Stem cell transplantation in strategies for curing HIV/AIDS.

abstract：INTRODUCTION:We report a case of an adult patient with human immunodeficiency virus (HIV), acute respiratory distress syndrome (ARDS) and ventilator associated pneumonia (VAP) caused by multidrug resistant (MDR) bacteria that was successfully managed with veno-venous extracorporeal membrane oxygenation (ECMO). CASE RE...

journal_title：AIDS research and therapy

authors： Samalavicius R,Serpytis M,Ringaitiene D,Grazulyte D,Bertasiute R,Rimkus B,Matulionyte R,Ambrazaitiene R,Sipylaite J,Kacergius T,Griskevicius L

更新日期：2014-11-21 00:00:00

abstract：OBJECTIVE:Recent studies have shown that the current guidelines suggesting immunologic monitoring to determine response to highly active antiretroviral therapy (HAART) are inadequate. We assessed whether routinely collected clinical markers could improve prediction of concurrent HIV RNA levels. METHODS:We included ind...

journal_title：AIDS research and therapy

authors： Lau B,Chander G,Gange SJ,Moore RD

更新日期：2010-07-23 00:00:00

abstract：PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...

journal_title：AIDS research and therapy

authors： Gibbons LE,Fredericksen R,Batey DS,Dant L,Edwards TC,Mayer KH,Mathews WC,Morales LS,Mugavero MJ,Yang FM,Paez E,Kitahata MM,Patrick DL,Crane HM,Crane PK,Centers for AIDS Research Network of Integrated Clinical Systems (CNICS

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). METHODS:The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went t...

journal_title：AIDS research and therapy

authors： Bucciardini R,Pugliese K,Francisci D,Costantini A,Schiaroli E,Cognigni M,Tontini C,Lucattini S,Fucili L,Di Gregorio M,Mirra M,Fragola V,Pompili S,Murri R,Vella S

更新日期：2016-04-09 00:00:00

abstract：BACKGROUND:The search for disease biomarkers within human peripheral fluids has become a favorable approach to preventative therapeutics throughout the past few years. The comparison of normal versus disease states can identify an overexpression or a suppression of critical proteins where illness has directly altered a...

journal_title：AIDS research and therapy

authors： Van Duyne R,Guendel I,Kehn-Hall K,Easley R,Klase Z,Liu C,Young M,Kashanchi F

更新日期：2010-07-06 00:00:00

abstract：:HIV-1 infects gut associated lymphoid tissues (GALT) very early after transmission by multiple routes. The infected GALT consequently serves as the major reservoir for HIV-1 infection and could constantly shed HIV-1 and CD4+ T cells into the intestinal lumen. To examine this hypothesis, we monitored HIV-1 RNA/DNA and ...

journal_title：AIDS research and therapy

authors： Chakrabarti AK,Caruso L,Ding M,Shen C,Buchanan W,Gupta P,Rinaldo CR,Chen Y

更新日期：2009-10-02 00:00:00

abstract：BACKGROUND:People who inject drugs (PWID) living with HIV often experience sub-optimal antiretroviral therapy (ART) treatment outcomes, including HIV plasma viral load (PVL) rebound. While previous studies have identified risk factors for PVL rebound among PWID, no study has examined the perspectives of PWID who have e...

journal_title：AIDS research and therapy

authors： Small W,Milloy MJ,McNeil R,Maher L,Kerr T

更新日期：2016-07-25 00:00:00

abstract：:Intracellular levels of glutathione are depleted in patients with acquired immunodeficiency syndrome in whom the risk of tuberculosis, particularly disseminated disease is many times that of healthy individuals. In this study, we examined the role of glutathione in immunity against tuberculosis infection in samples de...

journal_title：AIDS research and therapy

authors： Venketaraman V,Rodgers T,Linares R,Reilly N,Swaminathan S,Hom D,Millman AC,Wallis R,Connell ND

更新日期：2006-02-20 00:00:00

abstract：UNLABELLED: BACKGROUND:The high cost of CD4 count estimation in resource-limited countries is a major challenge in initiating patients on highly active antiretroviral therapy (HAART). Therefore, assessment of inexpensive and simple laboratory diagnostic marker is mandatory to diagnose immuno-suppression. OBJECTIVE:To...

journal_title：AIDS research and therapy

authors： Wondimeneh Y,Ferede G,Yismaw G,Muluye D

更新日期：2012-07-15 00:00:00

abstract：BACKGROUND:The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown to inhibit HIV-1 replication during various stages of the virus life cycle, and therefore represen...

journal_title：AIDS research and therapy

authors： Paskaleva EE,Lin X,Li W,Cotter R,Klein MT,Roberge E,Yu EK,Clark B,Veille JC,Liu Y,Lee DY,Canki M

更新日期：2006-05-25 00:00:00

abstract：PURPOSE:We studied the safety, tolerability, virologic, and immunologic effects of mycophenolate mofetil (MMF) added to a stable antiretroviral therapy (ART) in the setting of low-level viremia. METHODS:MMF 500 mg BID or placebo was given to patients thought to be adherent on stable ART with plasma viremia between 200...

journal_title：AIDS research and therapy

authors： Kaur R,Bedimo R,Kvanli MB,Turner D,Shaw L,Margolis D

更新日期：2006-05-26 00:00:00

abstract：OBJECTIVE:To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors. METHOD:We determine levels of NT-pro BNP in peripheral blood of HIV patients from Costa del Sol Hospital, ...

journal_title：AIDS research and therapy

authors： Olalla J,Crespo E,De la Torre J,Sempere M,Del Arco A,Prada JL,Malvarez R,Pérez J,García-Alegría J

更新日期：2015-05-10 00:00:00

abstract：: The December 2011 5th International Workshop on HIV Persistence during Therapy addressed the issue of HIV persistence among 210 scientists from 10 countries involved in the study of HIV reservoirs and the search of an HIV cure. High quality abstracts were selected and discussed as oral or poster presentations. The ai...

journal_title：AIDS research and therapy

authors： Stevenson M,Chomont N,Lafeuillade A

更新日期：2012-03-12 00:00:00

abstract：BACKGROUND:Non-AIDS defining cancers (NADCs) have been an increasing cause of morbidity and mortality in patients with HIV. There is no data on the spectrum of NADCs in Mexico. We describe the type of neoplasms, clinical characteristics, and outcomes of HIV-infected patients with NADCs. METHODS:We conducted a retrospe...

journal_title：AIDS research and therapy

authors： Cornejo-Juárez P,Cavildo-Jerónimo D,Volkow-Fernández P

更新日期：2018-10-27 00:00:00

abstract：BACKGROUND:Little is known about HIV-1 subtype distribution in Morocco. Some data suggest an emergence of new HIV subtypes. We conducted phylogenetic analysis on a nationally representative sample of 60 HIV-1 viral specimens collected during 2004-2005 through the Morocco national HIV sentinel surveillance survey. RESU...

journal_title：AIDS research and therapy

authors： Akrim M,Lemrabet S,Elharti E,Gray RR,Tardy JC,Cook RL,Salemi M,Andre P,Azarian T,Aouad RE

更新日期：2012-02-14 00:00:00

abstract：BACKGROUND:HIV spread continues at high rates from infected persons to their sexual partners. In 2009, an estimated 2.6 million new infections occurred globally. People living with HIV (PLHIV) receiving treatment are in contact with health workers and therefore exposed to prevention messages. By contrast, PLHIV not rec...

journal_title：AIDS research and therapy

authors： Sarna A,Luchters S,Pickett M,Chersich M,Okal J,Geibel S,Kingola N,Temmerman M

更新日期：2012-03-19 00:00:00

abstract：BACKGROUND:Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple drug-resistant HIV-1 variants. The few studies on HIV-1 mutagenesis in HIV infected children have no...

journal_title：AIDS research and therapy

authors： Malhotra A,Gaur S,Whitley-Williams P,Loomis C,Petrova A

更新日期：2007-07-09 00:00:00

abstract：BACKGROUND:Psychosocial factors have been linked with loss to follow-up (LTFU) and clinical outcomes among people living with HIV (PLH), however little is known about the effect of psychosocial support on LTFU among PLH in treatment and care. The purpose of this study was to explore the effect of NAMWEZA ("Yes, togethe...

journal_title：AIDS research and therapy

authors： Siril HN,Kaaya SF,Smith Fawzi MK,Mtisi E,Somba M,Kilewo J,Mugusi F,Minja A,Kaale A,Todd J

更新日期：2017-03-28 00:00:00

abstract：BACKGROUND:Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prodrug of tenofovir, causes less renal impairment and can improve renal function in patients switched f...

journal_title：AIDS research and therapy

authors： Turner D,Drak D,O'Connor CC,Templeton DJ,Gracey DM

更新日期：2019-12-07 00:00:00

abstract：BACKGROUND:Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neuropsychological testing for diagnosis. We aimed to develop a brief and clinically feasible battery t...

journal_title：AIDS research and therapy

authors： Chan LG,Ho MJ,Lin YC,Ong Y,Wong CS

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:Separately, chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements, including atrophy and wasting, weakness, and fatigue. One prospective cohort study reported that 41% of HIV-infected patients met the criteria for alcoholism, however; few reports exist on the c...

journal_title：AIDS research and therapy

authors： Clary CR,Guidot DM,Bratina MA,Otis JS

更新日期：2011-08-16 00:00:00

abstract：BACKGROUND:South Africa has a huge burden of illness due to HIV infection. Many health care workers managing HIV infected patients, particularly those in rural areas and primary care health facilities, have minimal access to information resources and to advice and support from experienced clinicians. The Medicines Info...

journal_title：AIDS research and therapy

authors： Chisholm BS,Cohen K,Blockman M,Kinkel HF,Kredo TJ,Swart AM

更新日期：2011-01-26 00:00:00

abstract：BACKGROUND:The population of HIV replicating within a host consists of independently evolving and interacting sub-populations that can be genetically distinct within anatomical compartments. HIV replicating within the brain causes neurocognitive disorders in up to 20-30% of infected individuals and is a viral sanctuary...

journal_title：AIDS research and therapy

authors： Holman AG,Mefford ME,O'Connor N,Gabuzda D

更新日期：2010-12-14 00:00:00

abstract：BACKGROUND:Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevirapine concentration and clinical response in African women are limited. We investigated the impact o...

journal_title：AIDS research and therapy

authors： Oluka MN,Okalebo FA,Guantai AN,McClelland RS,Graham SM

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming non-infected HIV-exposed infants (HEIs) and prompting timely initiation of ART in HIV-infected babi...

journal_title：AIDS research and therapy

authors： Dakum P,Tola M,Iboro N,Okolo CA,Anuforom O,Chime C,Peters S,Jumare J,Ogbanufe O,Ahmad A,Ndembi N

更新日期：2019-09-14 00:00:00

abstract：BACKGROUND:Most in vitro assays of drug potency may not adequately predict the performance in vivo. Methods to assess the persistence of antiviral activity of deoxynucleoside analogs, which require intracellular activation to the active metabolites that can persist in cells, will be important for designing dosages, com...

journal_title：AIDS research and therapy

authors： Paintsil E,Grill SP,Dutschman GE,Cheng YC

更新日期：2009-04-22 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART) use by people living with HIV reduces HIV transmission, morbidity, mortality, and improves quality of life. Good ART adherence is required to achieve these benefits. We investigated how the environmental, social, economic and behavioural experiences of people living with HIV with...

journal_title：AIDS research and therapy

authors： Bukenya D,Mayanja BN,Nakamanya S,Muhumuza R,Seeley J

更新日期：2019-01-21 00:00:00

abstract：BACKGROUND:A 4-week, uninterrupted treatment with 9-(2-phosphonyl-methoxypropyly)adenine (PMPA, commonly called tenofovir) completely prevents simian immunodeficiency virus (SIVmne) infection in cynomolgus macaques if treatment begins within 24 hours after SIVmne inoculation, but is less effective if treatment is delay...

journal_title：AIDS research and therapy

authors： Emau P,Jiang Y,Agy MB,Tian B,Bekele G,Tsai CC

更新日期：2006-11-28 00:00:00

abstract：:Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a unique vaccine for every world region or virus subtype may not be necessary. ...

journal_title：AIDS research and therapy

authors： Slobod KS,Coleclough C,Brown SA,Stambas J,Zhan X,Surman S,Jones BG,Zirkel A,Freiden PJ,Brown B,Sealy R,Bonsignori M,Hurwitz JL

更新日期：2005-04-28 00:00:00

abstract：BACKGROUND:HLA-B*57:01 screening was added to clinical care guidelines in 2008 to reduce the risk of hypersensitivity reaction from abacavir. The uptake of HLA-B*57:01 screening and incidence of hypersensitivity reaction were assessed in a prospective clinical cohort in the United States to evaluate the effectiveness o...

journal_title：AIDS research and therapy

authors： Mounzer K,Hsu R,Fusco JS,Brunet L,Henegar CE,Vannappagari V,Stainsby CM,Shaefer MS,Ragone L,Fusco GP

更新日期：2019-01-16 00:00:00