The healing effect of the collagen-glycosaminoglycan copolymer on corneal thinning.

Abstract:

BACKGROUND:To study the healing processes of partial thickness wounds in the adult rabbit cornea after grafting a porous collagen-glycosaminoglycan copolymer matrix (CG). METHODS:In this study, the regeneration of surgically-induced rabbit corneal defect implanted with CG was investigated. The corneal partial thickness wound was created by 7.5 mm trephine. The wound was implanted with CG. Effects on wound healing was analyzed using clinical data on epithelial migration and corneal thickness, and histological data on collagen and alpha smooth muscle actin distribution. RESULTS:Compared with control group, CG induced a relatively severe inflammatory reaction in grafted cornea until the CG matrix was completely degraded. The new vessel ingrowth and stromal regeneration maintained the corneal thickness. The grafted cornea was significantly thicker (P < 0.001) than the control group. On day 90, the corneal opacity score of the control group was one and the grafted cornea was two. CONCLUSION:CG copolymer matrix can successfully repair the damaged corneal stroma by injury, and regain its thickness. However, CG matrix induced inflammatory healing process thus causing mild corneal haziness and neovascularization.

journal_name

BMC Ophthalmol

journal_title

BMC ophthalmology

authors

Wu SY,Pan CY,Shen EP,Tzeng IS,Hsu WC

doi

10.1186/s12886-018-0947-3

subject

Has Abstract

pub_date

2018-10-25 00:00:00

pages

275

issue

1

issn

1471-2415

pii

10.1186/s12886-018-0947-3

journal_volume

18

pub_type

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