A meta-analysis comparing 48-week treatment outcomes of single and multi-tablet antiretroviral regimens for the treatment of people living with HIV.

abstract：: The December 2011 5th International Workshop on HIV Persistence during Therapy addressed the issue of HIV persistence among 210 scientists from 10 countries involved in the study of HIV reservoirs and the search of an HIV cure. High quality abstracts were selected and discussed as oral or poster presentations. The ai...

journal_title：AIDS research and therapy

authors： Stevenson M,Chomont N,Lafeuillade A

更新日期：2012-03-12 00:00:00

abstract：BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...

journal_title：AIDS research and therapy

authors： Monroe AK,Dobs AS,Palella FJ,Kingsley LA,Witt MD,Brown TT

更新日期：2014-01-22 00:00:00

abstract：PURPOSE:We studied the safety, tolerability, virologic, and immunologic effects of mycophenolate mofetil (MMF) added to a stable antiretroviral therapy (ART) in the setting of low-level viremia. METHODS:MMF 500 mg BID or placebo was given to patients thought to be adherent on stable ART with plasma viremia between 200...

journal_title：AIDS research and therapy

authors： Kaur R,Bedimo R,Kvanli MB,Turner D,Shaw L,Margolis D

更新日期：2006-05-26 00:00:00

abstract：: In HIV-1 infected patients, increase of liver enzymes may be mainly due to viral coinfections, alcohol intake, hepatotoxic drugs or autoimmune diseases. Three cases of aminotransferase elevation occurred during a phase of uncontrolled viral replication combined with a severe immunodeficiency and resolved by an effect...

journal_title：AIDS research and therapy

authors： Esposito A,Conti V,Cagliuso M,Pastori D,Fantauzzi A,Mezzaroma I

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Current German and European HIV guidelines recommend early evaluation of HCV treatment in all HIV/HCV co-infected patients. However, there are still considerable barriers to initiate HCV therapy in everyday clinical practice. This study evaluates baseline characteristics, "intention-to-treat" pattern and out...

journal_title：AIDS research and therapy

authors： Beisel C,Heuer M,Otto B,Jochum J,Schmiedel S,Hertling S,Degen O,Lüth S,van Lunzen J,Schulze Zur Wiesch J

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown to inhibit HIV-1 replication during various stages of the virus life cycle, and therefore represen...

journal_title：AIDS research and therapy

authors： Paskaleva EE,Lin X,Li W,Cotter R,Klein MT,Roberge E,Yu EK,Clark B,Veille JC,Liu Y,Lee DY,Canki M

更新日期：2006-05-25 00:00:00

abstract：BACKGROUND:About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with limited documentation of long-term trends in the numbers testing HIV positive and initiating ART. We ex...

journal_title：AIDS research and therapy

authors： Munthali T,Michelo C,Mee P,Moyo C,Kashoka A,Liswaniso L,Chiboma I,Todd J

更新日期：2020-05-14 00:00:00

abstract：OBJECTIVE:Recent studies have shown that the current guidelines suggesting immunologic monitoring to determine response to highly active antiretroviral therapy (HAART) are inadequate. We assessed whether routinely collected clinical markers could improve prediction of concurrent HIV RNA levels. METHODS:We included ind...

journal_title：AIDS research and therapy

authors： Lau B,Chander G,Gange SJ,Moore RD

更新日期：2010-07-23 00:00:00

abstract：BACKGROUND:People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. METHODS:ART-n...

journal_title：AIDS research and therapy

authors： Sherman EM,Niu J,Elrod S,Clauson KA,Alkhateeb F,Eckardt P

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:Non-AIDS defining cancers (NADCs) have been an increasing cause of morbidity and mortality in patients with HIV. There is no data on the spectrum of NADCs in Mexico. We describe the type of neoplasms, clinical characteristics, and outcomes of HIV-infected patients with NADCs. METHODS:We conducted a retrospe...

journal_title：AIDS research and therapy

authors： Cornejo-Juárez P,Cavildo-Jerónimo D,Volkow-Fernández P

更新日期：2018-10-27 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reasons for hospitalization have changed; OIs are no longer the most common reason for admission. This s...

journal_title：AIDS research and therapy

authors： Álvarez Barreneche MF,Restrepo Castro CA,Hidrón Botero A,Villa Franco JP,Trompa Romero IM,Restrepo Carvajal L,Eusse García A,Ocampo Mesa A,Echeverri Toro LM,Porras Fernández de Castro GP,Ramírez Rivera JM,Agudelo Restrepo CA

更新日期：2017-11-13 00:00:00

abstract：:HIV-1 infects gut associated lymphoid tissues (GALT) very early after transmission by multiple routes. The infected GALT consequently serves as the major reservoir for HIV-1 infection and could constantly shed HIV-1 and CD4+ T cells into the intestinal lumen. To examine this hypothesis, we monitored HIV-1 RNA/DNA and ...

journal_title：AIDS research and therapy

authors： Chakrabarti AK,Caruso L,Ding M,Shen C,Buchanan W,Gupta P,Rinaldo CR,Chen Y

更新日期：2009-10-02 00:00:00

abstract：BACKGROUND:As a simplification strategy for treatment-experienced HIV-infected patients who have achieved virologic suppression on a multi-drug, multi-class antiretroviral regimen, the aim of this study was to evaluate the safety, efficacy, and pharmacokinetics of once-daily elvitegravir/cobicistat/emtricitabine/tenofo...

journal_title：AIDS research and therapy

authors： Harris M,Ganase B,Watson B,Harrigan PR,Montaner JSG,Hull MW

更新日期：2017-11-02 00:00:00

abstract：BACKGROUND:Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prodrug of tenofovir, causes less renal impairment and can improve renal function in patients switched f...

journal_title：AIDS research and therapy

authors： Turner D,Drak D,O'Connor CC,Templeton DJ,Gracey DM

更新日期：2019-12-07 00:00:00

abstract：BACKGROUND:Tubular dysfunction is common in HIV-infected people and detection of proteinuria is essential to identify this problem. In low-income countries, resources for detection of proteinuria using the Kidney Disease Improve Global Outcomes (KDIGO) gold standard urinary protein/creatinine ratio (uPCR) is rarely pos...

journal_title：AIDS research and therapy

authors： López De León JI,Mata-Marín JA,Andrade-Fuentes K,Huerta-Garcia G,Domínguez-Hemosillo JC,Gaytán-Martínez J

更新日期：2015-03-21 00:00:00

abstract：OBJECTIVE:To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors. METHOD:We determine levels of NT-pro BNP in peripheral blood of HIV patients from Costa del Sol Hospital, ...

journal_title：AIDS research and therapy

authors： Olalla J,Crespo E,De la Torre J,Sempere M,Del Arco A,Prada JL,Malvarez R,Pérez J,García-Alegría J

更新日期：2015-05-10 00:00:00

abstract：BACKGROUND:Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to ...

journal_title：AIDS research and therapy

authors： Feller L,Masipa J,Wood N,Raubenheimer E,Lemmer J

更新日期：2008-01-29 00:00:00

abstract：BACKGROUND:Community-drug distribution point is a care model for stable patients in the community designed to make ART delivery more efficient for the health system and provide appropriate support to encourage long-term retention of patients. We examined program retention among ART program participants in rural Uganda,...

journal_title：AIDS research and therapy

authors： Okoboi S,Ding E,Persuad S,Wangisi J,Birungi J,Shurgold S,Kato D,Nyonyintono M,Egessa A,Bakanda C,Munderi P,Kaleebu P,Moore DM

更新日期：2015-11-12 00:00:00

abstract：:APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entrapment in inactive ...

journal_title：AIDS research and therapy

authors： Grant M,Larijani M

更新日期：2017-09-12 00:00:00

abstract：PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...

journal_title：AIDS research and therapy

authors： Gibbons LE,Fredericksen R,Batey DS,Dant L,Edwards TC,Mayer KH,Mathews WC,Morales LS,Mugavero MJ,Yang FM,Paez E,Kitahata MM,Patrick DL,Crane HM,Crane PK,Centers for AIDS Research Network of Integrated Clinical Systems (CNICS

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Despite the conventional approaches to HIV prevention being the bedrock for early reductions in HIV infections in Uganda, innovations that demonstrate reduction in risk to infection in vulnerable populations need to be embraced urgently. In the past 2 years, a USAID-funded project tested a quality improvemen...

journal_title：AIDS research and therapy

authors： Karamagi E,Sensalire S,Nabwire J,Byabagambi J,Awio AO,Aluma G,Rahimzai M,Calnan J,Kyobutungi S

更新日期：2018-01-25 00:00:00

abstract：:High rates of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was a key consideration in the WHO policies transitioning first-line regimens to include integrase inhibitors (dolutegravir [DTG]). However, recent data suggests a relationship between DTG and neural tube defects among women exposed durin...

journal_title：AIDS research and therapy

authors： Rutstein SE,Chen JS,Nelson JAE,Phiri S,Miller WC,Hosseinipour MC

更新日期：2019-02-22 00:00:00

abstract：BACKGROUND:To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). METHODS:The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went t...

journal_title：AIDS research and therapy

authors： Bucciardini R,Pugliese K,Francisci D,Costantini A,Schiaroli E,Cognigni M,Tontini C,Lucattini S,Fucili L,Di Gregorio M,Mirra M,Fragola V,Pompili S,Murri R,Vella S

更新日期：2016-04-09 00:00:00

abstract：BACKGROUND:Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple drug-resistant HIV-1 variants. The few studies on HIV-1 mutagenesis in HIV infected children have no...

journal_title：AIDS research and therapy

authors： Malhotra A,Gaur S,Whitley-Williams P,Loomis C,Petrova A

更新日期：2007-07-09 00:00:00

abstract：:Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such ...

journal_title：AIDS research and therapy

authors： Pankrac J,Klein K,Mann JFS

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevirapine concentration and clinical response in African women are limited. We investigated the impact o...

journal_title：AIDS research and therapy

authors： Oluka MN,Okalebo FA,Guantai AN,McClelland RS,Graham SM

更新日期：2015-04-15 00:00:00

abstract：UNLABELLED: BACKGROUND:The high cost of CD4 count estimation in resource-limited countries is a major challenge in initiating patients on highly active antiretroviral therapy (HAART). Therefore, assessment of inexpensive and simple laboratory diagnostic marker is mandatory to diagnose immuno-suppression. OBJECTIVE:To...

journal_title：AIDS research and therapy

authors： Wondimeneh Y,Ferede G,Yismaw G,Muluye D

更新日期：2012-07-15 00:00:00

abstract：BACKGROUND:In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter might be due to high levels of sero-discordant couples and increasing transmission from male to fema...

journal_title：AIDS research and therapy

authors： Van Tam V,Cuong DD,Alfven T,Phuc HD,Chuc NT,Hoa NP,Diwan V,Larsson M

更新日期：2016-11-15 00:00:00

abstract：BACKGROUND:Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharmacokinetics (PK) of antiretroviral drugs metabolized via the same pathways. However, in vitro drug interaction activity may no...

journal_title：AIDS research and therapy

authors： Monera-Penduka TG,Maponga CC,Wolfe AR,Wiesner L,Morse GD,Nhachi CF

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:Voriconazole is metabolized by cytochrome P450 (CYP) 2C19 and CYP 3A4. Drug-drug interactions and genetic polymorphisms modulate their activities. CASE PRESENTATION:A 35-year old African female patient with resistant HIV and a cerebral mass of unknown origin was treated with voriconazole for a suspicion of ...

journal_title：AIDS research and therapy

authors： Bouatou Y,Samer CF,Ing Lorenzini KR,Daali Y,Daou S,Fathi M,Rebsamen M,Desmeules J,Calmy A,Escher M

更新日期：2014-08-04 00:00:00