Abstract:
BACKGROUND:With age, the human lens accumulates variety of substances that absorbs and fluorescence, which explains the color of yellow, brunescent and nigrescent cataract in terms of aging. The aim of this study was to assess lens fluorophores with properties comparable to those of advanced glycated end products (AGEs) in relation to age in human lenses. These fluorescent compounds are believed to be involved in the development of cataract. METHODS:Spectroscopic (UV-Vis-NIR) and fluorescence photography (CCD-Digital based image analysis) studies were carried out in randomly selected intact human lenses (2-85 years). AGE-like fluorophores were also measured in water soluble and insoluble (alkali soluble) fractions of human lenses (20-80 years). RESULTS:Our experimental findings suggest that there was a progressive shift in the absorbance characteristic of intact lens in the range of lambda210 nm-lambda470 nm. A relative increase in the absorptivity at lambda(511-520 nm), with age, was also observed. In addition, the ratio of absorptivity at lambda(511-520 nm) versus the maximum absorbance recorded at blue-end cut-off (210-470 nm) was also found to increase, with age. The fluorescent intensity in the intact lens at both UV-B (lambdaEx312 nm) and UV-A (lambdaEx365 nm) were found to be positively correlated (r2 = 0.91 & 0.94, respectively; Confidence interval 95%) upto 50 years of age. In addition, a concomitant changes in AGE- like fluorophores were also observed in the processed lens samples (soluble and insoluble fractions) along the age. A significant increase in the concentration of AGE- like fluorophores, both in intact and processed lens was observed during the period of 40 - 50 years. CONCLUSION:Based on the present investigation, it was concluded that significant changes do occur in the AGE-like fluorophores of human lenses during the period of 40-50 years.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Ranjan M,Beedu SRdoi
10.1186/1471-2415-6-10keywords:
subject
Has Abstractpub_date
2006-03-06 00:00:00pages
10issn
1471-2415pii
1471-2415-6-10journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Retinal vein occlusion (RVO) is a common retinal venous disorder that causes vision loss. No specific therapy has been developed. Controversy exists regarding two treatments: intravitreal dexamethasone implants and anti-vascular endothelial growth factor (VEGF). The goal of this study is to compare the effec...
journal_title:BMC ophthalmology
pub_type: 杂志文章,meta分析
doi:10.1186/s12886-018-1016-7
更新日期:2019-01-08 00:00:00
abstract:BACKGROUND:To evaluate results after seven years using prophylactic intracameral cefazolin for the prevention of endophthalmitis in cataract surgery. METHODS:A prospective, observational study of all patients submitted to cataract surgery over the period January 1996 to December 2009. All cases of postoperative endoph...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-12-2
更新日期:2012-01-24 00:00:00
abstract:BACKGROUND:Uncorrected refractive errors contribute enormously to the burden of avoidable visual impairment worldwide. There is a huge disparity in different parts of the globe in context to spectacle coverage for distance vision. This study was undertaken with objectives of determining prevalence of spectacle coverage...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1262-3
更新日期:2019-12-12 00:00:00
abstract:BACKGROUND:Orbital exenteration is a disfiguring procedure that aims to achieve local control. It is commonly a part of the management of malignant orbital tumor which is a life-threatening condition. It is necessary to determine predictive factors associated with overall survival (OS) following orbital exenteration. ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0850-y
更新日期:2018-07-28 00:00:00
abstract:BACKGROUND:To report a patient who presented with bluish scleral discoloration, keratoconus, and progressive high myopia. CASE PRESENTATION:A 6-year-old Chinese female patient presented with a significant bluish discoloration of the sclera in both eyes and extreme corneal thinning with anterior corneal protrusion. Gen...
journal_title:BMC ophthalmology
pub_type: 杂志文章,评审
doi:10.1186/s12886-018-0903-2
更新日期:2018-09-18 00:00:00
abstract:BACKGROUND:Aiming at spectacle independence, conventional pseudophakic monovision has been widely used in myopia patients with bilateral monofocal intraocular lens implantation. However, the crossed monovision, which is to correct the dominant eye for near vision and the non-dominant eye for distant vision, has been me...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01694-5
更新日期:2020-11-16 00:00:00
abstract:BACKGROUND:Macular thickening (MT) without clinically recognized macular edema has been described in anterior uveitis (AU). Although fellow-eyes of patients have been used as controls in several studies, little is known about macular thickness in these eyes. We studied the rate and extent of MT in both AU-affected and ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-12-30
更新日期:2012-07-29 00:00:00
abstract:BACKGROUND:Congenital cataract is the most frequent cause of blindness during infancy or early childhood. To date, more than 40 loci associated with congenital cataract have been identified, including at least 26 genes on different chromosomes associated with inherited cataract. This present study aimed to identify the...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0476-5
更新日期:2017-05-19 00:00:00
abstract:BACKGROUND:To evaluate therapeutic outcomes of interferon alpha-2a (IFNα2a) treatment in patients with Behcet's disease who were refractory to immunosuppressive agents. METHODS:This retrospective case series reviewed the medical records of 5 patients with refractory Behcet uveitis from January 2011 to February 2017. I...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0719-0
更新日期:2018-02-20 00:00:00
abstract:BACKGROUND:This study evaluates the efficacy and tolerability (ie, occurrence and severity of hyperemia) of bimatoprost 0.01% in treatment-naïve patients with open-angle glaucoma (OAG) or ocular hypertension in the Korean clinical setting. METHODS:In this multicenter, open-label, observational study, treatment-naïve p...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2415-14-160
更新日期:2014-12-17 00:00:00
abstract:BACKGROUND:Idiopathic elevated episcleral venous pressure (IEEVP) or idiopathic dilated episcleral veins (IDEV) is a rare abnormality, and thus therapeutic treatment for this condition rarely is discussed. We report a case of a patient with bilateral glaucoma secondary to IDEV for whom intraocular pressures (IOPs) were...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0892-1
更新日期:2018-08-23 00:00:00
abstract:BACKGROUND:Goldenhar Syndrome is characterized by malformations of multiple anatomical districts. Between these, bulbar dermoids are common and represent a significant clinical problem as they can affect both ocular function and aesthetic comfort.Histologic characterization of dermoids has been extensively performed; h...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-13-55
更新日期:2013-10-16 00:00:00
abstract:BACKGROUND:To report a case series in which a modified technique was used to remove retained submacular perfluorocarbon liquid (PFCL) secondary to vitreoretinal surgery for rhegmatogenous retinal detachment. CASE PRESENTATION:Four patients who had undergone pars plana vitrectomy for rhegmatogenous retinal detachment w...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0798-y
更新日期:2018-06-04 00:00:00
abstract:BACKGROUND:Tibetan Plateau is a highland area with special geographical location, time zone, and ethnic composition. We herein report the rationale, methodology and baseline data of the school-based childhood cohort study named Lhasa Childhood Eye Study (LCES), with the primary objective to pursue a comprehensive under...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01522-w
更新日期:2020-06-22 00:00:00
abstract:BACKGROUND:Glaucoma is a major cause of blindness worldwide and an increasingly significant global health problem. Glaucoma prevention and management efforts have been challenging due to inherent difficulty in developing a simple and cost-effective screening plan, limited access to health care and educational resources...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-8-21
更新日期:2008-10-26 00:00:00
abstract:BACKGROUND:Recently, instruments for the measurement of wavefront aberration in the living human eye have been widely available for clinical applications. Despite the extensive background experience on wavefront sensing for research purposes, the information derived from such instrumentation in a clinical setting shoul...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-4-1
更新日期:2004-02-11 00:00:00
abstract:BACKGROUND:Patient education materials should be written at a level that is understandable for patients with low health literacy. The aims of this study are (1) to review the literature on readability of ophthalmic patient education materials and (2) to evaluate and revise our institution's patient education materials ...
journal_title:BMC ophthalmology
pub_type: 杂志文章,评审
doi:10.1186/s12886-016-0315-0
更新日期:2016-08-03 00:00:00
abstract:BACKGROUND:This paper presents and tests a comprehensive computerised system of analysis of digital images of posterior capsule opacification (PCO). It updates and expands significantly on a previous presentation to include facilities for selecting user defined central areas and for registering and subsequent merging o...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-6-30
更新日期:2006-08-23 00:00:00
abstract:BACKGROUND:To describe the characteristics of patients with syphilitic uveitis in northern China. METHODS:A case series of 21 patients (33 eyes) diagnosed with syphilitic uveitis from 2011 to 2016 at a tertiary center in northern China was retrospectively analyzed. RESULTS:Twenty-one patients (33 eyes) were diagnosed...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0491-6
更新日期:2017-06-19 00:00:00
abstract:BACKGROUND:To investigate the expression and significance of mechanistic target of rapamycin complex 1(mTORC1) in diabetic retinopathy (DR), and to find new targets and new methods for the treatment of DR. METHODS:A DR rat model was prepared by general feeding combined with intraperitoneal injection of 10% streptozoto...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01553-3
更新日期:2020-07-20 00:00:00
abstract:BACKGROUND:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening conditions that initially affect the skin and mucous membranes. The aim of this study was to compare the acute ocular manifestations between SJS and TEN. METHODS:The initial presenting ophthalmic records of pat...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0464-9
更新日期:2017-05-12 00:00:00
abstract:BACKGROUND:To assess the reliability of the measurements obtained with the PalmScan, when compared with another standardized A-mode ultrasound device, and assess the consistency and correlation between the two methods. METHODS:Transversal, descriptive, and comparative study. We recorded the axial length (AL), anterior...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-10-8
更新日期:2010-03-24 00:00:00
abstract:BACKGROUND:This is a case of spontaneous toric implantable collamer lens (TICL) rotation that occurred twice in the left eye of a patient. CASE PRESENTATION:A 24-year-old gentleman received TICL implantation for treatment of myopic astigmatism encountered with spontaneous rotation of approximately 90° from its origina...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01597-5
更新日期:2020-08-28 00:00:00
abstract:BACKGROUND:To understand the clinical and economic outcomes of treatments for managing complications of ischemic central retinal vein occlusion (iCRVO). METHODS:We conducted a systematic literature review by searching multiple databases and ophthalmology conferences from 2004 to 2015. Studies published in English lang...
journal_title:BMC ophthalmology
pub_type: 杂志文章,评审
doi:10.1186/s12886-016-0282-5
更新日期:2016-07-11 00:00:00
abstract:BACKGROUND:Reports of central corneal thickness (CCT) among glaucoma patients, particularly for pseudoexfoliative glaucoma (PXG) and Primary Angle Closure Glaucoma (PACG) are scarce in the Sub-Saharan African (SSA) population. The aim of this study is to evaluate CCT in black patients with newly diagnosed glaucoma and ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0334-x
更新日期:2016-08-31 00:00:00
abstract:BACKGROUND:To investigate the clinical relevance of two different preservative formulations, we compared 1-year incidence rates of additional coding of dry eye, ocular infection, or ocular surface disease (either dry eye or ocular infection) in open-angle glaucoma and ocular hypertension patients newly treated with lat...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-11-14
更新日期:2011-06-14 00:00:00
abstract:BACKGROUND:To evaluate the safety and effectiveness of the Visian Implantable Collamer Lens (ICL) implantation in high myopic patients with inactive Graves' ophthalmopathy (GO) by observing the changes of choroidal thickness (CT). METHODS:Eight patients (16 eyes) with high myopia accompanied with inactive GO were sele...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01612-9
更新日期:2020-08-25 00:00:00
abstract:BACKGROUND:To evaluate the retinal function before and soon after an intravitreal injection of an anti-vascular endothelial growth factor (anti-VEGF) agents. METHODS:Seventy-nine eyes of 79 patients that were treated by an intravitreal injection of an anti-VEGF agent for age-related macular degeneration (AMD), diabeti...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1129-7
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:The effectiveness of ranibizumab in the treatment of diabetic macular edema has been proven with large clinical trials. For bevacizumab only two clinical trials have been published and a head-to-head comparison is lacking to date. However, if proved non-inferior to ranibizumab, use of the off-label bevacizum...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12886-015-0043-x
更新日期:2015-07-07 00:00:00
abstract:BACKGROUND:To evaluate the 6-month clinical outcomes of Flexivue Microlens refractive corneal inlay in emmetropic patients in Asia for the surgical compensation of presbyopia. METHODS:In this retrospective study, corneal inlay implantation was done using a femtosecond laser. The follow-up period was 6 months. Near/int...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1069-2
更新日期:2019-03-05 00:00:00