerónimo D,Volkow-Fernández Pdoi
10.1186/s12981-018-0202-2subject
Has Abstractpub_date
2018-10-27 00:00:00pages
16issue
1issn
1742-6405pii
10.1186/s12981-018-0202-2journal_volume
15pub_type
杂志文章abstract：BACKGROUND:Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reasons for hospitalization have changed; OIs are no longer the most common reason for admission. This s...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-017-0186-3
更新日期：2017-11-13 00:00:00
abstract：BACKGROUND:Antiretroviral therapy (ART) use by people living with HIV reduces HIV transmission, morbidity, mortality, and improves quality of life. Good ART adherence is required to achieve these benefits. We investigated how the environmental, social, economic and behavioural experiences of people living with HIV with...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-018-0214-y
更新日期：2019-01-21 00:00:00
abstract：BACKGROUND:Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings. We assessed the effect of HAART on patient mortality and tuberculosis incidence rate under routine clinical care conditions in Ethiopia. The objective of this stu...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-10
更新日期：2006-04-07 00:00:00
abstract：:Bone health status is largely absent in South Africa, the main reasons being the absence and cost-effectiveness of specific screening equipment for assessing bone mineral density (BMD). Various risk factors seem to play a role, some of which can be modified to change bone health status. Urbanisation is also a public h...
journal_title：AIDS research and therapy
pub_type： 杂志文章,评审
doi：10.1186/s12981-017-0162-y
更新日期：2017-07-26 00:00:00
abstract：OBJECTIVE:To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors. METHOD:We determine levels of NT-pro BNP in peripheral blood of HIV patients from Costa del Sol Hospital, ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0058-7
更新日期：2015-05-10 00:00:00
abstract：BACKGROUND:To quarantine the spreading possibility of HIV virus to general population boosting public awareness is must. But the proper awareness level is substantially low in Bangladesh. This paper aims to identify the factors associated with the awareness regarding HIV/AIDS through a bivariate and multivariate analys...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-4-10
更新日期：2007-05-12 00:00:00
abstract：BACKGROUND:Despite the conventional approaches to HIV prevention being the bedrock for early reductions in HIV infections in Uganda, innovations that demonstrate reduction in risk to infection in vulnerable populations need to be embraced urgently. In the past 2 years, a USAID-funded project tested a quality improvemen...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-018-0190-2
更新日期：2018-01-25 00:00:00
abstract：BACKGROUND:Voriconazole is metabolized by cytochrome P450 (CYP) 2C19 and CYP 3A4. Drug-drug interactions and genetic polymorphisms modulate their activities. CASE PRESENTATION:A 35-year old African female patient with resistant HIV and a cerebral mass of unknown origin was treated with voriconazole for a suspicion of ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-11-25
更新日期：2014-08-04 00:00:00
abstract：BACKGROUND:Most in vitro assays of drug potency may not adequately predict the performance in vivo. Methods to assess the persistence of antiviral activity of deoxynucleoside analogs, which require intracellular activation to the active metabolites that can persist in cells, will be important for designing dosages, com...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-6-5
更新日期：2009-04-22 00:00:00
abstract：:HIV-1 can persist in a latent form in resting memory CD4+ cells and macrophages carrying an integrated copy of the HIV genome. Because of the presence of these stable reservoir cells, eradication by antiretroviral therapy is unlikely and in order to achieve eradication, alternative treatment options are required. Stem...
journal_title：AIDS research and therapy
pub_type： 杂志文章,评审
doi：10.1186/s12981-016-0114-y
更新日期：2016-09-13 00:00:00
abstract：BACKGROUND:In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter might be due to high levels of sero-discordant couples and increasing transmission from male to fema...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-016-0124-9
更新日期：2016-11-15 00:00:00
abstract：PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-017-0146-y
更新日期：2017-04-11 00:00:00
abstract：BACKGROUND:Current German and European HIV guidelines recommend early evaluation of HCV treatment in all HIV/HCV co-infected patients. However, there are still considerable barriers to initiate HCV therapy in everyday clinical practice. This study evaluates baseline characteristics, "intention-to-treat" pattern and out...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-11-16
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:The population of HIV replicating within a host consists of independently evolving and interacting sub-populations that can be genetically distinct within anatomical compartments. HIV replicating within the brain causes neurocognitive disorders in up to 20-30% of infected individuals and is a viral sanctuary...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-7-43
更新日期：2010-12-14 00:00:00
abstract：:HIV-1 infects gut associated lymphoid tissues (GALT) very early after transmission by multiple routes. The infected GALT consequently serves as the major reservoir for HIV-1 infection and could constantly shed HIV-1 and CD4+ T cells into the intestinal lumen. To examine this hypothesis, we monitored HIV-1 RNA/DNA and ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-6-20
更新日期：2009-10-02 00:00:00
abstract：BACKGROUND:As a simplification strategy for treatment-experienced HIV-infected patients who have achieved virologic suppression on a multi-drug, multi-class antiretroviral regimen, the aim of this study was to evaluate the safety, efficacy, and pharmacokinetics of once-daily elvitegravir/cobicistat/emtricitabine/tenofo...
journal_title：AIDS research and therapy
pub_type： 临床试验,杂志文章
doi：10.1186/s12981-017-0185-4
更新日期：2017-11-02 00:00:00
abstract：BACKGROUND:Highly active antiretroviral therapy (HAART) improves the immune function and decreases morbidity, mortality and opportunistic infections (OIs) in HIV-infected patients. However, since the use of HAART, immune restoration disease (IRD) has been described in association with many OIs. Our objective was to det...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-7-46
更新日期：2010-12-21 00:00:00
abstract：:High rates of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was a key consideration in the WHO policies transitioning first-line regimens to include integrase inhibitors (dolutegravir [DTG]). However, recent data suggests a relationship between DTG and neural tube defects among women exposed durin...
journal_title：AIDS research and therapy
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12981-019-0220-8
更新日期：2019-02-22 00:00:00
abstract：:A segment of the HIV infected population develops abnormal and excessive accumulation of adipose tissue in the trunk, including accumulation of visceral (deep abdominal) adipose tissue. This condition, known as HIV-related adipose redistribution syndrome (HARS), may also be accompanied by fat accumulation in the upper...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-4-16
更新日期：2007-07-16 00:00:00
abstract：BACKGROUND:Tubular dysfunction is common in HIV-infected people and detection of proteinuria is essential to identify this problem. In low-income countries, resources for detection of proteinuria using the Kidney Disease Improve Global Outcomes (KDIGO) gold standard urinary protein/creatinine ratio (uPCR) is rarely pos...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0047-x
更新日期：2015-03-21 00:00:00
abstract：BACKGROUND:Drug resistance testing before initiation of, or during, antiretroviral therapy (ART) is not routinely performed in resource-limited settings. High levels of viral resistance circulating within the population will have impact on treatment programs by increasing the chances of transmission of resistant strain...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-38
更新日期：2011-10-13 00:00:00
abstract：BACKGROUND:Vitamin D is an important determinant of bone health and also plays a major role in the regulation of the immune system. Interestingly, vitamin D status before the start of highly active antiretroviral therapy (HAART) has been recently associated with HIV disease progression and overall mortality in HIV-posi...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-7-40
更新日期：2010-11-23 00:00:00
abstract：BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-11-6
更新日期：2014-01-22 00:00:00
abstract：UNLABELLED: OBJECTIVE:To investigate anti-infective treatments in HIV-infected surgical patients during the perioperative period. METHODS:A retrospective study of sepsis and surgical site infections (SSIs) was conducted in 266 HIV-infected patients. The patients were divided into 3 groups based on CD4+ T cells counts...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-9-36
更新日期：2012-11-27 00:00:00
abstract：BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced partic...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-9-14
更新日期：2012-05-14 00:00:00
abstract：:Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a unique vaccine for every world region or virus subtype may not be necessary. ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-2-3
更新日期：2005-04-28 00:00:00
abstract：BACKGROUND:A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming non-infected HIV-exposed infants (HEIs) and prompting timely initiation of ART in HIV-infected babi...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-019-0245-z
更新日期：2019-09-14 00:00:00
abstract：BACKGROUND:Sustained use of antiretroviral therapy has been consistently shown to be one of the primary predictors of long-term effectiveness. Switching and discontinuation reflect patient and provider decisions that may limit future treatment options. In this study, we utilize data reported at semi-annual study visits...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-4-12
更新日期：2007-06-06 00:00:00
abstract：BACKGROUND:Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharmacokinetics (PK) of antiretroviral drugs metabolized via the same pathways. However, in vitro drug interaction activity may no...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-017-0140-4
更新日期：2017-03-14 00:00:00
abstract：:Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples de...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-5
更新日期：2006-02-20 00:00:00
