Abstract:
BACKGROUND:To evaluate the effectiveness of intravitreal bevacizumab (IVB) and intravitreal ranibizumab (IVR) in actual practice for treating patients with retinal diseases in Thailand. METHODS:A prospective, multi-centre, observational study was conducted among eight hospitals in their ophthalmology outpatient departments. Participants consisted of patients who had previously not received any IVB or IVR treatment between 2013 and 2014. The primary outcome measurement was the change in best-corrected visual acuity (BCVA) at the end of the follow-up period compared to baseline. RESULTS:There were 1629 treatment-naïve patients for the pro re nata (PRN) treatment pattern and 226 treatment-naive patients for the three-injections (3Inj) treatment pattern. BCVA improvements were found in 35% of the PRN group and 47% of the 3Inj group; however, it was not clinically meaningful between the IVB and IVR groups (P-value = 0.568 for PRN, P-value = 0.103 for 3Inj). A multivariable logistic regression (using the propensity score) showed that positive factors associated with vision improvement for the PRN pattern were the number of drug injections, having retinal vein occlusion, and under 60 years of age, while good BCVA at baseline was a negative predictive factor. For the 3Inj pattern, under 60 years of age and baseline BCVA were statistically significant predictors. Nonetheless, diabetes mellitus (DM) without other comorbidities was a statistically significant predictor of low response to vision improvement compared to DM with other comorbidities. CONCLUSIONS:This study was the first observational, prospective study to evaluate the real-life effectiveness of IVB and IVR in Thailand. The majority of participants who used IVB or IVR showed improvements in BCVA after treatment. Further evaluation such as long-term follow-ups and subsequent comparison of effectiveness between IVB and IVR should be investigated due to the limited sample of IVR patients. TRIAL REGISTRATION:Thai Clinical Trial Registry TCTR20141002001 . Registered 02 October 2014 (retrospectively registered).
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Kumluang S,Ingsrisawang L,Sangroongruangsri S,Chaikledkaew U,Ratanapakorn T,Ruamviboonsuk P,Taweebanjongsin W,Choovuthayakorn J,Thoongsuwan S,Hanutsaha P,Kulvichit K,Ratanapojnard T,Wongsawad W,Leelahavarong P,Teerawattananondoi
10.1186/s12886-019-1086-1subject
Has Abstractpub_date
2019-03-29 00:00:00pages
82issue
1issn
1471-2415pii
10.1186/s12886-019-1086-1journal_volume
19pub_type
杂志文章,多中心研究abstract:BACKGROUND:Adenovirus (Ad), associated with significant morbidity, has no topical treatment. A leading CTC compound (CTC-96), a Co(III) chelate, was found to have potent in vitro and in vivo antiviral efficacy against herpes viruses. In this study CTC-96 is being tested for possible anti-Adenovirus activity. METHODS:T...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-6-22
更新日期:2006-06-05 00:00:00
abstract:BACKGROUND:The gold standard treatments in amblyopia are penalizing therapies, such as patching or blurring vision with atropine that are aimed at forcing the use of the amblyopic eye. However, in the last years, new therapies are being developed and validated, such as dichoptic visual training, aimed at stimulating th...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0501-8
更新日期:2017-06-28 00:00:00
abstract:BACKGROUND:The performance of glaucoma diagnostic systems could be conceivably improved by the integration of functional and structural test measurements that provide relevant and complementary information for reaching a diagnosis. The purpose of this study was to investigate the performance of data fusion methods and ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-11-20
更新日期:2011-08-04 00:00:00
abstract:BACKGROUND:Patients with primary angle closure/glaucoma (PAC/PACG) with extensive peripheral anterior synechiae (PAS), and coexisting cataract, increasingly have been treated with phacoemulsification combined with goniosynechialysis (Phaco-GSL). Since the mechanisms of acute and chronic PAC/PACG may differ, the treatme...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1070-9
更新日期:2019-03-04 00:00:00
abstract:BACKGROUND:Aiming at spectacle independence, conventional pseudophakic monovision has been widely used in myopia patients with bilateral monofocal intraocular lens implantation. However, the crossed monovision, which is to correct the dominant eye for near vision and the non-dominant eye for distant vision, has been me...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01694-5
更新日期:2020-11-16 00:00:00
abstract:BACKGROUND:Tibetan Plateau is a highland area with special geographical location, time zone, and ethnic composition. We herein report the rationale, methodology and baseline data of the school-based childhood cohort study named Lhasa Childhood Eye Study (LCES), with the primary objective to pursue a comprehensive under...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01522-w
更新日期:2020-06-22 00:00:00
abstract:BACKGROUND:To report a case of multiple evanescent white dot syndrome (MEWDS) following simultaneous rabies vaccination. CASE PRESENTATION:Review of the clinical, laboratory, photographic, optical coherence tomographic (OCT), fundus autofluorescent, angiographic, electrophysiologic, and perimetric records of a patient...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0968-y
更新日期:2018-12-07 00:00:00
abstract:BACKGROUND:The short-term effects of intravitreal ranibizumab (IVR) on diabetic macular edema (DME) remains unclear. We assessed the short-term effects of IVR on DME. METHODS:Eighteen eyes of 14 patients with DME were enrolled in this prospective interventional case series. After intravitreal ranibizumab was injected ...
journal_title:BMC ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12886-017-0420-8
更新日期:2017-03-14 00:00:00
abstract:BACKGROUND:Highly aggressive Burkitt lymphoma (BL) with rapidly progressive painful proptosis of the right eye is rarely encountered. CASE PRESENTATION:A 31-year-old Caucasian female presented with rapidly progressive painful proptosis of the right eye and poor visual acuity. Diagnostic Computer tomography, magnetic r...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-109
更新日期:2014-09-08 00:00:00
abstract:BACKGROUND:The presence of an intraocular cilium is very rare and the response of the eye to the cilium is variable. We present the case of a patient with a cilium found in the vitreous cavity during vitrectomy for rhegmatogenous retinal detachment 40 years following penetrating eye injury. To our knowledge, this is th...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0010-6
更新日期:2015-03-12 00:00:00
abstract:BACKGROUND:Ocular hypotony results in an increased break down of the blood-aqueous barrier and an increase in inflammatory mediator release. We postulate that this release may lead to an increased risk of trabeculectomy failure through increased bleb scarring. This study was designed to try to address the question if h...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-5-7
更新日期:2005-04-05 00:00:00
abstract:BACKGROUND:Glaucoma is a progressive disease responsible for the second commonest cause of blindness in the UK. Identifying appropriate patients for hospital care remains an ongoing challenge for all UK hospital glaucoma services. The purpose of our study is to evaluate accuracy and outcome of community optometry refer...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0161-5
更新日期:2015-12-07 00:00:00
abstract:BACKGROUND:Monocular infantile blindness may be associated with bilateral horizontal nystagmus, a subtype of fusion maldevelopment nystagmus syndrome (FMNS). Patients often adopt a significant anomalous head posture (AHP) towards the fixing eye in order to dampen the nystagmus. This clinical entity has also been report...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-137
更新日期:2014-11-20 00:00:00
abstract:BACKGROUND:Previous studies described cases of Ocriplasmin injections in patients with vitreo-macular traction and reduced central visual acuity. We describe the first case of a patient with 20/20 visual acuity and vitreo-macular traction treated with Ocriplasmin, and, for the first time in literature, we evaluated the...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0141-9
更新日期:2015-10-29 00:00:00
abstract:BACKGROUND:To report a patient who presented with bluish scleral discoloration, keratoconus, and progressive high myopia. CASE PRESENTATION:A 6-year-old Chinese female patient presented with a significant bluish discoloration of the sclera in both eyes and extreme corneal thinning with anterior corneal protrusion. Gen...
journal_title:BMC ophthalmology
pub_type: 杂志文章,评审
doi:10.1186/s12886-018-0903-2
更新日期:2018-09-18 00:00:00
abstract:BACKGROUND:To compare corneal hysteresis (CH) measurements between patients with glaucoma, ocular hypertension (OHT) and glaucoma-like optic discs (GLD)- defined as a cup to disc ratio greater than or equal to 0.6 with normal intraocular pressure (IOP) and visual fields. The secondary aim was to investigate whether cor...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0396-9
更新日期:2017-01-10 00:00:00
abstract:BACKGROUND:A patient's health literacy is fundamental for navigating the health system and managing disease. This study aimed to compare the health literacy levels of patients with chronic retinal disease in Denmark. METHODS:This cross-sectional questionnaire study used the validated HLS-EU-Q16 questionnaire to determ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1191-1
更新日期:2019-08-08 00:00:00
abstract:BACKGROUND:The aim of this study was to prove the relationship between the intraocular straylight level and diabetic retinopathy (DR) according to disease severity. Also, we aimed to evaluate whether diabetes mellitus (DM) per se could be a risk factor of increased intraocular straylight although we did not rely on a d...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0120-1
更新日期:2015-10-13 00:00:00
abstract:BACKGROUND:The Heimann-Bielschowsky phenomenon (HBP) is an underrecognized condition characterized by slow, pendular, vertical oscillations of the eye accompanying monocular vision loss. Hypotropic dissociated vertical deviation (DVD) is another rare condition induced by asymmetric visual input. This report documents a...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01502-0
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:Artificial iris anterior chamber implants were originally developed for therapeutic purposes but have been used recently for the cosmetic alteration of eye colour. There is a growing body of evidence surrounding their associated risks. We report a case presenting with complications secondary to bilateral New...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0084-1
更新日期:2015-08-08 00:00:00
abstract:BACKGROUND:Central Serous Chorioretinopathy (CSC) has been previously reported as an infrequent complication of pregnancy that usually resolves spontaneously after delivery, with minimal or no sequel. We report a case of a severe form of CSC in an uncomplicated pregnancy with extensive subfoveal exudates and severe per...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0169-x
更新日期:2015-12-22 00:00:00
abstract:BACKGROUND:To report a case series in which a modified technique was used to remove retained submacular perfluorocarbon liquid (PFCL) secondary to vitreoretinal surgery for rhegmatogenous retinal detachment. CASE PRESENTATION:Four patients who had undergone pars plana vitrectomy for rhegmatogenous retinal detachment w...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0798-y
更新日期:2018-06-04 00:00:00
abstract:BACKGROUND:This study compared the postoperative outcomes of 27-gauge (G) and 25-G vitrectomy performed for the treatment of idiopathic epiretinal membrane (ERM). METHODS:The study design was single center, retrospective, interventional case series. Two hundred consecutive eyes that underwent primary vitrectomy for ER...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0585-1
更新日期:2017-10-10 00:00:00
abstract:BACKGROUND:There is no generally accepted medical or surgical treatment to stop the progressive course of retinitis pigmentosa. Previous studies have suggested lutein as a potential treatment with positive effects on macular pigment density. The objective of this study was to examine the effect of lutein supplementatio...
journal_title:BMC ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2415-6-23
更新日期:2006-06-07 00:00:00
abstract:BACKGROUND:Patients' feedback is of great importance in health care policy decisions. The Consumer Quality Index Cataract Questionnaire (CQI Cataract) was used to measure patients' experiences with quality of care after a cataract operation. This study aims to evaluate the reliability and the dimensional structure of t...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-7-14
更新日期:2007-09-19 00:00:00
abstract:BACKGROUND:Differences in the increase in matrix metalloproteinase (MMP) and decrease in tissue inhibitor of metalloproteinase (TIMP) activity may contribute to the different characteristics observed clinically on decreased intraocular pressure in patients with glaucoma or ocular hypertension. The purpose of this study...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0202-8
更新日期:2016-03-08 00:00:00
abstract:BACKGROUND:To report the prevalence of ocular abnormalities and investigate visual acuity in a large cohort of retinitis pigmentosa (RP) patients in Western China. METHODS:The medical records and ophthalmic examination reports of 2127 eyes of 1065 RP patients at one eye hospital were retrospectively reviewed to determ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01797-z
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND:Suture exposure remains to be a potential problem of transscleral fixated posterior chamber intraocular lens (PCIOL). We report a modified technique to minimize the risk of suture exposure for the transscleral fixation of PCIOL. METHODS:The modified surgical technique is as following: at first, two 3 mm × 4...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0118-8
更新日期:2015-10-02 00:00:00
abstract:BACKGROUND:The signaling pathway of epithelial to mesenchymal transition (EMT) is regulated by c-Src kinase in many cells. The purpose of this study was to investigate the effects of c-Src kinase on EMT of human lens epithelial cells in vivo stimulated by different factors. METHODS:Human lens epithelial cells, HLE-B3,...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1229-4
更新日期:2019-11-08 00:00:00
abstract:BACKGROUND:To investigate the corneal biomechanical changes in primary open angle glaucoma (POAG) patients treated with long-term prostaglandin analogue (PGA). METHODS:One hundred eleven newly diagnosed POAG patients, including 43 high tension glaucoma (HTG) and 68 normal tension glaucoma (NTG), were measured by Corvi...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01693-6
更新日期:2020-10-20 00:00:00