Abstract:
:High rates of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was a key consideration in the WHO policies transitioning first-line regimens to include integrase inhibitors (dolutegravir [DTG]). However, recent data suggests a relationship between DTG and neural tube defects among women exposed during conception, giving providers and policymakers pause regarding the planned regimen changes. We examined HIV drug resistance among a cohort of 46 acutely infected persons in Malawi. Our data demonstrates high levels of transmitted resistance, 11% using standard resistance surveillance mutations and 20% when additional NNRTI polymorphisms that may affect treatment response are included. High resistance rates in this treatment-naïve patient population reinforces the critical nature of DTG-based options in the context of public-health driven treatment programs.
journal_name
AIDS Res Therjournal_title
AIDS research and therapyauthors
Rutstein SE,Chen JS,Nelson JAE,Phiri S,Miller WC,Hosseinipour MCdoi
10.1186/s12981-019-0220-8subject
Has Abstractpub_date
2019-02-22 00:00:00pages
5issue
1issn
1742-6405pii
10.1186/s12981-019-0220-8journal_volume
16pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Tubular dysfunction is common in HIV-infected people and detection of proteinuria is essential to identify this problem. In low-income countries, resources for detection of proteinuria using the Kidney Disease Improve Global Outcomes (KDIGO) gold standard urinary protein/creatinine ratio (uPCR) is rarely pos...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0047-x
更新日期:2015-03-21 00:00:00
abstract:BACKGROUND:To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). METHODS:The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went t...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-016-0102-2
更新日期:2016-04-09 00:00:00
abstract:BACKGROUND:Minocycline is a tetracycline antibiotic that has been shown to attenuate central nervous system (CNS) lentivirus infection, immune activation, and brain injury in model systems. To initiate assessment of minocycline as an adjuvant therapy in human CNS HIV infection, we conducted an open-labelled pilot study...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-17
更新日期:2011-05-12 00:00:00
abstract:BACKGROUND:Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neuropsychological testing for diagnosis. We aimed to develop a brief and clinically feasible battery t...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-019-0224-4
更新日期:2019-04-15 00:00:00
abstract:BACKGROUND:Separately, chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements, including atrophy and wasting, weakness, and fatigue. One prospective cohort study reported that 41% of HIV-infected patients met the criteria for alcoholism, however; few reports exist on the c...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-30
更新日期:2011-08-16 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) use by people living with HIV reduces HIV transmission, morbidity, mortality, and improves quality of life. Good ART adherence is required to achieve these benefits. We investigated how the environmental, social, economic and behavioural experiences of people living with HIV with...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0214-y
更新日期:2019-01-21 00:00:00
abstract:BACKGROUND:Drug resistance testing before initiation of, or during, antiretroviral therapy (ART) is not routinely performed in resource-limited settings. High levels of viral resistance circulating within the population will have impact on treatment programs by increasing the chances of transmission of resistant strain...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-38
更新日期:2011-10-13 00:00:00
abstract::A segment of the HIV infected population develops abnormal and excessive accumulation of adipose tissue in the trunk, including accumulation of visceral (deep abdominal) adipose tissue. This condition, known as HIV-related adipose redistribution syndrome (HARS), may also be accompanied by fat accumulation in the upper...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-16
更新日期:2007-07-16 00:00:00
abstract:BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced partic...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-9-14
更新日期:2012-05-14 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reasons for hospitalization have changed; OIs are no longer the most common reason for admission. This s...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0186-3
更新日期:2017-11-13 00:00:00
abstract:BACKGROUND:Vitamin D is an important determinant of bone health and also plays a major role in the regulation of the immune system. Interestingly, vitamin D status before the start of highly active antiretroviral therapy (HAART) has been recently associated with HIV disease progression and overall mortality in HIV-posi...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-7-40
更新日期:2010-11-23 00:00:00
abstract:BACKGROUND:Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-5-2
更新日期:2008-01-29 00:00:00
abstract:BACKGROUND:In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter might be due to high levels of sero-discordant couples and increasing transmission from male to fema...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-016-0124-9
更新日期:2016-11-15 00:00:00
abstract:BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-6
更新日期:2014-01-22 00:00:00
abstract::Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-10-22
更新日期:2013-09-03 00:00:00
abstract::APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entrapment in inactive ...
journal_title:AIDS research and therapy
pub_type: 杂志文章,评审
doi:10.1186/s12981-017-0173-8
更新日期:2017-09-12 00:00:00
abstract:PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0146-y
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:To quarantine the spreading possibility of HIV virus to general population boosting public awareness is must. But the proper awareness level is substantially low in Bangladesh. This paper aims to identify the factors associated with the awareness regarding HIV/AIDS through a bivariate and multivariate analys...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-10
更新日期:2007-05-12 00:00:00
abstract::Bone health status is largely absent in South Africa, the main reasons being the absence and cost-effectiveness of specific screening equipment for assessing bone mineral density (BMD). Various risk factors seem to play a role, some of which can be modified to change bone health status. Urbanisation is also a public h...
journal_title:AIDS research and therapy
pub_type: 杂志文章,评审
doi:10.1186/s12981-017-0162-y
更新日期:2017-07-26 00:00:00
abstract:BACKGROUND:People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. METHODS:ART-n...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-020-00275-2
更新日期:2020-05-13 00:00:00
abstract:BACKGROUND:The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown to inhibit HIV-1 replication during various stages of the virus life cycle, and therefore represen...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-3-15
更新日期:2006-05-25 00:00:00
abstract:BACKGROUND:People who inject drugs (PWID) living with HIV often experience sub-optimal antiretroviral therapy (ART) treatment outcomes, including HIV plasma viral load (PVL) rebound. While previous studies have identified risk factors for PVL rebound among PWID, no study has examined the perspectives of PWID who have e...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-016-0108-9
更新日期:2016-07-25 00:00:00
abstract:UNLABELLED: OBJECTIVE:To investigate anti-infective treatments in HIV-infected surgical patients during the perioperative period. METHODS:A retrospective study of sepsis and surgical site infections (SSIs) was conducted in 266 HIV-infected patients. The patients were divided into 3 groups based on CD4+ T cells counts...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-9-36
更新日期:2012-11-27 00:00:00
abstract:BACKGROUND:Sustained use of antiretroviral therapy has been consistently shown to be one of the primary predictors of long-term effectiveness. Switching and discontinuation reflect patient and provider decisions that may limit future treatment options. In this study, we utilize data reported at semi-annual study visits...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-12
更新日期:2007-06-06 00:00:00
abstract:BACKGROUND:A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine (PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques if treatment begins within 24 hours after SIVmne inoculation, but is less effective if treatment is delay...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-3-29
更新日期:2006-11-28 00:00:00
abstract:BACKGROUND:Psychosocial factors have been linked with loss to follow-up (LTFU) and clinical outcomes among people living with HIV (PLH), however little is known about the effect of psychosocial support on LTFU among PLH in treatment and care. The purpose of this study was to explore the effect of NAMWEZA ("Yes, togethe...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0145-z
更新日期:2017-03-28 00:00:00
abstract:BACKGROUND:Identifying those at increased risk of death during TB treatment is a priority in resource-constrained settings. We performed this study to determine predictors of mortality during TB treatment. METHODS:We performed a retrospective analysis of a TB surveillance population in a high HIV prevalence area that ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0076-5
更新日期:2015-10-06 00:00:00
abstract:OBJECTIVE:To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors. METHOD:We determine levels of NT-pro BNP in peripheral blood of HIV patients from Costa del Sol Hospital, ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-015-0058-7
更新日期:2015-05-10 00:00:00
abstract::Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples de...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-3-5
更新日期:2006-02-20 00:00:00
abstract:BACKGROUND:Non-AIDS defining cancers (NADCs) have been an increasing cause of morbidity and mortality in patients with HIV. There is no data on the spectrum of NADCs in Mexico. We describe the type of neoplasms, clinical characteristics, and outcomes of HIV-infected patients with NADCs. METHODS:We conducted a retrospe...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0202-2
更新日期:2018-10-27 00:00:00