The expression and significance of mTORC1 in diabetic retinopathy.

abstract：BACKGROUND:To evaluate the efficacy, complications, and clinical characteristics, including the ocular toxicity, of intravitreal melphalan(IVM) treatment for vitreous seeding in Chinese retinoblastoma patients. METHODS:This was a retrospective, non-comparative analysis including 30 consecutive eyes of 23 patients with...

journal_title：BMC ophthalmology

authors： Xue K,Ren H,Meng F,Zhang R,Qian J

更新日期：2019-02-26 00:00:00

abstract：BACKGROUND:Raised intraocular pressure (IOP) is the only causal risk factor for glaucoma that can be therapeutically manipulated to change the course of the disease process. Though Goldman applanation tonometry (GAT) is the "gold standard" for IOP measurement, readings of IOP with GAT are affected by central corneal th...

journal_title：BMC ophthalmology

authors： Gelaw Y

更新日期：2012-11-27 00:00:00

abstract：BACKGROUND:The tear film breakup time (tBUT) is a clinical evaluation of evaporative dry eye disease assessed by instilling topical fluorescein into the eyes. In the present study, we introduce a new diagnostic test, blinking tolerance time (BTT), for self-evaluation of tear-film stability. We compared the results with...

journal_title：BMC ophthalmology

authors： Hwang HB,Ku YH,Kim EC,Kim HS,Kim MS,Hwang HS

更新日期：2020-11-04 00:00:00

abstract：BACKGROUND:To investigate the clinical relevance of two different preservative formulations, we compared 1-year incidence rates of additional coding of dry eye, ocular infection, or ocular surface disease (either dry eye or ocular infection) in open-angle glaucoma and ocular hypertension patients newly treated with lat...

journal_title：BMC ophthalmology

authors： Schwartz GF,Kotak S,Mardekian J,Fain JM

更新日期：2011-06-14 00:00:00

abstract：BACKGROUND:To report a patient who presented with bluish scleral discoloration, keratoconus, and progressive high myopia. CASE PRESENTATION:A 6-year-old Chinese female patient presented with a significant bluish discoloration of the sclera in both eyes and extreme corneal thinning with anterior corneal protrusion. Gen...

journal_title：BMC ophthalmology

authors： Wan Q,Tang J,Han Y,Xiao Q,Deng Y

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Older drivers aged ≥70 years old have among the highest rates of motor vehicle collisions (MVC) compared to other age groups. Driving is a highly visual task, and older adults have a high prevalence of vision impairment compared to other ages. Most studies addressing visual risk factors for MVCs by older dri...

journal_title：BMC ophthalmology

authors： Owsley C,McGwin G Jr,Antin JF,Wood JM,Elgin J

更新日期：2018-02-07 00:00:00

abstract：BACKGROUND:Dry eye is a common problem that affects many people worldwide, reducing quality of life and impacting daily activities. A qualitative approach often used in medicine and other disciplines is used to evaluate how people with dry eye cope with this impact. METHODS:Six focus group sessions were conducted at t...

journal_title：BMC ophthalmology

authors： Yeo S,Tong L

更新日期：2018-01-16 00:00:00

abstract：BACKGROUND:There is no generally accepted medical or surgical treatment to stop the progressive course of retinitis pigmentosa. Previous studies have suggested lutein as a potential treatment with positive effects on macular pigment density. The objective of this study was to examine the effect of lutein supplementatio...

journal_title：BMC ophthalmology

authors： Bahrami H,Melia M,Dagnelie G

更新日期：2006-06-07 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the efficacy and safety of transepithelial corneal collagen crosslinking (transepithelial CXL) versus standard corneal collagen crosslinking (epithelium-off CXL) on keratoconus. METHODS:Eligible studies were identified by systematically searching PubMed, the Cochrane Li...

journal_title：BMC ophthalmology

authors： Li W,Wang B

更新日期：2017-12-28 00:00:00

abstract：BACKGROUND:Central Serous Chorioretinopathy (CSC) has been previously reported as an infrequent complication of pregnancy that usually resolves spontaneously after delivery, with minimal or no sequel. We report a case of a severe form of CSC in an uncomplicated pregnancy with extensive subfoveal exudates and severe per...

journal_title：BMC ophthalmology

authors： Maggio E,Polito A,Freno MC,Pertile G

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Immune responses play a key role in the pathogenesis and progression of polypoidal choroidal vasculopath (PCV) and age-related macular degeneration (AMD). In this study, we determined the Th cell-associated immune responses by measuring the cytokine expression of peripheral blood mononuclear cells (PBMC) in ...

journal_title：BMC ophthalmology

authors： Yu Y,Ren XR,Wen F,Chen H,Su SB

更新日期：2016-06-07 00:00:00

abstract：BACKGROUND:The aim of this study was to compare superior and temporal clear corneal incisions of uneventful phacoemulsification and in-the-bag intraocular lens implantation on intraocular pressure control and the bleb morphology in eyes that have undergone previous successful trabeculectomy. METHODS:In this Prospectiv...

journal_title：BMC ophthalmology

authors： Anbar M,Ammar H

更新日期：2017-06-26 00:00:00

abstract：BACKGROUND:Glaucoma is a progressive disease responsible for the second commonest cause of blindness in the UK. Identifying appropriate patients for hospital care remains an ongoing challenge for all UK hospital glaucoma services. The purpose of our study is to evaluate accuracy and outcome of community optometry refer...

journal_title：BMC ophthalmology

authors： El-Assal K,Foulds J,Dobson S,Sanders R

更新日期：2015-12-07 00:00:00

abstract：BACKGROUND:Refraction change of silicone oil (SO) tamponade in phakic and aphakic eye has been studied thoroughly; however, it is rarely studied in pseudophakic eye. In this paper we aimed to deduce a theoretical formula predicting refractive shift of silicone oil tamponade in pseudophakic eye and compared it with clin...

journal_title：BMC ophthalmology

authors： Fang W,Li J,Jin X,Zhai J,Dai Y,Li Y

更新日期：2016-08-16 00:00:00

abstract：BACKGROUND:Classification of optical coherence tomography (OCT) images can be achieved with high accuracy using classical convolution neural networks (CNN), a commonly used deep learning network for computer-aided diagnosis. Classical CNN has often been criticized for suppressing positional relations in a pooling layer...

journal_title：BMC ophthalmology

authors： Tsuji T,Hirose Y,Fujimori K,Hirose T,Oyama A,Saikawa Y,Mimura T,Shiraishi K,Kobayashi T,Mizota A,Kotoku J

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:Differences in the increase in matrix metalloproteinase (MMP) and decrease in tissue inhibitor of metalloproteinase (TIMP) activity may contribute to the different characteristics observed clinically on decreased intraocular pressure in patients with glaucoma or ocular hypertension. The purpose of this study...

journal_title：BMC ophthalmology

authors： Yamada H,Yoneda M,Gosho M,Kato T,Zako M

更新日期：2016-03-08 00:00:00

abstract：BACKGROUND:To understand which irregular corneal parameters determine the visual quality in keratoconus subjects. METHODS:The cross-sectional study examined the eyes of 44 subjects, graded from the first to third keratoconus stages by Amsler-Krumeich classification. We obtained measurements in two ways: (a) by project...

journal_title：BMC ophthalmology

authors： Liduma S,Luguzis A,Krumina G

更新日期：2020-11-26 00:00:00

abstract：:Meibomian gland dysfunction (MGD) is the major cause of evaporative dry eye disease (EDED) and dysfunction is widely thought to mechanistically involve ductal hyperkeratinization, plugging and obstruction. This review re-evaluates the role of hyperkeratinization in MGD based on more recent findings from mouse models. ...

journal_title：BMC ophthalmology

authors： Jester JV,Parfitt GJ,Brown DJ

更新日期：2015-12-17 00:00:00

abstract：BACKGROUND:Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial extraocular muscle myopathy, orbital inflammation and pain which may mimic ophthalmic Graves' diseas...

journal_title：BMC ophthalmology

authors： Erdei A,Steiber Z,Molnar C,Berenyi E,Nagy EV

更新日期：2018-01-12 00:00:00

abstract：BACKGROUND:A description of the diagnostic features of Miller Fisher syndrome. CASE PRESENTATION:The clinical presentation, investigation, and subsequent progress of our patient with clinical unilateral external ophthalmoplegia. CONCLUSION:Our case demonstrates the presentation of clinical unilateral external ophthal...

journal_title：BMC ophthalmology

authors： Smith J,Clarke L,Severn P,Boyce R

更新日期：2007-04-17 00:00:00

abstract：BACKGROUND:Fat embolism in the deep retinal capillary plexus is one of the reported mechanisms underlying central/paracentral scotoma in patients with Purtscher's retinopathy. Here we report the clear delineation of capillary dropout in the deep capillary plexus using optical coherence tomography angiography (OCTA) in ...

journal_title：BMC ophthalmology

authors： Tokimitsu M,Murata M,Toriyama Y,Hirano T,Iesato Y,Murata T

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:Polypoidal choroidal vasculopathy (PCV) consists of polyps that potentially cause massive subretinal hemorrhage and their branching vascular network (BVN) of feeder vessels. Although conventional indocyanine green angiography (IA) has shown anti-vascular endothelial growth factor (VEGF) agents and/or photody...

journal_title：BMC ophthalmology

authors： Iesato Y,Tanaka M,Murata M,Kitahara J,Hirano T,Kurenuma T,Yoshida N,Murata T

更新日期：2018-11-03 00:00:00

abstract：BACKGROUND:To evaluate the efficacy and safety of intravitreal conbercept (KH902) as the primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy. METHODS:This study was a retrospective, consecutive, observational case series. We reviewed medical records of 16 eyes (16 patients) with...

journal_title：BMC ophthalmology

authors： Peng Y,Zhang X,Mi L,Liu B,Zuo C,Li M,Wen F

更新日期：2017-06-12 00:00:00

abstract：BACKGROUND:To investigate machine learning methods, ranging from simpler interpretable techniques to complex (non-linear) "black-box" approaches, for automated diagnosis of Age-related Macular Degeneration (AMD). METHODS:Data from healthy subjects and patients diagnosed with AMD or other retinal diseases were collecte...

journal_title：BMC ophthalmology

authors： Fraccaro P,Nicolo M,Bonetto M,Giacomini M,Weller P,Traverso CE,Prosperi M,OSullivan D

更新日期：2015-01-27 00:00:00

abstract：BACKGROUND:Tibetan Plateau is a highland area with special geographical location, time zone, and ethnic composition. We herein report the rationale, methodology and baseline data of the school-based childhood cohort study named Lhasa Childhood Eye Study (LCES), with the primary objective to pursue a comprehensive under...

journal_title：BMC ophthalmology

authors： Chen W,Fu J,Meng Z,Li L,Su H,Dai W,Yao Y

更新日期：2020-06-22 00:00:00

abstract：BACKGROUND:To report the prevalence of ocular abnormalities and investigate visual acuity in a large cohort of retinitis pigmentosa (RP) patients in Western China. METHODS:The medical records and ophthalmic examination reports of 2127 eyes of 1065 RP patients at one eye hospital were retrospectively reviewed to determ...

journal_title：BMC ophthalmology

authors： Tan L,Long Y,Li Z,Ying X,Ren J,Sun C,Meng X,Li S

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:Cavernous carotid aneurysm (CCA) represents 2-9% of all intracranial aneurysms and 15% of internal carotid artery (ICA) aneurysms; additionally, giant aneurysms are those aneurysms that are > 25 mm in size. Bilateral CCAs account for 11-29% of patients and are commonly associated with structural weaknesses i...

journal_title：BMC ophthalmology

authors： Vanikieti K,Poonyathalang A,Jindahra P,Cheecharoen P,Chokthaweesak W

更新日期：2018-02-02 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the changes in corneal epithelial thickness along the principle meridians of astigmatic corneas after six months of overnight spherical myopic orthokeratology (OK) lens wear. METHODS:This is a prospective study. Fifty-seven subjects with up to 1.50 diopters (D) of co...

journal_title：BMC ophthalmology

authors： Zhou J,Xue F,Zhou X,Naidu RK,Qian Y

更新日期：2020-06-19 00:00:00

abstract：BACKGROUND:The case describes a rare entity. Most cases of IOL dislocation are associated with surgical trauma or preexisting zonulopathy. This patient presents IOL dislocation following routine exam, suggesting the need of careful evaluation of zonular integrity on pseudopahkic patients. METHODS:Patient is a 65 year ...

journal_title：BMC ophthalmology

authors： Castanos MV,Najac T,Dauhajre J,Buxton DF

更新日期：2020-01-30 00:00:00

abstract：BACKGROUND:A cyclodialysis cleft often leads to direct communication between the anterior chamber and the suprachoroidal space. It is a rare condition that is encountered with blunt trauma, and less commonly, after surgery. Hypotony is the major sequelae that may lead to hypotonous maculopathy, optic disc edema, cornea...

journal_title：BMC ophthalmology

authors： Bair H,Lin CJ,Lai CT,Hsia NY,Tsai YY

更新日期：2020-03-23 00:00:00