High rates of transmitted NNRTI resistance among persons with acute HIV infection in Malawi: implications for first-line dolutegravir scale-up.

Abstract:

:High rates of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was a key consideration in the WHO policies transitioning first-line regimens to include integrase inhibitors (dolutegravir [DTG]). However, recent data suggests a relationship between DTG and neural tube defects among women exposed during conception, giving providers and policymakers pause regarding the planned regimen changes. We examined HIV drug resistance among a cohort of 46 acutely infected persons in Malawi. Our data demonstrates high levels of transmitted resistance, 11% using standard resistance surveillance mutations and 20% when additional NNRTI polymorphisms that may affect treatment response are included. High resistance rates in this treatment-naïve patient population reinforces the critical nature of DTG-based options in the context of public-health driven treatment programs.

journal_name

AIDS Res Ther

authors

Rutstein SE,Chen JS,Nelson JAE,Phiri S,Miller WC,Hosseinipour MC

doi

10.1186/s12981-019-0220-8

subject

Has Abstract

pub_date

2019-02-22 00:00:00

pages

5

issue

1

issn

1742-6405

pii

10.1186/s12981-019-0220-8

journal_volume

16

pub_type

杂志文章,随机对照试验
  • HIV sero-discordance among married HIV patients initiating anti-retroviral therapy in northern Vietnam.

    abstract:BACKGROUND:In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter might be due to high levels of sero-discordant couples and increasing transmission from male to fema...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-016-0124-9

    authors: Van Tam V,Cuong DD,Alfven T,Phuc HD,Chuc NT,Hoa NP,Diwan V,Larsson M

    更新日期:2016-11-15 00:00:00

  • Renal function change after switching tenofovir disoproxil fumarate for tenofovir alafenamide in the HIV-positive patients of a metropolitan sexual health service.

    abstract:BACKGROUND:Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prodrug of tenofovir, causes less renal impairment and can improve renal function in patients switched f...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-019-0256-9

    authors: Turner D,Drak D,O'Connor CC,Templeton DJ,Gracey DM

    更新日期:2019-12-07 00:00:00

  • Bone mineral density in people living with HIV: a narrative review of the literature.

    abstract::Bone health status is largely absent in South Africa, the main reasons being the absence and cost-effectiveness of specific screening equipment for assessing bone mineral density (BMD). Various risk factors seem to play a role, some of which can be modified to change bone health status. Urbanisation is also a public h...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章,评审

    doi:10.1186/s12981-017-0162-y

    authors: Kruger MJ,Nell TA

    更新日期:2017-07-26 00:00:00

  • Is the Sexual Behaviour of HIV Patients on Antiretroviral therapy safe or risky in Sub-Saharan Africa? Meta-Analysis and Meta-Regression.

    abstract:BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced partic...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-9-14

    authors: Berhan A,Berhan Y

    更新日期:2012-05-14 00:00:00

  • HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector.

    abstract::BACKGROUND: RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs against cellular coreceptors CXCR4 and CCR5 had shown that down regulation of these surface molecules co...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-2-1

    authors: Anderson J,Akkina R

    更新日期:2005-01-13 00:00:00

  • Estimating the impact of expanded access to antiretroviral therapy on maternal, paternal and double orphans in sub-Saharan Africa, 2009-2020.

    abstract:BACKGROUND:HIV/AIDS has orphaned 11.6 million children in sub-Saharan Africa. Expanded antiretroviral therapy (ART) use may reduce AIDS orphanhood by decreasing adult mortality and population-level HIV transmission. METHODS:We modeled two scenarios to measure the impact of adult ART use on the incidence of orphanhood ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-8-13

    authors: Anema A,Au-Yeung CG,Joffres M,Kaida A,Vasarhelyi K,Kanters S,Montaner JS,Hogg RS

    更新日期:2011-03-07 00:00:00

  • Total Lymphocyte Count as surrogate marker for CD4 Cell Count in HIV-Infected Individuals in Gondar University Hospital, Northwest Ethiopia.

    abstract:UNLABELLED: BACKGROUND:The high cost of CD4 count estimation in resource-limited countries is a major challenge in initiating patients on highly active antiretroviral therapy (HAART). Therefore, assessment of inexpensive and simple laboratory diagnostic marker is mandatory to diagnose immuno-suppression. OBJECTIVE:To...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-9-21

    authors: Wondimeneh Y,Ferede G,Yismaw G,Muluye D

    更新日期:2012-07-15 00:00:00

  • Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus-1 (HIV-1) infected pediatric patients: a cross-sectional study.

    abstract:BACKGROUND:Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple drug-resistant HIV-1 variants. The few studies on HIV-1 mutagenesis in HIV infected children have no...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-4-15

    authors: Malhotra A,Gaur S,Whitley-Williams P,Loomis C,Petrova A

    更新日期:2007-07-09 00:00:00

  • Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study.

    abstract:BACKGROUND:Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharmacokinetics (PK) of antiretroviral drugs metabolized via the same pathways. However, in vitro drug interaction activity may no...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-017-0140-4

    authors: Monera-Penduka TG,Maponga CC,Wolfe AR,Wiesner L,Morse GD,Nhachi CF

    更新日期:2017-03-14 00:00:00

  • Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot study.

    abstract:BACKGROUND:Minocycline is a tetracycline antibiotic that has been shown to attenuate central nervous system (CNS) lentivirus infection, immune activation, and brain injury in model systems. To initiate assessment of minocycline as an adjuvant therapy in human CNS HIV infection, we conducted an open-labelled pilot study...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-8-17

    authors: Ho EL,Spudich SS,Lee E,Fuchs D,Sinclair E,Price RW

    更新日期:2011-05-12 00:00:00

  • Eradication of HIV-1 latent reservoirs through therapeutic vaccination.

    abstract::Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章,评审

    doi:10.1186/s12981-017-0177-4

    authors: Pankrac J,Klein K,Mann JFS

    更新日期:2017-09-12 00:00:00

  • German cohort of HCV mono-infected and HCV/HIV co-infected patients reveals relative under-treatment of co-infected patients.

    abstract:BACKGROUND:Current German and European HIV guidelines recommend early evaluation of HCV treatment in all HIV/HCV co-infected patients. However, there are still considerable barriers to initiate HCV therapy in everyday clinical practice. This study evaluates baseline characteristics, "intention-to-treat" pattern and out...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-11-16

    authors: Beisel C,Heuer M,Otto B,Jochum J,Schmiedel S,Hertling S,Degen O,Lüth S,van Lunzen J,Schulze Zur Wiesch J

    更新日期:2014-07-01 00:00:00

  • Development of a neurocognitive test battery for HIV-associated neurocognitive disorder (HAND) screening: suggested solutions for resource-limited clinical settings.

    abstract:BACKGROUND:Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neuropsychological testing for diagnosis. We aimed to develop a brief and clinically feasible battery t...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-019-0224-4

    authors: Chan LG,Ho MJ,Lin YC,Ong Y,Wong CS

    更新日期:2019-04-15 00:00:00

  • Association between quantitative varicella-zoster virus antibody levels and zoster reactivation in HIV-infected persons.

    abstract:BACKGROUND:Varicella-zoster virus (VZV) reactivation is common but difficult to predict in HIV-infected persons. OBJECTIVE:Since qualitative VZV antibodies can determine past VZV disease or vaccination, we evaluated whether quantitative VZV antibody levels over time can predict future zoster. STUDY DESIGN:US Military...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-018-0212-0

    authors: Pomerantz HS,Xu X,White J,Sunil TS,Deiss RG,Ganesan A,Agan BK,Okulicz JF

    更新日期:2018-12-11 00:00:00

  • Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture.

    abstract:BACKGROUND:Most in vitro assays of drug potency may not adequately predict the performance in vivo. Methods to assess the persistence of antiviral activity of deoxynucleoside analogs, which require intracellular activation to the active metabolites that can persist in cells, will be important for designing dosages, com...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-6-5

    authors: Paintsil E,Grill SP,Dutschman GE,Cheng YC

    更新日期:2009-04-22 00:00:00

  • Implementation of antiretroviral therapy (ART) in former Soviet Union countries.

    abstract::Against the current global trends, in the former Soviet Union (FSU) countries HIV prevalence is on the rise. Visa-free movement across borders has facilitated migrant-associated HIV transmission within this region. Despite efforts from the governments to curtail the growing epidemic, there is still a serious need for ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章,评审

    doi:10.1186/s12981-019-0251-1

    authors: Amangaldiyeva A,Davlidova S,Baiserkin B,Dzissyuk N,DeHovitz J,Ali S

    更新日期:2019-11-19 00:00:00

  • Factors related to NT-proBNP levels in HIV patients aged over 40 years.

    abstract:OBJECTIVE:To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors. METHOD:We determine levels of NT-pro BNP in peripheral blood of HIV patients from Costa del Sol Hospital, ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-015-0058-7

    authors: Olalla J,Crespo E,De la Torre J,Sempere M,Del Arco A,Prada JL,Malvarez R,Pérez J,García-Alegría J

    更新日期:2015-05-10 00:00:00

  • Cytochrome P450 2B6 genetic variants are associated with plasma nevirapine levels and clinical response in HIV-1 infected Kenyan women: a prospective cohort study.

    abstract:BACKGROUND:Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevirapine concentration and clinical response in African women are limited. We investigated the impact o...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-015-0052-0

    authors: Oluka MN,Okalebo FA,Guantai AN,McClelland RS,Graham SM

    更新日期:2015-04-15 00:00:00

  • Antiretroviral therapy at a district hospital in Ethiopia prevents death and tuberculosis in a cohort of HIV patients.

    abstract:BACKGROUND:Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings. We assessed the effect of HAART on patient mortality and tuberculosis incidence rate under routine clinical care conditions in Ethiopia. The objective of this stu...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-3-10

    authors: Jerene D,Naess A,Lindtjørn B

    更新日期:2006-04-07 00:00:00

  • Morning free and total testosterone in HIV-infected men: implications for the assessment of hypogonadism.

    abstract:BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-11-6

    authors: Monroe AK,Dobs AS,Palella FJ,Kingsley LA,Witt MD,Brown TT

    更新日期:2014-01-22 00:00:00

  • Successful use of extracorporeal membrane oxygenation in a human immunodeficiency virus infected patient with severe acute respiratory distress syndrome.

    abstract:INTRODUCTION:We report a case of an adult patient with human immunodeficiency virus (HIV), acute respiratory distress syndrome (ARDS) and ventilator associated pneumonia (VAP) caused by multidrug resistant (MDR) bacteria that was successfully managed with veno-venous extracorporeal membrane oxygenation (ECMO). CASE RE...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-11-37

    authors: Samalavicius R,Serpytis M,Ringaitiene D,Grazulyte D,Bertasiute R,Rimkus B,Matulionyte R,Ambrazaitiene R,Sipylaite J,Kacergius T,Griskevicius L

    更新日期:2014-11-21 00:00:00

  • Reverse transcriptase drug resistance mutations in HIV-1 subtype C infected patients on ART in Karonga District, Malawi.

    abstract:BACKGROUND:Drug resistance testing before initiation of, or during, antiretroviral therapy (ART) is not routinely performed in resource-limited settings. High levels of viral resistance circulating within the population will have impact on treatment programs by increasing the chances of transmission of resistant strain...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-8-38

    authors: Bansode VB,Travers SA,Crampin AC,Ngwira B,French N,Glynn JR,McCormack GP

    更新日期:2011-10-13 00:00:00

  • Impact of WHO guidelines on trends in HIV testing and ART initiation among children living with HIV in Zambia.

    abstract:BACKGROUND:About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with limited documentation of long-term trends in the numbers testing HIV positive and initiating ART. We ex...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-020-00277-0

    authors: Munthali T,Michelo C,Mee P,Moyo C,Kashoka A,Liswaniso L,Chiboma I,Todd J

    更新日期:2020-05-14 00:00:00

  • Clade, Country and Region-specific HIV-1 Vaccines: Are they necessary?

    abstract::Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a unique vaccine for every world region or virus subtype may not be necessary. ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-2-3

    authors: Slobod KS,Coleclough C,Brown SA,Stambas J,Zhan X,Surman S,Jones BG,Zirkel A,Freiden PJ,Brown B,Sealy R,Bonsignori M,Hurwitz JL

    更新日期:2005-04-28 00:00:00

  • Validity assessment of the PROMIS fatigue domain among people living with HIV.

    abstract:PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-017-0146-y

    authors: Gibbons LE,Fredericksen R,Batey DS,Dant L,Edwards TC,Mayer KH,Mathews WC,Morales LS,Mugavero MJ,Yang FM,Paez E,Kitahata MM,Patrick DL,Crane HM,Crane PK,Centers for AIDS Research Network of Integrated Clinical Systems (CNICS

    更新日期:2017-04-11 00:00:00

  • Correlates and determinants of Early Infant Diagnosis outcomes in North-Central Nigeria.

    abstract:BACKGROUND:A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming non-infected HIV-exposed infants (HEIs) and prompting timely initiation of ART in HIV-infected babi...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-019-0245-z

    authors: Dakum P,Tola M,Iboro N,Okolo CA,Anuforom O,Chime C,Peters S,Jumare J,Ogbanufe O,Ahmad A,Ndembi N

    更新日期:2019-09-14 00:00:00

  • Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats.

    abstract:BACKGROUND:Separately, chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements, including atrophy and wasting, weakness, and fatigue. One prospective cohort study reported that 41% of HIV-infected patients met the criteria for alcoholism, however; few reports exist on the c...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-8-30

    authors: Clary CR,Guidot DM,Bratina MA,Otis JS

    更新日期:2011-08-16 00:00:00

  • Sexual behavior of HIV-positive adults not accessing HIV treatment in Mombasa, Kenya: Defining their prevention needs.

    abstract:BACKGROUND:HIV spread continues at high rates from infected persons to their sexual partners. In 2009, an estimated 2.6 million new infections occurred globally. People living with HIV (PLHIV) receiving treatment are in contact with health workers and therefore exposed to prevention messages. By contrast, PLHIV not rec...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-9-9

    authors: Sarna A,Luchters S,Pickett M,Chersich M,Okal J,Geibel S,Kingola N,Temmerman M

    更新日期:2012-03-19 00:00:00

  • Community-based ART distribution system can effectively facilitate long-term program retention and low-rates of death and virologic failure in rural Uganda.

    abstract:BACKGROUND:Community-drug distribution point is a care model for stable patients in the community designed to make ART delivery more efficient for the health system and provide appropriate support to encourage long-term retention of patients. We examined program retention among ART program participants in rural Uganda,...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-015-0077-4

    authors: Okoboi S,Ding E,Persuad S,Wangisi J,Birungi J,Shurgold S,Kato D,Nyonyintono M,Egessa A,Bakanda C,Munderi P,Kaleebu P,Moore DM

    更新日期:2015-11-12 00:00:00

  • Immune restoration disease and changes in CD4+ T-cell count in HIV- infected patients during highly active antiretroviral therapy at Zewditu memorial hospital, Addis Ababa, Ethiopia.

    abstract:BACKGROUND:Highly active antiretroviral therapy (HAART) improves the immune function and decreases morbidity, mortality and opportunistic infections (OIs) in HIV-infected patients. However, since the use of HAART, immune restoration disease (IRD) has been described in association with many OIs. Our objective was to det...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-7-46

    authors: Huruy K,Kassu A,Mulu A,Wondie Y

    更新日期:2010-12-21 00:00:00