The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma.

Abstract:

BACKGROUND:Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable. RESULTS AND CONCLUSION:Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis.

journal_name

AIDS Res Ther

authors

Feller L,Masipa J,Wood N,Raubenheimer E,Lemmer J

doi

10.1186/1742-6405-5-2

subject

Has Abstract

pub_date

2008-01-29 00:00:00

pages

2

issn

1742-6405

pii

1742-6405-5-2

journal_volume

5

pub_type

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