Abstract：
:Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the understanding of the HIV infection process and insights from vaccine development in other biomedical fields such as cancer, imaging, and genetic engineering have fueled rapid advancements in HIV cure research. In the last few years, several studies have focused on the development of "Kick and Kill" therapies to reverse HIV latency and kick start viral translational activity. This has been done with the aim that concomitant anti-retroviral treatment and the elicited immune responses will prevent de novo infections while eradicating productively infected cells. In this review, we describe our perspective on HIV cure and the new approaches we are undertaking to eradicate the established pro-viral reservoir.
journal_name
AIDS Res Therjournal_title
AIDS research and therapyauthors
Pankrac J,Klein K,Mann JFSdoi
10.1186/s12981-017-0177-4subject
Has Abstractpub_date
2017-09-12 00:00:00pages
45issue
1issn
1742-6405pii
10.1186/s12981-017-0177-4journal_volume
14pub_type
杂志文章,评审abstract：PURPOSE:We studied the safety, tolerability, virologic, and immunologic effects of mycophenolate mofetil (MMF) added to a stable antiretroviral therapy (ART) in the setting of low-level viremia. METHODS:MMF 500 mg BID or placebo was given to patients thought to be adherent on stable ART with plasma viremia between 200...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-16
更新日期：2006-05-26 00:00:00
abstract：BACKGROUND:Antiretroviral therapy (ART) use by people living with HIV reduces HIV transmission, morbidity, mortality, and improves quality of life. Good ART adherence is required to achieve these benefits. We investigated how the environmental, social, economic and behavioural experiences of people living with HIV with...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-018-0214-y
更新日期：2019-01-21 00:00:00
abstract：BACKGROUND:Drug resistance testing before initiation of, or during, antiretroviral therapy (ART) is not routinely performed in resource-limited settings. High levels of viral resistance circulating within the population will have impact on treatment programs by increasing the chances of transmission of resistant strain...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-38
更新日期：2011-10-13 00:00:00
abstract：:BACKGROUND: RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs against cellular coreceptors CXCR4 and CCR5 had shown that down regulation of these surface molecules co...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-2-1
更新日期：2005-01-13 00:00:00
abstract：BACKGROUND:Varicella-zoster virus (VZV) reactivation is common but difficult to predict in HIV-infected persons. OBJECTIVE:Since qualitative VZV antibodies can determine past VZV disease or vaccination, we evaluated whether quantitative VZV antibody levels over time can predict future zoster. STUDY DESIGN:US Military...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-018-0212-0
更新日期：2018-12-11 00:00:00
abstract：:Against the current global trends, in the former Soviet Union (FSU) countries HIV prevalence is on the rise. Visa-free movement across borders has facilitated migrant-associated HIV transmission within this region. Despite efforts from the governments to curtail the growing epidemic, there is still a serious need for ...
journal_title：AIDS research and therapy
pub_type： 杂志文章,评审
doi：10.1186/s12981-019-0251-1
更新日期：2019-11-19 00:00:00
abstract：BACKGROUND:Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prodrug of tenofovir, causes less renal impairment and can improve renal function in patients switched f...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-019-0256-9
更新日期：2019-12-07 00:00:00
abstract：BACKGROUND:To quarantine the spreading possibility of HIV virus to general population boosting public awareness is must. But the proper awareness level is substantially low in Bangladesh. This paper aims to identify the factors associated with the awareness regarding HIV/AIDS through a bivariate and multivariate analys...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-4-10
更新日期：2007-05-12 00:00:00
abstract：:Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-10-22
更新日期：2013-09-03 00:00:00
abstract：:Bone health status is largely absent in South Africa, the main reasons being the absence and cost-effectiveness of specific screening equipment for assessing bone mineral density (BMD). Various risk factors seem to play a role, some of which can be modified to change bone health status. Urbanisation is also a public h...
journal_title：AIDS research and therapy
pub_type： 杂志文章,评审
doi：10.1186/s12981-017-0162-y
更新日期：2017-07-26 00:00:00
abstract：:APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entrapment in inactive ...
journal_title：AIDS research and therapy
pub_type： 杂志文章,评审
doi：10.1186/s12981-017-0173-8
更新日期：2017-09-12 00:00:00
abstract：UNLABELLED: BACKGROUND:The high cost of CD4 count estimation in resource-limited countries is a major challenge in initiating patients on highly active antiretroviral therapy (HAART). Therefore, assessment of inexpensive and simple laboratory diagnostic marker is mandatory to diagnose immuno-suppression. OBJECTIVE:To...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-9-21
更新日期：2012-07-15 00:00:00
abstract：:Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples de...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-5
更新日期：2006-02-20 00:00:00
abstract：PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-017-0146-y
更新日期：2017-04-11 00:00:00
abstract：BACKGROUND:People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. METHODS:ART-n...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-020-00275-2
更新日期：2020-05-13 00:00:00
abstract：OBJECTIVE:To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors. METHOD:We determine levels of NT-pro BNP in peripheral blood of HIV patients from Costa del Sol Hospital, ...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0058-7
更新日期：2015-05-10 00:00:00
abstract：BACKGROUND:Little is known about HIV-1 subtype distribution in Morocco. Some data suggest an emergence of new HIV subtypes. We conducted phylogenetic analysis on a nationally representative sample of 60 HIV-1 viral specimens collected during 2004-2005 through the Morocco national HIV sentinel surveillance survey. RESU...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-9-5
更新日期：2012-02-14 00:00:00
abstract：BACKGROUND:A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine (PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques if treatment begins within 24 hours after SIVmne inoculation, but is less effective if treatment is delay...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-3-29
更新日期：2006-11-28 00:00:00
abstract：BACKGROUND:Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple drug-resistant HIV-1 variants. The few studies on HIV-1 mutagenesis in HIV infected children have no...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-4-15
更新日期：2007-07-09 00:00:00
abstract：BACKGROUND:HLA-B*57:01 screening was added to clinical care guidelines in 2008 to reduce the risk of hypersensitivity reaction from abacavir. The uptake of HLA-B*57:01 screening and incidence of hypersensitivity reaction were assessed in a prospective clinical cohort in the United States to evaluate the effectiveness o...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-019-0217-3
更新日期：2019-01-16 00:00:00
abstract：BACKGROUND:Psychosocial factors have been linked with loss to follow-up (LTFU) and clinical outcomes among people living with HIV (PLH), however little is known about the effect of psychosocial support on LTFU among PLH in treatment and care. The purpose of this study was to explore the effect of NAMWEZA ("Yes, togethe...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-017-0145-z
更新日期：2017-03-28 00:00:00
abstract：: In HIV-1 infected patients, increase of liver enzymes may be mainly due to viral coinfections, alcohol intake, hepatotoxic drugs or autoimmune diseases. Three cases of aminotransferase elevation occurred during a phase of uncontrolled viral replication combined with a severe immunodeficiency and resolved by an effect...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-9
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Current German and European HIV guidelines recommend early evaluation of HCV treatment in all HIV/HCV co-infected patients. However, there are still considerable barriers to initiate HCV therapy in everyday clinical practice. This study evaluates baseline characteristics, "intention-to-treat" pattern and out...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-11-16
更新日期：2014-07-01 00:00:00
abstract：: After the introduction of highly active antiretroviral therapies (HAART), an increased incidence of insulin resistance, diabetes mellitus (DM), and cardiovascular diseases has been described. The impact of such conditions on mortality in the post-HAART era has been also assessed in various modes in the literature. In...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-7-11
更新日期：2010-05-24 00:00:00
abstract：BACKGROUND:Highly active antiretroviral therapy (HAART) improves the immune function and decreases morbidity, mortality and opportunistic infections (OIs) in HIV-infected patients. However, since the use of HAART, immune restoration disease (IRD) has been described in association with many OIs. Our objective was to det...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-7-46
更新日期：2010-12-21 00:00:00
abstract：BACKGROUND:To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). METHODS:The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went t...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-016-0102-2
更新日期：2016-04-09 00:00:00
abstract：BACKGROUND:Community-drug distribution point is a care model for stable patients in the community designed to make ART delivery more efficient for the health system and provide appropriate support to encourage long-term retention of patients. We examined program retention among ART program participants in rural Uganda,...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/s12981-015-0077-4
更新日期：2015-11-12 00:00:00
abstract：BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced partic...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-9-14
更新日期：2012-05-14 00:00:00
abstract：BACKGROUND:Separately, chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements, including atrophy and wasting, weakness, and fatigue. One prospective cohort study reported that 41% of HIV-infected patients met the criteria for alcoholism, however; few reports exist on the c...
journal_title：AIDS research and therapy
pub_type： 杂志文章
doi：10.1186/1742-6405-8-30
更新日期：2011-08-16 00:00:00
abstract：BACKGROUND:As a simplification strategy for treatment-experienced HIV-infected patients who have achieved virologic suppression on a multi-drug, multi-class antiretroviral regimen, the aim of this study was to evaluate the safety, efficacy, and pharmacokinetics of once-daily elvitegravir/cobicistat/emtricitabine/tenofo...
journal_title：AIDS research and therapy
pub_type： 临床试验,杂志文章
doi：10.1186/s12981-017-0185-4
更新日期：2017-11-02 00:00:00
