Abstract：
BACKGROUND:P66Shc is partially localised within the mitochondrial fraction. It is primarily related to the generation of mitochondrial reactive oxygen species and apoptosis. Based on previous studies, we hypothesize that in the retina, p66Shc may exist and affect the development of diabetic retinopathy. The purpose of this study was to investigate p66Shc expression in retinal in streptozotocin-induced diabetic (SD) rats, which may provide a pathway to study the pathogenesis of diabetic retinopathy. METHODS:Reverse transcription-polymerase chain reaction (RT-PCR) and western blot were used to detect retinal p66Shc mRNA and protein expression in SD rats, respectively. Immunohistochemical staining was applied to detect the location of rat retinal p66Shc expression. TUNEL assay was applied to detect the number of apoptotic cells. RESULTS:P66Shc expression was found in the retina of normal and diabetic rats, and the level of mRNA and protein expression increased with the progression of diabetes mellitus (DM). P66Shc expression was mainly located in the retinal ganglion cell layer and inner nuclear layer. Compared with the normal group, retinal cell tissue apoptosis rate in the D12w group was significantly increased. CONCLUSION:Rat retinal p66Shc expression was mainly in the ganglion cell layer and inner nuclear layer. As the degree of DM progressed, p66Shc expression gradually increased, and the number of apoptotic cells also increased.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Zhao MH,Hu J,Li S,Wu Q,Lu Pdoi
10.1186/s12886-018-0724-3subject
Has Abstractpub_date
2018-02-27 00:00:00pages
58issue
1issn
1471-2415pii
10.1186/s12886-018-0724-3journal_volume
18pub_type
杂志文章abstract：BACKGROUND:Monocular infantile blindness may be associated with bilateral horizontal nystagmus, a subtype of fusion maldevelopment nystagmus syndrome (FMNS). Patients often adopt a significant anomalous head posture (AHP) towards the fixing eye in order to dampen the nystagmus. This clinical entity has also been report...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-137
更新日期：2014-11-20 00:00:00
abstract：BACKGROUND:This is a case of spontaneous toric implantable collamer lens (TICL) rotation that occurred twice in the left eye of a patient. CASE PRESENTATION:A 24-year-old gentleman received TICL implantation for treatment of myopic astigmatism encountered with spontaneous rotation of approximately 90° from its origina...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01597-5
更新日期：2020-08-28 00:00:00
abstract：BACKGROUND:Surgeons may be unaware of the ability of plant toxins to cause corneal damage. Therefore, corneal damage following intraocular surgery due to plant toxins may be misdiagnosed as postoperative infection. CASE PRESENTATION:A 74-year-old man presented with hyperemia and reduced visual acuity in both eyes 6 we...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-017-0400-z
更新日期：2017-01-18 00:00:00
abstract：BACKGROUND:Recently, instruments for the measurement of wavefront aberration in the living human eye have been widely available for clinical applications. Despite the extensive background experience on wavefront sensing for research purposes, the information derived from such instrumentation in a clinical setting shoul...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-4-1
更新日期：2004-02-11 00:00:00
abstract：PURPOSE:To report a case of atypical herpes simplex keratitis initially diagnosed as bacterial keratitis, in a contact lens wearer. RESULTS:Case report of an 18-year-old woman using contact lenses who presented with pain, redness and gradual decrease in vision in the right eye. Examination revealed a paracentral large...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-1-1
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:To report a case of orbital inflammation after bisphosphonate infusion in a patient who was already receiving immunosuppressive therapy. CASE PRESENTATION:A 56-year-old woman presented to the ophthalmology clinic with acute onset of right eye pain 24 h after receiving her first Zolendronic acid infusion. Sh...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-019-1063-8
更新日期：2019-02-14 00:00:00
abstract：BACKGROUND:Suture exposure remains to be a potential problem of transscleral fixated posterior chamber intraocular lens (PCIOL). We report a modified technique to minimize the risk of suture exposure for the transscleral fixation of PCIOL. METHODS:The modified surgical technique is as following: at first, two 3 mm × 4...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-015-0118-8
更新日期：2015-10-02 00:00:00
abstract：BACKGROUND:To determine the most effective route of administration of corticosteroids in the treatment of ocular surface disease, by characterizing the difference between oral prednisolone and topical dexamethasone administration using an animal model. METHODS:Pharmacokinetic analyses determined the corticosteroid con...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-016-0339-5
更新日期：2016-09-05 00:00:00
abstract：BACKGROUND:To investigate the clinical features of diabetic macular edema (DME) in eyes with pachychoroid phenotypes using multimodal retinal imaging. METHODS:We retrospectively reviewed 210 eyes from 210 DME patients and analyzed the clinical and imaging parameters, including visual acuity, central macular thickness ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01663-y
更新日期：2020-10-02 00:00:00
abstract：BACKGROUND:Raised intraocular pressure (IOP) is the only causal risk factor for glaucoma that can be therapeutically manipulated to change the course of the disease process. Though Goldman applanation tonometry (GAT) is the "gold standard" for IOP measurement, readings of IOP with GAT are affected by central corneal th...
journal_title：BMC ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2415-12-58
更新日期：2012-11-27 00:00:00
abstract：BACKGROUND:Combined branch retinal artery and central retinal vein occlusion is a rare condition that has been infrequently reported. This case report, aside from reporting the above-mentioned condition, highlights the importance of performing spectral domain optical coherence tomography in establishing a complete diag...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-91
更新日期：2014-07-12 00:00:00
abstract：BACKGROUND:Adenovirus (Ad), associated with significant morbidity, has no topical treatment. A leading CTC compound (CTC-96), a Co(III) chelate, was found to have potent in vitro and in vivo antiviral efficacy against herpes viruses. In this study CTC-96 is being tested for possible anti-Adenovirus activity. METHODS:T...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-6-22
更新日期：2006-06-05 00:00:00
abstract：BACKGROUND:A patient's health literacy is fundamental for navigating the health system and managing disease. This study aimed to compare the health literacy levels of patients with chronic retinal disease in Denmark. METHODS:This cross-sectional questionnaire study used the validated HLS-EU-Q16 questionnaire to determ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-019-1191-1
更新日期：2019-08-08 00:00:00
abstract：BACKGROUND:We present a case of post-traumatic endophthalmitis with relatively good prognosis caused by Gordonia sputi, which, to our knowledge is the first case in the literature. CASE PRESENTATION:A 24 year old man, who underwent an intraocular foreign body extraction half a month before presentation in the left eye...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-017-0573-5
更新日期：2017-10-11 00:00:00
abstract：BACKGROUND:Differences in the increase in matrix metalloproteinase (MMP) and decrease in tissue inhibitor of metalloproteinase (TIMP) activity may contribute to the different characteristics observed clinically on decreased intraocular pressure in patients with glaucoma or ocular hypertension. The purpose of this study...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-016-0202-8
更新日期：2016-03-08 00:00:00
abstract：BACKGROUND:Dry eye is a common problem that affects many people worldwide, reducing quality of life and impacting daily activities. A qualitative approach often used in medicine and other disciplines is used to evaluate how people with dry eye cope with this impact. METHODS:Six focus group sessions were conducted at t...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0671-z
更新日期：2018-01-16 00:00:00
abstract：BACKGROUND:To report a case of late closure of idiopathic full-thickness macular hole (FTMH) after vitrectomy with the inverted internal limiting membrane (ILM) technique. CASE PRESENTATION:A 68-year-old lady with a stage IV FTMH underwent pars plana vitrectomy with 25 gauge plus transconjunctival system, ILM peeling ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-015-0104-1
更新日期：2015-08-26 00:00:00
abstract：BACKGROUND:This study sought to identify factors associated with retinal detachment and retreatment of aggressive posterior retinopathy of prematurity (APROP) initially treated with intravitreal ranibizumab (IVR) injection as well as the efficacy of IVR treatment. METHODS:This was a retrospective study. A total of 83 ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0815-1
更新日期：2018-06-26 00:00:00
abstract：BACKGROUND:Investigating the efficacy and safety of phacoemulsification with intraocular lens (IOL) implantation in corneal opacities. METHODS:This retrospective study was conducted in a tertiary medical center. Twenty-three eyes of 19 patients with cataracts and corneal opacities obscuring the pupillary center having...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0765-7
更新日期：2018-04-23 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear. METHODS:This is a prospective study. Fifty-seven subjects with up to 1.50 diopters (D) of co...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01477-y
更新日期：2020-06-19 00:00:00
abstract：BACKGROUND:To compare scleral buckling (SB) and pars plana vitrectomy (PPV) using a wide angle viewing system (WAVS) for uncomplicated phakic rhegmatogenous retinal detachment (RRD). METHODS:The medical records of patients with uncomplicated phakic RRD were retrospectively reviewed. Eyes with pseudophakic or attached ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-015-0109-9
更新日期：2015-09-11 00:00:00
abstract：BACKGROUND:Retinitis pigmentosa (RP) is a kind of inherited retinal degenerative diseases characterized by the progressive loss of photoreceptors. RP has been a conundrum without satisfactory countermeasures in clinic until now. Acetaldehyde dehydrogenase 2 (ALDH2), a major enzyme involved in aldehyde detoxification, h...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-1330-8
更新日期：2020-02-18 00:00:00
abstract：BACKGROUND:The ability to image wide fundus fields and to conduct swift, non-invasive examinations is increasingly important with the escalation in patients with diabetic retinopathy (DR). METHODS:Fifty eyes of 28 consecutive patients with DR were examined in this prospective observational study. A total of 46 eyes, 2...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-1011-z
更新日期：2018-12-20 00:00:00
abstract：BACKGROUND:To evaluate therapeutic outcomes of interferon alpha-2a (IFNα2a) treatment in patients with Behcet's disease who were refractory to immunosuppressive agents. METHODS:This retrospective case series reviewed the medical records of 5 patients with refractory Behcet uveitis from January 2011 to February 2017. I...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0719-0
更新日期：2018-02-20 00:00:00
abstract：BACKGROUND:The current study compared optical quality before and after implantation of a posterior chamber phakic intraocular lens with a central hole [V4c implantable collamer lens (ICL)] under bright and dark lighting conditions by means of the Optical Quality Analysis System™ (OQAS; Visiometrics, Terrassa, Spain). ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01340-0
更新日期：2020-03-04 00:00:00
abstract：BACKGROUND:To study the value and safety of aqueous humor polymerase chain reaction (PCR) analysis for Herpes simplex, varicella zoster, cytomegalovirus, Epstein-Barr virus and Toxoplasma gondii in patients with uveitis. METHODS:Records of 45 consecutive patients with anterior and posterior uveitis who underwent AC pa...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-016-0369-z
更新日期：2016-10-28 00:00:00
abstract：BACKGROUND:To investigate the effect of idiopathic epiretinal membrane (ERM) on the retinal-image quality and psychophysical contrast sensitivity function (CSF). METHODS:Forty-four subjects with diagnosis of idiopathic unilateral ERM were enrolled in this cross-sectional observational clinical study. The fellow unaffe...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0957-1
更新日期：2018-11-07 00:00:00
abstract：BACKGROUND:We report a case of Meige's syndrome induced by an atypical antipsychotic (blonanserin) that presented with refractory dry eye disease. CASE PRESENTATION:A 37-year-old woman with a 6-month history of foreign body sensation in the eyes and difficulty in opening her eyes was treated at a local clinic for dry ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01738-w
更新日期：2020-12-02 00:00:00
abstract：BACKGROUND:Acute acquired comitant esotropia (AACE) is a type of strabismus characterized by a sudden onset of large angle esotropia with diplopia, which often occurs in children after infancy, teenagers, and young adolescents. However, studies on the surgical outcomes of only adults are rare. The purpose of this artic...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01793-3
更新日期：2021-01-18 00:00:00
abstract：BACKGROUND:To investigate the clinical relevance of two different preservative formulations, we compared 1-year incidence rates of additional coding of dry eye, ocular infection, or ocular surface disease (either dry eye or ocular infection) in open-angle glaucoma and ocular hypertension patients newly treated with lat...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-11-14
更新日期：2011-06-14 00:00:00
