Abstract：
BACKGROUND:Immune responses play a key role in the pathogenesis and progression of polypoidal choroidal vasculopath (PCV) and age-related macular degeneration (AMD). In this study, we determined the Th cell-associated immune responses by measuring the cytokine expression of peripheral blood mononuclear cells (PBMC) in both PCV and neovascular AMD (nAMD) patients. METHODS:Twenty-seven nAMD patients, 33 PCV patients and a gender- and age-matched group of 18 healthy individuals were involved in this study. The Th-cell cytokine profiles including levels of interferon-gamma (INF-γ), interleukin (IL)-17A and IL-4 in cultures of PBMCs were determined by enzyme-linked immunosorbent assay (ELISA). RESULTS:IFN-γ,IL-17A and IL-4 production was significantly increased after stimulation with PHA. The levels of IFN-γ and IL-4 in PHA-stimulated cultures were higher in PCV and nAMD patients than that in healthy controls (P = 0.038,P = 0.014), while no difference was found between PCV and nAMD (all P > 0.05). No significant difference in IL-17A level in PHA-stimulated cultures was found among PCV, nAMD and control groups (P > 0.05). CONCLUSIONS:These findings suggest that circulating IFN-γ and IL-4 producing Th1 and Th2 cells may involve in the pathogenesis of PCV and nAMD. PCV may have the similar immune responses with nAMD.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Yu Y,Ren XR,Wen F,Chen H,Su SBdoi
10.1186/s12886-016-0251-zsubject
Has Abstractpub_date
2016-06-07 00:00:00pages
80issn
1471-2415pii
10.1186/s12886-016-0251-zjournal_volume
16pub_type
杂志文章abstract：BACKGROUND:The case describes a rare entity. Most cases of IOL dislocation are associated with surgical trauma or preexisting zonulopathy. This patient presents IOL dislocation following routine exam, suggesting the need of careful evaluation of zonular integrity on pseudopahkic patients. METHODS:Patient is a 65 year ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-1327-3
更新日期：2020-01-30 00:00:00
abstract：BACKGROUND:To study the healing processes of partial thickness wounds in the adult rabbit cornea after grafting a porous collagen-glycosaminoglycan copolymer matrix (CG). METHODS:In this study, the regeneration of surgically-induced rabbit corneal defect implanted with CG was investigated. The corneal partial thicknes...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0947-3
更新日期：2018-10-25 00:00:00
abstract：BACKGROUND:Classification of optical coherence tomography (OCT) images can be achieved with high accuracy using classical convolution neural networks (CNN), a commonly used deep learning network for computer-aided diagnosis. Classical CNN has often been criticized for suppressing positional relations in a pooling layer...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01382-4
更新日期：2020-03-19 00:00:00
abstract：BACKGROUND:This study compared the postoperative outcomes of 27-gauge (G) and 25-G vitrectomy performed for the treatment of idiopathic epiretinal membrane (ERM). METHODS:The study design was single center, retrospective, interventional case series. Two hundred consecutive eyes that underwent primary vitrectomy for ER...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-017-0585-1
更新日期：2017-10-10 00:00:00
abstract：BACKGROUND:We report the enhanced depth imaging optical coherence tomography (EDI-OCT) characteristics and variations in a patient with subretinal fluid secondary to a carotid cavernous fistula. CASE PRESENTATION:A 59-year-old man presented with blurred vision in his right eye. Venous congestion of the epiescleral and...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-016-0240-2
更新日期：2016-05-26 00:00:00
abstract：BACKGROUND:The aim of this study was to prove the relationship between the intraocular straylight level and diabetic retinopathy (DR) according to disease severity. Also, we aimed to evaluate whether diabetes mellitus (DM) per se could be a risk factor of increased intraocular straylight although we did not rely on a d...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-015-0120-1
更新日期：2015-10-13 00:00:00
abstract：BACKGROUND:Silicone oil tamponade has become a mainstay in treatment of advanced retinal detachment due to multiple etiologies. The aim of this study is to assess the characteristics, fates and complications of long-term silicone oil tamponade after par plana vitrectomy (PPV), and to compare the outcomes of different s...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01608-5
更新日期：2020-08-17 00:00:00
abstract：BACKGROUND:Patients' feedback is of great importance in health care policy decisions. The Consumer Quality Index Cataract Questionnaire (CQI Cataract) was used to measure patients' experiences with quality of care after a cataract operation. This study aims to evaluate the reliability and the dimensional structure of t...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-7-14
更新日期：2007-09-19 00:00:00
abstract：BACKGROUND:Suture exposure remains to be a potential problem of transscleral fixated posterior chamber intraocular lens (PCIOL). We report a modified technique to minimize the risk of suture exposure for the transscleral fixation of PCIOL. METHODS:The modified surgical technique is as following: at first, two 3 mm × 4...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-015-0118-8
更新日期：2015-10-02 00:00:00
abstract：BACKGROUND:Characterization of the neuro-glial profile of cells growing out of human idiopathic epiretinal membranes (iERMs) and testing their proliferative and pluripotent properties ex vivo is needed to better understand the pathogenesis of their formation. METHODS:iERMs obtained during uneventful vitrectomies were ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-165
更新日期：2014-12-23 00:00:00
abstract：BACKGROUND:To evaluate the safety and effectiveness of the Visian Implantable Collamer Lens (ICL) implantation in high myopic patients with inactive Graves' ophthalmopathy (GO) by observing the changes of choroidal thickness (CT). METHODS:Eight patients (16 eyes) with high myopia accompanied with inactive GO were sele...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01612-9
更新日期：2020-08-25 00:00:00
abstract：BACKGROUND:To evaluate results after seven years using prophylactic intracameral cefazolin for the prevention of endophthalmitis in cataract surgery. METHODS:A prospective, observational study of all patients submitted to cataract surgery over the period January 1996 to December 2009. All cases of postoperative endoph...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-12-2
更新日期：2012-01-24 00:00:00
abstract：BACKGROUND:This multicentre, retro-prospective real-world study evaluated the visual, refractive and safety outcomes of a monofocal lens 1 year after implantation in cataract patients with or without pre-existing ocular pathologies. METHODS:Records from 4 centres in Germany and Sweden were reviewed to select eyes with...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01493-y
更新日期：2020-06-11 00:00:00
abstract：BACKGROUND:Previous studies described cases of Ocriplasmin injections in patients with vitreo-macular traction and reduced central visual acuity. We describe the first case of a patient with 20/20 visual acuity and vitreo-macular traction treated with Ocriplasmin, and, for the first time in literature, we evaluated the...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-015-0141-9
更新日期：2015-10-29 00:00:00
abstract：BACKGROUND:To evaluate the structural changes associated with visual acuity (VA) in patients with idiopathic macular telangiectasia (MT) type 1 using multimodal imaging modalities. METHODS:A retrospective study of 14 patients with MT type 1 and of 10 eyes from 10 healthy individuals as age-matched controls was conduct...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0737-y
更新日期：2018-03-05 00:00:00
abstract：BACKGROUND:Uncorrected refractive errors contribute enormously to the burden of avoidable visual impairment worldwide. There is a huge disparity in different parts of the globe in context to spectacle coverage for distance vision. This study was undertaken with objectives of determining prevalence of spectacle coverage...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-019-1262-3
更新日期：2019-12-12 00:00:00
abstract：BACKGROUND:Retinoblastoma (RB) is the most frequent pediatric retinal tumor. In the present study, to elucidate chemoresistance mechanisms and identify potential biomarkers in RB, we utilized RNA sequencing (RNAseq) technological platforms to reveal transcriptome profiles and identify any differentially expressed genes...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01348-6
更新日期：2020-03-06 00:00:00
abstract：BACKGROUND:To evaluate the effectiveness of intravitreal bevacizumab (IVB) and intravitreal ranibizumab (IVR) in actual practice for treating patients with retinal diseases in Thailand. METHODS:A prospective, multi-centre, observational study was conducted among eight hospitals in their ophthalmology outpatient depart...
journal_title：BMC ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1186/s12886-019-1086-1
更新日期：2019-03-29 00:00:00
abstract：BACKGROUND:Combined branch retinal artery and central retinal vein occlusion is a rare condition that has been infrequently reported. This case report, aside from reporting the above-mentioned condition, highlights the importance of performing spectral domain optical coherence tomography in establishing a complete diag...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-91
更新日期：2014-07-12 00:00:00
abstract：BACKGROUND:Older drivers have a crash rate nearly equal to that of young drivers whose crash rate is the highest among all age groups. Contrast sensitivity impairment is common in older adults. The purpose of this study is to examine whether parameters from the photopic and mesopic contrast sensitivity functions (CSF) ...
journal_title：BMC ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1186/s12886-020-1331-7
更新日期：2020-02-04 00:00:00
abstract：BACKGROUND:With age, the human lens accumulates variety of substances that absorbs and fluorescence, which explains the color of yellow, brunescent and nigrescent cataract in terms of aging. The aim of this study was to assess lens fluorophores with properties comparable to those of advanced glycated end products (AGEs...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-6-10
更新日期：2006-03-06 00:00:00
abstract：BACKGROUND:Few reports have described the ophthalmic complications that occur after maxillary orthognathic surgery. Since cases of decreased reflex tearing after maxillary orthognathic surgery are extremely rare, we describe 2 cases of loss of reflex tearing after maxillary orthognathic surgery. CASE PRESENTATION:Two ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-37
更新日期：2014-03-28 00:00:00
abstract：BACKGROUND:Surgeons may be unaware of the ability of plant toxins to cause corneal damage. Therefore, corneal damage following intraocular surgery due to plant toxins may be misdiagnosed as postoperative infection. CASE PRESENTATION:A 74-year-old man presented with hyperemia and reduced visual acuity in both eyes 6 we...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-017-0400-z
更新日期：2017-01-18 00:00:00
abstract：BACKGROUND:The signaling pathway of epithelial to mesenchymal transition (EMT) is regulated by c-Src kinase in many cells. The purpose of this study was to investigate the effects of c-Src kinase on EMT of human lens epithelial cells in vivo stimulated by different factors. METHODS:Human lens epithelial cells, HLE-B3,...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-019-1229-4
更新日期：2019-11-08 00:00:00
abstract：BACKGROUND:Physical cooling of the eye surface relieves ocular discomfort, but translating this event to drug treatment of dry eye discomfort not been studied. Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively activates TRPM8 (linked to co...
journal_title：BMC ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12886-017-0495-2
更新日期：2017-06-26 00:00:00
abstract：BACKGROUND:We explore and compare the advantages and disadvantages of different operating methods for a peripheral iridectomy (PI) for phakic posterior chamber implantable contact lens (ICL) implantation in patients with dark-brown irides. METHODS:Forty-six patients completed this prospective comparative study. Neodym...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-016-0229-x
更新日期：2016-05-05 00:00:00
abstract：BACKGROUND:Raised intraocular pressure (IOP) is the only causal risk factor for glaucoma that can be therapeutically manipulated to change the course of the disease process. Though Goldman applanation tonometry (GAT) is the "gold standard" for IOP measurement, readings of IOP with GAT are affected by central corneal th...
journal_title：BMC ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2415-12-58
更新日期：2012-11-27 00:00:00
abstract：BACKGROUND:To report a case of proliferative diabetic retinopathy (PDR) exhibiting the appearance of scintillating particles presumed to be crystallin inside the intravitreal cavity after laser photocoagulation. CASE PRESENTATION:A 56-year-old male patient presented at our outpatient clinic after becoming aware of dec...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-017-0654-5
更新日期：2017-12-19 00:00:00
abstract：BACKGROUND:We present a case of post-traumatic endophthalmitis with relatively good prognosis caused by Gordonia sputi, which, to our knowledge is the first case in the literature. CASE PRESENTATION:A 24 year old man, who underwent an intraocular foreign body extraction half a month before presentation in the left eye...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-017-0573-5
更新日期：2017-10-11 00:00:00
abstract：BACKGROUND:Numerous studies have suggested that the integrity of the cone interdigitation zone (IZ) could be considered to be a marker of photoreceptor damage and its recovery. However, little is known about the IZ in healthy eyes. Our present study was to measure the cone IZ area by optical coherence tomography (OCT),...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0862-7
更新日期：2018-08-01 00:00:00
