Disseminated Nocardiosis with subretinal abscess in a patient with nephrotic syndrome-a case report.

Abstract:

BACKGROUND:Nocardia infection is uncommon in clinical practice, with most cases occuring as the result of opportunistic infection in immunocompromsed patients. Here, we report a case of disseminated nocardiosis with subretinal abscess in a patient with nephrotic syndrome, and whom is receiving immunosuppressive therapy. CASE PRESENTATION:A 58-year-old male presented with decreased vision in his left eye, without redness or floaters, which had persisted for three days. The patient had previously been diagnosed with membranous nephropathy, and as such, had received systemic corticosteroid therapy for four months. Further, the patient had developed pneumonia three weeks prior to this presentation. The ocular lesion appeared as a creamy-white subretinal abscess, with overlying retinal hemorrhages. Subsequent administration of three intravitreal injections of vancomycin and ceftazidime ultimately led to eradication of the intraocular infection, however, two months later, the patient developed a brain abcess. Pathogens isolated from the blood were subsequently identified as Nocardia. The patient was successfully treated via systemic administration of imipenem and trimethoprim-sulfamethoxazole. CONCLUSIONS:Clinicians should be aware of the possibility of Nocardia infections within all immunocompromised patients, as well as the tendency of this infection to disseminate--particularly in the brain. The early detection of Nocardia infections and prolonged treatment of the proper antibiotics may significantly improve the prognosis of this life-threatening infection.

journal_name

BMC Ophthalmol

journal_title

BMC ophthalmology

authors

Xu H,Fu B,Xu L,Sun J

doi

10.1186/s12886-018-0883-2

subject

Has Abstract

pub_date

2018-09-03 00:00:00

pages

234

issue

1

issn

1471-2415

pii

10.1186/s12886-018-0883-2

journal_volume

18

pub_type

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