Abstract:
BACKGROUND:To evaluate the efficacy and safety of intravitreal conbercept (KH902) as the primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy. METHODS:This study was a retrospective, consecutive, observational case series. We reviewed medical records of 16 eyes (16 patients) with naive subfoveal or juxtafoveal choroidal neovascularization secondary to punctuate inner choroidopathy that were treated with intravitreal conbercept injections. All patients completed at least six months of follow-up. Best-corrected visual acuity (BCVA) was measured, and anatomical features were assessed with fluorescein angiography, indocyanine green angiography, and optical coherence tomography. RESULTS:At the month-6 follow-up visit, best-corrected visual acuity improved from 0.70 ± 0.36 (with approximate Snellen equivalent of 20/100) to 0.44 ± 0.25 (20/50 in Snellen) logarithm of the minimum angle of resolution (logMAR) (P = 0.003). Mean improvement of vision was 2.6 lines, with 50% treated eyes (8 eyes of 16) showing an improvement of ≥3 lines and 62.5% (10 eyes of 16), obtaining an improvement of ≥2 lines; all 16 eyes had stable or improved vision. Mean central retinal thickness decreased from 294.94 ± 102.68 μm to 206.56 ± 61.71 μm (P = 0.005). Fifteen eyes (93.75%) showed absence of CNV leakage at the end of the study period. No conbercrept-related systemic or ocular adverse events were observed. CONCLUSION:Intravitreal injection of conbercept significantly improved visual and anatomical outcomes in choroidal neovascularization secondary to punctate inner choroidopathy over a 6-month follow-up period. TRIAL REGISTRATION:ISRCTN85678307 , retrospectively registered on May 11, 2017.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Peng Y,Zhang X,Mi L,Liu B,Zuo C,Li M,Wen Fdoi
10.1186/s12886-017-0481-8subject
Has Abstractpub_date
2017-06-12 00:00:00pages
87issue
1issn
1471-2415pii
10.1186/s12886-017-0481-8journal_volume
17pub_type
杂志文章abstract:BACKGROUND:Docetaxel is a chemotherapeutic agent of the taxane class of drugs for the treatment of breast cancer. We present a female patient who noted decreased vision after docetaxel treatment. CASE PRESENTATION:A 45-year-old female patient received docetaxel treatment after resection of a breast carcinoma. Fundusco...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0020-4
更新日期:2015-03-29 00:00:00
abstract:BACKGROUND:The purpose of this study was to identify the genetic cause and describe the clinical phenotype of Schnyder corneal dystrophy (SCD) in six unrelated probands. METHODS:We identified two white Czech, two white British and two South Asian families with a clinical diagnosis of SCD. Ophthalmic assessment include...
journal_title:BMC ophthalmology
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abstract:BACKGROUND:Glaucoma will undoubtedly impact on a person's ability to function as they go about their day-to-day life. The purpose of this study is to investigate the amount of published knowledge in quality of life (QoL) and visual disability studies for glaucoma, and make comparisons with similar research in other chr...
journal_title:BMC ophthalmology
pub_type: 信件
doi:10.1186/1471-2415-11-19
更新日期:2011-08-04 00:00:00
abstract:BACKGROUND:The tear film breakup time (tBUT) is a clinical evaluation of evaporative dry eye disease assessed by instilling topical fluorescein into the eyes. In the present study, we introduce a new diagnostic test, blinking tolerance time (BTT), for self-evaluation of tear-film stability. We compared the results with...
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pub_type: 杂志文章
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abstract:BACKGROUND:To study the value and safety of aqueous humor polymerase chain reaction (PCR) analysis for Herpes simplex, varicella zoster, cytomegalovirus, Epstein-Barr virus and Toxoplasma gondii in patients with uveitis. METHODS:Records of 45 consecutive patients with anterior and posterior uveitis who underwent AC pa...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0369-z
更新日期:2016-10-28 00:00:00
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更新日期:2019-03-08 00:00:00
abstract:BACKGROUND:Older drivers have a crash rate nearly equal to that of young drivers whose crash rate is the highest among all age groups. Contrast sensitivity impairment is common in older adults. The purpose of this study is to examine whether parameters from the photopic and mesopic contrast sensitivity functions (CSF) ...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究
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更新日期:2020-02-04 00:00:00
abstract:BACKGROUND:The presence of an intraocular cilium is very rare and the response of the eye to the cilium is variable. We present the case of a patient with a cilium found in the vitreous cavity during vitrectomy for rhegmatogenous retinal detachment 40 years following penetrating eye injury. To our knowledge, this is th...
journal_title:BMC ophthalmology
pub_type: 杂志文章
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更新日期:2015-03-12 00:00:00
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更新日期:2020-11-16 00:00:00
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doi:10.1186/s12886-016-0202-8
更新日期:2016-03-08 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12886-018-0729-y
更新日期:2018-02-27 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-12-30
更新日期:2012-07-29 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-2415-14-124
更新日期:2014-10-21 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-2415-6-21
更新日期:2006-05-31 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12886-020-01502-0
更新日期:2020-06-26 00:00:00
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pub_type: 杂志文章
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abstract::An amendment to this paper has been published and can be accessed via the original article. ...
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更新日期:2018-02-27 00:00:00
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pub_type: 杂志文章
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更新日期:2017-07-27 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
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更新日期:2017-11-25 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0687-4
更新日期:2018-02-02 00:00:00
abstract:BACKGROUND:A few case reports have described accidental eye injuries caused by fish hooks. The severity of ocular injuries is dependent on the involved ocular structures. Severe ocular injuries due to fish hooks are rare. We describe open globe and penetrating eyelid injuries from fish hooks at the Baltic Sea. METHODS...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1040-2
更新日期:2019-01-21 00:00:00
abstract:BACKGROUND:To compare the efficacy of phacoemulsification (PKE) combined with nonpenetrating deep sclerectomy (NPDS) with mitomycin C (MMC) versus XEN® gel stent with MMC. METHODS:In this nonrandomized, retrospective, comparative, single-center pilot study, 105 consecutive eyes of 75 patients with uncontrolled primary...
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pub_type: 杂志文章
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更新日期:2020-06-16 00:00:00
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pub_type: 杂志文章
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更新日期:2018-12-14 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0947-3
更新日期:2018-10-25 00:00:00
abstract:BACKGROUND:Silicone oil tamponade is more frequently reserved for cases of complex retinal detachment. We describe the effects of different variations in oil ratios with the relatively unknown technique of double oil tamponade. METHODS:Retrospective case note review of nine patients with complex rhegmatogenous retinal...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0660-7
更新日期:2017-12-28 00:00:00