Reverse transcriptase drug resistance mutations in HIV-1 subtype C infected patients on ART in Karonga District, Malawi.

abstract：PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...

journal_title：AIDS research and therapy

authors： Gibbons LE,Fredericksen R,Batey DS,Dant L,Edwards TC,Mayer KH,Mathews WC,Morales LS,Mugavero MJ,Yang FM,Paez E,Kitahata MM,Patrick DL,Crane HM,Crane PK,Centers for AIDS Research Network of Integrated Clinical Systems (CNICS

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:The search for disease biomarkers within human peripheral fluids has become a favorable approach to preventative therapeutics throughout the past few years. The comparison of normal versus disease states can identify an overexpression or a suppression of critical proteins where illness has directly altered a...

journal_title：AIDS research and therapy

authors： Van Duyne R,Guendel I,Kehn-Hall K,Easley R,Klase Z,Liu C,Young M,Kashanchi F

更新日期：2010-07-06 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reasons for hospitalization have changed; OIs are no longer the most common reason for admission. This s...

journal_title：AIDS research and therapy

authors： Álvarez Barreneche MF,Restrepo Castro CA,Hidrón Botero A,Villa Franco JP,Trompa Romero IM,Restrepo Carvajal L,Eusse García A,Ocampo Mesa A,Echeverri Toro LM,Porras Fernández de Castro GP,Ramírez Rivera JM,Agudelo Restrepo CA

更新日期：2017-11-13 00:00:00

abstract：: In HIV-1 infected patients, increase of liver enzymes may be mainly due to viral coinfections, alcohol intake, hepatotoxic drugs or autoimmune diseases. Three cases of aminotransferase elevation occurred during a phase of uncontrolled viral replication combined with a severe immunodeficiency and resolved by an effect...

journal_title：AIDS research and therapy

authors： Esposito A,Conti V,Cagliuso M,Pastori D,Fantauzzi A,Mezzaroma I

更新日期：2011-03-01 00:00:00

abstract：:Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a unique vaccine for every world region or virus subtype may not be necessary. ...

journal_title：AIDS research and therapy

authors： Slobod KS,Coleclough C,Brown SA,Stambas J,Zhan X,Surman S,Jones BG,Zirkel A,Freiden PJ,Brown B,Sealy R,Bonsignori M,Hurwitz JL

更新日期：2005-04-28 00:00:00

abstract：:Against the current global trends, in the former Soviet Union (FSU) countries HIV prevalence is on the rise. Visa-free movement across borders has facilitated migrant-associated HIV transmission within this region. Despite efforts from the governments to curtail the growing epidemic, there is still a serious need for ...

journal_title：AIDS research and therapy

authors： Amangaldiyeva A,Davlidova S,Baiserkin B,Dzissyuk N,DeHovitz J,Ali S

更新日期：2019-11-19 00:00:00

abstract：BACKGROUND:Minocycline is a tetracycline antibiotic that has been shown to attenuate central nervous system (CNS) lentivirus infection, immune activation, and brain injury in model systems. To initiate assessment of minocycline as an adjuvant therapy in human CNS HIV infection, we conducted an open-labelled pilot study...

journal_title：AIDS research and therapy

authors： Ho EL,Spudich SS,Lee E,Fuchs D,Sinclair E,Price RW

更新日期：2011-05-12 00:00:00

abstract：BACKGROUND:People who inject drugs (PWID) living with HIV often experience sub-optimal antiretroviral therapy (ART) treatment outcomes, including HIV plasma viral load (PVL) rebound. While previous studies have identified risk factors for PVL rebound among PWID, no study has examined the perspectives of PWID who have e...

journal_title：AIDS research and therapy

authors： Small W,Milloy MJ,McNeil R,Maher L,Kerr T

更新日期：2016-07-25 00:00:00

abstract：OBJECTIVES:To compare outcomes with single tablet regimens (STR) versus multi-tablet regimens (MTR) for human immunodeficiency virus (HIV) treatment using published data. DESIGN:Systematic review and random-effects meta-analysis of literature on approved and investigational HIV regimens. METHODS:The research followed...

journal_title：AIDS research and therapy

authors： Clay PG,Yuet WC,Moecklinghoff CH,Duchesne I,Tronczyński KL,Shah S,Shao D

更新日期：2018-10-30 00:00:00

abstract：BACKGROUND:Identifying those at increased risk of death during TB treatment is a priority in resource-constrained settings. We performed this study to determine predictors of mortality during TB treatment. METHODS:We performed a retrospective analysis of a TB surveillance population in a high HIV prevalence area that ...

journal_title：AIDS research and therapy

authors： Pepper DJ,Schomaker M,Wilkinson RJ,de Azevedo V,Maartens G

更新日期：2015-10-06 00:00:00

abstract：BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...

journal_title：AIDS research and therapy

authors： Monroe AK,Dobs AS,Palella FJ,Kingsley LA,Witt MD,Brown TT

更新日期：2014-01-22 00:00:00

abstract：BACKGROUND:Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharmacokinetics (PK) of antiretroviral drugs metabolized via the same pathways. However, in vitro drug interaction activity may no...

journal_title：AIDS research and therapy

authors： Monera-Penduka TG,Maponga CC,Wolfe AR,Wiesner L,Morse GD,Nhachi CF

更新日期：2017-03-14 00:00:00

abstract：OBJECTIVE:Recent studies have shown that the current guidelines suggesting immunologic monitoring to determine response to highly active antiretroviral therapy (HAART) are inadequate. We assessed whether routinely collected clinical markers could improve prediction of concurrent HIV RNA levels. METHODS:We included ind...

journal_title：AIDS research and therapy

authors： Lau B,Chander G,Gange SJ,Moore RD

更新日期：2010-07-23 00:00:00

abstract：BACKGROUND:HIV spread continues at high rates from infected persons to their sexual partners. In 2009, an estimated 2.6 million new infections occurred globally. People living with HIV (PLHIV) receiving treatment are in contact with health workers and therefore exposed to prevention messages. By contrast, PLHIV not rec...

journal_title：AIDS research and therapy

authors： Sarna A,Luchters S,Pickett M,Chersich M,Okal J,Geibel S,Kingola N,Temmerman M

更新日期：2012-03-19 00:00:00

abstract：BACKGROUND:Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings. We assessed the effect of HAART on patient mortality and tuberculosis incidence rate under routine clinical care conditions in Ethiopia. The objective of this stu...

journal_title：AIDS research and therapy

authors： Jerene D,Naess A,Lindtjørn B

更新日期：2006-04-07 00:00:00

abstract：BACKGROUND:Voriconazole is metabolized by cytochrome P450 (CYP) 2C19 and CYP 3A4. Drug-drug interactions and genetic polymorphisms modulate their activities. CASE PRESENTATION:A 35-year old African female patient with resistant HIV and a cerebral mass of unknown origin was treated with voriconazole for a suspicion of ...

journal_title：AIDS research and therapy

authors： Bouatou Y,Samer CF,Ing Lorenzini KR,Daali Y,Daou S,Fathi M,Rebsamen M,Desmeules J,Calmy A,Escher M

更新日期：2014-08-04 00:00:00

abstract：:HIV-1 can persist in a latent form in resting memory CD4+ cells and macrophages carrying an integrated copy of the HIV genome. Because of the presence of these stable reservoir cells, eradication by antiretroviral therapy is unlikely and in order to achieve eradication, alternative treatment options are required. Stem...

journal_title：AIDS research and therapy

authors： Hütter G

更新日期：2016-09-13 00:00:00

abstract：BACKGROUND:Tubular dysfunction is common in HIV-infected people and detection of proteinuria is essential to identify this problem. In low-income countries, resources for detection of proteinuria using the Kidney Disease Improve Global Outcomes (KDIGO) gold standard urinary protein/creatinine ratio (uPCR) is rarely pos...

journal_title：AIDS research and therapy

authors： López De León JI,Mata-Marín JA,Andrade-Fuentes K,Huerta-Garcia G,Domínguez-Hemosillo JC,Gaytán-Martínez J

更新日期：2015-03-21 00:00:00

abstract：BACKGROUND:Varicella-zoster virus (VZV) reactivation is common but difficult to predict in HIV-infected persons. OBJECTIVE:Since qualitative VZV antibodies can determine past VZV disease or vaccination, we evaluated whether quantitative VZV antibody levels over time can predict future zoster. STUDY DESIGN:US Military...

journal_title：AIDS research and therapy

authors： Pomerantz HS,Xu X,White J,Sunil TS,Deiss RG,Ganesan A,Agan BK,Okulicz JF

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND:The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown to inhibit HIV-1 replication during various stages of the virus life cycle, and therefore represen...

journal_title：AIDS research and therapy

authors： Paskaleva EE,Lin X,Li W,Cotter R,Klein MT,Roberge E,Yu EK,Clark B,Veille JC,Liu Y,Lee DY,Canki M

更新日期：2006-05-25 00:00:00

abstract：BACKGROUND:Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neuropsychological testing for diagnosis. We aimed to develop a brief and clinically feasible battery t...

journal_title：AIDS research and therapy

authors： Chan LG,Ho MJ,Lin YC,Ong Y,Wong CS

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced partic...

journal_title：AIDS research and therapy

authors： Berhan A,Berhan Y

更新日期：2012-05-14 00:00:00

abstract：BACKGROUND:Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to ...

journal_title：AIDS research and therapy

authors： Feller L,Masipa J,Wood N,Raubenheimer E,Lemmer J

更新日期：2008-01-29 00:00:00

abstract：BACKGROUND:To quarantine the spreading possibility of HIV virus to general population boosting public awareness is must. But the proper awareness level is substantially low in Bangladesh. This paper aims to identify the factors associated with the awareness regarding HIV/AIDS through a bivariate and multivariate analys...

journal_title：AIDS research and therapy

authors： Rahman MS,Rahman ML

更新日期：2007-05-12 00:00:00

abstract：:Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (...

journal_title：AIDS research and therapy

authors： Ferretti F,Gerevini S,Colombo B,Testa M,Guffanti M,Franciotta D,Bernardi G,Lazzarin A,Cinque P

更新日期：2013-09-03 00:00:00

abstract：BACKGROUND:Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prodrug of tenofovir, causes less renal impairment and can improve renal function in patients switched f...

journal_title：AIDS research and therapy

authors： Turner D,Drak D,O'Connor CC,Templeton DJ,Gracey DM

更新日期：2019-12-07 00:00:00

abstract：BACKGROUND:Community-drug distribution point is a care model for stable patients in the community designed to make ART delivery more efficient for the health system and provide appropriate support to encourage long-term retention of patients. We examined program retention among ART program participants in rural Uganda,...

journal_title：AIDS research and therapy

authors： Okoboi S,Ding E,Persuad S,Wangisi J,Birungi J,Shurgold S,Kato D,Nyonyintono M,Egessa A,Bakanda C,Munderi P,Kaleebu P,Moore DM

更新日期：2015-11-12 00:00:00

abstract：BACKGROUND:The population of HIV replicating within a host consists of independently evolving and interacting sub-populations that can be genetically distinct within anatomical compartments. HIV replicating within the brain causes neurocognitive disorders in up to 20-30% of infected individuals and is a viral sanctuary...

journal_title：AIDS research and therapy

authors： Holman AG,Mefford ME,O'Connor N,Gabuzda D

更新日期：2010-12-14 00:00:00

abstract：BACKGROUND:To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). METHODS:The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went t...

journal_title：AIDS research and therapy

authors： Bucciardini R,Pugliese K,Francisci D,Costantini A,Schiaroli E,Cognigni M,Tontini C,Lucattini S,Fucili L,Di Gregorio M,Mirra M,Fragola V,Pompili S,Murri R,Vella S

更新日期：2016-04-09 00:00:00

abstract：BACKGROUND:Non-AIDS defining cancers (NADCs) have been an increasing cause of morbidity and mortality in patients with HIV. There is no data on the spectrum of NADCs in Mexico. We describe the type of neoplasms, clinical characteristics, and outcomes of HIV-infected patients with NADCs. METHODS:We conducted a retrospe...

journal_title：AIDS research and therapy

authors： Cornejo-Juárez P,Cavildo-Jerónimo D,Volkow-Fernández P

更新日期：2018-10-27 00:00:00