Abstract:
BACKGROUND:To study the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSC) against retinal neovascularization and to compare with anti-vascular endothelial growth factor (VEGF) therapy. METHODS:Neonatal C57BL/6 mice were exposed in hyperoxygen and returned to room air to develop oxygen-induced retinopathy (OIR). Red fluorescent protein-labeled BMSC and Conbercept were intravitreally injected into OIR mice, respectively. Inhibition of neovascularization and apoptosis in OIR mice were assessed through retinal angiography, histopathology and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. RESULTS:BMSC were able to migrate and integrate into the host retina, significantly inhibit retinal neovascular tufts and remodel the capillary network after injecton. Treatment with BMSC increased the retinal vascular density, decreased the number of acellular capillaries and inhibited retinal cell death. This effect was not inferior to current anti-VEGF therapy by using Conbercept. CONCLUSIONS:Intravitreal injection of BMSC exerts a protective effect against retinal neovascularization and offers a therapeutic strategy for oxygen-induced retinopathy.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Xu W,Cheng W,Cui X,Xu Gdoi
10.1186/s12886-019-1292-xsubject
Has Abstractpub_date
2020-01-06 00:00:00pages
7issue
1issn
1471-2415pii
10.1186/s12886-019-1292-xjournal_volume
20pub_type
杂志文章abstract:BACKGROUND:A cyclodialysis cleft often leads to direct communication between the anterior chamber and the suprachoroidal space. It is a rare condition that is encountered with blunt trauma, and less commonly, after surgery. Hypotony is the major sequelae that may lead to hypotonous maculopathy, optic disc edema, cornea...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01375-3
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:To assess visual outcomes over 24 months in patients with neovascular age-related macular degeneration (nAMD) who initiated intravitreal aflibercept therapy under a treat-and-extend (TE) regimen in real-world settings. METHODS:In this retrospective, observational, multicentre study in Slovenia, medical reco...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12886-018-1005-x
更新日期:2018-12-20 00:00:00
abstract:BACKGROUND:Blank cartridge guns are generally regarded as being harmless and relative safe. However recent published articles demonstrated that the gas pressure from the exploding propellant of blank cartridge is powerful enough to penetrate the thoracic wall, abdominal muscle, small intestine and the skull. And there ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-23
更新日期:2014-03-03 00:00:00
abstract:BACKGROUND:The effectiveness of ranibizumab in the treatment of diabetic macular edema has been proven with large clinical trials. For bevacizumab only two clinical trials have been published and a head-to-head comparison is lacking to date. However, if proved non-inferior to ranibizumab, use of the off-label bevacizum...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12886-015-0043-x
更新日期:2015-07-07 00:00:00
abstract:BACKGROUND:Endogenous endophthalmitis could lead to a devastating outcome without a prompt and appropriate management. We report a case of advanced endogenous Klebsiella pneumoniae endophthalmitis with extensive subretinal abscess that was successfully treated with a vitrectomy. CASE PRESENTATION:A systemically well 6...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0908-x
更新日期:2018-09-05 00:00:00
abstract:BACKGROUND:To report the successful treatment of ocular toxoplasmosis and present the use of multimodal imaging to describe the changes in ocular toxoplasmic lesions subsequent to treatment. CASE PRESENTATION:A 73-year-old female visited the clinic with decreased visual acuity in the left eye. Fundus examination showe...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1209-8
更新日期:2019-09-05 00:00:00
abstract:BACKGROUND:Few reports have described the ophthalmic complications that occur after maxillary orthognathic surgery. Since cases of decreased reflex tearing after maxillary orthognathic surgery are extremely rare, we describe 2 cases of loss of reflex tearing after maxillary orthognathic surgery. CASE PRESENTATION:Two ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-37
更新日期:2014-03-28 00:00:00
abstract:BACKGROUND:Acute acquired comitant esotropia (AACE) is a type of strabismus characterized by a sudden onset of large angle esotropia with diplopia, which often occurs in children after infancy, teenagers, and young adolescents. However, studies on the surgical outcomes of only adults are rare. The purpose of this artic...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01793-3
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND:Currently, various types of toric intraocular lenses (IOL) have been manufactured and can be divided into three types according to the location of correction component; front-toric IOL (correction on anterior IOL surface), back-toric IOL (correction on posterior IOL surface), and bi-toric IOL (correction on ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01439-4
更新日期:2020-04-28 00:00:00
abstract:BACKGROUND:To evaluate the effectiveness of intravitreal bevacizumab (IVB) and intravitreal ranibizumab (IVR) in actual practice for treating patients with retinal diseases in Thailand. METHODS:A prospective, multi-centre, observational study was conducted among eight hospitals in their ophthalmology outpatient depart...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12886-019-1086-1
更新日期:2019-03-29 00:00:00
abstract:BACKGROUND:To compare scleral buckling (SB) and pars plana vitrectomy (PPV) using a wide angle viewing system (WAVS) for uncomplicated phakic rhegmatogenous retinal detachment (RRD). METHODS:The medical records of patients with uncomplicated phakic RRD were retrospectively reviewed. Eyes with pseudophakic or attached ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0109-9
更新日期:2015-09-11 00:00:00
abstract:BACKGROUND:To evaluate inner retinal dimples after peeling of the inner limiting membrane (ILM) for macular holes (lamellar macular hole [LMH] and full-thickness macular hole [FTMH]) via multiple imaging modes of spectral-domain optical coherence tomography (OCT) and to assess their relationship with preoperative vitre...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0828-9
更新日期:2018-06-27 00:00:00
abstract:BACKGROUND:The use of capsular tension ring (CTR) implantation to treat cataract patients with weak zonules is still controversial. The aim of this study was to examine the effects of CTR implantation on capsular stability after phacoemulsification in patients with weak zonules, especially patients who have undergone p...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01772-8
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:To predict the effectiveness of topical glaucoma medications based on initial uniocular and binocular treatment. To test a traditional hypothesis that effectiveness following a uniocular trial is associated with the change in IOP in the initially treated eye minus the change in the initially untreated eye. T...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-7-17
更新日期:2007-10-05 00:00:00
abstract:BACKGROUND:To evaluate the efficacy of triple therapy consisting of single-session photodynamic therapy (PDT), intravitreal bevacizumab (IVB) and intravitreal triamcinolone (IVT) as initial pulse therapy followed by repeat intravitreal bevacizumab injections for maintenance treatment in neovascular age-related macular ...
journal_title:BMC ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2415-7-10
更新日期:2007-06-07 00:00:00
abstract:PURPOSE:More than 3 million cataract extractions are undertaken in India annually. Almost 60% of these operations are intracapsular Cataract Extractions. The subsequent optical correction is provided by aphakic spectacles. The aim of this study is to assess visual outcome and perceived benefits of post-operative use of...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-3-9
更新日期:2003-07-28 00:00:00
abstract:BACKGROUND:Although most patients with visual impairment due to corneal diseases can be treated successfully with surgery, some require visual rehabilitation to restore reading ability. To evaluate the best LVAs especially in terms of reading speed and characterize this specific patient group we performed a prospective...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01436-7
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:To investigate the accommodative loads change needed to maintain binocular fusion in patients with intermittent exotropia (IXT). METHODS:Seventeen consecutive patients with basic IXT and 15 normal controls were recruited. The WAM-5500 autorefractor (GrandSeiko, Fukuyama, Japan) was used to measure refractiv...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0260-y
更新日期:2016-06-07 00:00:00
abstract:BACKGROUND:Proliferative retinopathy is an uncommon feature of Vogt Koyanagi Harada (VKH) disease which might indicate poor uveitis control in these patients. We aim to describe the clinical features and outcome of management of proliferative retinopathy in 2 patients with VKH. CASE PRESENTATION:19 and 33 years old fe...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01736-y
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The presence of an intraocular cilium is very rare and the response of the eye to the cilium is variable. We present the case of a patient with a cilium found in the vitreous cavity during vitrectomy for rhegmatogenous retinal detachment 40 years following penetrating eye injury. To our knowledge, this is th...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0010-6
更新日期:2015-03-12 00:00:00
abstract:BACKGROUND:This multicentre, retro-prospective real-world study evaluated the visual, refractive and safety outcomes of a monofocal lens 1 year after implantation in cataract patients with or without pre-existing ocular pathologies. METHODS:Records from 4 centres in Germany and Sweden were reviewed to select eyes with...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01493-y
更新日期:2020-06-11 00:00:00
abstract:BACKGROUND:To evaluate the changes of choroidal vascular structures in patients after phacoemulsification surgery. METHODS:A self-control study was conducted on 36 eyes of 36 patients who had uneventful phacoemulsification. Choroidal images were acquired preoperatively, 7 days (D7), 1 month (M1), and 3 months (M3) aft...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0749-7
更新日期:2018-03-23 00:00:00
abstract:BACKGROUND:Refractive errors, strabismus, nystagmus, amblyopia, and cortical visual impairment are observed in 50 to 90 % of patients with cerebral palsy. Ocular abnormalities are known to differ according to cerebral palsy type, and spastic type has been reported to be more likely to be associated with ocular defects ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0367-1
更新日期:2016-11-08 00:00:00
abstract:BACKGROUND:Fat embolism in the deep retinal capillary plexus is one of the reported mechanisms underlying central/paracentral scotoma in patients with Purtscher's retinopathy. Here we report the clear delineation of capillary dropout in the deep capillary plexus using optical coherence tomography angiography (OCTA) in ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0298-x
更新日期:2016-07-19 00:00:00
abstract:BACKGROUND:To evaluate the effects of anterior capsular opening size on deviation from predicted refraction and the effective position of the intraocular lens (ELP) in cataract surgery. METHODS:Nonrandomized clinical trial. Eighty patients (80 eyes) with simple age-related cataracts were treated from May 2018 to Septe...
journal_title:BMC ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1186/s12886-019-1068-3
更新日期:2019-02-21 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear. METHODS:This is a prospective study. Fifty-seven subjects with up to 1.50 diopters (D) of co...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01477-y
更新日期:2020-06-19 00:00:00
abstract:BACKGROUND:To describe the characteristics of patients with syphilitic uveitis in northern China. METHODS:A case series of 21 patients (33 eyes) diagnosed with syphilitic uveitis from 2011 to 2016 at a tertiary center in northern China was retrospectively analyzed. RESULTS:Twenty-one patients (33 eyes) were diagnosed...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0491-6
更新日期:2017-06-19 00:00:00
abstract:BACKGROUND:Idiopathic elevated episcleral venous pressure (IEEVP) or idiopathic dilated episcleral veins (IDEV) is a rare abnormality, and thus therapeutic treatment for this condition rarely is discussed. We report a case of a patient with bilateral glaucoma secondary to IDEV for whom intraocular pressures (IOPs) were...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0892-1
更新日期:2018-08-23 00:00:00
abstract:BACKGROUND:To compare the corneal high-order aberrations (HOAs), asphericity and regularity after Q-value guided laser in situ keratomileusis (LASIK) and laser epithelial keratomileusis (LASEK) in high myopic astigmatism. METHODS:In this retrospectively comparative study, we measured the corneal HOAs, asphericity indi...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-12-15
更新日期:2012-06-18 00:00:00
abstract:BACKGROUND:To assess the socio-demographic and health-related risk factors associated with cataract subtypes in Korea. METHODS:A total of 11,591 participants (aged ≥40 years) were selected from the Korean National Health and Nutrition Examination Survey between 2008 and 2010. The Korean Ophthalmologic Society conducte...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-4
更新日期:2014-01-10 00:00:00