Abstract:
BACKGROUND:To evaluate the correlation between visual acuity improvement and vision-related QOL after ranibizumab treatment in Japanese patients with AMD. METHODS:In this one-year prospective, interventional, open-label, multicenter study involving four sites, patients with neovascular AMD were enrolled and observed for 12 months. Treatment-naïve patients received 0.5 mg ranibizumab as needed after three initial monthly doses. The best corrected visual acuity (BCVA) and central macular thickness (CMT) were measured at every visit. Evaluations with the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and patient satisfaction questionnaire were performed at baseline and 3 and 12 months after initial treatment. The primary endpoint was change in BCVA and QOL 3 months after ranibizumab treatment. QOL outcomes were also assessed in the better and poor BVCA subgroups. RESULTS:The study enrolled 100 patients. The mean logMAR BCVA after treatment improved significantly from 0.43 to 0.30 at 3 months (p< 0.0001), and 0.28 at 12 months (p< 0.0001). The mean NEI-VFQ-25 composite scores improved from 79.48 to 84.13 at 3 months (p< 0.0001), and 86.0 at 12 months (p< 0.0001). The 3 and 12-month changes in NEI-VFQ-25 score and BCVA showed significant correlation. In the poor baseline visual acuity group (decimal BCVA ≤0.5), there was a significant correlation between the changes in the NEI-VFQ-25 score and BCVA (p=0.02) but not in the better baseline visual acuity group (decimal BCVA > 0.6, p=0.1) at 3 months. There were no significant differences in the satisfaction questionnaire score from baseline to at 3 months (p=0.54) and 12 months (p=0.23). The average CMT improved significantly from 340 to 264 μm at 3 months (p< 0.0001) and to 268 μm at 12 months (p< 0.0001). CONCLUSIONS:Intravitreal ranibizumab treatment resulted in improvement in visual acuity, anatomical change, and visual function change in Japanese AMD patients. Significant improvement was seen in patient visual function, and this was correlated with changes in VA, except immediately after loading dose treatment in patients with higher baseline VA. The patients' satisfaction with the treatment remained unchanged during the study period. TRIAL REGISTRATION:This study is registered at UMIN Clinical Trials Registry ( UMIN000012013 ). Registered October 10, 2013, as prospective study.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Oshima Y,Ishibashi Y,Umeda N,Nagata T,Yoshida S,Uchio E,Kondo H,Sonoda KH,Ishibashi Tdoi
10.1186/s12886-021-01816-7subject
Has Abstractpub_date
2021-01-23 00:00:00pages
58issue
1issn
1471-2415pii
10.1186/s12886-021-01816-7journal_volume
21pub_type
杂志文章abstract:BACKGROUND:The gold standard treatments in amblyopia are penalizing therapies, such as patching or blurring vision with atropine that are aimed at forcing the use of the amblyopic eye. However, in the last years, new therapies are being developed and validated, such as dichoptic visual training, aimed at stimulating th...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0501-8
更新日期:2017-06-28 00:00:00
abstract:BACKGROUND:Retinal dystrophies display a considerably wide range of phenotypic variability, which can make diagnosis and clinical staging difficult. The aim of the study is to analyze the contribution of retro-mode imaging (RMI) and fundus autofluorescence (FAF) to the characterization of retinal dystrophies. METHODS:...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-12-8
更新日期:2012-05-15 00:00:00
abstract:BACKGROUND:A 23 year old white male with a history of social and behavioural problems attempted to blind himself chemically, with alcohol, and mechanically, with a razor blade. METHODS:Observational case report of a patient who self-inflicted bilateral scleral lacerations with a razor blade, after losing his job. RES...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-9-14
更新日期:2009-12-10 00:00:00
abstract:BACKGROUND:Patient education materials should be written at a level that is understandable for patients with low health literacy. The aims of this study are (1) to review the literature on readability of ophthalmic patient education materials and (2) to evaluate and revise our institution's patient education materials ...
journal_title:BMC ophthalmology
pub_type: 杂志文章,评审
doi:10.1186/s12886-016-0315-0
更新日期:2016-08-03 00:00:00
abstract:BACKGROUND:To evaluate the 6-month clinical outcomes of Flexivue Microlens refractive corneal inlay in emmetropic patients in Asia for the surgical compensation of presbyopia. METHODS:In this retrospective study, corneal inlay implantation was done using a femtosecond laser. The follow-up period was 6 months. Near/int...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1069-2
更新日期:2019-03-05 00:00:00
abstract:BACKGROUND:Ocular coloboma is an excavation of ocular structures that occurs due to abnormal fusion of the embryonic optic fissure. Further, cleft lip/palate (CL/P), a congenital midline abnormality, is caused by a defect in the fusion of the frontonasal, maxillary, and mandibular prominences. No study has reported the...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01696-3
更新日期:2020-10-19 00:00:00
abstract:BACKGROUND:To gain more insight into genetic causes of cerebral visual impairment (CVI) in children and to compare ophthalmological findings between genetic and acquired forms of CVI. METHODS:The clinical data of 309 individuals (mainly children) with CVI, and a visual acuity ≤ 0.3 were analyzed for etiology and ocula...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-59
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the interocular differences in the peripapillary retinal nerve fibre layer (RNFL), peripapillary choroidal thickness (PCT) and subfoveal choroidal thickness (SFCT) in healthy adults with isometropia, using enhanced depth imaging optical coherence tomography (EDI SD-OCT)...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0361-7
更新日期:2016-10-19 00:00:00
abstract:BACKGROUND:Ocular signs of Fabry disease can be seen in the first decade of life. METHODS:We examined the occurrence of ocular signs in 232 paediatric patients in the Fabry Outcome Survey (FOS) international registry and looked for relationships between the presence of eye findings and disease severity as measured by ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0374-2
更新日期:2016-11-16 00:00:00
abstract:BACKGROUND:To report patients with age-related macular degeneration and atypical central retinal pigment epithelium (RPE) defects not attributable to geographic atrophy (GA) or RPE-tears with overlying preserved photoreceptor layers. METHODS:Multimodal imaging case-series evaluating the course of atypical RPE- defects...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12886-017-0452-0
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND:To evaluate the safety and effectiveness of the Visian Implantable Collamer Lens (ICL) implantation in high myopic patients with inactive Graves' ophthalmopathy (GO) by observing the changes of choroidal thickness (CT). METHODS:Eight patients (16 eyes) with high myopia accompanied with inactive GO were sele...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01612-9
更新日期:2020-08-25 00:00:00
abstract:BACKGROUND:To investigate the effect of idiopathic epiretinal membrane (ERM) on the retinal-image quality and psychophysical contrast sensitivity function (CSF). METHODS:Forty-four subjects with diagnosis of idiopathic unilateral ERM were enrolled in this cross-sectional observational clinical study. The fellow unaffe...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0957-1
更新日期:2018-11-07 00:00:00
abstract:BACKGROUND:Idiopathic elevated episcleral venous pressure (IEEVP) or idiopathic dilated episcleral veins (IDEV) is a rare abnormality, and thus therapeutic treatment for this condition rarely is discussed. We report a case of a patient with bilateral glaucoma secondary to IDEV for whom intraocular pressures (IOPs) were...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0892-1
更新日期:2018-08-23 00:00:00
abstract:BACKGROUND:Perfluorocarbon liquid (PFCL) is widely used as an intraoperative heavy tamponade to flatten the retina and is replaced with silicone oil (SO) at the end of the surgery. Due to the long tamponade period, the SO is known to remain attached to the retina at the time of removal, and is commonly termed "sticky o...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0745-y
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:To report a case of branch retinal artery occlusion (BRAO) secondary to high-altitude exposure and diabetic retinopathy (DR), and to characterize the retinal changes before and after hyperbaric oxygen (HBO) treatment. CASE PRESENTATION:We present a case of a 42-year-old man with DR who travelled to Tibet (i...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01563-1
更新日期:2020-07-11 00:00:00
abstract:BACKGROUND:Glaucoma is a major cause of blindness worldwide and an increasingly significant global health problem. Glaucoma prevention and management efforts have been challenging due to inherent difficulty in developing a simple and cost-effective screening plan, limited access to health care and educational resources...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-8-21
更新日期:2008-10-26 00:00:00
abstract:BACKGROUND:With age, the human lens accumulates variety of substances that absorbs and fluorescence, which explains the color of yellow, brunescent and nigrescent cataract in terms of aging. The aim of this study was to assess lens fluorophores with properties comparable to those of advanced glycated end products (AGEs...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-6-10
更新日期:2006-03-06 00:00:00
abstract:BACKGROUND:Older drivers aged ≥70 years old have among the highest rates of motor vehicle collisions (MVC) compared to other age groups. Driving is a highly visual task, and older adults have a high prevalence of vision impairment compared to other ages. Most studies addressing visual risk factors for MVCs by older dri...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0686-5
更新日期:2018-02-07 00:00:00
abstract:BACKGROUND:Refraction change of silicone oil (SO) tamponade in phakic and aphakic eye has been studied thoroughly; however, it is rarely studied in pseudophakic eye. In this paper we aimed to deduce a theoretical formula predicting refractive shift of silicone oil tamponade in pseudophakic eye and compared it with clin...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0243-z
更新日期:2016-08-16 00:00:00
abstract:BACKGROUND:Sturge-Weber syndrome (SWS) is a sporadic congenital disorder, characterized by unilateral facial nevus flammeus associated with ipsilateral glaucoma, choroidal angioma and leptomeningeal hemangiomas. SWS can comorbid with other disorders in some patients, however, there has been no prior described case of S...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01761-x
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:To report a case of orbital inflammation after bisphosphonate infusion in a patient who was already receiving immunosuppressive therapy. CASE PRESENTATION:A 56-year-old woman presented to the ophthalmology clinic with acute onset of right eye pain 24 h after receiving her first Zolendronic acid infusion. Sh...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1063-8
更新日期:2019-02-14 00:00:00
abstract::Mucins locate to the apical surfaces of all wet-surfaced epithelia including ocular surface. The functions of the mucins include anti-adhesive, lubrication, water retention, allergens and pathogen barrier function. Ocular surface pathologies, i.e. dry eye syndrome or allergic conjunctivitis, are reportedly associated ...
journal_title:BMC ophthalmology
pub_type: 杂志文章,评审
doi:10.1186/s12886-015-0137-5
更新日期:2015-12-17 00:00:00
abstract:BACKGROUND:To report a case of disseminated fusariosis with endogenous endophthalmitis in a patient with acute lymphoblastic leukemia. Transfusion-associated immune modulation secondary to platelet transfusion could play an important role in the pathophysiology of this case. CASE PRESENTATION:A 9 year-old male with ac...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-11-30
更新日期:2011-11-02 00:00:00
abstract:BACKGROUND:The repertoire of free-living protozoa in contact lens solutions is poorly known despite the fact that such protozoa may act as direct pathogens and may harbor intra-cellular pathogens. METHODS:Between 2009 and 2014, the contact lens solutions collected from patients presenting at our Ophthalmology Departme...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0370-6
更新日期:2016-10-29 00:00:00
abstract:BACKGROUND:Graves' disease is a common autoimmune inflammatory condition of the thyroid. About one in four of affected patients also develop orbital symptoms like exophthalmos, proptosis and diplopia - called Graves' Ophthalmopathy. Not all patients respond well to the standard therapy of systemic glucocorticoid admini...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0718-1
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:Blank cartridge guns are generally regarded as being harmless and relative safe. However recent published articles demonstrated that the gas pressure from the exploding propellant of blank cartridge is powerful enough to penetrate the thoracic wall, abdominal muscle, small intestine and the skull. And there ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-23
更新日期:2014-03-03 00:00:00
abstract:BACKGROUND:To evaluate the relationships between Reichert Ocular Response Analyzer (ORA) parameters corneal hysteresis (CH) and corneal response factor (CRF) and ocular dimensions, age and intraocular pressure. METHODS:Two hundred and twelve eyes of 212 participants with no ocular pathology had CH and CRF measured wit...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-11
更新日期:2014-01-30 00:00:00
abstract:BACKGROUND:To report clinical features and risk factors of post-cataract surgery endophthalmitis (PE) due to Stenotrophomonas maltophilia. METHODS:A retrospective case review from December 10, 2010 to April 7, 2011 was performed at the Eye & ENT Hospital, Fudan University. Data were collected for surgical details, dis...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-15-14
更新日期:2015-01-24 00:00:00
abstract:BACKGROUND:Patients with primary angle closure/glaucoma (PAC/PACG) with extensive peripheral anterior synechiae (PAS), and coexisting cataract, increasingly have been treated with phacoemulsification combined with goniosynechialysis (Phaco-GSL). Since the mechanisms of acute and chronic PAC/PACG may differ, the treatme...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1070-9
更新日期:2019-03-04 00:00:00
abstract:BACKGROUND:we conducted our meta-analysis of published studies to assess existing evidence about the efficacy and safety of vitrectomy with ILM peeling vs. that of vitrectomy with no ILM peeling for Macular hole-induced retinal detachment. METHODS:Databases, including Pubmed, Cochrane Library, Ovid, Web of Science, Wa...
journal_title:BMC ophthalmology
pub_type: 杂志文章,meta分析
doi:10.1186/s12886-015-0048-5
更新日期:2015-06-20 00:00:00