Abstract：
BACKGROUND:To evaluate therapeutic outcomes of interferon alpha-2a (IFNα2a) treatment in patients with Behcet's disease who were refractory to immunosuppressive agents. METHODS:This retrospective case series reviewed the medical records of 5 patients with refractory Behcet uveitis from January 2011 to February 2017. IFNα2a was administered at a dose of 3 million IU 3 times per week. Clinical response, relapse rate, and change of visual acuity were evaluated. RESULTS:The mean age of patients was 39.60 ± 9.21 years, and the median treatment duration was 6 months. Four of the 5 patients (80%) presented with responses to IFNα2a without any uveitis attack during the treatment period. The mean number of uveitis attacks/year per patient during the treatment was 0.40 ± 0.89. The mean log of the Minimum Angle of Resolution visual acuity improved from 1.44 ± 0.38 at baseline to 1.02 ± 0.58 at the final follow up. CONCLUSIONS:IFNα2a is an effective therapy for Behcet uveitis refractory to conventional immunosuppressants in Korean patients.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Lee JH,Lee CS,Lee SCdoi
10.1186/s12886-018-0719-0subject
Has Abstractpub_date
2018-02-20 00:00:00pages
52issue
1issn
1471-2415pii
10.1186/s12886-018-0719-0journal_volume
18pub_type
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更新日期：2007-09-19 00:00:00
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更新日期：2016-07-11 00:00:00
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更新日期：2016-11-16 00:00:00
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更新日期：2005-04-05 00:00:00
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