Abstract:
BACKGROUND:To understand the clinical and economic outcomes of treatments for managing complications of ischemic central retinal vein occlusion (iCRVO). METHODS:We conducted a systematic literature review by searching multiple databases and ophthalmology conferences from 2004 to 2015. Studies published in English language and populations of age ≥45 years were included. For clinical endpoints, we defined eligibility criteria as randomized controlled trials, prospective before-and-after study designs, and non-randomized studies reporting on treatments in patients with iCRVO. For economic endpoints, all types of study design except cost-of-illness studies were included. We evaluated the definitions of ischemia, clinical and economic endpoints, and rate of development of complications. Risk of bias was assessed for clinical studies using the Cochrane risk-of-bias tool. RESULTS:A total of 20 studies (1338 patients) were included. Treatments included anti-vascular endothelial growth factors (anti-VEGFs), steroids, and procedures primarily targeting macular edema and neovascularization. Ischemia was not defined consistently in the included studies. The level of evidence was mostly low. Most treatments did not improve visual acuity significantly. Development of treatment complications ranged from 11 to 57 %. Incremental cost-effectiveness ratios reported for anti-VEGFs and steroids were below the accepted threshold of GB£30,000, but considering such treatments only ameliorate disease symptoms they seem relatively expensive. CONCLUSIONS:There is a lack of evidence for any intervention being effective in iCRVO, especially in the prevention of neovascularisation. iCRVO poses a significant clinical and economic burden. There is a need to standardize the definition of ischemia, and for innovative treatments which can significantly improve visual outcomes and prevent neovascular complications.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Bradshaw SE,Gala S,Nanavaty M,Shah A,Mwamburi M,Kefalas Pdoi
10.1186/s12886-016-0282-5subject
Has Abstractpub_date
2016-07-11 00:00:00pages
104issn
1471-2415pii
10.1186/s12886-016-0282-5journal_volume
16pub_type
杂志文章,评审abstract:BACKGROUND:Previous analyses of real-life data indicated that injection frequency and health care costs did not differ for anti-VEGF treatment with aflibercept and ranibizumab. The objective of this study was to investigate whether this finding persisted when analysing a longer time period after licensing. METHODS:Ret...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0617-x
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:This study evaluates the efficacy and tolerability (ie, occurrence and severity of hyperemia) of bimatoprost 0.01% in treatment-naïve patients with open-angle glaucoma (OAG) or ocular hypertension in the Korean clinical setting. METHODS:In this multicenter, open-label, observational study, treatment-naïve p...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2415-14-160
更新日期:2014-12-17 00:00:00
abstract:BACKGROUND:To report the first case of a cerebral arteriovenous malformation (AVM) with ocular symptoms and review the characteristics of this case and the main point of confusion for the diagnosis of such a case. CASE PRESENTATION:A 58-year-old woman presented to the ophthalmology clinic with 1 and a half years of ri...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1160-8
更新日期:2019-07-12 00:00:00
abstract:BACKGROUND:Glial heterotopias are rare, benign, congenital, midline, non-teratomatous extracranial glial tissue. They may masquerade as encephalocoele or dermoid cyst and mostly present in nose. Herein, we present an unusual case of glial heterotopia of the orbit with unilateral blindness. CASE PRESENTATION:A 6 year-o...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-11-34
更新日期:2011-11-16 00:00:00
abstract:BACKGROUND:Aiming at spectacle independence, conventional pseudophakic monovision has been widely used in myopia patients with bilateral monofocal intraocular lens implantation. However, the crossed monovision, which is to correct the dominant eye for near vision and the non-dominant eye for distant vision, has been me...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01694-5
更新日期:2020-11-16 00:00:00
abstract:BACKGROUND:Cataract surgery in diabetics is more technically challenging due to a number of factors including poor intraoperative pupil dilation and a higher risk of vision threatening complications. This study evaluates the safety and efficacy of an intracameral combination of 2 mydriatics and 1 anesthetic (ICMA, Mydr...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12886-020-01343-x
更新日期:2020-03-03 00:00:00
abstract:BACKGROUND:To investigate the corneal biomechanical changes in primary open angle glaucoma (POAG) patients treated with long-term prostaglandin analogue (PGA). METHODS:One hundred eleven newly diagnosed POAG patients, including 43 high tension glaucoma (HTG) and 68 normal tension glaucoma (NTG), were measured by Corvi...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01693-6
更新日期:2020-10-20 00:00:00
abstract:BACKGROUND:To describe the characteristics of patients with syphilitic uveitis in northern China. METHODS:A case series of 21 patients (33 eyes) diagnosed with syphilitic uveitis from 2011 to 2016 at a tertiary center in northern China was retrospectively analyzed. RESULTS:Twenty-one patients (33 eyes) were diagnosed...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0491-6
更新日期:2017-06-19 00:00:00
abstract:BACKGROUND:To screen for visual impairment in Malaysian preschool children. METHODS:Visual screening was conducted in 400 preschool children aged 4 to 6 years. The screening involved two basic procedures; the distant visual acuity test using the Sheridan Gardiner chart and the depth perception test using the Langs ste...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-13-16
更新日期:2013-04-19 00:00:00
abstract:BACKGROUND:Adenovirus (Ad), associated with significant morbidity, has no topical treatment. A leading CTC compound (CTC-96), a Co(III) chelate, was found to have potent in vitro and in vivo antiviral efficacy against herpes viruses. In this study CTC-96 is being tested for possible anti-Adenovirus activity. METHODS:T...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-6-22
更新日期:2006-06-05 00:00:00
abstract:BACKGROUND:To evaluate the correlation between visual acuity improvement and vision-related QOL after ranibizumab treatment in Japanese patients with AMD. METHODS:In this one-year prospective, interventional, open-label, multicenter study involving four sites, patients with neovascular AMD were enrolled and observed f...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-021-01816-7
更新日期:2021-01-23 00:00:00
abstract:BACKGROUND:Nocardia infection is uncommon in clinical practice, with most cases occuring as the result of opportunistic infection in immunocompromsed patients. Here, we report a case of disseminated nocardiosis with subretinal abscess in a patient with nephrotic syndrome, and whom is receiving immunosuppressive therapy...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0883-2
更新日期:2018-09-03 00:00:00
abstract:BACKGROUND:To report a case series in which a modified technique was used to remove retained submacular perfluorocarbon liquid (PFCL) secondary to vitreoretinal surgery for rhegmatogenous retinal detachment. CASE PRESENTATION:Four patients who had undergone pars plana vitrectomy for rhegmatogenous retinal detachment w...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0798-y
更新日期:2018-06-04 00:00:00
abstract:BACKGROUND:The current study compared optical quality before and after implantation of a posterior chamber phakic intraocular lens with a central hole [V4c implantable collamer lens (ICL)] under bright and dark lighting conditions by means of the Optical Quality Analysis System™ (OQAS; Visiometrics, Terrassa, Spain). ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01340-0
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:To report a patient who presented with bluish scleral discoloration, keratoconus, and progressive high myopia. CASE PRESENTATION:A 6-year-old Chinese female patient presented with a significant bluish discoloration of the sclera in both eyes and extreme corneal thinning with anterior corneal protrusion. Gen...
journal_title:BMC ophthalmology
pub_type: 杂志文章,评审
doi:10.1186/s12886-018-0903-2
更新日期:2018-09-18 00:00:00
abstract:BACKGROUND:To study the value and safety of aqueous humor polymerase chain reaction (PCR) analysis for Herpes simplex, varicella zoster, cytomegalovirus, Epstein-Barr virus and Toxoplasma gondii in patients with uveitis. METHODS:Records of 45 consecutive patients with anterior and posterior uveitis who underwent AC pa...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0369-z
更新日期:2016-10-28 00:00:00
abstract:BACKGROUND:With age, the human lens accumulates variety of substances that absorbs and fluorescence, which explains the color of yellow, brunescent and nigrescent cataract in terms of aging. The aim of this study was to assess lens fluorophores with properties comparable to those of advanced glycated end products (AGEs...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-6-10
更新日期:2006-03-06 00:00:00
abstract:BACKGROUND:To report the prevalence of ocular abnormalities and investigate visual acuity in a large cohort of retinitis pigmentosa (RP) patients in Western China. METHODS:The medical records and ophthalmic examination reports of 2127 eyes of 1065 RP patients at one eye hospital were retrospectively reviewed to determ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01797-z
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND:To analyse the associated factors, diagnosis, clinical manifestations and therapeutic effects of Acanthamoeba keratitis at a tertiary ophthalmic centre in Southern China. METHODS:A retrospective clinical study was performed in fifteen patients who were admitted to Zhongshan Ophthalmic Centre (ZOC) from Janu...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0571-7
更新日期:2017-10-02 00:00:00
abstract:BACKGROUND:Refractive errors, strabismus, nystagmus, amblyopia, and cortical visual impairment are observed in 50 to 90 % of patients with cerebral palsy. Ocular abnormalities are known to differ according to cerebral palsy type, and spastic type has been reported to be more likely to be associated with ocular defects ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0367-1
更新日期:2016-11-08 00:00:00
abstract:BACKGROUND:Epidemic keratoconjunctivitis (EKC) is one of the most common eye infections worldwide. The analysis of clinical manifestations in different age groups help better know the disease. This study aims to provide more detailed analysis of 272 cases of EKC in 8 years, describe the differences of the clinical feat...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1266-z
更新日期:2019-12-19 00:00:00
abstract:BACKGROUND:The purpose of this study is to determine whether the lifestyle and body stature are significantly associated with the axial length (AL) of the eyes of Japanese third grade students. METHODS:A prospective, cross sectional, observational study was performed on 122 third grade students consisting of 61 boys a...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0519-y
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:To evaluate the efficacy and safety of intravitreal conbercept (KH902) as the primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy. METHODS:This study was a retrospective, consecutive, observational case series. We reviewed medical records of 16 eyes (16 patients) with...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0481-8
更新日期:2017-06-12 00:00:00
abstract:BACKGROUND:Glaucoma will undoubtedly impact on a person's ability to function as they go about their day-to-day life. The purpose of this study is to investigate the amount of published knowledge in quality of life (QoL) and visual disability studies for glaucoma, and make comparisons with similar research in other chr...
journal_title:BMC ophthalmology
pub_type: 信件
doi:10.1186/1471-2415-11-19
更新日期:2011-08-04 00:00:00
abstract:BACKGROUND:To evaluate the differences between the predicted and achieved lenticule thickness (ΔLT) after small incision lenticule extraction (SMILE) surgery and investigate relationships between ΔLT and predicted lenticule thickness in SMILE. METHODS:A total of 184 eyes from 184 consecutive patients who underwent SMI...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01374-4
更新日期:2020-03-17 00:00:00
abstract:BACKGROUND:Anterior chamber depth (ACD) is becoming a hot topic and plays an important role in correcting the refractive errors (REs) after cataract surgery. The aim of this study was to assess the ACD changes and their relationship with the REs after phacoemulsification and intraocular lens (IOL) implantation in patie...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1144-8
更新日期:2019-06-25 00:00:00
abstract:BACKGROUND:Monocular infantile blindness may be associated with bilateral horizontal nystagmus, a subtype of fusion maldevelopment nystagmus syndrome (FMNS). Patients often adopt a significant anomalous head posture (AHP) towards the fixing eye in order to dampen the nystagmus. This clinical entity has also been report...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-137
更新日期:2014-11-20 00:00:00
abstract:BACKGROUND:Dry eye is a common problem that affects many people worldwide, reducing quality of life and impacting daily activities. A qualitative approach often used in medicine and other disciplines is used to evaluate how people with dry eye cope with this impact. METHODS:Six focus group sessions were conducted at t...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0671-z
更新日期:2018-01-16 00:00:00
abstract:BACKGROUND:The SRK/T formula is one of the third generation IOL calculation formulas. The purpose of this study was to evaluate the performance of the SRK/T formula in predicting a target refraction ±1.0D in short and long eyes using ultrasound biometry after phacoemulsification. METHODS:The present study was a retros...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0271-8
更新日期:2016-07-08 00:00:00
abstract:BACKGROUND:Primary lacrimal sac melanoma is an extremely rare condition with fewer than 50 cases reported so far. Clinically, its symptoms resemble those of dacryocystitis, leading to frequent misdiagnosis. During diagnosis, imaging examination is often performed to differentiate tumors from inflammation. In this repor...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01356-6
更新日期:2020-05-14 00:00:00