Abstract：
BACKGROUND:Numerous studies have suggested that the integrity of the cone interdigitation zone (IZ) could be considered to be a marker of photoreceptor damage and its recovery. However, little is known about the IZ in healthy eyes. Our present study was to measure the cone IZ area by optical coherence tomography (OCT), and determine its distribution in healthy adults. METHODS:This was a cross-sectional non-interventional study. We involved a group of 158 emmetropic or low myopic (from -3D to + 0.5D) eyes in 97 healthy adult volunteers. All subjects underwent thorough ophthalmologic examinations and the posterior pole was scanned by OCT. The cone IZ area in healthy adults and its correlation with macular volume and other factors was analyzed. RESULTS:The cone IZ was visible and clear in all 158 eyes, and the IZ area was successfully measured by 6 radical scans centered on the fovea. The mean IZ area was 30.22 ± 12.70 mm2, and ranged from 5.91 to 57.47 mm2. The IZ area exhibited a normal distribution (P = 0.635) with 95% confidence interval of 28.06-32.29 mm2. The IZ area was significantly correlated with the retinal and outer nuclear layer (ONL) volumes within the macula. CONCLUSIONS:The cone IZ area could be measured using a commercially available OCT system. The IZ area showed high variability among healthy adults, and this might be related to the variability in the photoreceptor distribution in healthy adults.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Gu R,Deng G,Jiang Y,Jiang C,Xu Gdoi
10.1186/s12886-018-0862-7subject
Has Abstractpub_date
2018-08-01 00:00:00pages
188issue
1issn
1471-2415pii
10.1186/s12886-018-0862-7journal_volume
18pub_type
杂志文章abstract：BACKGROUND:The influence of serous retinal detachment (SRD) on retinal sensitivity in patients with branch retinal vein occlusion (BRVO) and macular edema remains unclear. This is despite the frequent co-existence of SRD and cystoid macular edema (CME) in BRVO patients on optical coherence tomography (OCT) and the fact...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-11-29
更新日期：2011-09-26 00:00:00
abstract：BACKGROUND:The performance of glaucoma diagnostic systems could be conceivably improved by the integration of functional and structural test measurements that provide relevant and complementary information for reaching a diagnosis. The purpose of this study was to investigate the performance of data fusion methods and ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-11-20
更新日期：2011-08-04 00:00:00
abstract：BACKGROUND:A cyclodialysis cleft often leads to direct communication between the anterior chamber and the suprachoroidal space. It is a rare condition that is encountered with blunt trauma, and less commonly, after surgery. Hypotony is the major sequelae that may lead to hypotonous maculopathy, optic disc edema, cornea...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01375-3
更新日期：2020-03-23 00:00:00
abstract：BACKGROUND:With age, the human lens accumulates variety of substances that absorbs and fluorescence, which explains the color of yellow, brunescent and nigrescent cataract in terms of aging. The aim of this study was to assess lens fluorophores with properties comparable to those of advanced glycated end products (AGEs...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-6-10
更新日期：2006-03-06 00:00:00
abstract：BACKGROUND:To report the prevalence of ocular abnormalities and investigate visual acuity in a large cohort of retinitis pigmentosa (RP) patients in Western China. METHODS:The medical records and ophthalmic examination reports of 2127 eyes of 1065 RP patients at one eye hospital were retrospectively reviewed to determ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01797-z
更新日期：2021-01-18 00:00:00
abstract：BACKGROUND:To compare the efficacy of phacoemulsification (PKE) combined with nonpenetrating deep sclerectomy (NPDS) with mitomycin C (MMC) versus XEN® gel stent with MMC. METHODS:In this nonrandomized, retrospective, comparative, single-center pilot study, 105 consecutive eyes of 75 patients with uncontrolled primary...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01492-z
更新日期：2020-06-16 00:00:00
abstract：BACKGROUND:To present a case of conjunctival lymphoma in a young woman complicated by pregnancy. CASE PRESENTATION:A 38-year-old previously healthy woman presented with a 2-year history of progressive right blepharoptosis. Giant papillomatous sessile masses were identified in the upper and lower fornix bilaterally and...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-017-0518-z
更新日期：2017-07-27 00:00:00
abstract：BACKGROUND:To screen for visual impairment in Malaysian preschool children. METHODS:Visual screening was conducted in 400 preschool children aged 4 to 6 years. The screening involved two basic procedures; the distant visual acuity test using the Sheridan Gardiner chart and the depth perception test using the Langs ste...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-13-16
更新日期：2013-04-19 00:00:00
abstract：BACKGROUND:To predict the effectiveness of topical glaucoma medications based on initial uniocular and binocular treatment. To test a traditional hypothesis that effectiveness following a uniocular trial is associated with the change in IOP in the initially treated eye minus the change in the initially untreated eye. T...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-7-17
更新日期：2007-10-05 00:00:00
abstract：BACKGROUND:Acute acquired comitant esotropia (AACE) is a type of strabismus characterized by a sudden onset of large angle esotropia with diplopia, which often occurs in children after infancy, teenagers, and young adolescents. However, studies on the surgical outcomes of only adults are rare. The purpose of this artic...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01793-3
更新日期：2021-01-18 00:00:00
abstract：BACKGROUND:Idiopathic orbital pseudotumour is rare in children. We report a case of bilateral paediatric idiopathic orbital pseudotumour and review the characteristics of this case. CASE PRESENTATION:A 14-year-old female patient presented at our Department of Pulmonary and Critical Care Medicine (PCCM) with complaints...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01718-0
更新日期：2020-11-16 00:00:00
abstract：BACKGROUND:Older drivers have a crash rate nearly equal to that of young drivers whose crash rate is the highest among all age groups. Contrast sensitivity impairment is common in older adults. The purpose of this study is to examine whether parameters from the photopic and mesopic contrast sensitivity functions (CSF) ...
journal_title：BMC ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1186/s12886-020-1331-7
更新日期：2020-02-04 00:00:00
abstract：BACKGROUND:There is no generally accepted medical or surgical treatment to stop the progressive course of retinitis pigmentosa. Previous studies have suggested lutein as a potential treatment with positive effects on macular pigment density. The objective of this study was to examine the effect of lutein supplementatio...
journal_title：BMC ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-2415-6-23
更新日期：2006-06-07 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the efficacy and safety of transepithelial corneal collagen crosslinking (transepithelial CXL) versus standard corneal collagen crosslinking (epithelium-off CXL) on keratoconus. METHODS:Eligible studies were identified by systematically searching PubMed, the Cochrane Li...
journal_title：BMC ophthalmology
pub_type： 杂志文章,meta分析,评审
doi：10.1186/s12886-017-0657-2
更新日期：2017-12-28 00:00:00
abstract：BACKGROUND:To examine the clinical features of acute acquired comitant esotropia (AACE) and to evaluate the clinical effectiveness of a single injection of botulinum toxin type A (BTXA) on binocular visual function (BVF). METHODS:This retrospective, observational case series study enrolled patients with AACE examined ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01739-9
更新日期：2020-11-25 00:00:00
abstract：BACKGROUND:Because latanoprost and the original formulation of travoprost that included benzalkonium chloride (BAK) have been shown to be similar with regard to tolerability, we compared initial topical intraocular pressure (IOP)-lowering medication change rates in patients newly treated with latanoprost or travoprost-...
journal_title：BMC ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2415-11-13
更新日期：2011-06-13 00:00:00
abstract：BACKGROUND:Sclopetaria is a rare ophthalmic finding in trauma CASE PRESENTATION:This is a report of a patient who developed macular holes from sclopetaria induced by indirect trauma. A 22-year-old male, suffered a gunshot wound that passed behind his eyes, resulting in bilateral macular hole formation CONCLUSION:To o...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-10-6
更新日期：2010-03-19 00:00:00
abstract：BACKGROUND:Since the normative value of the retinal macular thickness is undocumented in the Middle East, the aim of this work is to assess the normative values of the macular thickness in healthy eyes in a Middle Eastern population and its relationship with age, sex, and laterality. METHODS:One hundred sixteen indivi...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01391-3
更新日期：2020-04-07 00:00:00
abstract：BACKGROUND:Recently, instruments for the measurement of wavefront aberration in the living human eye have been widely available for clinical applications. Despite the extensive background experience on wavefront sensing for research purposes, the information derived from such instrumentation in a clinical setting shoul...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-4-1
更新日期：2004-02-11 00:00:00
abstract：BACKGROUND:Previous techniques resulted with low rates of successful fusion after the surgeries and high necessity of additional surgeries in the treatment of thyroid orbitopathy related strabismus. In this study, reviewing the results of our patients who had surgical correction with relaxed muscle positioning techniqu...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0974-0
更新日期：2018-11-23 00:00:00
abstract：BACKGROUND:The ability to image wide fundus fields and to conduct swift, non-invasive examinations is increasingly important with the escalation in patients with diabetic retinopathy (DR). METHODS:Fifty eyes of 28 consecutive patients with DR were examined in this prospective observational study. A total of 46 eyes, 2...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-1011-z
更新日期：2018-12-20 00:00:00
abstract：BACKGROUND:A description of the diagnostic features of Miller Fisher syndrome. CASE PRESENTATION:The clinical presentation, investigation, and subsequent progress of our patient with clinical unilateral external ophthalmoplegia. CONCLUSION:Our case demonstrates the presentation of clinical unilateral external ophthal...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-7-7
更新日期：2007-04-17 00:00:00
abstract：BACKGROUND:To investigate the 3-month postoperative performance and safety after implantation of a trifocal intraocular lens (IOL) in a Korean population. METHODS:This was a clinical, prospective, multicenter, single-arm study. Forty-four subjects (88 eyes) with bilateral cataract with expected postoperative corneal a...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01549-z
更新日期：2020-07-15 00:00:00
abstract：BACKGROUND:Retinoblastoma (RB) is the most frequent pediatric retinal tumor. In the present study, to elucidate chemoresistance mechanisms and identify potential biomarkers in RB, we utilized RNA sequencing (RNAseq) technological platforms to reveal transcriptome profiles and identify any differentially expressed genes...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01348-6
更新日期：2020-03-06 00:00:00
abstract：BACKGROUND:Bone marrow transplantation retinopathy is a rare condition affecting the posterior pole. The purpose of this case report is to highlight the possible risk factors and clinical features. CASE PRESENTATION:A 19y old male with relapsed and refractory acute lymphoblastic leukaemia was admitted under haematolog...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0855-6
更新日期：2018-09-14 00:00:00
abstract：BACKGROUND:To understand the clinical and economic outcomes of treatments for managing complications of ischemic central retinal vein occlusion (iCRVO). METHODS:We conducted a systematic literature review by searching multiple databases and ophthalmology conferences from 2004 to 2015. Studies published in English lang...
journal_title：BMC ophthalmology
pub_type： 杂志文章,评审
doi：10.1186/s12886-016-0282-5
更新日期：2016-07-11 00:00:00
abstract：BACKGROUND:Proliferative retinopathy is an uncommon feature of Vogt Koyanagi Harada (VKH) disease which might indicate poor uveitis control in these patients. We aim to describe the clinical features and outcome of management of proliferative retinopathy in 2 patients with VKH. CASE PRESENTATION:19 and 33 years old fe...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01736-y
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:To report a patient who presented with bluish scleral discoloration, keratoconus, and progressive high myopia. CASE PRESENTATION:A 6-year-old Chinese female patient presented with a significant bluish discoloration of the sclera in both eyes and extreme corneal thinning with anterior corneal protrusion. Gen...
journal_title：BMC ophthalmology
pub_type： 杂志文章,评审
doi：10.1186/s12886-018-0903-2
更新日期：2018-09-18 00:00:00
abstract：BACKGROUND:This study compared the postoperative outcomes of 27-gauge (G) and 25-G vitrectomy performed for the treatment of idiopathic epiretinal membrane (ERM). METHODS:The study design was single center, retrospective, interventional case series. Two hundred consecutive eyes that underwent primary vitrectomy for ER...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-017-0585-1
更新日期：2017-10-10 00:00:00
abstract：BACKGROUND:To evaluate results after seven years using prophylactic intracameral cefazolin for the prevention of endophthalmitis in cataract surgery. METHODS:A prospective, observational study of all patients submitted to cataract surgery over the period January 1996 to December 2009. All cases of postoperative endoph...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-12-2
更新日期：2012-01-24 00:00:00
