Abstract:
BACKGROUND:Tibetan Plateau is a highland area with special geographical location, time zone, and ethnic composition. We herein report the rationale, methodology and baseline data of the school-based childhood cohort study named Lhasa Childhood Eye Study (LCES), with the primary objective to pursue a comprehensive understanding on the longitudinal trends of refractive error as well as other ocular diseases and to address the differences between Tibetan Plateau and other parts of the world. METHODS:Grade one students from primary schools in Lhasa were cluster randomly selected. They were examined and would be conducted with follow-up annually for 5 years. The examination procedures for LCES consisted of standardized ocular, systematic examinations, and questionnaires, identical to the Anyang Childhood Eye Study (ACES) conducted in central China. RESULTS:One thousand nine hundred two Grade one students eligible for the LCES, 1856 (97.58%) participated in the study, with a mean age of 6.83 ± 0.46 years (range 5.89-10.32 years), and the proportions of male to be 53.02%. 1762 (94.93%) of the 1856 participants in the baseline exam were Tibetans. 1837 (98.98%) of the students examined had cycloplegic autorefraction performed. The numbers of hyperopia, emmetropia, myopia, and high myopia were 127 (6.91%), 1639 (89.22%), 71 (3.86%) and 3 (0.16%) respectively. Compared with ACES, students from LCES baseline had a younger age (p < 0.001), lower cycloplegic spherical equivalent (p < 0.001), similar myopia prevalence (p = 0.886), lower hyperopia prevalence (p < 0.001), and a higher emmetropia prevalence (p < 0.001). CONCLUSIONS:LCES was a school-based cohort study in Tibetan Plateau with a high baseline response rate. A higher emmetropic trend was found in LCES compared with ACES. Continuous documentation of this cohort might potentially provide useful reference information for the areas of China which was previously not well studied. TRIAL REGISTRATION:The study has finished the clinical registration on Chinese Clinical Trial Registry. (ChiCTR1900026693).
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Chen W,Fu J,Meng Z,Li L,Su H,Dai W,Yao Ydoi
10.1186/s12886-020-01522-wsubject
Has Abstractpub_date
2020-06-22 00:00:00pages
250issue
1issn
1471-2415pii
10.1186/s12886-020-01522-wjournal_volume
20pub_type
杂志文章abstract:BACKGROUND:Endogenous endophthalmitis could lead to a devastating outcome without a prompt and appropriate management. We report a case of advanced endogenous Klebsiella pneumoniae endophthalmitis with extensive subretinal abscess that was successfully treated with a vitrectomy. CASE PRESENTATION:A systemically well 6...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0908-x
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abstract:BACKGROUND:Anterior chamber depth (ACD) is becoming a hot topic and plays an important role in correcting the refractive errors (REs) after cataract surgery. The aim of this study was to assess the ACD changes and their relationship with the REs after phacoemulsification and intraocular lens (IOL) implantation in patie...
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pub_type: 杂志文章
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更新日期:2018-02-27 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章,随机对照试验
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journal_title:BMC ophthalmology
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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abstract:BACKGROUND:Adolescent KC is a special segment of the general KC population because an adolescents's eyes are still susceptible to blurred vision and optical defocus during the sensitive period of ocular and visual development. In the present study, we evaluated the ocular dimensions of 53 KC adolescents. METHODS:One h...
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更新日期:2018-02-13 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-2415-6-32
更新日期:2006-10-11 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2019-01-08 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12886-020-01567-x
更新日期:2020-09-03 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-10-02 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-07-11 00:00:00
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pub_type: 杂志文章
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更新日期:2014-07-02 00:00:00
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pub_type: 杂志文章
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更新日期:2012-06-06 00:00:00
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更新日期:2018-11-23 00:00:00
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pub_type: 杂志文章
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更新日期:2016-06-06 00:00:00
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pub_type: 杂志文章,meta分析,评审
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