Plasma HIV-1 RNA viral load rebound among people who inject drugs receiving antiretroviral therapy (ART) in a Canadian setting: an ethno-epidemiological study.

Abstract:

BACKGROUND:People who inject drugs (PWID) living with HIV often experience sub-optimal antiretroviral therapy (ART) treatment outcomes, including HIV plasma viral load (PVL) rebound. While previous studies have identified risk factors for PVL rebound among PWID, no study has examined the perspectives of PWID who have experienced PVL rebound episodes. We conducted an ethno-epidemiological study to investigate the circumstances surrounding the emergence of rebound episodes among PWID in Vancouver, BC, Canada. METHODS:Comprehensive clinical records linked to a community-based prospective observational cohort of HIV-positive drug users were used to identify PWID who had recently experienced viral rebound. In-depth qualitative interviews with 16 male and 11 female participants explored participant perspectives regarding the emergence of viral rebound. A timeline depicting each participant's HIV viral load and adherence to ART was used to elicit discussion of circumstances surrounding viral rebound. FINDINGS:Viral rebound episodes were shaped by interplay between various individual, social, and environmental factors that disrupted routines facilitating adherence. Structural-environmental influences resulting in non-adherence included housing transitions, changes in drug use patterns and intense drug scene involvement, and inadequate care for co-morbid health conditions. Social-environmental influences on ART adherence included poor interactions between care providers and patients producing non-adherence, and understandings of HIV treatment that fostered intentional treatment discontinuation. CONCLUSIONS:This study describes key pathways which led to rebound episodes among PWID receiving ART and illustrates how environmental forces may increase vulnerability for non-adherence leading to treatment failure. Our findings have potential to help inform interventions and supports that address social-structural forces that foster non-adherence among PWID.

journal_name

AIDS Res Ther

authors

Small W,Milloy MJ,McNeil R,Maher L,Kerr T

doi

10.1186/s12981-016-0108-9

subject

Has Abstract

pub_date

2016-07-25 00:00:00

pages

26

issn

1742-6405

pii

108

journal_volume

13

pub_type

杂志文章
  • Total Lymphocyte Count as surrogate marker for CD4 Cell Count in HIV-Infected Individuals in Gondar University Hospital, Northwest Ethiopia.

    abstract:UNLABELLED: BACKGROUND:The high cost of CD4 count estimation in resource-limited countries is a major challenge in initiating patients on highly active antiretroviral therapy (HAART). Therefore, assessment of inexpensive and simple laboratory diagnostic marker is mandatory to diagnose immuno-suppression. OBJECTIVE:To...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-9-21

    authors: Wondimeneh Y,Ferede G,Yismaw G,Muluye D

    更新日期:2012-07-15 00:00:00

  • Development of a neurocognitive test battery for HIV-associated neurocognitive disorder (HAND) screening: suggested solutions for resource-limited clinical settings.

    abstract:BACKGROUND:Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neuropsychological testing for diagnosis. We aimed to develop a brief and clinically feasible battery t...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-019-0224-4

    authors: Chan LG,Ho MJ,Lin YC,Ong Y,Wong CS

    更新日期:2019-04-15 00:00:00

  • A placebo-controlled pilot study of intensification of antiretroviral therapy with mycophenolate mofetil.

    abstract:PURPOSE:We studied the safety, tolerability, virologic, and immunologic effects of mycophenolate mofetil (MMF) added to a stable antiretroviral therapy (ART) in the setting of low-level viremia. METHODS:MMF 500 mg BID or placebo was given to patients thought to be adherent on stable ART with plasma viremia between 200...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-3-16

    authors: Kaur R,Bedimo R,Kvanli MB,Turner D,Shaw L,Margolis D

    更新日期:2006-05-26 00:00:00

  • Renal function change after switching tenofovir disoproxil fumarate for tenofovir alafenamide in the HIV-positive patients of a metropolitan sexual health service.

    abstract:BACKGROUND:Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prodrug of tenofovir, causes less renal impairment and can improve renal function in patients switched f...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-019-0256-9

    authors: Turner D,Drak D,O'Connor CC,Templeton DJ,Gracey DM

    更新日期:2019-12-07 00:00:00

  • The impact of the National HIV Health Care Worker Hotline on patient care in South Africa.

    abstract:BACKGROUND:South Africa has a huge burden of illness due to HIV infection. Many health care workers managing HIV infected patients, particularly those in rural areas and primary care health facilities, have minimal access to information resources and to advice and support from experienced clinicians. The Medicines Info...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-8-4

    authors: Chisholm BS,Cohen K,Blockman M,Kinkel HF,Kredo TJ,Swart AM

    更新日期:2011-01-26 00:00:00

  • Conference highlights of the 5th international workshop on HIV persistence during therapy, 6-9 December 2011, St. Maartin, West Indies.

    abstract:: The December 2011 5th International Workshop on HIV Persistence during Therapy addressed the issue of HIV persistence among 210 scientists from 10 countries involved in the study of HIV reservoirs and the search of an HIV cure. High quality abstracts were selected and discussed as oral or poster presentations. The ai...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-9-7

    authors: Stevenson M,Chomont N,Lafeuillade A

    更新日期:2012-03-12 00:00:00

  • Sexual behavior of HIV-positive adults not accessing HIV treatment in Mombasa, Kenya: Defining their prevention needs.

    abstract:BACKGROUND:HIV spread continues at high rates from infected persons to their sexual partners. In 2009, an estimated 2.6 million new infections occurred globally. People living with HIV (PLHIV) receiving treatment are in contact with health workers and therefore exposed to prevention messages. By contrast, PLHIV not rec...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-9-9

    authors: Sarna A,Luchters S,Pickett M,Chersich M,Okal J,Geibel S,Kingola N,Temmerman M

    更新日期:2012-03-19 00:00:00

  • HIVBrainSeqDB: a database of annotated HIV envelope sequences from brain and other anatomical sites.

    abstract:BACKGROUND:The population of HIV replicating within a host consists of independently evolving and interacting sub-populations that can be genetically distinct within anatomical compartments. HIV replicating within the brain causes neurocognitive disorders in up to 20-30% of infected individuals and is a viral sanctuary...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-7-43

    authors: Holman AG,Mefford ME,O'Connor N,Gabuzda D

    更新日期:2010-12-14 00:00:00

  • Cytochrome P450 2B6 genetic variants are associated with plasma nevirapine levels and clinical response in HIV-1 infected Kenyan women: a prospective cohort study.

    abstract:BACKGROUND:Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. CYP2B6 516G>T and 983T>C are common in African populations, but data on their influence on plasma nevirapine concentration and clinical response in African women are limited. We investigated the impact o...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-015-0052-0

    authors: Oluka MN,Okalebo FA,Guantai AN,McClelland RS,Graham SM

    更新日期:2015-04-15 00:00:00

  • Inhibition of highly productive HIV-1 infection in T cells, primary human macrophages, microglia, and astrocytes by Sargassum fusiforme.

    abstract:BACKGROUND:The high rate of HIV-1 mutation and increasing resistance to currently available antiretroviral (ART) therapies highlight the need for new antiviral agents. Products derived from natural sources have been shown to inhibit HIV-1 replication during various stages of the virus life cycle, and therefore represen...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-3-15

    authors: Paskaleva EE,Lin X,Li W,Cotter R,Klein MT,Roberge E,Yu EK,Clark B,Veille JC,Liu Y,Lee DY,Canki M

    更新日期:2006-05-25 00:00:00

  • HLA-B*57:01 screening and hypersensitivity reaction to abacavir between 1999 and 2016 in the OPERA® observational database: a cohort study.

    abstract:BACKGROUND:HLA-B*57:01 screening was added to clinical care guidelines in 2008 to reduce the risk of hypersensitivity reaction from abacavir. The uptake of HLA-B*57:01 screening and incidence of hypersensitivity reaction were assessed in a prospective clinical cohort in the United States to evaluate the effectiveness o...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-019-0217-3

    authors: Mounzer K,Hsu R,Fusco JS,Brunet L,Henegar CE,Vannappagari V,Stainsby CM,Shaefer MS,Ragone L,Fusco GP

    更新日期:2019-01-16 00:00:00

  • Elevated risks of death for diabetes mellitus and cardiovascular diseases in Italian AIDS cases.

    abstract:: After the introduction of highly active antiretroviral therapies (HAART), an increased incidence of insulin resistance, diabetes mellitus (DM), and cardiovascular diseases has been described. The impact of such conditions on mortality in the post-HAART era has been also assessed in various modes in the literature. In...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-7-11

    authors: Serraino D,Bruzzone S,Zucchetto A,Suligoi B,De Paoli A,Pennazza S,Camoni L,Dal Maso L,De Paoli P,Rezza G

    更新日期:2010-05-24 00:00:00

  • High rates of transmitted NNRTI resistance among persons with acute HIV infection in Malawi: implications for first-line dolutegravir scale-up.

    abstract::High rates of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was a key consideration in the WHO policies transitioning first-line regimens to include integrase inhibitors (dolutegravir [DTG]). However, recent data suggests a relationship between DTG and neural tube defects among women exposed durin...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12981-019-0220-8

    authors: Rutstein SE,Chen JS,Nelson JAE,Phiri S,Miller WC,Hosseinipour MC

    更新日期:2019-02-22 00:00:00

  • Antiretroviral therapy at a district hospital in Ethiopia prevents death and tuberculosis in a cohort of HIV patients.

    abstract:BACKGROUND:Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings. We assessed the effect of HAART on patient mortality and tuberculosis incidence rate under routine clinical care conditions in Ethiopia. The objective of this stu...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-3-10

    authors: Jerene D,Naess A,Lindtjørn B

    更新日期:2006-04-07 00:00:00

  • Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activity.

    abstract:BACKGROUND:Voriconazole is metabolized by cytochrome P450 (CYP) 2C19 and CYP 3A4. Drug-drug interactions and genetic polymorphisms modulate their activities. CASE PRESENTATION:A 35-year old African female patient with resistant HIV and a cerebral mass of unknown origin was treated with voriconazole for a suspicion of ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-11-25

    authors: Bouatou Y,Samer CF,Ing Lorenzini KR,Daali Y,Daou S,Fathi M,Rebsamen M,Desmeules J,Calmy A,Escher M

    更新日期:2014-08-04 00:00:00

  • Is the Sexual Behaviour of HIV Patients on Antiretroviral therapy safe or risky in Sub-Saharan Africa? Meta-Analysis and Meta-Regression.

    abstract:BACKGROUND:Reports on the sexual behavior of people on antiretroviral therapy (ART) are inconsistent. We selected 14 articles that compared the sexual behavior of people with and without ART for this analysis. METHODS:We included both cross-sectional studies that compared different ART-naïve and ART-experienced partic...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-9-14

    authors: Berhan A,Berhan Y

    更新日期:2012-05-14 00:00:00

  • Anti-infective treatment in HIV-infected patients during perioperative period.

    abstract:UNLABELLED: OBJECTIVE:To investigate anti-infective treatments in HIV-infected surgical patients during the perioperative period. METHODS:A retrospective study of sepsis and surgical site infections (SSIs) was conducted in 266 HIV-infected patients. The patients were divided into 3 groups based on CD4+ T cells counts...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-9-36

    authors: Liu B,Zhang L,Guo R,Su J,Li L,Si Y

    更新日期:2012-11-27 00:00:00

  • Reverse transcriptase drug resistance mutations in HIV-1 subtype C infected patients on ART in Karonga District, Malawi.

    abstract:BACKGROUND:Drug resistance testing before initiation of, or during, antiretroviral therapy (ART) is not routinely performed in resource-limited settings. High levels of viral resistance circulating within the population will have impact on treatment programs by increasing the chances of transmission of resistant strain...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-8-38

    authors: Bansode VB,Travers SA,Crampin AC,Ngwira B,French N,Glynn JR,McCormack GP

    更新日期:2011-10-13 00:00:00

  • The identification of unique serum proteins of HIV-1 latently infected long-term non-progressor patients.

    abstract:BACKGROUND:The search for disease biomarkers within human peripheral fluids has become a favorable approach to preventative therapeutics throughout the past few years. The comparison of normal versus disease states can identify an overexpression or a suppression of critical proteins where illness has directly altered a...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-7-21

    authors: Van Duyne R,Guendel I,Kehn-Hall K,Easley R,Klase Z,Liu C,Young M,Kashanchi F

    更新日期:2010-07-06 00:00:00

  • Validity assessment of the PROMIS fatigue domain among people living with HIV.

    abstract:PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-017-0146-y

    authors: Gibbons LE,Fredericksen R,Batey DS,Dant L,Edwards TC,Mayer KH,Mathews WC,Morales LS,Mugavero MJ,Yang FM,Paez E,Kitahata MM,Patrick DL,Crane HM,Crane PK,Centers for AIDS Research Network of Integrated Clinical Systems (CNICS

    更新日期:2017-04-11 00:00:00

  • Decrease of vitamin D concentration in patients with HIV infection on a non nucleoside reverse transcriptase inhibitor-containing regimen.

    abstract:BACKGROUND:Vitamin D is an important determinant of bone health and also plays a major role in the regulation of the immune system. Interestingly, vitamin D status before the start of highly active antiretroviral therapy (HAART) has been recently associated with HIV disease progression and overall mortality in HIV-posi...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-7-40

    authors: Conesa-Botella A,Florence E,Lynen L,Colebunders R,Menten J,Moreno-Reyes R

    更新日期:2010-11-23 00:00:00

  • Correlates and determinants of Early Infant Diagnosis outcomes in North-Central Nigeria.

    abstract:BACKGROUND:A negative status following confirmatory Early Infant Diagnosis (EID) is the desired pediatric outcome of prevention of Mother to Child Transmission (PMTCT) programs. EID impacts epidemic control by confirming non-infected HIV-exposed infants (HEIs) and prompting timely initiation of ART in HIV-infected babi...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-019-0245-z

    authors: Dakum P,Tola M,Iboro N,Okolo CA,Anuforom O,Chime C,Peters S,Jumare J,Ogbanufe O,Ahmad A,Ndembi N

    更新日期:2019-09-14 00:00:00

  • Susac's syndrome as HIV-associated immune reconstitution inflammatory syndrome.

    abstract::Susac's Syndrome (SS) is an autoimmune endotheliopathy of cerebral, retinal and cochlear arterioles. We report of an HIV-infected woman who developed a first SS episode following a spontaneous reduction of plasma viral load and several relapses six years later, following initiation of combined antiretroviral therapy (...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-10-22

    authors: Ferretti F,Gerevini S,Colombo B,Testa M,Guffanti M,Franciotta D,Bernardi G,Lazzarin A,Cinque P

    更新日期:2013-09-03 00:00:00

  • Management of HIV-1 associated hepatitis in patients with acquired immunodeficiency syndrome: role of a successful control of viral replication.

    abstract:: In HIV-1 infected patients, increase of liver enzymes may be mainly due to viral coinfections, alcohol intake, hepatotoxic drugs or autoimmune diseases. Three cases of aminotransferase elevation occurred during a phase of uncontrolled viral replication combined with a severe immunodeficiency and resolved by an effect...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-8-9

    authors: Esposito A,Conti V,Cagliuso M,Pastori D,Fantauzzi A,Mezzaroma I

    更新日期:2011-03-01 00:00:00

  • HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector.

    abstract::BACKGROUND: RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) has proved to be a highly effective gene silencing mechanism with great potential for HIV/AIDS gene therapy. Previous work with siRNAs against cellular coreceptors CXCR4 and CCR5 had shown that down regulation of these surface molecules co...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-2-1

    authors: Anderson J,Akkina R

    更新日期:2005-01-13 00:00:00

  • Validation of a self-reported HIV symptoms list: the ISS-HIV symptoms scale.

    abstract:BACKGROUND:To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). METHODS:The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went t...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-016-0102-2

    authors: Bucciardini R,Pugliese K,Francisci D,Costantini A,Schiaroli E,Cognigni M,Tontini C,Lucattini S,Fucili L,Di Gregorio M,Mirra M,Fragola V,Pompili S,Murri R,Vella S

    更新日期:2016-04-09 00:00:00

  • Evasion of adaptive immunity by HIV through the action of host APOBEC3G/F enzymes.

    abstract::APOBEC3G (A3G) and APOBEC3F (A3F) are DNA-mutating enzymes expressed in T cells, dendritic cells and macrophages. A3G/F have been considered innate immune host factors, based on reports that they lethally mutate the HIV genome in vitro. In vivo, A3G/F effectiveness is limited by viral proteins, entrapment in inactive ...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章,评审

    doi:10.1186/s12981-017-0173-8

    authors: Grant M,Larijani M

    更新日期:2017-09-12 00:00:00

  • HIV-associated adipose redistribution syndrome (HARS): definition, epidemiology and clinical impact.

    abstract::A segment of the HIV infected population develops abnormal and excessive accumulation of adipose tissue in the trunk, including accumulation of visceral (deep abdominal) adipose tissue. This condition, known as HIV-related adipose redistribution syndrome (HARS), may also be accompanied by fat accumulation in the upper...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/1742-6405-4-16

    authors: Lichtenstein K,Balasubramanyam A,Sekhar R,Freedland E

    更新日期:2007-07-16 00:00:00

  • Stem cell transplantation in strategies for curing HIV/AIDS.

    abstract::HIV-1 can persist in a latent form in resting memory CD4+ cells and macrophages carrying an integrated copy of the HIV genome. Because of the presence of these stable reservoir cells, eradication by antiretroviral therapy is unlikely and in order to achieve eradication, alternative treatment options are required. Stem...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章,评审

    doi:10.1186/s12981-016-0114-y

    authors: Hütter G

    更新日期:2016-09-13 00:00:00

  • Non-AIDS defining cancer (NADC) among HIV-infected patients at an oncology tertiary-care center in Mexico.

    abstract:BACKGROUND:Non-AIDS defining cancers (NADCs) have been an increasing cause of morbidity and mortality in patients with HIV. There is no data on the spectrum of NADCs in Mexico. We describe the type of neoplasms, clinical characteristics, and outcomes of HIV-infected patients with NADCs. METHODS:We conducted a retrospe...

    journal_title:AIDS research and therapy

    pub_type: 杂志文章

    doi:10.1186/s12981-018-0202-2

    authors: Cornejo-Juárez P,Cavildo-Jerónimo D,Volkow-Fernández P

    更新日期:2018-10-27 00:00:00