Abstract:
BACKGROUND:The eMERGE (electronic MEdical Records and Genomics) network, funded by the National Human Genome Research Institute, is a national consortium formed to develop, disseminate, and apply approaches to research that combine DNA biorepositories with electronic health record (EHR) systems for large-scale, high-throughput genetic research. Marshfield Clinic is one of five sites in the eMERGE network and primarily studied: 1) age-related cataract and 2) HDL-cholesterol levels. The purpose of this paper is to describe the approach to electronic evaluation of the epidemiology of cataract using the EHR for a large biobank and to assess previously identified epidemiologic risk factors in cases identified by electronic algorithms. METHODS:Electronic algorithms were used to select individuals with cataracts in the Personalized Medicine Research Project database. These were analyzed for cataract prevalence, age at cataract, and previously identified risk factors. RESULTS:Cataract diagnoses and surgeries, though not type of cataract, were successfully identified using electronic algorithms. Age specific prevalence of both cataract (22% compared to 17.2%) and cataract surgery (11% compared to 5.1%) were higher when compared to the Eye Diseases Prevalence Research Group. The risk factors of age, gender, diabetes, and steroid use were confirmed. CONCLUSIONS:Using electronic health records can be a viable and efficient tool to identify cataracts for research. However, using retrospective data from this source can be confounded by historical limits on data availability, differences in the utilization of healthcare, and changes in exposures over time.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Waudby CJ,Berg RL,Linneman JG,Rasmussen LV,Peissig PL,Chen L,McCarty CAdoi
10.1186/1471-2415-11-32subject
Has Abstractpub_date
2011-11-11 00:00:00pages
32issn
1471-2415pii
1471-2415-11-32journal_volume
11pub_type
杂志文章abstract:BACKGROUND:To evaluate the relationships between Reichert Ocular Response Analyzer (ORA) parameters corneal hysteresis (CH) and corneal response factor (CRF) and ocular dimensions, age and intraocular pressure. METHODS:Two hundred and twelve eyes of 212 participants with no ocular pathology had CH and CRF measured wit...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-11
更新日期:2014-01-30 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01340-0
更新日期:2020-03-04 00:00:00
abstract:BACKGROUND:This study sought to identify factors associated with retinal detachment and retreatment of aggressive posterior retinopathy of prematurity (APROP) initially treated with intravitreal ranibizumab (IVR) injection as well as the efficacy of IVR treatment. METHODS:This was a retrospective study. A total of 83 ...
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更新日期:2018-06-26 00:00:00
abstract:BACKGROUND:The influence of serous retinal detachment (SRD) on retinal sensitivity in patients with branch retinal vein occlusion (BRVO) and macular edema remains unclear. This is despite the frequent co-existence of SRD and cystoid macular edema (CME) in BRVO patients on optical coherence tomography (OCT) and the fact...
journal_title:BMC ophthalmology
pub_type: 杂志文章
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更新日期:2011-09-26 00:00:00
abstract:BACKGROUND:This paper presents and tests a comprehensive computerised system of analysis of digital images of posterior capsule opacification (PCO). It updates and expands significantly on a previous presentation to include facilities for selecting user defined central areas and for registering and subsequent merging o...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-6-30
更新日期:2006-08-23 00:00:00
abstract:BACKGROUND:Retinal detachment is a disorder of the eye in which sensory retina separates from the retinal pigment epithelium (RPE) due to accumulation of fluid in subretinal space. Pharmacological stimulation of fluid reabsorption from subretinal space to choroid across the RPE has been suggested as a treatment strateg...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-11-33
更新日期:2011-11-15 00:00:00
abstract:BACKGROUND:There is a huge need for the availability of transplantable donor corneas worldwide to reduce the burden of corneal blindness due to corneal opacity. Voluntary eye donation depends on the awareness levels of various stakeholders in the community. This study aimed to assess the awareness level regarding eye d...
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pub_type: 杂志文章
doi:10.1186/1471-2415-14-25
更新日期:2014-03-06 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0737-y
更新日期:2018-03-05 00:00:00
abstract:BACKGROUND:Previous analyses of real-life data indicated that injection frequency and health care costs did not differ for anti-VEGF treatment with aflibercept and ranibizumab. The objective of this study was to investigate whether this finding persisted when analysing a longer time period after licensing. METHODS:Ret...
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pub_type: 杂志文章
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journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12886-015-0043-x
更新日期:2015-07-07 00:00:00
abstract:BACKGROUND:To evaluate the prognosis of Chinese patients with lacrimal gland adenoid cystic carcinoma treated with eye-sparing surgery and adjuvant multimodal therapy. METHODS:The study included 24 consecutive patients with lacrimal gland adenoid cystic carcinoma treated at the Ninth People's Hospital of Shanghai from...
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pub_type: 杂志文章
doi:10.1186/s12886-019-1110-5
更新日期:2019-06-08 00:00:00
abstract:BACKGROUND:To investigate the ability of characterizing neonatal retinal hemorrhage (RH) using RetCam in healthy newborns and the systemic effects during the procedure. METHODS:This prospective study enrolled 68 healthy newborns aged 2 to 4 days old. The RH was imaged and classified according to the location and numbe...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0887-y
更新日期:2018-08-20 00:00:00
abstract::Meibomian gland dysfunction (MGD) is the major cause of evaporative dry eye disease (EDED) and dysfunction is widely thought to mechanistically involve ductal hyperkeratinization, plugging and obstruction. This review re-evaluates the role of hyperkeratinization in MGD based on more recent findings from mouse models. ...
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pub_type: 杂志文章,评审
doi:10.1186/s12886-015-0132-x
更新日期:2015-12-17 00:00:00
abstract:BACKGROUND:To evaluate the retinal function before and soon after an intravitreal injection of an anti-vascular endothelial growth factor (anti-VEGF) agents. METHODS:Seventy-nine eyes of 79 patients that were treated by an intravitreal injection of an anti-VEGF agent for age-related macular degeneration (AMD), diabeti...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1129-7
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:Although the association between metabolic syndrome and intraocular pressure is well known, the relationship between the intraocular pressure and different combination of the components of metabolic syndrome has not been actively researched yet. The study aimed to investigate the relationship between the int...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0263-8
更新日期:2016-06-06 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0862-7
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:This study compared the postoperative outcomes of 27-gauge (G) and 25-G vitrectomy performed for the treatment of idiopathic epiretinal membrane (ERM). METHODS:The study design was single center, retrospective, interventional case series. Two hundred consecutive eyes that underwent primary vitrectomy for ER...
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pub_type: 杂志文章
doi:10.1186/s12886-017-0585-1
更新日期:2017-10-10 00:00:00
abstract:BACKGROUND:To evaluate the safety and effectiveness of the Visian Implantable Collamer Lens (ICL) implantation in high myopic patients with inactive Graves' ophthalmopathy (GO) by observing the changes of choroidal thickness (CT). METHODS:Eight patients (16 eyes) with high myopia accompanied with inactive GO were sele...
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pub_type: 杂志文章
doi:10.1186/s12886-020-01612-9
更新日期:2020-08-25 00:00:00
abstract:BACKGROUND:Immune responses play a key role in the pathogenesis and progression of polypoidal choroidal vasculopath (PCV) and age-related macular degeneration (AMD). In this study, we determined the Th cell-associated immune responses by measuring the cytokine expression of peripheral blood mononuclear cells (PBMC) in ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0251-z
更新日期:2016-06-07 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0892-1
更新日期:2018-08-23 00:00:00
abstract:BACKGROUND:Graves' disease is a common autoimmune inflammatory condition of the thyroid. About one in four of affected patients also develop orbital symptoms like exophthalmos, proptosis and diplopia - called Graves' Ophthalmopathy. Not all patients respond well to the standard therapy of systemic glucocorticoid admini...
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pub_type: 杂志文章
doi:10.1186/s12886-018-0718-1
更新日期:2018-02-27 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-4-1
更新日期:2004-02-11 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01356-6
更新日期:2020-05-14 00:00:00
abstract:BACKGROUND:Glaucoma is a major cause of blindness worldwide and an increasingly significant global health problem. Glaucoma prevention and management efforts have been challenging due to inherent difficulty in developing a simple and cost-effective screening plan, limited access to health care and educational resources...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-8-21
更新日期:2008-10-26 00:00:00
abstract:BACKGROUND:To assess the reliability of the measurements obtained with the PalmScan, when compared with another standardized A-mode ultrasound device, and assess the consistency and correlation between the two methods. METHODS:Transversal, descriptive, and comparative study. We recorded the axial length (AL), anterior...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-10-8
更新日期:2010-03-24 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0990-0
更新日期:2018-12-12 00:00:00
abstract:BACKGROUND:Surgeons may be unaware of the ability of plant toxins to cause corneal damage. Therefore, corneal damage following intraocular surgery due to plant toxins may be misdiagnosed as postoperative infection. CASE PRESENTATION:A 74-year-old man presented with hyperemia and reduced visual acuity in both eyes 6 we...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0400-z
更新日期:2017-01-18 00:00:00
abstract:BACKGROUND:This objective of the review and analysis is to demonstrate that acyclovir (ACV) 3% ophthalmic ointment is superior to idoxuridine (IDU) in treating herpetic keratitis (HK) presenting as dendritic and geographic ulcer sub-types. METHODS: DATA SOURCES:Publications in human subjects were identified by search...
journal_title:BMC ophthalmology
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-04-17 00:00:00
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pub_type: 杂志文章
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更新日期:2019-12-21 00:00:00
abstract:BACKGROUND:Cataract surgery in diabetics is more technically challenging due to a number of factors including poor intraoperative pupil dilation and a higher risk of vision threatening complications. This study evaluates the safety and efficacy of an intracameral combination of 2 mydriatics and 1 anesthetic (ICMA, Mydr...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2020-03-03 00:00:00