Abstract:
BACKGROUND:The gold standard treatments in amblyopia are penalizing therapies, such as patching or blurring vision with atropine that are aimed at forcing the use of the amblyopic eye. However, in the last years, new therapies are being developed and validated, such as dichoptic visual training, aimed at stimulating the amblyopic eye and eliminating the interocular supression. PURPOSE:To evaluate the effect of dichoptic visual training using a virtual reality head mounted display in a sample of anisometropic amblyopic adults and to evaluate the potential usefulness of this option of treatment. METHODS:A total of 17 subjects (10 men, 7 women) with a mean age of 31.2 years (range, 17-69 year) and anisometropic amblyopia were enrolled. Best corrected visual acuity (BCVA) and stereoacuity (Stereo Randot graded circle test) changes were evaluated after 8 sessions (40 min per session) of dichoptic training with the computer game Diplopia Game (Vivid Vision) run in the Oculus Rift OC DK2 virtual reality head mounted display (Oculus VR). RESULTS:Mean BCVA in amblyopic eye improved significantly from a logMAR value of 0.58 ± 0.35 before training to a post-training value of 0.43 ± 0.38 (p < 0.01). Forty-seven percent of the participants achieved BCVA of 20/40 or better after the training as compared to 30% before the training. Mean stereoacuity changed from a value of 263.3 ± 135.1 before dichoptic training to a value of 176.7 ± 152.4 s of arc after training (p < 0.01). A total of 8 patients (47.1%) before dichoptic treatment had unmeasurable stereoacuity while this only occurred in 2 patients (11.8%) after training. CONCLUSIONS:Dichoptic training using a virtual reality head mounted display seems to be an effective option of treatment in adults with anisometropic amblyopia. Future clinical trials are needed to confirm this preliminary evidence. TRIAL REGISTRATION:Trial ID: ISRCTN62086471 . Date registered: 13/06/2017. Retrospectively registered.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Žiak P,Holm A,Halička J,Mojžiš P,Piñero DPdoi
10.1186/s12886-017-0501-8subject
Has Abstractpub_date
2017-06-28 00:00:00pages
105issue
1issn
1471-2415pii
10.1186/s12886-017-0501-8journal_volume
17pub_type
杂志文章abstract:BACKGROUND:To report the successful treatment of ocular toxoplasmosis and present the use of multimodal imaging to describe the changes in ocular toxoplasmic lesions subsequent to treatment. CASE PRESENTATION:A 73-year-old female visited the clinic with decreased visual acuity in the left eye. Fundus examination showe...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1209-8
更新日期:2019-09-05 00:00:00
abstract:BACKGROUND:Dry eye is a common problem that affects many people worldwide, reducing quality of life and impacting daily activities. A qualitative approach often used in medicine and other disciplines is used to evaluate how people with dry eye cope with this impact. METHODS:Six focus group sessions were conducted at t...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0671-z
更新日期:2018-01-16 00:00:00
abstract:BACKGROUND:To evaluate the correlation between visual acuity improvement and vision-related QOL after ranibizumab treatment in Japanese patients with AMD. METHODS:In this one-year prospective, interventional, open-label, multicenter study involving four sites, patients with neovascular AMD were enrolled and observed f...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-021-01816-7
更新日期:2021-01-23 00:00:00
abstract:BACKGROUND:With age, the human lens accumulates variety of substances that absorbs and fluorescence, which explains the color of yellow, brunescent and nigrescent cataract in terms of aging. The aim of this study was to assess lens fluorophores with properties comparable to those of advanced glycated end products (AGEs...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-6-10
更新日期:2006-03-06 00:00:00
abstract:BACKGROUND:To report a case of disseminated fusariosis with endogenous endophthalmitis in a patient with acute lymphoblastic leukemia. Transfusion-associated immune modulation secondary to platelet transfusion could play an important role in the pathophysiology of this case. CASE PRESENTATION:A 9 year-old male with ac...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-11-30
更新日期:2011-11-02 00:00:00
abstract:BACKGROUND:To report a case of late closure of idiopathic full-thickness macular hole (FTMH) after vitrectomy with the inverted internal limiting membrane (ILM) technique. CASE PRESENTATION:A 68-year-old lady with a stage IV FTMH underwent pars plana vitrectomy with 25 gauge plus transconjunctival system, ILM peeling ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0104-1
更新日期:2015-08-26 00:00:00
abstract:BACKGROUND:Previous analyses of real-life data indicated that injection frequency and health care costs did not differ for anti-VEGF treatment with aflibercept and ranibizumab. The objective of this study was to investigate whether this finding persisted when analysing a longer time period after licensing. METHODS:Ret...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0617-x
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:Characterization of the neuro-glial profile of cells growing out of human idiopathic epiretinal membranes (iERMs) and testing their proliferative and pluripotent properties ex vivo is needed to better understand the pathogenesis of their formation. METHODS:iERMs obtained during uneventful vitrectomies were ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-165
更新日期:2014-12-23 00:00:00
abstract:BACKGROUND:To assess the reliability of the measurements obtained with the PalmScan, when compared with another standardized A-mode ultrasound device, and assess the consistency and correlation between the two methods. METHODS:Transversal, descriptive, and comparative study. We recorded the axial length (AL), anterior...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-10-8
更新日期:2010-03-24 00:00:00
abstract:BACKGROUND:The purpose of this study is to determine whether the lifestyle and body stature are significantly associated with the axial length (AL) of the eyes of Japanese third grade students. METHODS:A prospective, cross sectional, observational study was performed on 122 third grade students consisting of 61 boys a...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0519-y
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:To report a rare case of bilateral Purtscher-like retinopathy in a Chinese female patient with dermatomyositis. CASE PRESENTATION:An 18-year-old woman with lower extremity muscle weakness was admitted due to decreased vision of both eyes for two weeks. Ophthalmic examination revealed violaceous eruption on ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-13-36
更新日期:2013-07-24 00:00:00
abstract:BACKGROUND:To report a case of multiple evanescent white dot syndrome (MEWDS) following simultaneous rabies vaccination. CASE PRESENTATION:Review of the clinical, laboratory, photographic, optical coherence tomographic (OCT), fundus autofluorescent, angiographic, electrophysiologic, and perimetric records of a patient...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0968-y
更新日期:2018-12-07 00:00:00
abstract:BACKGROUND:To examine the clinical features of acute acquired comitant esotropia (AACE) and to evaluate the clinical effectiveness of a single injection of botulinum toxin type A (BTXA) on binocular visual function (BVF). METHODS:This retrospective, observational case series study enrolled patients with AACE examined ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01739-9
更新日期:2020-11-25 00:00:00
abstract:BACKGROUND:A cyclodialysis cleft often leads to direct communication between the anterior chamber and the suprachoroidal space. It is a rare condition that is encountered with blunt trauma, and less commonly, after surgery. Hypotony is the major sequelae that may lead to hypotonous maculopathy, optic disc edema, cornea...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01375-3
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:Acute acquired comitant esotropia (AACE) is a type of strabismus characterized by a sudden onset of large angle esotropia with diplopia, which often occurs in children after infancy, teenagers, and young adolescents. However, studies on the surgical outcomes of only adults are rare. The purpose of this artic...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01793-3
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND:Proliferative retinopathy is an uncommon feature of Vogt Koyanagi Harada (VKH) disease which might indicate poor uveitis control in these patients. We aim to describe the clinical features and outcome of management of proliferative retinopathy in 2 patients with VKH. CASE PRESENTATION:19 and 33 years old fe...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01736-y
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:There is no generally accepted medical or surgical treatment to stop the progressive course of retinitis pigmentosa. Previous studies have suggested lutein as a potential treatment with positive effects on macular pigment density. The objective of this study was to examine the effect of lutein supplementatio...
journal_title:BMC ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2415-6-23
更新日期:2006-06-07 00:00:00
abstract:BACKGROUND:The effectiveness of ranibizumab in the treatment of diabetic macular edema has been proven with large clinical trials. For bevacizumab only two clinical trials have been published and a head-to-head comparison is lacking to date. However, if proved non-inferior to ranibizumab, use of the off-label bevacizum...
journal_title:BMC ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12886-015-0043-x
更新日期:2015-07-07 00:00:00
abstract:BACKGROUND:To evaluate results after seven years using prophylactic intracameral cefazolin for the prevention of endophthalmitis in cataract surgery. METHODS:A prospective, observational study of all patients submitted to cataract surgery over the period January 1996 to December 2009. All cases of postoperative endoph...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-12-2
更新日期:2012-01-24 00:00:00
abstract:BACKGROUND:To report a case of branch retinal artery occlusion (BRAO) secondary to high-altitude exposure and diabetic retinopathy (DR), and to characterize the retinal changes before and after hyperbaric oxygen (HBO) treatment. CASE PRESENTATION:We present a case of a 42-year-old man with DR who travelled to Tibet (i...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01563-1
更新日期:2020-07-11 00:00:00
abstract:BACKGROUND:The purpose of this study was to identify the genetic cause and describe the clinical phenotype of Schnyder corneal dystrophy (SCD) in six unrelated probands. METHODS:We identified two white Czech, two white British and two South Asian families with a clinical diagnosis of SCD. Ophthalmic assessment include...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0918-8
更新日期:2018-09-17 00:00:00
abstract:BACKGROUND:Endogenous endophthalmitis could lead to a devastating outcome without a prompt and appropriate management. We report a case of advanced endogenous Klebsiella pneumoniae endophthalmitis with extensive subretinal abscess that was successfully treated with a vitrectomy. CASE PRESENTATION:A systemically well 6...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0908-x
更新日期:2018-09-05 00:00:00
abstract:BACKGROUND:With the diabetes mellitus (DM) prevalence increasing annually, the human grading of retinal images to evaluate DR has posed a substantial burden worldwide. SmartEye is a recently developed fundus image processing and analysis system with lesion quantification function for DR screening. It is sensitive to th...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1196-9
更新日期:2019-08-14 00:00:00
abstract:BACKGROUND:To assess the socio-demographic and health-related risk factors associated with cataract subtypes in Korea. METHODS:A total of 11,591 participants (aged ≥40 years) were selected from the Korean National Health and Nutrition Examination Survey between 2008 and 2010. The Korean Ophthalmologic Society conducte...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-4
更新日期:2014-01-10 00:00:00
abstract:BACKGROUND:Combined branch retinal artery and central retinal vein occlusion is a rare condition that has been infrequently reported. This case report, aside from reporting the above-mentioned condition, highlights the importance of performing spectral domain optical coherence tomography in establishing a complete diag...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-91
更新日期:2014-07-12 00:00:00
abstract:BACKGROUND:The tear film breakup time (tBUT) is a clinical evaluation of evaporative dry eye disease assessed by instilling topical fluorescein into the eyes. In the present study, we introduce a new diagnostic test, blinking tolerance time (BTT), for self-evaluation of tear-film stability. We compared the results with...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01686-5
更新日期:2020-11-04 00:00:00
abstract:BACKGROUND:Nocardia infection is uncommon in clinical practice, with most cases occuring as the result of opportunistic infection in immunocompromsed patients. Here, we report a case of disseminated nocardiosis with subretinal abscess in a patient with nephrotic syndrome, and whom is receiving immunosuppressive therapy...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0883-2
更新日期:2018-09-03 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the efficacy and safety of transepithelial corneal collagen crosslinking (transepithelial CXL) versus standard corneal collagen crosslinking (epithelium-off CXL) on keratoconus. METHODS:Eligible studies were identified by systematically searching PubMed, the Cochrane Li...
journal_title:BMC ophthalmology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12886-017-0657-2
更新日期:2017-12-28 00:00:00
abstract:BACKGROUND:Graves' disease is a common autoimmune inflammatory condition of the thyroid. About one in four of affected patients also develop orbital symptoms like exophthalmos, proptosis and diplopia - called Graves' Ophthalmopathy. Not all patients respond well to the standard therapy of systemic glucocorticoid admini...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0718-1
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:Silicone oil tamponade is more frequently reserved for cases of complex retinal detachment. We describe the effects of different variations in oil ratios with the relatively unknown technique of double oil tamponade. METHODS:Retrospective case note review of nine patients with complex rhegmatogenous retinal...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0660-7
更新日期:2017-12-28 00:00:00