Abstract:
:Against the current global trends, in the former Soviet Union (FSU) countries HIV prevalence is on the rise. Visa-free movement across borders has facilitated migrant-associated HIV transmission within this region. Despite efforts from the governments to curtail the growing epidemic, there is still a serious need for the development of strategies that focus on high-risk behaviors and practices responsible for the continued transmission of HIV in this region. While governments of FSU countries have taken commendable steps in recent years to address hurdles at each step of the HIV care continuum, to ensure 100% antiretroviral treatment (ART) accessibility to people living with HIV (PLHIV), testing for HIV needs to be enforced widely in FSU countries. Stigma against people who inject drugs (PWID), men who have sex with men (MSM), migrants, and PLHIV need to be addressed. Finally, to avoid breaks in ART supply, FSU countries need to gain independence in funding HIV care so that the provision of ART to PLHIV is made available without interruption.
journal_name
AIDS Res Therjournal_title
AIDS research and therapyauthors
Amangaldiyeva A,Davlidova S,Baiserkin B,Dzissyuk N,DeHovitz J,Ali Sdoi
10.1186/s12981-019-0251-1subject
Has Abstractpub_date
2019-11-19 00:00:00pages
35issue
1issn
1742-6405pii
10.1186/s12981-019-0251-1journal_volume
16pub_type
杂志文章,评审abstract:BACKGROUND:To describe the development and the psychometric properties of the Istituto Superiore di Sanità-HIV symptoms scale (lSS-HIV symptoms scale). METHODS:The ISS-HIV symptom scale was developed by an Italian working team including researchers, physicians and people living with HIV. The development process went t...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-016-0102-2
更新日期:2016-04-09 00:00:00
abstract:BACKGROUND:Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-5-2
更新日期:2008-01-29 00:00:00
abstract:BACKGROUND:As a simplification strategy for treatment-experienced HIV-infected patients who have achieved virologic suppression on a multi-drug, multi-class antiretroviral regimen, the aim of this study was to evaluate the safety, efficacy, and pharmacokinetics of once-daily elvitegravir/cobicistat/emtricitabine/tenofo...
journal_title:AIDS research and therapy
pub_type: 临床试验,杂志文章
doi:10.1186/s12981-017-0185-4
更新日期:2017-11-02 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) use by people living with HIV reduces HIV transmission, morbidity, mortality, and improves quality of life. Good ART adherence is required to achieve these benefits. We investigated how the environmental, social, economic and behavioural experiences of people living with HIV with...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0214-y
更新日期:2019-01-21 00:00:00
abstract:PURPOSE:To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS® Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0146-y
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:Varicella-zoster virus (VZV) reactivation is common but difficult to predict in HIV-infected persons. OBJECTIVE:Since qualitative VZV antibodies can determine past VZV disease or vaccination, we evaluated whether quantitative VZV antibody levels over time can predict future zoster. STUDY DESIGN:US Military...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0212-0
更新日期:2018-12-11 00:00:00
abstract:BACKGROUND:Despite the conventional approaches to HIV prevention being the bedrock for early reductions in HIV infections in Uganda, innovations that demonstrate reduction in risk to infection in vulnerable populations need to be embraced urgently. In the past 2 years, a USAID-funded project tested a quality improvemen...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-018-0190-2
更新日期:2018-01-25 00:00:00
abstract:UNLABELLED: OBJECTIVE:To investigate anti-infective treatments in HIV-infected surgical patients during the perioperative period. METHODS:A retrospective study of sepsis and surgical site infections (SSIs) was conducted in 266 HIV-infected patients. The patients were divided into 3 groups based on CD4+ T cells counts...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-9-36
更新日期:2012-11-27 00:00:00
abstract::A segment of the HIV infected population develops abnormal and excessive accumulation of adipose tissue in the trunk, including accumulation of visceral (deep abdominal) adipose tissue. This condition, known as HIV-related adipose redistribution syndrome (HARS), may also be accompanied by fat accumulation in the upper...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-16
更新日期:2007-07-16 00:00:00
abstract:BACKGROUND:HIV/AIDS has orphaned 11.6 million children in sub-Saharan Africa. Expanded antiretroviral therapy (ART) use may reduce AIDS orphanhood by decreasing adult mortality and population-level HIV transmission. METHODS:We modeled two scenarios to measure the impact of adult ART use on the incidence of orphanhood ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-13
更新日期:2011-03-07 00:00:00
abstract:BACKGROUND:Voriconazole is metabolized by cytochrome P450 (CYP) 2C19 and CYP 3A4. Drug-drug interactions and genetic polymorphisms modulate their activities. CASE PRESENTATION:A 35-year old African female patient with resistant HIV and a cerebral mass of unknown origin was treated with voriconazole for a suspicion of ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-25
更新日期:2014-08-04 00:00:00
abstract:BACKGROUND:Sustained use of antiretroviral therapy has been consistently shown to be one of the primary predictors of long-term effectiveness. Switching and discontinuation reflect patient and provider decisions that may limit future treatment options. In this study, we utilize data reported at semi-annual study visits...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-4-12
更新日期:2007-06-06 00:00:00
abstract:BACKGROUND:Practical screening strategies are necessary to detect neurocognitive impairment of all severities in HIV populations, which remains prevalent despite highly active antiretroviral therapy and requires full neuropsychological testing for diagnosis. We aimed to develop a brief and clinically feasible battery t...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-019-0224-4
更新日期:2019-04-15 00:00:00
abstract:BACKGROUND:Moringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharmacokinetics (PK) of antiretroviral drugs metabolized via the same pathways. However, in vitro drug interaction activity may no...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0140-4
更新日期:2017-03-14 00:00:00
abstract:BACKGROUND:In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter might be due to high levels of sero-discordant couples and increasing transmission from male to fema...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-016-0124-9
更新日期:2016-11-15 00:00:00
abstract::Today, scientists are often encouraged to custom-design vaccines based on a particular country or clade. Here, we review the scientific literature and then suggest that the overwhelming endeavor to produce a unique vaccine for every world region or virus subtype may not be necessary. ...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-2-3
更新日期:2005-04-28 00:00:00
abstract::HIV-1 can persist in a latent form in resting memory CD4+ cells and macrophages carrying an integrated copy of the HIV genome. Because of the presence of these stable reservoir cells, eradication by antiretroviral therapy is unlikely and in order to achieve eradication, alternative treatment options are required. Stem...
journal_title:AIDS research and therapy
pub_type: 杂志文章,评审
doi:10.1186/s12981-016-0114-y
更新日期:2016-09-13 00:00:00
abstract:OBJECTIVES:To compare outcomes with single tablet regimens (STR) versus multi-tablet regimens (MTR) for human immunodeficiency virus (HIV) treatment using published data. DESIGN:Systematic review and random-effects meta-analysis of literature on approved and investigational HIV regimens. METHODS:The research followed...
journal_title:AIDS research and therapy
pub_type: 杂志文章,meta分析
doi:10.1186/s12981-018-0204-0
更新日期:2018-10-30 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) has modified the natural history of HIV-infection: the incidence of opportunistic infections (OIs) has decreased and mortality associated to HIV has improved dramatically. The reasons for hospitalization have changed; OIs are no longer the most common reason for admission. This s...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0186-3
更新日期:2017-11-13 00:00:00
abstract:BACKGROUND:Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients. Tenofovir alafenamide (TAF), a novel prodrug of tenofovir, causes less renal impairment and can improve renal function in patients switched f...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-019-0256-9
更新日期:2019-12-07 00:00:00
abstract::High rates of non-nucleoside reverse transcriptase inhibitors (NNRTI) resistance was a key consideration in the WHO policies transitioning first-line regimens to include integrase inhibitors (dolutegravir [DTG]). However, recent data suggests a relationship between DTG and neural tube defects among women exposed durin...
journal_title:AIDS research and therapy
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12981-019-0220-8
更新日期:2019-02-22 00:00:00
abstract:PURPOSE:We studied the safety, tolerability, virologic, and immunologic effects of mycophenolate mofetil (MMF) added to a stable antiretroviral therapy (ART) in the setting of low-level viremia. METHODS:MMF 500 mg BID or placebo was given to patients thought to be adherent on stable ART with plasma viremia between 200...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-3-16
更新日期:2006-05-26 00:00:00
abstract:INTRODUCTION:We report a case of an adult patient with human immunodeficiency virus (HIV), acute respiratory distress syndrome (ARDS) and ventilator associated pneumonia (VAP) caused by multidrug resistant (MDR) bacteria that was successfully managed with veno-venous extracorporeal membrane oxygenation (ECMO). CASE RE...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-37
更新日期:2014-11-21 00:00:00
abstract:BACKGROUND:Hypogonadism is common among HIV-infected men, even among men receiving antiretroviral therapy (ART). Our objective in this study was to determine the prevalence of biochemical hypogonadism among HIV-infected men compared with HIV-uninfected controls. We also examined the use of free testosterone (FT) and to...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-11-6
更新日期:2014-01-22 00:00:00
abstract:BACKGROUND:About 13 years since the introduction of antiretroviral therapy (ART) for children living with HIV (CLHIV) in Zambia, HIV/AIDS testing and treatment guidelines for children have evolved over the years with limited documentation of long-term trends in the numbers testing HIV positive and initiating ART. We ex...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-020-00277-0
更新日期:2020-05-14 00:00:00
abstract:BACKGROUND:Psychosocial factors have been linked with loss to follow-up (LTFU) and clinical outcomes among people living with HIV (PLH), however little is known about the effect of psychosocial support on LTFU among PLH in treatment and care. The purpose of this study was to explore the effect of NAMWEZA ("Yes, togethe...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-017-0145-z
更新日期:2017-03-28 00:00:00
abstract:UNLABELLED: BACKGROUND:The high cost of CD4 count estimation in resource-limited countries is a major challenge in initiating patients on highly active antiretroviral therapy (HAART). Therefore, assessment of inexpensive and simple laboratory diagnostic marker is mandatory to diagnose immuno-suppression. OBJECTIVE:To...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-9-21
更新日期:2012-07-15 00:00:00
abstract::Bone health status is largely absent in South Africa, the main reasons being the absence and cost-effectiveness of specific screening equipment for assessing bone mineral density (BMD). Various risk factors seem to play a role, some of which can be modified to change bone health status. Urbanisation is also a public h...
journal_title:AIDS research and therapy
pub_type: 杂志文章,评审
doi:10.1186/s12981-017-0162-y
更新日期:2017-07-26 00:00:00
abstract:BACKGROUND:Minocycline is a tetracycline antibiotic that has been shown to attenuate central nervous system (CNS) lentivirus infection, immune activation, and brain injury in model systems. To initiate assessment of minocycline as an adjuvant therapy in human CNS HIV infection, we conducted an open-labelled pilot study...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/1742-6405-8-17
更新日期:2011-05-12 00:00:00
abstract:BACKGROUND:People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. METHODS:ART-n...
journal_title:AIDS research and therapy
pub_type: 杂志文章
doi:10.1186/s12981-020-00275-2
更新日期:2020-05-13 00:00:00